DK278488A - Cycliske peptider med antikoagulerende virkning - Google Patents

Cycliske peptider med antikoagulerende virkning

Info

Publication number
DK278488A
DK278488A DK278488A DK278488A DK278488A DK 278488 A DK278488 A DK 278488A DK 278488 A DK278488 A DK 278488A DK 278488 A DK278488 A DK 278488A DK 278488 A DK278488 A DK 278488A
Authority
DK
Denmark
Prior art keywords
cyclic peptides
anticoagulative effect
anticoagulative
effect
cyclic
Prior art date
Application number
DK278488A
Other languages
Danish (da)
English (en)
Other versions
DK278488D0 (da
Inventor
John L Krstenansky
Simon J T Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK278488D0 publication Critical patent/DK278488D0/da
Publication of DK278488A publication Critical patent/DK278488A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK278488A 1987-05-21 1988-05-20 Cycliske peptider med antikoagulerende virkning DK278488A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5316987A 1987-05-21 1987-05-21

Publications (2)

Publication Number Publication Date
DK278488D0 DK278488D0 (da) 1988-05-20
DK278488A true DK278488A (da) 1988-11-22

Family

ID=21982364

Family Applications (1)

Application Number Title Priority Date Filing Date
DK278488A DK278488A (da) 1987-05-21 1988-05-20 Cycliske peptider med antikoagulerende virkning

Country Status (17)

Country Link
EP (1) EP0291982B1 (fr)
JP (1) JP2858249B2 (fr)
KR (1) KR970010926B1 (fr)
CN (1) CN88103015A (fr)
AT (1) ATE91490T1 (fr)
AU (1) AU613627B2 (fr)
CA (1) CA1340646C (fr)
DE (1) DE3882279T2 (fr)
DK (1) DK278488A (fr)
ES (1) ES2058176T3 (fr)
FI (1) FI89063C (fr)
HU (1) HU198513B (fr)
IL (1) IL86438A (fr)
NO (1) NO882238L (fr)
NZ (1) NZ224678A (fr)
PT (1) PT87536B (fr)
ZA (1) ZA883443B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2026377A1 (fr) * 1989-10-03 1991-04-04 John L. Krstenansky Peptides anticoagulants avec marqueur radioactif
AU641215B2 (en) * 1990-02-13 1993-09-16 Merrell Dow Pharmaceuticals Inc. Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
FR2667071A1 (fr) * 1990-09-26 1992-03-27 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
SE468628B (sv) * 1991-11-26 1993-02-22 Flaekt Ab Saett att reglera stroempulsmatningen till en elektrostatisk stoftavskiljare
GB9303275D0 (en) * 1993-02-18 1993-04-07 Ciba Geigy Ag Pharmaceutical compositions
CA2144523A1 (fr) * 1993-08-04 1995-02-16 Hugo Grossenbacher Desulfatohirudine de masse moleculaire elevee
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten

Also Published As

Publication number Publication date
DE3882279T2 (de) 1993-10-28
JPS63303996A (ja) 1988-12-12
AU1634288A (en) 1988-11-24
HUT46933A (en) 1988-12-28
IL86438A0 (en) 1988-11-15
EP0291982A2 (fr) 1988-11-23
JP2858249B2 (ja) 1999-02-17
HU198513B (en) 1989-10-30
FI882358A (fi) 1988-11-22
ZA883443B (en) 1988-11-16
ES2058176T3 (es) 1994-11-01
CA1340646C (fr) 1999-07-13
NZ224678A (en) 1990-08-28
PT87536A (pt) 1989-05-31
FI89063B (fi) 1993-04-30
ATE91490T1 (de) 1993-07-15
CN88103015A (zh) 1988-12-21
FI89063C (fi) 1993-08-10
EP0291982A3 (en) 1990-07-11
IL86438A (en) 1992-11-15
KR970010926B1 (ko) 1997-07-02
DK278488D0 (da) 1988-05-20
DE3882279D1 (de) 1993-08-19
NO882238D0 (no) 1988-05-20
KR880013976A (ko) 1988-12-22
NO882238L (no) 1988-11-22
EP0291982B1 (fr) 1993-07-14
AU613627B2 (en) 1991-08-08
FI882358A0 (fi) 1988-05-19
PT87536B (pt) 1992-09-30

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Legal Events

Date Code Title Description
ATS Application withdrawn