DK2777050T3 - Systemer og fremgangsmåder til tilvejebringelse af overladningsbeskyttelse i ka-pacitivt koblede biomedicinske elektroder - Google Patents
Systemer og fremgangsmåder til tilvejebringelse af overladningsbeskyttelse i ka-pacitivt koblede biomedicinske elektroder Download PDFInfo
- Publication number
- DK2777050T3 DK2777050T3 DK12778009.6T DK12778009T DK2777050T3 DK 2777050 T3 DK2777050 T3 DK 2777050T3 DK 12778009 T DK12778009 T DK 12778009T DK 2777050 T3 DK2777050 T3 DK 2777050T3
- Authority
- DK
- Denmark
- Prior art keywords
- composite material
- composite
- conductive particles
- conductive
- electrically conductive
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 17
- 239000000463 material Substances 0.000 claims abstract description 126
- 239000002131 composite material Substances 0.000 claims abstract description 105
- 239000002245 particle Substances 0.000 claims abstract description 99
- 239000011230 binding agent Substances 0.000 claims abstract description 36
- 238000010168 coupling process Methods 0.000 claims abstract description 8
- 230000008878 coupling Effects 0.000 claims abstract description 7
- 238000005859 coupling reaction Methods 0.000 claims abstract description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 29
- 229910052799 carbon Inorganic materials 0.000 claims description 17
- 239000004020 conductor Substances 0.000 claims description 10
- 239000002071 nanotube Substances 0.000 claims description 6
- 229910002804 graphite Inorganic materials 0.000 claims description 5
- 239000010439 graphite Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims description 3
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims 3
- 230000005684 electric field Effects 0.000 abstract description 31
- 230000001070 adhesive effect Effects 0.000 description 30
- 239000000853 adhesive Substances 0.000 description 28
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 21
- 238000012360 testing method Methods 0.000 description 19
- 238000001962 electrophoresis Methods 0.000 description 16
- 239000010410 layer Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000002609 medium Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 238000005054 agglomeration Methods 0.000 description 9
- 230000002776 aggregation Effects 0.000 description 9
- 239000000017 hydrogel Substances 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 239000003522 acrylic cement Substances 0.000 description 5
- 239000002041 carbon nanotube Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920002799 BoPET Polymers 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 229910021393 carbon nanotube Inorganic materials 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000000151 deposition Methods 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- -1 e.g. Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000003989 dielectric material Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000000469 dry deposition Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000002646 transcutaneous electrical nerve stimulation Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B1/00—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
- H01B1/14—Conductive material dispersed in non-conductive inorganic material
- H01B1/18—Conductive material dispersed in non-conductive inorganic material the conductive material comprising carbon-silicon compounds, carbon or silicon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/276—Protection against electrode failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/251—Means for maintaining electrode contact with the body
- A61B5/257—Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes
- A61B5/259—Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes using conductive adhesive means, e.g. gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/277—Capacitive electrodes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B1/00—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
- H01B1/20—Conductive material dispersed in non-conductive organic material
- H01B1/24—Conductive material dispersed in non-conductive organic material the conductive material comprising carbon-silicon compounds, carbon or silicon
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B3/00—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties
- H01B3/002—Inhomogeneous material in general
- H01B3/004—Inhomogeneous material in general with conductive additives or conductive layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
- A61B2562/0214—Capacitive electrodes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Inorganic Chemistry (AREA)
- Conductive Materials (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Materials For Medical Uses (AREA)
- Electrotherapy Devices (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Non-Insulated Conductors (AREA)
- Organic Chemistry (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Carbon And Carbon Compounds (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geology (AREA)
Claims (15)
1. Medicinsk kompositmateriale, som reagerer på et elektrisk vekselfelt, og som tilvejebringer kapacitiv kobling via kompositmaterialet, kendetegnet ved, at det biomedicinske kompositmateriale omfatter et bindemiddelmateriale, et polmateriale, som er i alt væsentligt dispergeret i bindemiddelmaterialet, og elektrisk ledende partikler i bindemiddelmaterialet, hvorved polmaterialet reagerer på tilstedeværelsen af et elektrisk vekselfelt, og hvorved de elektrisk ledende partikler ikke er af tilstrækkelig koncentration til at danne et ledende netværk igennem kompositmaterialet.
2. Kompositmateriale ifølge krav 1, hvorved bindemiddelmaterialet omfatter et polymerisk materiale.
3. Kompositmateriale ifølge krav 1, hvorved de elektrisk ledende partikler omfatter et hvilket som helst af carbonpulver, -spåner, -granuler eller -nanorør.
4. Kompositmateriale ifølge krav 3, hvorved carbonen foreligger i form af grafit.
5. Kompositmateriale ifølge krav 1, hvorved de elektrisk ledende partikler har massefylder, der ligger i intervallet fra ca. 0,35 g/cm3 til ca. 1,20 g/cm3.
6. Kompositmateriale ifølge krav 1, hvorved de elektrisk ledende partikler har massefylder, der ligger i intervallet fra ca. 0,5 g/cm3 til ca. 1,0 g/cm3.
7. Kompositmateriale ifølge krav 1, hvorved de ledende partiklers overfladeenergi er højere end bindemiddelmaterialets overfladeenergi.
8. Kompositmateriale ifølge krav 1, hvorved de ledende partikler er vilkårligt fordelte i kompositmaterialet.
9. Kompositmateriale ifølge krav 1, hvorved de ledende partikler er tilvejebragt i kompositmaterialet i et ordnet arrangement.
10. Kompositmateriale ifølge krav 1, hvorved det har et ledende lag, som er dannet af carbon.
11. Kompositmateriale ifølge krav 1, hvorved det har et ledende lag, som ikke indeholder sølv/sølvchlorid.
12. Kompositmateriale ifølge krav 1, hvorved det har et antal fobindelsestyper til elektronisk kobling til overvågningsudstyr.
13. Kompositmateriale ifølge krav 1, hvorved bindemiddelmaterialet og polmaterialet udviser indbyrdes molekylær forenelighed, og hvorved de elektrisk ledende partikler forbliver i alt væsentligt isoleret fra hinanden i bindemiddelmaterialet.
14. Kompositmateriale ifølge krav 13, hvorved de elektrisk ledende partikler omfatter et hvilket som helst af carbonpulver, -spåner, -granuler eller -nanorør.
15. Kompositmateriale ifølge krav 13, hvorved de elektrisk ledende partikler har massefylder, der ligger i intervallet fra ca. 0,5 g/cm3 til ca. 1,0 g/cm3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/272,545 US8673184B2 (en) | 2011-10-13 | 2011-10-13 | Systems and methods for providing overcharge protection in capacitive coupled biomedical electrodes |
| PCT/US2012/059654 WO2013055857A1 (en) | 2011-10-13 | 2012-10-11 | Systems and methods for providing overcharge protection in capacitive coupled biomedical electrodes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2777050T3 true DK2777050T3 (da) | 2018-05-07 |
Family
ID=47073542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12778009.6T DK2777050T3 (da) | 2011-10-13 | 2012-10-11 | Systemer og fremgangsmåder til tilvejebringelse af overladningsbeskyttelse i ka-pacitivt koblede biomedicinske elektroder |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8673184B2 (da) |
| EP (1) | EP2777050B1 (da) |
| JP (3) | JP6054974B2 (da) |
| KR (2) | KR101743090B1 (da) |
| CN (2) | CN104011805B (da) |
| AU (2) | AU2012322780B2 (da) |
| CA (2) | CA2987188C (da) |
| DK (1) | DK2777050T3 (da) |
| ES (1) | ES2665825T3 (da) |
| NO (1) | NO2660189T3 (da) |
| PL (1) | PL2777050T3 (da) |
| WO (1) | WO2013055857A1 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NO333507B1 (no) * | 2009-06-22 | 2013-06-24 | Condalign As | Fremgangsmate for a lage et anisotropisk, ledende lag og en derav frembrakt gjenstand |
| US9818499B2 (en) * | 2011-10-13 | 2017-11-14 | Flexcon Company, Inc. | Electrically conductive materials formed by electrophoresis |
| CN108949772A (zh) * | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| AU2013243954A1 (en) * | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| CN104828804B (zh) * | 2015-03-25 | 2017-01-25 | 清华大学 | 一种多孔碳纳米管‑炭球形复合材料的制备方法 |
| JP2017057256A (ja) * | 2015-09-15 | 2017-03-23 | リンテック株式会社 | 導電性粘着シート |
| US11058314B1 (en) | 2016-07-12 | 2021-07-13 | Mahesh M. Galgalikar | Remote individual monitoring, training and recording system |
| EP4125590A1 (en) | 2020-03-25 | 2023-02-08 | Flexcon Company, Inc. | Isotropic non-aqueous electrode sensing material |
| WO2022046405A1 (en) * | 2020-08-28 | 2022-03-03 | Specialty Electronic Materials Belgium, Srl | Electrically conductive compositions |
| MX2024002361A (es) | 2021-08-31 | 2024-03-07 | Novocure Gmbh | Montaje de electrodo que comprende capa de material anisotropico y capa de contacto de piel que comprende compuesto de adhesivo conductivo. |
| EP4631562A3 (en) | 2021-11-17 | 2025-12-10 | Novocure GmbH | Electrode assembly with non-hydrogel conductive adhesive layer |
| US20230166119A1 (en) | 2021-11-30 | 2023-06-01 | Novocure Gmbh | Devices, Systems, And Methods For Applying Tumor-Treating Fields |
| IL312122A (en) | 2021-12-17 | 2024-06-01 | Novocure Gmbh | Systems and methods for removing and replacing conductive adhesive layers of an electrode array |
| US20230310850A1 (en) | 2022-03-31 | 2023-10-05 | Novocure Gmbh | Devices, Systems, And Methods For Applying Tumor-Treating Fields |
| KR20240168972A (ko) | 2022-03-31 | 2024-12-02 | 노보큐어 게엠베하 | 천공된 이방성 층을 가지는 전극 어셈블리, 및 이를 사용하여 종양 처리장을 인가하는 시스템 및 그 방법 |
| US12496438B2 (en) | 2022-06-28 | 2025-12-16 | Novocure Gmbh | Apparatus comprising dielectric layer coupled to anisotropic layer |
| US20240100321A1 (en) | 2022-09-22 | 2024-03-28 | Novocure Gmbh | Electrode Assembly With Filler Structure Between Electrode Elements |
| US20240108881A1 (en) | 2022-09-29 | 2024-04-04 | Novocure Gmbh | Flexible Electrode Arrays |
| IL322625A (en) | 2023-03-31 | 2025-10-01 | Novocure Gmbh | Devices, systems, and assemblies for removing and replacing electrode assembly sub-assemblies |
| CN121398880A (zh) | 2023-06-30 | 2026-01-23 | 诺沃库勒有限责任公司 | 具有由柔性耦合器耦合在一起的电极阵列子组件的装置 |
| US20250205477A1 (en) | 2023-12-20 | 2025-06-26 | Novocure Gmbh | Devices, Systems, And Methods For Removing And Replacing A Subassembly Of An Electrode Assembly |
| TW202547574A (zh) | 2024-03-15 | 2025-12-16 | 瑞士商諾沃庫勒有限責任公司 | 用於施加交流電場之降低阻抗轉換器陣列及其生產與使用方法 |
| US20250303142A1 (en) | 2024-03-29 | 2025-10-02 | Novocure Gmbh | Electrode Assembly With Fluoroelastomer |
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-
2011
- 2011-10-13 US US13/272,545 patent/US8673184B2/en active Active
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2012
- 2012-10-11 WO PCT/US2012/059654 patent/WO2013055857A1/en not_active Ceased
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- 2012-10-11 EP EP12778009.6A patent/EP2777050B1/en active Active
- 2012-10-11 KR KR1020147012827A patent/KR101743090B1/ko active Active
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- 2012-10-11 JP JP2014535852A patent/JP6054974B2/ja active Active
- 2012-10-11 DK DK12778009.6T patent/DK2777050T3/da active
- 2012-10-11 PL PL12778009T patent/PL2777050T3/pl unknown
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- 2012-10-11 KR KR1020177014559A patent/KR101966121B1/ko active Active
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2016
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| Publication number | Publication date |
|---|---|
| JP2017021371A (ja) | 2017-01-26 |
| WO2013055857A1 (en) | 2013-04-18 |
| EP2777050B1 (en) | 2018-01-17 |
| US20140124711A1 (en) | 2014-05-08 |
| KR20140103913A (ko) | 2014-08-27 |
| CN107230513B (zh) | 2020-06-12 |
| CN104011805A (zh) | 2014-08-27 |
| KR20170063985A (ko) | 2017-06-08 |
| PL2777050T3 (pl) | 2018-07-31 |
| US20130092882A1 (en) | 2013-04-18 |
| JP6054974B2 (ja) | 2016-12-27 |
| ES2665825T3 (es) | 2018-04-27 |
| CA2852025C (en) | 2018-03-06 |
| CA2987188A1 (en) | 2013-04-18 |
| CA2987188C (en) | 2019-07-09 |
| NO2660189T3 (da) | 2018-02-10 |
| AU2012322780B2 (en) | 2016-01-28 |
| CA2852025A1 (en) | 2013-04-18 |
| US9899121B2 (en) | 2018-02-20 |
| JP6216854B2 (ja) | 2017-10-18 |
| CN104011805B (zh) | 2017-04-26 |
| AU2012322780A1 (en) | 2014-05-01 |
| KR101743090B1 (ko) | 2017-06-02 |
| AU2016202623A1 (en) | 2016-05-19 |
| JP2017059544A (ja) | 2017-03-23 |
| US8673184B2 (en) | 2014-03-18 |
| KR101966121B1 (ko) | 2019-04-05 |
| JP2015504569A (ja) | 2015-02-12 |
| CN107230513A (zh) | 2017-10-03 |
| EP2777050A1 (en) | 2014-09-17 |
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