DK2708145T3 - Næringssammensætninger til anvendelse i fremgangsmåder til at modulere corticosteronniveauer hos psykologisk stressede individer - Google Patents
Næringssammensætninger til anvendelse i fremgangsmåder til at modulere corticosteronniveauer hos psykologisk stressede individer Download PDFInfo
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- DK2708145T3 DK2708145T3 DK12382354.4T DK12382354T DK2708145T3 DK 2708145 T3 DK2708145 T3 DK 2708145T3 DK 12382354 T DK12382354 T DK 12382354T DK 2708145 T3 DK2708145 T3 DK 2708145T3
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- nutritional
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- fucosyl
- lactose
- powder
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Claims (15)
1. Næringssammensætning omfattende 2-fucosyl-laktose til anvendelse i forebyggelse, kontrol, reduktion eller behandling af angst- eller stressrelaterede responser eller aggressivitet associeret med en hyperaktivering af hypothalamus-hypofyse-binyre-respons i et dyr.
2. Næringssammensætning ifølge krav 1, hvori de angst- eller stressrelaterede responser eller aggressivitet er associeret med overproduktionen af corticosteron som følge af det hyperaktiverede hypothalamus-hypofyse-binyre-respons i dyret.
3. Næringssammensætning ifølge krav 1, hvori næringssammensætningen er en væske og omfatter fra 0,001 mg/ml til 20 mg/ml 2-fucosyl-laktose, eller fra 0,001 mg/ml til 10 mg/ml 2-fucosyl-laktose.
4. Næringssammensætning ifølge krav 1, hvori næringssammensætningen er en væske og omfatter fra 0,001 mg/ml til 5 mg/ml 2-fucosyl-laktose.
5. Næringssammensætning ifølge krav 1, hvori næringssammensætningen er et pulver og omfatter fra 0,0005 vægt% til 5 vægt% 2-fucosyl-laktose af pulverets vægt.
6. Næringssammensætning ifølge krav 1, hvori næringssammensætningen er et pulver og omfatter fra 0,01 vægt% til 1 vægt% 2-fucosyl-laktose af pulverets vægt.
7. Næringssammensætning ifølge krav 1, hvori næringssammensætningen yderligere omfatter mindst ét af fedt, protein og kulhydrat.
8. Næringssammensætning ifølge krav 1, hvori næringssammensætningen er en modermælkserstatning.
9. Næringssammensætning omfattende 2-fucosyl-laktose til anvendelse i forebyggelse, kontrol, reduktion eller behandling af sindsstemningslidelser eller depression associeret med overproduktion af corticosteron i et individ.
10. Næringssammensætning ifølge krav 9, hvori næringssammensætningen er en væske og omfatter fra 0,001 mg/ml til 20 mg/ml 2-fucosyl-laktose.
11. Næringssammensætning ifølge krav 9, hvori næringssammensætningen er en væske og omfatter fra 0,001 mg/ml til 10 mg/ml 2-fucosyl-laktose.
12. Næringssammensætning ifølge krav 9, hvori næringssammensætningen er en væske og omfatter fra 0,001 mg/ml til 5 mg/ml 2-fucosyl-laktose.
13. Næringssammensætning ifølge krav 9, hvori næringssammensætningen er et pulver og omfatter fra 0,0005 vægt% til 5 vægt% 2-fucosyl-laktose af pulverets vægt.
14. Næringssammensætning ifølge krav 9, hvor næringssammensætningen er et pulver og omfatter fra 0,01 vægt% til 1 vægt% 2-fucosyl-laktose af pulverets vægt.
15. Næringssammensætning omfattende 2-fucosyl-laktose til anvendelse ved modulering, forebyggelse, kontrol, reduktion eller behandling af ændringer i adfærd associeret med overproduktion af corticosteron i et individ.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382354.4A EP2708145B1 (en) | 2012-09-14 | 2012-09-14 | Nutritional compositions for use in methods for modulating corticosterone levels in psychologically stressed individuals |
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| DK12382354.4T DK2708145T3 (da) | 2012-09-14 | 2012-09-14 | Næringssammensætninger til anvendelse i fremgangsmåder til at modulere corticosteronniveauer hos psykologisk stressede individer |
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| US (3) | US10398716B2 (da) |
| EP (1) | EP2708145B1 (da) |
| CN (1) | CN104780781B (da) |
| BR (1) | BR112015005758A2 (da) |
| CA (1) | CA2884487C (da) |
| DK (1) | DK2708145T3 (da) |
| ES (1) | ES2572831T3 (da) |
| HK (1) | HK1195856A1 (da) |
| IL (1) | IL237589A0 (da) |
| MX (1) | MX369453B (da) |
| MY (1) | MY182944A (da) |
| PH (1) | PH12015500545A1 (da) |
| SG (1) | SG11201501976SA (da) |
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| ES2572831T3 (es) * | 2012-09-14 | 2016-06-02 | Abbott Laboratories | Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico |
| EP3704957A1 (en) | 2012-09-14 | 2020-09-09 | Abbott Laboratories | Methods for increasing brain functionality using 2-fucosyl-lactose |
| DK2934189T3 (da) | 2012-12-18 | 2019-11-25 | Abbott Lab | Humane mælkeoligosaccharider til reduktion af stress-symptomer |
| EP3469912A1 (en) * | 2012-12-20 | 2019-04-17 | Abbott Laboratories | Nutritional formulations using human milk oligosaccharides for modulating inflammation |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| US10828313B2 (en) | 2014-12-08 | 2020-11-10 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| US20160287637A1 (en) * | 2014-12-08 | 2016-10-06 | Glycom A/S | Synthetic composition and method for modulating emotion and mood disorders |
| CN108348535B (zh) | 2015-10-28 | 2021-08-31 | 格礼卡姆股份公司 | 用于调节脑功能和行为的合成组合物和方法 |
| EP3368047B1 (en) * | 2015-10-28 | 2023-04-26 | Glycom A/S | Synthetic composition and method for modulating emotion and mood disorders |
| WO2017215722A1 (en) * | 2016-06-15 | 2017-12-21 | Glycom A/S | Synthetic composition comprising hmo and method for modulating emotion and mood disorders |
| WO2018157900A1 (en) * | 2017-03-01 | 2018-09-07 | Glycom A/S | Synthetic composition for microbiota modulation |
| US20180333426A1 (en) * | 2017-05-17 | 2018-11-22 | Mead Johnson Nutrition Company | Nutritional composition with human milk oligosaccharides and uses thereof |
| WO2024052406A1 (en) * | 2022-09-06 | 2024-03-14 | Inbiose N.V. | Baked nutritional compositions comprising human milk oligosaccharides |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09509847A (ja) * | 1994-03-09 | 1997-10-07 | アボツト・ラボラトリーズ | 人乳化乳 |
| US5891689A (en) | 1994-04-12 | 1999-04-06 | Innovir Laboratories, Inc. | Heme-bearing microparticles for targeted delivery of drugs |
| WO1996009299A1 (en) | 1994-09-20 | 1996-03-28 | The Regents Of The University Of California | Drugs to improved synaptic transmission |
| CA2281706C (en) | 1997-02-21 | 2008-08-05 | Abbott Laboratories | Methods and compositions for reducing the incidence of necrotizing enterocolitis |
| US6365218B1 (en) | 2000-02-04 | 2002-04-02 | Abbott Laboratories | Pediatric formula and methods for providing nutrition and improving tolerance |
| US6811801B2 (en) | 2001-12-12 | 2004-11-02 | Abbott Laboratories | Methods and compositions for brightening the color of thermally processed nutritionals |
| US20110104716A1 (en) | 2003-08-08 | 2011-05-05 | Hasan Mohejeri | Novel method for screening brain-active compounds |
| US7897637B2 (en) | 2006-07-19 | 2011-03-01 | The Salk Institute For Biological Studies | Methods of using flavonoids to enhance memory |
| EP2072052A1 (en) * | 2007-12-17 | 2009-06-24 | Nestec S.A. | Prevention of opportunistic infections in immune-compromised subjects |
| MY160376A (en) * | 2008-11-03 | 2017-03-15 | Nestec Sa | A nutritional composition comprising probiotics and improving sleep patterns |
| US9012625B2 (en) | 2009-04-07 | 2015-04-21 | Glycom A/S | Method for the synthesis of a trisaccharide |
| JP2012532195A (ja) * | 2009-07-06 | 2012-12-13 | チルドレンズ ホスピタル メディカル センター | 乳オリゴ糖による炎症の阻害 |
| RU2530641C2 (ru) | 2009-07-15 | 2014-10-10 | Н.В. Нютрисиа | Фукозиллактоза в качестве неусвояемого олигосахарида, идентичного грудному молоку, с новой функциональной пользой |
| NZ612386A (en) | 2010-12-31 | 2015-02-27 | Abbott Lab | Synbiotic combination of probiotic and human milk oligosaccharides to promote growth of beneficial microbiota |
| SG191792A1 (en) | 2010-12-31 | 2013-08-30 | Abbott Lab | Human milk oligosaccharides for modulating inflammation |
| CN103379908B (zh) * | 2010-12-31 | 2020-02-14 | 雅培制药有限公司 | 使用人乳寡糖、维生素c和抗炎剂减少氧化应激的发病率的方法 |
| WO2012092157A2 (en) | 2010-12-31 | 2012-07-05 | Abbott Laboratories | Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof |
| WO2012092156A1 (en) * | 2010-12-31 | 2012-07-05 | Abbott Laboratories | Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human milk oligosaccharides |
| SG10201707519PA (en) | 2010-12-31 | 2017-10-30 | Abbott Lab | Neutral human milk oligosaccharides to promote growth of beneficial bacteria |
| AU2012215042B2 (en) | 2011-02-10 | 2016-01-14 | Société des Produits Nestlé S.A. | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk |
| CN103889238B (zh) | 2011-10-18 | 2017-10-13 | 雀巢产品技术援助有限公司 | 用于脑生长和/或认知和/或心理运动发育的组合物 |
| ES2572831T3 (es) | 2012-09-14 | 2016-06-02 | Abbott Laboratories | Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico |
| EP3704957A1 (en) | 2012-09-14 | 2020-09-09 | Abbott Laboratories | Methods for increasing brain functionality using 2-fucosyl-lactose |
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