DK2652479T3 - Måleudstyr til kvantitativ optisk evaluering af en kemisk reaktion - Google Patents

Måleudstyr til kvantitativ optisk evaluering af en kemisk reaktion Download PDF

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DK2652479T3
DK2652479T3 DK11799157.0T DK11799157T DK2652479T3 DK 2652479 T3 DK2652479 T3 DK 2652479T3 DK 11799157 T DK11799157 T DK 11799157T DK 2652479 T3 DK2652479 T3 DK 2652479T3
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sample
layer
light
photosensitive sensor
photodetectors
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DK11799157.0T
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Max Sonnleitner
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Greiner Bio One Gmbh
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
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    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • B01L2300/046—Function or devices integrated in the closure
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7783—Transmission, loss
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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  • Optical Measuring Cells (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Claims (21)

1. Måleudstyr (1) til kvantitativ optisk evaluering af en kemisk reaktion, omfattende prøvebærer (2) med et bærelag (3) og et prøvelag (4), en fotosensitiv føler (5) med en flerhed af fotodektektorer (6) på et bærelegeme samt et transparent dæklag (7) arrangeret over fotodetektorerne (6), hvilket bærelag (3) omfatter et leveringsafsnit (22), et mikrofluidisk system (10) og et reservoir (24), hvilken leveringssektion (22) er tilsluttet reservoiret (24) via det mikrofluidiske system (10), hvor det mikrofluidiske system (10) omfatter en kanal (23), og prøvelaget (4) har en analyseside (8) og overfor sidstnævnte en lysudgangsside (14), hvor der på analysesiden (8) er arrangeret en flerhed af testafsnit (9) i indbyrdes afstand i prøvelagets (2) længderetning, og prøvelaget (4) er arrangeret med analysesiden (8) på bærelaget (3) sådan, at testafsnittene (9) vender mod et volumen af det mikrofluidiske system (10), og hvor prøvebæreren (2) er arrangeret aftagelig i en optagelsesindretning (20), sådan at lysudgangssiden (14) vender mod den fotosensitive føler (5), hvor testafsnittene (9) er arrangeret over fotodetektorerne (6), og hvor afstanden (11) mellem testafsnittene (9) og fotodetektorerne (6) er mindre end 700 pm, og hvor mindst 99,5% af den elektromagnetiske stråling, der kommer fra et testafsnit (9) og når den fotosensitive føler (5), falder ind på højst tre fotodetektorer (6).
2. Måleudstyr ifølge krav 1, kendetegnet ved, at dæklagets (7) tykkelse (12) er mindre end 500 pm.
3. Måleudstyr ifølge krav 1 eller 2, kendetegnet ved, at prøvelagets (4) tykkelse (13) er mindre end 200 pm.
4. Måleudstyr ifølge et af krav 1 til 3, kendetegnet ved, at mellemrummet mellem to tilstødende fotodetektorer (6) er mindre end 150 pm.
5. Måleudstyr ifølge et af krav 1 til 4, kendetegnet ved, at kanalen (23) i det mikrofluidiske system (10) arrangeret over fotodetektoren (5) har en længde på 30 - 50 mm, en bredde på 1 - 4 mm og en højde på 10 - 200 pm.
6. Måleudstyr ifølge et af krav 1 til 5, kendetegnet ved, at ved aflægning af en prøve på leveringssektionen (22) i kanalen (23) dannes en trykgradient med en resulterende kapillærkraft i retning af reservoiret (24).
7. Maleudstyr ifølge et af krav 1 til 6, kendetegnet ved, at centerafstanden mellem to tilstødende testafsnit (9) er større end eller lig med 3 gange centerafstanden af fotodetektorerne (6).
8. Måleudstyr ifølge et af krav 1 til 7, kendetegnet ved, at grænsefladen (43) af kanalen (23) arrangeret overfor den fotosensitive føler (5) er konfigureret til at være optisk reflekterende, og/eller at bærelaget (3) er udformet optisk reflekterende.
9. Måleudstyr ifølge et af krav 1 til 8, kendetegnet ved, at kanalen (23) har et konkavt tværsnit i forhold til den fotosensitive føler (5), eller at kanalen (23) er udformet konkav i nogle afsnit i længderetningen.
10. Måleudstyr ifølge et af krav 1 til 9, kendetegnet ved, at lysudgangssiden (14) har en lysafbøjende struktur i det mindste afsnitsvist.
11. Måleudstyr ifølge et af krav 1 til 10, kendetegnet ved, at prøvelaget (4) i retning af sin tykkelse i det mindst afsnitsvist har et brydningsindekstrinprofil eller et brydningsindeksgradientprofil.
12. Måleudstyr ifølge et af krav 1 til 11, kendetegnet ved, at et immersionslag er påført lysudgangssiden (14) eller dæklaget (7).
13. Måleudstyr ifølge et af krav 1 til 12, kendetegnet ved, at et identitets- eller identifikationsmærke (41) er arrangeret på prøvebæreren (2).
14. Måleudstyr ifølge et af krav 1 til 13, kendetegnet ved, at prøvelaget (4) og/eller bærelaget (3) er konfigureret som en optisk polarisator.
15. Måleapparat (26) til optisk evaluering af en kemisk reaktion, omfattende et måleudstyr (1), som er konfigureret ifølge et af krav 1 til 14, med en fotosensitiv føler (5) og en prøvebærer (2), et basislegeme (27), en dækhætte (28), som kan svinges om en svingakse (29) mellem en måleposition og en udtagningsposition (30), endvidere et styremodul (37) til at behandle lysstyrkeinformation registreret af føleren (5), hvor den fotosensitive føler (5) er arrangeret i basislegemet (27), og hvor dækhætten (28) i målepositionen lukker prøvebæreren (2) og et afsnit af basislegemet (27) lystæt mod omgivelserne.
16. Måleapparat ifølge krav 15, kendetegnet ved, at en belysningsindretning (40) er tilvejebragt i dækhætten (28).
17. Måleapparat ifølge krav 16, kendetegnet ved, at belysningsindretningen (49) på selektiv styrbar måde udsender lys i en flerhed af bølgelængder og/eller til forskellige positioner.
18. Måleapparat ifølge krav 16 eller 17, kendetegnet ved, at belysningsindretningen (49) omfatter en polarisator.
19. Måleapparat ifølge krav 15 eller 18, kendetegnet ved, at der i dækhætten (28) eller basislegemet (27) er arrangeret en udledningsindretning (35) for reagenser.
20. Måleapparat ifølge krav 19, kendetegnet ved, at udledningsindretningen (35) omfatter et aktiveringselement (36) og et depot (33) for reagenser.
21. Måleapparat ifølge krav 15 eller 20, kendetegnet ved, at dækhætten (28) omfatter et tilførselsafsnit (34), som har kontakt med prøvebærerens (2) leveringsafsnit (22).
DK11799157.0T 2010-12-14 2011-12-14 Måleudstyr til kvantitativ optisk evaluering af en kemisk reaktion DK2652479T3 (da)

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ATA2066/2010A AT510750B1 (de) 2010-12-14 2010-12-14 Messanordnung zur quantitativen optischen auswertung einer chemischen reaktion
PCT/EP2011/072763 WO2012080339A1 (de) 2010-12-14 2011-12-14 Messanordnung zur quantitativen optischen auswertung einer chemischen reaktion

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EP (1) EP2652479B1 (da)
CN (1) CN103430011B (da)
AT (1) AT510750B1 (da)
BR (1) BR112013014930B1 (da)
DK (1) DK2652479T3 (da)
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT514210B1 (de) 2013-04-25 2016-08-15 Greiner Bio-One Gmbh Dispenser-befülltes mikrofluidisches Testsystem und Verfahren dazu
CN103808710A (zh) * 2014-01-21 2014-05-21 曹际娟 化学发光检测设备和方法
EP3315963A1 (de) * 2016-10-26 2018-05-02 Fuchs Petrolub SE Probenaufnahmeelement, analysenset und verfahren zur analyse eines liquids, insbesondere einer kühlschmierstoffemulsion
WO2018170412A1 (en) * 2017-03-16 2018-09-20 Case Western Reserve University Biochip having microchannel provided with capturing agent for performing cytological analysis
US10053059B1 (en) * 2017-10-04 2018-08-21 Ford Global Technologies, Llc Detection and identification of opaqueness of vehicle windows
CN111408549B (zh) * 2020-03-24 2022-05-27 广东长盈精密技术有限公司 一种检验铜箔焊接效果的装置及方法
WO2022019919A1 (en) * 2020-07-24 2022-01-27 Hewlett-Packard Development Company, L.P. Plasmonic sensors with microfluidic channels
AT525192A1 (de) 2021-06-15 2023-01-15 Genspeed Biotech Gmbh Mikrofluidischer chip

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK142388A (da) * 1987-03-17 1988-09-18 Diagnostic Systems Inc Fremgangsmaade og apparat til detektering af analyter i fluidumproever, navnlig glucose i legemesvaesker
ZA948782B (en) * 1993-11-12 1996-05-07 Unipath Ltd Reading devices and assay devices for use therewith
DE19611347A1 (de) * 1996-03-22 1997-09-25 Boehringer Mannheim Gmbh System zur quantitativen ortsaufgelösten Auswertung von Testelementen
US6784982B1 (en) * 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
US6949377B2 (en) * 2001-03-05 2005-09-27 Ho Winston Z Chemiluminescence-based microfluidic biochip
JP2003098068A (ja) * 2001-09-25 2003-04-03 Hitachi Ltd 平面型セル及びそれを用いた分析装置
US7524459B2 (en) 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
US7122153B2 (en) * 2003-01-08 2006-10-17 Ho Winston Z Self-contained microfluidic biochip and apparatus
CA2468014C (en) * 2003-06-04 2016-03-22 Inverness Medical Switzerland Gmbh Flow sensing for determination of assay results
AT500855B1 (de) 2004-09-08 2006-04-15 Bioident Biometric Technologie Vorrichtung zum auswerten biochemischer proben
US7524672B2 (en) 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
US7280201B2 (en) * 2004-12-17 2007-10-09 Avago Technologies General Ip Pte Ltd Sensor having integrated light detector and/or light source
FR2892196B1 (fr) * 2005-10-18 2008-06-20 Genewave Soc Par Actions Simpl Procede de fabrication d'un biocapteur a detection integree
JP2009516162A (ja) * 2005-11-11 2009-04-16 モレキュラー・ビジョン・リミテッド マイクロ流体装置
AT504919B1 (de) * 2007-02-15 2008-09-15 Nanoident Technologies Ag Durchlichtmessvorrichtung
GB0820889D0 (en) * 2008-11-14 2008-12-24 Univ St Andrews Optical detection system
DK2510335T3 (da) * 2009-12-07 2016-09-05 Meso Scale Technologies Llc Testkassette

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CN103430011B (zh) 2015-09-16
EP2652479B1 (de) 2014-10-15
CN103430011A (zh) 2013-12-04
AT510750B1 (de) 2012-09-15
US9557260B2 (en) 2017-01-31
PL2652479T3 (pl) 2015-03-31
AT510750A1 (de) 2012-06-15
ES2526075T3 (es) 2015-01-05
EP2652479A1 (de) 2013-10-23
US20130294973A1 (en) 2013-11-07
BR112013014930B1 (pt) 2021-05-25
BR112013014930A2 (pt) 2016-09-13
WO2012080339A1 (de) 2012-06-21

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