DK2650008T3 - Anvendelse af cellepermeable peptidinhibitorer af JNK-signaltransduktionsvejen til behandlingen af forskellige cancersygdomme - Google Patents

Anvendelse af cellepermeable peptidinhibitorer af JNK-signaltransduktionsvejen til behandlingen af forskellige cancersygdomme Download PDF

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DK2650008T3
DK2650008T3 DK13002793.1T DK13002793T DK2650008T3 DK 2650008 T3 DK2650008 T3 DK 2650008T3 DK 13002793 T DK13002793 T DK 13002793T DK 2650008 T3 DK2650008 T3 DK 2650008T3
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cancer
sequence
peptide
jnk
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Christophe Bonny
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Xigen Inflammation Ltd
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Claims (10)

1. JNK-inhibitorpeptid bestående af en aminosyresekvens ifølge SEQ ID NO: 2 eller et kimærisk peptid bestående af et første domæne og et andet domæne forbundet ved en kovalent binding, hvor det første domæne omfatter en transportsekvens, og det andet domæne består af en JNK-inhibitorsekvens ifølge SEQ ID NO: 2 til anvendelse i en fremgangsmåde til behandling af cancersygdomme valgt blandt Kaposi's sarkom, akut myeloid leukæmi omfattende erythroleukæmi, melanomer, maligne melanomer, coloncar-cinomer, lymfomer, sarkomer, biastomer, nyrecarcinomer, gastrointestinale tumorer, gli-omer, prostatatumorer, blærecancer, rektale tumorer, mavecancer, øsofageal cancer, pan-creascancer, levercancer, mammacarcinomer (= brystkræft), livmoderkræft, livmoderhalskræft, akut myeloid leukæmi (AML), akut lymfoid leukæmi (ALL), kronisk myeloid leukæmi (CML), kronisk lymfocytær leukæmi (CLL), hepatomer, diverse virus-inducerede tumorer, såsom f.eks. papillomavirus-inducerede carcinomer (f.eks. cervixcarcinom = livmoderhalskræft), adenocarcinomer, herpesvirus-inducerede tumorer (f.eks. Burkitts lymfom, EBV-induceret B-cellelymfom), hepatitis B-inducerede tumorer (levercellecarcino-mer), HTLV-1- og HTLV-2-inducerede lymfomer, akustikusneurinom, lungekræft (= lunge cancer = bronchial carcinom), småcellet lungekræft, halscancer, analcarcinom, glioblas-tom, rectumcarcinom, astrocytom, hjernetumorer, retinoblastom, basaliom, hjernemetastaser, medulloblastomer, vaginalcancer, testi kel kræft, skjoldbruskkirtelcarcinom, Hodgkins syndrom, meningeomas, SchneeBergers sygdom, hypofysetumor, mycosis fungoider, car-cinoider, neurinom, spinaliom, Burkitts lymfom, laryngal cancer, nyrecancer, thymom, legemecarcinom, knoglecancer, non-Hodgkins lymfomer, urinrørscancer, CUP-syndrom, hoved/nakke-tumorer, oligodendrogliom, vulvacancer, intestinal cancer, coloncarcinom, øsofageal carcinom (=øsofageal cancer), vortetilstande, tyndtarmstumorer, craniopharyn-geom, ovariecarcinom, blødvævstumorer, ovariecancer (= ovariecarcinom), pancreatisk carcinom (= pancreascancer), endometrium carcinom, levermetastaser, peniscancer, tungecancer, galdeblærecancer, leukæmi, plasmocytom, øjenlågstumor og prostata-cancer (= prostatatumorer).
2. Kimærisk peptid til anvendelse ifølge krav 1, hvor den første domæne er bundet til den C-terminale ende af det andet domæne.
3. Kimærisk peptid til anvendelse ifølge krav 1 eller 2, hvor det første domæne og det andet domæne er direkte forbundet med hinanden eller forbundet med hinanden via en linkersekvens omfattende 1 til 10 aminosyrer.
4. Kimærisk peptid til anvendelse ifølge et hvilket som helst af krav 1 til 3, hvor transportsekvensen omfatter aminosyresekvensen af et humant immundefektvirus-TAT-polypeptid.
5. Kimærisk peptid til anvendelse ifølge et hvilket som helst af krav 1 til 4, hvor transportsekvensen består af eller omfatter aminosyresekvensen ifølge SEQ ID NO: 5, 6, 7,8, 21 eller 22.
6. Kimærisk peptid til anvendelse ifølge et hvilket som helst af krav 1 til 5, hvor transportsekvensen øger cellulær optagelse af peptidet og/eller styre nukleær lokalisering af peptidet.
7. Kimærisk peptid til anvendelse ifølge et hvilket som helst af krav 1 til 6, hvor det kimæriske peptid består af aminosyresekvensen ifølge SEQ ID NO: 11.
8. JNK-inhibitorpeptid til anvendelse ifølge krav 1 eller det kimæriske peptid til anvendelse ifølge et hvilket som helst af krav 1 til 7, hvor JNK-inhibitorpeptidet eller det kimæriske peptid er til indgivelse ved en indgivelsesvej valgt fra gruppen bestående af pa-renterale veje, omfattende intravenøse, intramuskulære, subkutane, intradermale, trans-dermale, enteriske veje, omfattende orale, rektale, topiske veje, omfattende nasale, intra-nasale og andre veje, omfattende epidermale eller plasterfremføring.
9. JNK-inhibitorpeptid til anvendelse ifølge krav 1 eller 8 eller det kimæriske peptid til anvendelse ifølge et hvilket som helst af krav 1 til 8, hvor en dosis (per kg kropsvægt) af JNK-inhibitorpeptidet eller det kimæriske peptid er i området af op til 10 mmol/kg, fortrinsvis op til 1 mmol/kg, mere fortrinsvis op til 100 pmol/kg, endnu mere fortrinsvis op til 10 pmol/kg, endnu mere fortrinsvis op til 1 pmol/kg, endnu mere fortrinsvis op til 100 nmol/kg, mest fortrinsvis op til 50 nmol/kg.
10. JNK-inhibitorpeptid til anvendelse ifølge krav 1, 8 eller 9 eller det kimæriske peptid til anvendelse ifølge et hvilket som helst af krav 1 til 8, hvor en dosis af JNK-inhibitorpeptidet eller det kimæriske peptid er i området af fra omkring 1 pmol/kg til omkring 1 mmol/kg, fra omkring 10 pmol/kg til omkring 0,1 mmol/kg, fra omkring 10 pmol/kg til omkring 0,01 mmol/kg, fra omkring 50 pmol/kg til omkring 1 pmol/kg, fra omkring 100 pmol/kg til omkring 500 nmol/kg, fra omkring 200 pmol/kg til omkring 300 nmol/kg, fra omkring 300 pmol/kg til omkring 100 nmol/kg, fra omkring 500 pmol/kg til omkring 50 nmol/kg, fra omkring 750 pmol/kg til omkring 30 nmol/kg, fra omkring 250 pmol/kg til omkring 5 nmol/kg, fra omkring 1 nmol/kg til omkring 10 nmol/kg eller en kombination af to af hvilke som helst af værdierne.
DK13002793.1T 2008-05-30 2009-06-02 Anvendelse af cellepermeable peptidinhibitorer af JNK-signaltransduktionsvejen til behandlingen af forskellige cancersygdomme DK2650008T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2008/004341 WO2009143865A1 (en) 2008-05-30 2008-05-30 Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
EP20120000665 EP2491942B1 (en) 2008-05-30 2009-06-02 Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various cardiovascular diseases

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DK09753692T DK2296684T3 (da) 2008-05-30 2009-06-02 Anvendelse af cellegennemtrængelige peptidinhibitorer fra JNK-signaltransduktionsvejen til behandling af forskellige sygdomme.
DK12000665.5T DK2491942T3 (da) 2008-05-30 2009-06-02 Anvendelse af cellepermeable peptidinhibitorer af JNK-signaltransduktionsvejen til behandling af forskellige kardiovaskulære sygdomme.
DK12000663T DK2489361T3 (da) 2008-05-30 2009-06-02 Anvendelse af cellepermeable peptidinhibitorer af JNK-signaltransduktionsvejentil behandling af forskellige sygdomme.
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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
TWI468417B (zh) 2007-11-30 2015-01-11 Genentech Inc 抗－ｖｅｇｆ抗體
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
EP2340040B1 (en) 2008-10-22 2019-01-16 F.Hoffmann-La Roche Ag Modulation of axon degeneration
WO2010065850A2 (en) * 2008-12-04 2010-06-10 University Of Massachusetts Interleukin 6 and tumor necrosis factor alpha as biomarkers of jnk inhibition
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
WO2011160653A1 (en) * 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
CA2807036C (en) 2010-10-14 2018-01-16 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
ES2575226T3 (es) * 2010-10-14 2016-06-27 Xigen Inflammation Ltd. Péptidos permeables celulares inhibidores de la ruta de transducción de la señal JNK para su uso en el tratamiento de la uiveítis
CN101974083A (zh) * 2010-10-20 2011-02-16 中国医学科学院医学生物学研究所 抗hsv1病毒感染的人源hirrp蛋白分子
WO2013091670A1 (en) * 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2014206426A1 (en) * 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2016207413A1 (en) * 2015-06-26 2016-12-29 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of mild cognitive impairment
WO2016055160A2 (en) * 2014-10-08 2016-04-14 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
EP3013353B1 (en) * 2013-06-26 2021-04-21 Xigen Inflammation Ltd. Cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of cystitis
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
WO2015197098A1 (en) * 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
CN103911462B (zh) * 2014-04-03 2015-06-10 河北国际旅行卫生保健中心 黄热、乙型脑炎、基孔肯雅、西尼罗的鉴别检测方法及引物和探针
EP3125917B1 (en) * 2014-04-04 2019-12-11 Peptitech S.R.L. Cell-permeable peptide system for treating diseases caused by glutamate excitotoxicity
EP3160489B9 (en) * 2014-06-26 2023-10-04 Xigen Inflammation Ltd. Cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of cystitis
EP3160989A2 (en) * 2014-06-26 2017-05-03 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
CN104250640A (zh) 2014-08-22 2014-12-31 普莱柯生物工程股份有限公司 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用
TW201802093A (zh) * 2016-06-02 2018-01-16 西建公司 動物及人類抗錐蟲及抗利什曼原蟲藥劑
US20210137960A1 (en) * 2018-02-01 2021-05-13 Yale University Compositions and methods for inhibition of nuclear-penetrating antibodies
CN116003530B (zh) * 2022-12-27 2023-12-15 西湖大学 一种针对白细胞介素-6的d-蛋白抑制剂及其应用

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1195304B (it) 1981-12-22 1988-10-12 Anic Spa Metodo per la preparazione di gem-diammino derivati n-monoacilati
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5169933A (en) * 1988-08-15 1992-12-08 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
IT1227907B (it) 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
EP0832980B1 (en) 1989-01-23 2002-06-19 Chiron Corporation Recombinant therapies for infection and hyperproliferative disorders
GB8919607D0 (en) 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
US6316003B1 (en) * 1989-12-21 2001-11-13 Whitehead Institute For Biomedical Research Tat-derived transport polypeptides
US5747641A (en) * 1989-12-21 1998-05-05 Biogen Inc Tat-derived transport polypeptide conjugates
US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
US5840313A (en) * 1990-09-27 1998-11-24 Syntello Vaccine Development Kb Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus
WO1992018138A1 (en) 1991-04-10 1992-10-29 The General Hospital Corporation Mammalian gap-43 compositions and methods of use
US5350835A (en) * 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
US5994108A (en) * 1991-11-05 1999-11-30 Board Of Regents, The University Of Texas System Mutant TAR virus and transdominant tat mutants as pharmacological agents
AU671450B2 (en) 1992-03-20 1996-08-29 Baylor College Of Medicine A DNA transporter system and method of use
EP1236473A3 (en) * 1992-04-03 2003-01-15 The Regents Of The University Of California Self-assembling polynucleotide delivery system
WO1994004562A1 (en) 1992-08-13 1994-03-03 The General Hospital Corporation Mammalian gap-43 compositions and methods of use
EP0903408A3 (en) 1992-08-21 2005-11-02 Biogen, Inc. Tat-derived transport polypeptide
CN1091138A (zh) 1992-08-27 1994-08-24 迪金研究有限公司 疫苗
US5545551A (en) * 1992-08-28 1996-08-13 Mt. Sinai School Of Medicine Of The City University Of New York Cloning and expression of pur protein
KR950703640A (ko) 1992-10-09 1995-09-20 가일 케이,나우톤. 간 보존 세포(liver reserve cells)
AU6568594A (en) 1993-04-14 1994-11-08 Boehringer Mannheim Gmbh Nucleic acid tranfer peptides and their use for injecting nucleic acids into eucaryotic cells
AU8116494A (en) 1993-11-12 1995-06-13 Kenichi Matsubara Gene signature
US5807746A (en) 1994-06-13 1998-09-15 Vanderbilt University Method for importing biologically active molecules into cells
JPH10508205A (ja) 1995-04-25 1998-08-18 バクスター インターナショナル インコーポレイテッド 肝細胞および膵臓ランゲルハンス島細胞を単離するためのコラーゲナーゼおよびキモパパインを含有する組成物
CA2227786A1 (en) 1995-07-28 1997-02-13 Marie Curie Cancer Care Transport proteins and their uses
WO1997010836A1 (en) 1995-09-21 1997-03-27 Innapharma, Inc. Peptides and peptidomimetics inhibiting the oncogenic action of p21 ras
IE80466B1 (en) * 1995-11-10 1998-07-29 Elan Corp Plc Peptides which enhance transport across tissues and methods of identifying and using the same
US5877282A (en) 1996-09-20 1999-03-02 Bristol-Myers Squibb Company Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof
US6187817B1 (en) * 1996-10-03 2001-02-13 Southern Illinois University School Of Medicine Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds
US6361938B1 (en) 1996-11-08 2002-03-26 Elan Corporation, Plc Peptides which enhance transport across tissues and methods of identifying and using the same
WO1998023781A1 (en) 1996-11-26 1998-06-04 Johns Hopkins University Ligand detection system and methods of use thereof
US5989814A (en) * 1997-04-01 1999-11-23 Reagents Of The University Of California Screening methods in eucaryotic cells
US5880261A (en) 1997-04-03 1999-03-09 Waeber; Gerard Transcription factor Islet-Brain 1 (IB1)
WO1998047913A2 (en) 1997-04-18 1998-10-29 The University Of Medicine And Dentistry Of New Jersey Inhibition of hiv-1 replication by a tat rna-binding domain peptide analog
US6043083A (en) * 1997-04-28 2000-03-28 Davis; Roger J. Inhibitors of the JNK signal transduction pathway and methods of use
JP4129298B2 (ja) 1997-05-15 2008-08-06 サイトジェン コーポレーション 胃腸管（ｇｉｔ）輸送受容体に結合するランダムペプチド、及び関連した方法
US20040152084A1 (en) 2003-01-31 2004-08-05 Slattum Paul M. Compounds and processes for single-pot attachment of a label to nucleic acid
DE69818987T2 (de) 1997-05-21 2004-07-29 The Board Of Trustees Of The Leland Stanford Junior University, Stanford Zusammensetzung und verfahren zur verzögerung des transports durch biologische membranen
FR2767323B1 (fr) 1997-08-12 2001-01-05 Synt Em Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives
EP0897002A3 (en) 1997-08-14 2001-10-04 Smithkline Beecham Plc U62317, a protein having a JNK-binding domain
AU9402898A (en) 1997-09-26 1999-04-23 Washington University Cell death agonists
US6420031B1 (en) * 1997-11-03 2002-07-16 The Trustees Of Princeton University Highly transparent non-metallic cathodes
HUP0100348A3 (en) 1997-10-20 2002-12-28 Hoffmann La Roche Bicycles containing a six menbered ring with one or two nitrogen atoms, process for their preparation, use of them, pharmaceutical compositions containing the same and intermediates
US6270956B1 (en) * 1997-12-11 2001-08-07 The Salk Institute For Biological Studies Transcriptional coactivator that interacts with Tat protein and regulates its binding to TAR RNA, methods for modulating Tat transactivation, and uses therefor
EP0947524A1 (en) 1998-03-30 1999-10-06 Upither B.V. Novel peptides for the treatment of autoimmune diseases
US6248558B1 (en) 1998-03-31 2001-06-19 Vanderbilt University Sequence and method for genetic engineering of proteins with cell membrane translocating activity
US20020042423A1 (en) * 1998-04-29 2002-04-11 John R. Richert Methods for identifying compounds that bind to hla molecules and use of such compounds as hla-agonists or antagonists
AU4184299A (en) * 1998-05-13 1999-11-29 Incyte Pharmaceuticals, Inc. Human apoptosis associated proteins
AU3714499A (en) 1998-05-14 1999-11-29 Pasteur Merieux Serums Et Vaccins Hepatitis c virus mimotopes
US6811992B1 (en) 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
WO1999066061A1 (fr) * 1998-06-18 1999-12-23 Dnavec Research, Inc. Phage de transfert d'acide nucleique
CA2328457A1 (en) 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
US6589503B1 (en) 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
JP2002528562A (ja) 1998-08-28 2002-09-03 グリフォン サイエンシーズ 長さのばらつきが小さいポリアミド連鎖、その連鎖の製造方法およびその連鎖とタンパク質の複合体
CN1329034C (zh) * 1998-09-25 2007-08-01 赛福伦公司 预防/治疗感觉毛细胞和耳蜗神经元损伤的药物
US6656474B1 (en) 1999-01-15 2003-12-02 Regeneron Pharmaceuticals, Inc. Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders
US6673908B1 (en) * 1999-02-22 2004-01-06 Nuvelo, Inc. Tumor necrosis factor receptor 2
AU765983B2 (en) 1999-05-28 2003-10-09 Apoptosis Technology, Inc. Compounds and methods for regulating apoptosis, and methods of making and screening for compounds that regulate apoptosis
US7510824B2 (en) * 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
WO2000075118A1 (en) * 1999-06-03 2000-12-14 Vertex Pharmaceuticals Incorporated INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK)
DK1102785T3 (da) * 1999-06-07 2013-05-13 Arrowhead Res Corp Sammensætninger til lægemiddeltilførsel ved anvendelse af pH-følsomme molekyler
US6669951B2 (en) 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
WO2001013957A2 (en) 1999-08-24 2001-03-01 Cellgate, Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
US6881825B1 (en) * 1999-09-01 2005-04-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identication of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and virues
US20030104622A1 (en) * 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
US6610820B1 (en) * 1999-10-12 2003-08-26 University Of Lausanne Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20040082509A1 (en) * 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20030108539A1 (en) * 2000-02-14 2003-06-12 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) * 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
IL149933A0 (en) 1999-12-06 2002-11-10 Gen Hospital Corp Pancreatic stem cells and their use in transplantation
US6586403B1 (en) * 2000-07-20 2003-07-01 Salpep Biotechnology, Inc. Treating allergic reactions and inflammatory responses with tri-and dipeptides
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
JP4387669B2 (ja) * 2000-10-13 2009-12-16 ザイジェン エス．アー． 新規なトランスポーターペプチド配列による生物学的エフェクターの細胞内送達
US7033597B2 (en) 2000-10-13 2006-04-25 Université de Lausanne Intracellular delivery of biological effectors
DK1333846T3 (da) 2000-10-17 2012-08-06 Diatranz Otsuka Ltd Fremstilling og xenotransplantation af porcine øer
US20030077826A1 (en) 2001-02-02 2003-04-24 Lena Edelman Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC)
EP1364949A4 (en) * 2001-02-02 2005-11-23 Takeda Pharmaceutical INHIBITOR OF JNK
AU2002240312A1 (en) 2001-02-08 2002-08-19 Pankaj Paranjp Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents using polymer conjugates
WO2002065986A2 (en) 2001-02-16 2002-08-29 Cellgate, Inc. Transporters comprising spaced arginine moieties
DE10117281A1 (de) 2001-04-06 2002-10-24 Inst Molekulare Biotechnologie Peptid zur Diagnose und Therapie der Alzheimer-Demenz
EP1373308B1 (en) * 2001-04-06 2006-10-25 Thomas Jefferson University Antagonist for multimerization of hiv-1 vif protein
AU2002322519A1 (en) 2001-07-17 2003-03-03 Incyte Genomics, Inc. Proteins associated with cell growth, differentiation, and death
IL160915A0 (en) * 2001-09-19 2004-08-31 Aventis Pharma Sa Indolizines inhibiting kinase proteins
EP1487870A2 (en) * 2002-01-09 2004-12-22 Université de Lausanne Cell-permeable peptide inhibitors of the jnk signal transduction pathway
JP2005533748A (ja) * 2002-03-08 2005-11-10 シグナル ファーマシューティカルズ，インコーポレイテッド 増殖性障害および癌を治療、予防、または管理するための併用療法
SE0201863D0 (en) 2002-06-18 2002-06-18 Cepep Ab Cell penetrating peptides
US20040171809A1 (en) 2002-09-09 2004-09-02 Korsmeyer Stanley J. BH3 peptides and method of use thereof
CA2497977A1 (en) 2002-09-20 2004-04-01 Alcon, Inc. Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
DK1408114T3 (da) 2002-10-11 2007-05-07 Imvision Gmbh Modulære antigen-transporter molekyler (MAT-molekyler) til modulation af immunreaktioner, tilhörende konstrukter, fremgangsmåder og anvendelser
AU2003286611A1 (en) 2002-10-24 2004-05-13 Sangstat Medical Corporation Cytomodulating peptides and methods for treating neurological disorders
EP1578365A4 (en) 2002-11-14 2009-09-23 Arbor Vita Corp MOLECULAR INTERACTIONS IN NEURONS
AU2003294312A1 (en) 2002-11-18 2004-07-09 Celgene Corporation Methods of usig and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
US20050019366A1 (en) 2002-12-31 2005-01-27 Zeldis Jerome B. Drug-coated stents and methods of use therefor
US7166692B2 (en) * 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
JP4787150B2 (ja) * 2003-03-06 2011-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｊｎｋ阻害剤
US20080090770A1 (en) 2003-04-11 2008-04-17 Belmares Michael P Modulation of Muc1 Mediated Signal Transduction
WO2004097017A2 (en) * 2003-04-29 2004-11-11 Avi Biopharma, Inc. Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells
AU2004316996A1 (en) 2003-06-20 2005-09-15 The Regents Of The University Of California Polypeptide transduction and fusogenic peptides
KR100685345B1 (ko) 2004-03-27 2007-02-22 학교법인조선대학교 세포사 유도 펩타이드
UA91676C2 (ru) * 2004-04-08 2010-08-25 Эплайд Рисерч Системз Эрс Холдинг Н.В. Композиция, которая содержит ингибитор jnk и циклоспорин
EP1786781A2 (en) 2004-08-27 2007-05-23 GPC Biotech AG Pyrimidine derivatives
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
EP1656951A1 (en) 2004-11-12 2006-05-17 Xigen S.A. Conjugates with enhanced cell uptake activity
EP1676574A3 (en) 2004-12-30 2006-07-26 Johnson & Johnson Vision Care, Inc. Methods for promoting survival of transplanted tissues and cells
US20060223807A1 (en) * 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
US20070015779A1 (en) 2005-04-29 2007-01-18 John Griffin Compositions and treatments for inhibiting kinase and/or hmg-coa reductase
ZA200709240B (en) * 2005-04-29 2009-06-24 Celgene Corp Solid forms of 1-(5-(IH-1,2,4-triazol-5-yl)(IH-indazol-3-yl)-3-(2-piperidylethoxy)benzene
US20070003531A1 (en) * 2005-06-30 2007-01-04 University Of Connecticut Methods for improving immunotherapy by enhancing survival of antigen-specific cytotoxic T lymphocytes
WO2007031098A1 (en) * 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en) * 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
AU2006311910A1 (en) * 2005-11-03 2007-05-18 Irm Llc Protein kinase inhibitors
EP2049152A2 (en) 2006-06-30 2009-04-22 Kim Laboratories, Inc. Antibodies for norovirus
US10045953B2 (en) * 2006-07-06 2018-08-14 Case Western Reserve University Ceramide composition and method of use
US20080051410A1 (en) 2006-08-02 2008-02-28 Northwestern University Protein Kinase Targeted Therapeutics
EP2066319B1 (en) * 2006-09-08 2012-02-01 F. Hoffmann-La Roche AG Benzotriazole kinase modulators
GB0702259D0 (en) 2007-02-06 2007-03-14 Eisai London Res Lab Ltd 7-azaindole derivatives
DK2915529T3 (da) 2008-05-07 2017-08-07 Univ California Terapeutisk regenerering og berigelse af okulær overfladesmøring
WO2009143865A1 (en) * 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2010065850A2 (en) 2008-12-04 2010-06-10 University Of Massachusetts Interleukin 6 and tumor necrosis factor alpha as biomarkers of jnk inhibition
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
BRPI1007923A2 (pt) 2009-02-06 2020-08-25 Elan Pharmaceuticals, Inc composto, composição farmacêutica, métodos para tratar uma doença neurodegenerativa, e para reduzir a concentração de p-cjun em tecido cerebral de um indivíduo em necessidade do mesmo, uso de um composto, e, método in vitro
JP2010254672A (ja) 2009-03-30 2010-11-11 Santen Pharmaceut Co Ltd ＪＮＫ（ｃ−Ｊｕｎアミノ末端キナーゼ）阻害ペプチドを有効成分として含有する網膜疾患の予防または治療剤
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
ES2575226T3 (es) 2010-10-14 2016-06-27 Xigen Inflammation Ltd. Péptidos permeables celulares inhibidores de la ruta de transducción de la señal JNK para su uso en el tratamiento de la uiveítis
CA2807036C (en) 2010-10-14 2018-01-16 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
US8471027B2 (en) 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2014206426A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases

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