DK2632468T3 - THERAPEUTIC COMPOSITIONS FOR SYMMETRIC DIABETIC POLYNEuropathy - Google Patents

THERAPEUTIC COMPOSITIONS FOR SYMMETRIC DIABETIC POLYNEuropathy Download PDF

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Publication number
DK2632468T3
DK2632468T3 DK11835385.3T DK11835385T DK2632468T3 DK 2632468 T3 DK2632468 T3 DK 2632468T3 DK 11835385 T DK11835385 T DK 11835385T DK 2632468 T3 DK2632468 T3 DK 2632468T3
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DK
Denmark
Prior art keywords
pirenzepine
composition
diabetic
mice
acetylcholine receptor
Prior art date
Application number
DK11835385.3T
Other languages
Danish (da)
English (en)
Inventor
Paul Fernyhough
Nigel A Calcutt
Lakshmi Kotra
Original Assignee
Univ Manitoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Manitoba filed Critical Univ Manitoba
Application granted granted Critical
Publication of DK2632468T3 publication Critical patent/DK2632468T3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK11835385.3T 2010-10-25 2011-10-24 THERAPEUTIC COMPOSITIONS FOR SYMMETRIC DIABETIC POLYNEuropathy DK2632468T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40650210P 2010-10-25 2010-10-25
US201161531803P 2011-09-07 2011-09-07
PCT/CA2011/001186 WO2012055018A1 (en) 2010-10-25 2011-10-24 Therapeutic compositions for diabetic symmetrical polyneuropathy

Publications (1)

Publication Number Publication Date
DK2632468T3 true DK2632468T3 (en) 2018-02-12

Family

ID=45993001

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11835385.3T DK2632468T3 (en) 2010-10-25 2011-10-24 THERAPEUTIC COMPOSITIONS FOR SYMMETRIC DIABETIC POLYNEuropathy

Country Status (13)

Country Link
US (3) US10307428B2 (enExample)
EP (3) EP4537829A3 (enExample)
CN (1) CN103298473B (enExample)
CA (1) CA2804797C (enExample)
DK (1) DK2632468T3 (enExample)
ES (2) ES2655688T3 (enExample)
HR (1) HRP20250395T1 (enExample)
HU (1) HUE070784T2 (enExample)
NO (1) NO2632468T3 (enExample)
PL (2) PL3363439T3 (enExample)
PT (1) PT2632468T (enExample)
RS (1) RS66691B1 (enExample)
WO (1) WO2012055018A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120661657A (zh) * 2013-12-20 2025-09-19 曼尼托巴大学 用于治疗周围神经病变的方法和组合物
US9743513B2 (en) 2014-12-26 2017-08-22 Industrial Technology Research Institute Flexible electronic device
EA202192334A1 (ru) * 2019-03-26 2022-02-08 Винсантор, Инк. Составы для местного применения для лечения периферических невропатий
WO2024192323A2 (en) * 2023-03-16 2024-09-19 Glaukos Corporation Ophthalmic cream formulations and their uses

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6512010B1 (en) * 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
EP1080226A4 (en) * 1998-05-21 2004-04-21 Isis Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF OLIGONUCLEOTIDES
US20030104041A1 (en) * 1999-12-16 2003-06-05 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
BR0210013A (pt) * 2001-05-25 2004-08-10 Valley Forge Pharmaceuticals Gel oftálmico de pirenzepina
EP1438001A4 (en) * 2001-09-26 2006-03-15 Alison B Lukacsko COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS
US20090325975A1 (en) * 2005-07-15 2009-12-31 Helmut H Buschmann Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
AR058193A1 (es) * 2005-11-21 2008-01-23 Schering Plough Ltd Composiciones farmaceuticas
US8748419B2 (en) * 2006-06-16 2014-06-10 Theracos, Inc. Treating obesity with muscarinic receptor M1 antagonists
US7893053B2 (en) * 2006-06-16 2011-02-22 Theracos, Inc. Treating psychological conditions using muscarinic receptor M1 antagonists
CN101472476B (zh) * 2006-06-16 2013-10-30 泰拉科斯有限公司 毒蕈碱型受体m1拮抗剂在制备治疗肥胖症的药物中的应用
US20080255062A1 (en) * 2007-02-13 2008-10-16 University Of Manitoba Axon regeneration from adult sensory neurons
CN101422610A (zh) * 2007-12-04 2009-05-06 袁才蔚 一种化学药复合物制剂及其应用

Also Published As

Publication number Publication date
US20240180922A1 (en) 2024-06-06
PL3363439T3 (pl) 2025-09-22
ES2655688T3 (es) 2018-02-21
WO2012055018A1 (en) 2012-05-03
CA2804797A1 (en) 2012-05-03
HUE070784T2 (hu) 2025-06-28
EP4537829A2 (en) 2025-04-16
PT2632468T (pt) 2018-03-02
EP3363439A3 (en) 2018-12-05
EP3363439A2 (en) 2018-08-22
HRP20250395T1 (hr) 2025-05-23
US10307428B2 (en) 2019-06-04
CN103298473A (zh) 2013-09-11
CA2804797C (en) 2014-12-23
US20130267506A1 (en) 2013-10-10
EP3363439C0 (en) 2025-01-08
EP2632468A1 (en) 2013-09-04
CN103298473B (zh) 2015-07-29
ES3016907T3 (en) 2025-05-12
US11925649B2 (en) 2024-03-12
RS66691B1 (sr) 2025-05-30
NO2632468T3 (enExample) 2018-05-12
EP3363439B1 (en) 2025-01-08
PL2632468T3 (pl) 2018-04-30
EP2632468B1 (en) 2017-12-13
US20190046540A1 (en) 2019-02-14
EP2632468A4 (en) 2014-08-27
EP4537829A3 (en) 2025-06-18

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