DK2629790T3 - Fremgangsmåde til at forøge væksthastigheden af menneskelige spædbørn - Google Patents
Fremgangsmåde til at forøge væksthastigheden af menneskelige spædbørn Download PDFInfo
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- DK2629790T3 DK2629790T3 DK10773032.7T DK10773032T DK2629790T3 DK 2629790 T3 DK2629790 T3 DK 2629790T3 DK 10773032 T DK10773032 T DK 10773032T DK 2629790 T3 DK2629790 T3 DK 2629790T3
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- rhbssl
- infant
- lipase
- milk
- salt
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01013—Sterol esterase (3.1.1.13)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pediatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Claims (8)
1. Rekombinant human galde-salt-stimuleret lipase (rhBSSL) til anvendelse til at forøge vækst-hastigheden af et for tidligt født menneskeligt spædbarn, hvor anvendelsen omfatter trinnet af enterisk indgivelse af rekombinant human galde-salt-stimuleret lipase til spædbarnet, hvor lipasen indgives i en mængde per dag af mellem 1 og 100 mg af lipasen per Kg vægt af spædbarn, mellem 5 og 50 mg af lipasen per Kg vægt af spædbarn, eller mellem 15 og 40 mg af lipasen per Kg vægt af spædbarn, over en periode af i det mindste omkring 4 uger, hvor spædbarnet er lille i forhold til gestationsalder.
2. RhBSSL til anvendelse ifølge krav 1, hvor lipasen isoleres fra et ekspressionsprodukt af en rekombinant kinesisk hamster-æggestok-(ENG: Chinese hamster ovarie)-cellelinie.
3. RhBSSL til anvendelse ifølge krav 2, hvor lipasen er yderligere defineret ved én eller flere træk valgt blandt: a. lipasen er fri for andre mælkeproteiner eller mælkebestanddele, såsom mælkeca-sein og valleproteiner, såsom lactoferrin, eller fri for andre kontaminanter naturligt forekommende i mælk, i særdeleshed hvor sådanne mælke-afledte proteiner eller andre kontaminanter er afledt fra mælken fra mennesker, får eller mus; b. lipasen har en renhed, der er højere end omkring 70%, såsom en renhed, der er højere end omkring 80%, 90% eller 95%; c. lipasen har et niveau af glykosylering, som er mindre end det af BSSL-MAM og/eller større end det af rhBSSL-OVI; d. lipasen har et glykosyleringsmønster, der er forskelligt fra det af BSSL-MAM og/eller forskelligt fra det af rhBSSL-OVI; e. lipasen har en molekylmasse på mellem 90 KDa og 75 KDa, mellem omkring 84 og 86 KDa, eller omkring 85 KDa; og/eller f. mængden af lipasemolekyler, som er til stede i en form, der ved C-terminalenden er kortere med 1 eller 2 aminosyrer, sammenlignet med fuldlængdeformen repræsenteret ved sekvensen vist i SEQ ID NO: 1 er større end 50%, såsom mellem omkring 100% og 500%, mellem omkring 200% og 400%, eller omkring 300% af mængden af lipasemolekyler foreliggende i fuldlængdeformen repræsenteret ved sekvensen vist i SEQ ID NO: 1.
4. RhBSSL til anvendelse ifølge et hvilket som helst af krav 1-3, hvor nævnte rhBSSL er tilvejebragt som en frysetørret formulering.
5. RhBSSL til anvendelse ifølge krav 4, hvor den frysetørrede formulering af rhBSSL først tilsættes til modermælkserstatning eller pasteuriseret brystmælk, som derefter mades til spædbarnet, for derved at indgive lipasen enteralt.
6. RhBSSL til anvendelse ifølge krav 5, hvor den frysetørrede formulering af rhBSSL er opløst, såsom med sterilt vand, forud for tilsætning til modermælkserstatningen eller den pasteuriserede brystmælk.
7. RhBSSL til anvendelse ifølge et hvilket som helst af krav 1-6, hvor nævnte rhBSSL er omfattet i en farmaceutisk sammensætning.
8. RhBSSL til anvendelse ifølge et hvilket som helst af krav 1-7, hvor det for tidligt fødte spædbarn er født før uge 37 af gestation, det for tidligt fødte spædbarn er fortrinsvis født mellem omkring uge 37 og omkring uge 32 af gestation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/EP2010/065916 WO2012052060A1 (en) | 2010-10-21 | 2010-10-21 | Method to increase the growth velocity of human infants |
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DK2629790T3 true DK2629790T3 (da) | 2016-10-24 |
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DK10773032.7T DK2629790T3 (da) | 2010-10-21 | 2010-10-21 | Fremgangsmåde til at forøge væksthastigheden af menneskelige spædbørn |
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US (2) | US8986759B2 (da) |
EP (1) | EP2629790B1 (da) |
JP (1) | JP5850940B2 (da) |
CN (1) | CN103200957A (da) |
AU (1) | AU2010362576A1 (da) |
CA (1) | CA2812857A1 (da) |
DK (1) | DK2629790T3 (da) |
ES (1) | ES2603328T3 (da) |
RU (1) | RU2013123053A (da) |
WO (1) | WO2012052060A1 (da) |
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JP5850940B2 (ja) | 2010-10-21 | 2016-02-03 | スウェディッシュ オーファン バイオビトラム パブリーク アクチエボラグ | ヒト乳児の発育速度を増大させる方法 |
BR112014006798A2 (pt) * | 2011-09-26 | 2017-06-13 | Swedish Orphan Biovitrum Ab (Publ) | formulações melhoradas de lípase estimulada por sal billiar humana recombinantes |
WO2013179290A1 (en) | 2012-05-31 | 2013-12-05 | Nutrinia Ltd. | Insulin-containing infant formula |
CN102930409B (zh) * | 2012-11-23 | 2016-02-24 | 重庆大学 | 基于婴儿配方奶摄入量及发育状态的应用服务系统 |
CN102968564B (zh) * | 2012-11-23 | 2015-11-18 | 重庆市科学技术研究院 | 基于配方奶摄入量监测的婴儿发育状态管理服务系统 |
JP2015536681A (ja) * | 2012-12-18 | 2015-12-24 | カラク アーゲー | 人乳の殺菌装置及び方法 |
BR112018069444A2 (pt) | 2016-03-24 | 2019-10-08 | Nutrinia Ltd | método para promover esvaziamento gástrico num sujeito em necessidade do mesmo, insulina para uso na promoção do esvaziamento gástrico num sujeito em necessidade do mesmo e kit para uso na promoção do esvaziamento gástrico |
FR3079303A1 (fr) * | 2018-03-20 | 2019-09-27 | Ab7 Innovation | Procede pour la detection de la presence d'un traceur dans les excrements |
US11147508B2 (en) | 2018-11-07 | 2021-10-19 | International Business Machines Corporation | Generating a maternal nutrition plan for pregnant women to prevent fetal chronic diseases |
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CA662815A (en) | 1963-05-07 | G. Farnham Merle | Treatment for "scours" in mammals | |
US326150A (en) | 1885-09-15 | Method of attaching soles of | ||
US3081225A (en) | 1962-03-28 | 1963-03-12 | Dairyland Food Lab | Enzyme treatment for "scours" in animals |
US4944944A (en) | 1987-11-19 | 1990-07-31 | Oklahoma Medical Research Foundation | Dietary compositions and methods using bile salt-activated lipase |
US5200183A (en) * | 1987-11-19 | 1993-04-06 | Oklahoma Medical Research Foundation | Recombinant bile salt activated lipases |
US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
SE9001985D0 (sv) | 1990-06-01 | 1990-06-01 | Astra Ab | New chemical products |
HRP930935A2 (en) * | 1992-06-11 | 1994-12-31 | Astra Ab | New dna sequences |
IS4130A (is) | 1993-03-01 | 1994-09-02 | Ab Astra | Ný fjölpeptíð |
SE9801424D0 (sv) * | 1998-04-22 | 1998-04-22 | Astra Ab | Expression methods |
JP5002442B2 (ja) | 2007-12-20 | 2012-08-15 | 森永乳業株式会社 | 脂質吸収促進剤 |
JP5850940B2 (ja) | 2010-10-21 | 2016-02-03 | スウェディッシュ オーファン バイオビトラム パブリーク アクチエボラグ | ヒト乳児の発育速度を増大させる方法 |
EP2629789A1 (en) | 2010-10-21 | 2013-08-28 | Swedish Orphan Biovitrum AB (Publ) | Method to increase the absorption of unsaturated fatty acids by human infants |
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2010
- 2010-10-21 JP JP2013534174A patent/JP5850940B2/ja not_active Expired - Fee Related
- 2010-10-21 WO PCT/EP2010/065916 patent/WO2012052060A1/en active Application Filing
- 2010-10-21 ES ES10773032.7T patent/ES2603328T3/es active Active
- 2010-10-21 DK DK10773032.7T patent/DK2629790T3/da active
- 2010-10-21 AU AU2010362576A patent/AU2010362576A1/en not_active Abandoned
- 2010-10-21 CA CA2812857A patent/CA2812857A1/en not_active Abandoned
- 2010-10-21 RU RU2013123053/15A patent/RU2013123053A/ru not_active Application Discontinuation
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2015
- 2015-03-12 US US14/656,486 patent/US20150283215A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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JP2013545445A (ja) | 2013-12-26 |
WO2012052060A1 (en) | 2012-04-26 |
ES2603328T3 (es) | 2017-02-27 |
EP2629790B1 (en) | 2016-08-24 |
EP2629790A1 (en) | 2013-08-28 |
CN103200957A (zh) | 2013-07-10 |
AU2010362576A1 (en) | 2013-04-04 |
JP5850940B2 (ja) | 2016-02-03 |
US20150283215A1 (en) | 2015-10-08 |
US20120100126A1 (en) | 2012-04-26 |
CA2812857A1 (en) | 2012-04-26 |
RU2013123053A (ru) | 2014-11-27 |
US8986759B2 (en) | 2015-03-24 |
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