DK2590661T3 - Forbedret fremgangsmåde til stamcelledifferentiering in vivo ved afgivelse af morfogener med mesoporøst siliciumdioxid og tilsvarende farmaceutisk aktive bestanddele - Google Patents

Forbedret fremgangsmåde til stamcelledifferentiering in vivo ved afgivelse af morfogener med mesoporøst siliciumdioxid og tilsvarende farmaceutisk aktive bestanddele Download PDF

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DK2590661T3
DK2590661T3 DK11745497.5T DK11745497T DK2590661T3 DK 2590661 T3 DK2590661 T3 DK 2590661T3 DK 11745497 T DK11745497 T DK 11745497T DK 2590661 T3 DK2590661 T3 DK 2590661T3
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morphogenes
vivo
delivering
silicon dioxide
stem cell
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DK11745497.5T
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Alfonso E Garcia-Bennett
Elena Nickolaevna Kozlova
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Nanologica Ab
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DK11745497.5T 2010-07-06 2011-07-06 Forbedret fremgangsmåde til stamcelledifferentiering in vivo ved afgivelse af morfogener med mesoporøst siliciumdioxid og tilsvarende farmaceutisk aktive bestanddele DK2590661T3 (da)

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Application Number Priority Date Filing Date Title
US36174110P 2010-07-06 2010-07-06
PCT/EP2011/061377 WO2012004291A1 (en) 2010-07-06 2011-07-06 Improved method for stem cell differentiation in vivo by delivery of morphogenes with mesoporous silica and corresponding pharmaceutical active ingredients.

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DK2590661T3 true DK2590661T3 (da) 2020-01-27

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US (2) US20130315962A1 (da)
EP (1) EP2590661B1 (da)
DK (1) DK2590661T3 (da)
ES (1) ES2768229T3 (da)
WO (1) WO2012004291A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012267519A1 (en) * 2011-06-09 2014-01-09 University Of Miami Methods of treatment for retinal diseases
US20150366943A1 (en) * 2012-05-17 2015-12-24 The Regents Of The University Of California MOBILIZATION OF HEMATOPOIETIC STEM CELLS FROM BONE MARROW TO BLOOD USING A COMBINATION OF A ROBO4 RECEPTOR ANTAGONIST AND A CXCR4 ANTAGONIST OR hrVEGF-165 AND A CXCR4 ANTAGONIST
EP2866816A4 (en) * 2012-05-31 2016-03-16 Caladrius Biosciences Inc VERY SMALL HUMAN EMBRYONIC STEM CELLS FOR THE TREATMENT OF EYE DISEASES
LT2916852T (lt) * 2012-11-06 2021-06-25 Sigrid Therapeutics Ab Poringa silicio dioksido medžiaga, skirta panaudoti kaip farmacinė arba arba dietinė aktyvi sudedamoji dalis
HUE051406T2 (hu) 2012-11-14 2021-03-01 Grace W R & Co Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók
WO2014102539A1 (en) * 2012-12-31 2014-07-03 Isis Innovation Limited Delivery method using mesoporous silica nanoparticles
US20140248696A1 (en) * 2013-03-01 2014-09-04 Wisconsin Alumni Research Foundation Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors
US10160950B2 (en) 2013-03-01 2018-12-25 Wisconsin Alumni Research Foundation Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors
WO2014194267A2 (en) * 2013-05-30 2014-12-04 The Board Of Trustees Of The Leland Stanford Junior University Wnt peptide pharmacophore compositions and methods of use thereof
WO2014202833A1 (en) * 2013-06-18 2014-12-24 University Of Helsinki Treatment of neuronal injuries
WO2015037535A1 (ja) * 2013-09-12 2015-03-19 株式会社カネカ 人工多能性幹細胞の分化誘導方法及び選別方法
SG11201605046YA (en) 2013-12-20 2016-07-28 Hutchinson Fred Cancer Res Tagged chimeric effector molecules and receptors thereof
WO2016176652A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
CN109010368B (zh) * 2018-08-01 2021-09-03 徐妍 用于治疗“女运动员三联征”和修复女运动员卵巢功能的细胞制剂及其制备方法
TWI675678B (zh) * 2018-08-23 2019-11-01 國為生醫科技股份有限公司 亞丁基苯酞於多巴胺神經前驅細胞移植治療的應用
DK3894857T3 (da) 2019-04-15 2022-11-07 Nanologica Ab Tomme porøse partikler til anvendelse ved behandling, forebyggelse og/eller udskydelse af degeneration af neurodegenerative sygdomme, neuroner og glia
US20220401397A1 (en) * 2019-09-18 2022-12-22 The Board Of Trustees Of The Leland Stanford Junior University Controlled nutrient delivery to pancreatic islets using a novel mesoporous silica-based nanoparticle platform
WO2023201361A1 (en) 2022-04-15 2023-10-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019801A1 (en) * 2003-06-04 2005-01-27 Curis, Inc. Stem cell-based methods for identifying and characterizing agents
US7981441B2 (en) * 2004-02-18 2011-07-19 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery systems using mesoporous oxide films
US20070031966A1 (en) * 2005-07-18 2007-02-08 Regents Of The University Of Michigan Renal progenitor cells from embryonic stem cells
WO2008002250A1 (en) 2006-06-30 2008-01-03 Elena Kozlova Improved stem cells for transplantation and methods for production thereof
US8642333B2 (en) * 2008-02-04 2014-02-04 Massachusetts Institute Of Technology Particulate delivery vehicles for embryoid bodies
AU2009214118B2 (en) * 2008-02-11 2014-06-12 Nanologica Ab Method for manufacturing mesoporous materials, materials so produced and use of mesoporous materials
WO2009145761A1 (en) * 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Methods and materials for using cells to treat heart tissue
CN101658533A (zh) * 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送

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ES2768229T3 (es) 2020-06-22
WO2012004291A1 (en) 2012-01-12
EP2590661A1 (en) 2013-05-15
US10273453B2 (en) 2019-04-30
EP2590661B1 (en) 2019-11-06
US20130315962A1 (en) 2013-11-28
US20170145382A1 (en) 2017-05-25

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