DK2590661T3 - Forbedret fremgangsmåde til stamcelledifferentiering in vivo ved afgivelse af morfogener med mesoporøst siliciumdioxid og tilsvarende farmaceutisk aktive bestanddele - Google Patents
Forbedret fremgangsmåde til stamcelledifferentiering in vivo ved afgivelse af morfogener med mesoporøst siliciumdioxid og tilsvarende farmaceutisk aktive bestanddele Download PDFInfo
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- DK2590661T3 DK2590661T3 DK11745497.5T DK11745497T DK2590661T3 DK 2590661 T3 DK2590661 T3 DK 2590661T3 DK 11745497 T DK11745497 T DK 11745497T DK 2590661 T3 DK2590661 T3 DK 2590661T3
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- Denmark
- Prior art keywords
- morphogenes
- vivo
- delivering
- silicon dioxide
- stem cell
- Prior art date
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title 2
- 239000004480 active ingredient Substances 0.000 title 1
- 230000024245 cell differentiation Effects 0.000 title 1
- 230000001976 improved effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 235000012239 silicon dioxide Nutrition 0.000 title 1
- 239000000377 silicon dioxide Substances 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
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- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36174110P | 2010-07-06 | 2010-07-06 | |
PCT/EP2011/061377 WO2012004291A1 (en) | 2010-07-06 | 2011-07-06 | Improved method for stem cell differentiation in vivo by delivery of morphogenes with mesoporous silica and corresponding pharmaceutical active ingredients. |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2590661T3 true DK2590661T3 (da) | 2020-01-27 |
Family
ID=44534302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11745497.5T DK2590661T3 (da) | 2010-07-06 | 2011-07-06 | Forbedret fremgangsmåde til stamcelledifferentiering in vivo ved afgivelse af morfogener med mesoporøst siliciumdioxid og tilsvarende farmaceutisk aktive bestanddele |
Country Status (5)
Country | Link |
---|---|
US (2) | US20130315962A1 (da) |
EP (1) | EP2590661B1 (da) |
DK (1) | DK2590661T3 (da) |
ES (1) | ES2768229T3 (da) |
WO (1) | WO2012004291A1 (da) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012267519A1 (en) * | 2011-06-09 | 2014-01-09 | University Of Miami | Methods of treatment for retinal diseases |
US20150366943A1 (en) * | 2012-05-17 | 2015-12-24 | The Regents Of The University Of California | MOBILIZATION OF HEMATOPOIETIC STEM CELLS FROM BONE MARROW TO BLOOD USING A COMBINATION OF A ROBO4 RECEPTOR ANTAGONIST AND A CXCR4 ANTAGONIST OR hrVEGF-165 AND A CXCR4 ANTAGONIST |
EP2866816A4 (en) * | 2012-05-31 | 2016-03-16 | Caladrius Biosciences Inc | VERY SMALL HUMAN EMBRYONIC STEM CELLS FOR THE TREATMENT OF EYE DISEASES |
LT2916852T (lt) * | 2012-11-06 | 2021-06-25 | Sigrid Therapeutics Ab | Poringa silicio dioksido medžiaga, skirta panaudoti kaip farmacinė arba arba dietinė aktyvi sudedamoji dalis |
HUE051406T2 (hu) | 2012-11-14 | 2021-03-01 | Grace W R & Co | Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók |
WO2014102539A1 (en) * | 2012-12-31 | 2014-07-03 | Isis Innovation Limited | Delivery method using mesoporous silica nanoparticles |
US20140248696A1 (en) * | 2013-03-01 | 2014-09-04 | Wisconsin Alumni Research Foundation | Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors |
US10160950B2 (en) | 2013-03-01 | 2018-12-25 | Wisconsin Alumni Research Foundation | Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors |
WO2014194267A2 (en) * | 2013-05-30 | 2014-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt peptide pharmacophore compositions and methods of use thereof |
WO2014202833A1 (en) * | 2013-06-18 | 2014-12-24 | University Of Helsinki | Treatment of neuronal injuries |
WO2015037535A1 (ja) * | 2013-09-12 | 2015-03-19 | 株式会社カネカ | 人工多能性幹細胞の分化誘導方法及び選別方法 |
SG11201605046YA (en) | 2013-12-20 | 2016-07-28 | Hutchinson Fred Cancer Res | Tagged chimeric effector molecules and receptors thereof |
WO2016176652A2 (en) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
CN109010368B (zh) * | 2018-08-01 | 2021-09-03 | 徐妍 | 用于治疗“女运动员三联征”和修复女运动员卵巢功能的细胞制剂及其制备方法 |
TWI675678B (zh) * | 2018-08-23 | 2019-11-01 | 國為生醫科技股份有限公司 | 亞丁基苯酞於多巴胺神經前驅細胞移植治療的應用 |
DK3894857T3 (da) | 2019-04-15 | 2022-11-07 | Nanologica Ab | Tomme porøse partikler til anvendelse ved behandling, forebyggelse og/eller udskydelse af degeneration af neurodegenerative sygdomme, neuroner og glia |
US20220401397A1 (en) * | 2019-09-18 | 2022-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Controlled nutrient delivery to pancreatic islets using a novel mesoporous silica-based nanoparticle platform |
WO2023201361A1 (en) | 2022-04-15 | 2023-10-19 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050019801A1 (en) * | 2003-06-04 | 2005-01-27 | Curis, Inc. | Stem cell-based methods for identifying and characterizing agents |
US7981441B2 (en) * | 2004-02-18 | 2011-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Drug delivery systems using mesoporous oxide films |
US20070031966A1 (en) * | 2005-07-18 | 2007-02-08 | Regents Of The University Of Michigan | Renal progenitor cells from embryonic stem cells |
WO2008002250A1 (en) | 2006-06-30 | 2008-01-03 | Elena Kozlova | Improved stem cells for transplantation and methods for production thereof |
US8642333B2 (en) * | 2008-02-04 | 2014-02-04 | Massachusetts Institute Of Technology | Particulate delivery vehicles for embryoid bodies |
AU2009214118B2 (en) * | 2008-02-11 | 2014-06-12 | Nanologica Ab | Method for manufacturing mesoporous materials, materials so produced and use of mesoporous materials |
WO2009145761A1 (en) * | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
CN101658533A (zh) * | 2008-08-29 | 2010-03-03 | 首都医科大学宣武医院 | 抗肿瘤药物的干细胞递送 |
-
2011
- 2011-07-06 WO PCT/EP2011/061377 patent/WO2012004291A1/en active Application Filing
- 2011-07-06 EP EP11745497.5A patent/EP2590661B1/en active Active
- 2011-07-06 US US13/808,809 patent/US20130315962A1/en not_active Abandoned
- 2011-07-06 ES ES11745497T patent/ES2768229T3/es active Active
- 2011-07-06 DK DK11745497.5T patent/DK2590661T3/da active
-
2016
- 2016-11-01 US US15/340,537 patent/US10273453B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2768229T3 (es) | 2020-06-22 |
WO2012004291A1 (en) | 2012-01-12 |
EP2590661A1 (en) | 2013-05-15 |
US10273453B2 (en) | 2019-04-30 |
EP2590661B1 (en) | 2019-11-06 |
US20130315962A1 (en) | 2013-11-28 |
US20170145382A1 (en) | 2017-05-25 |
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