DK2532648T3 - Lokalt aktive "bløde"antiandrogener - Google Patents

Lokalt aktive "bløde"antiandrogener

Info

Publication number
DK2532648T3
DK2532648T3 DK12179423.4T DK12179423T DK2532648T3 DK 2532648 T3 DK2532648 T3 DK 2532648T3 DK 12179423 T DK12179423 T DK 12179423T DK 2532648 T3 DK2532648 T3 DK 2532648T3
Authority
DK
Denmark
Prior art keywords
antiandrogens
soft
locally active
locally
active
Prior art date
Application number
DK12179423.4T
Other languages
English (en)
Inventor
Richard Hochberg
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Application granted granted Critical
Publication of DK2532648T3 publication Critical patent/DK2532648T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
DK12179423.4T 2007-05-03 2008-05-02 Lokalt aktive "bløde"antiandrogener DK2532648T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92742707P 2007-05-03 2007-05-03
EP08767482A EP2150256A4 (en) 2007-05-03 2008-05-02 LOCAL ACTIVE, SOFT ANTIANDROGENE

Publications (1)

Publication Number Publication Date
DK2532648T3 true DK2532648T3 (da) 2014-04-22

Family

ID=39943833

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12179423.4T DK2532648T3 (da) 2007-05-03 2008-05-02 Lokalt aktive "bløde"antiandrogener

Country Status (9)

Country Link
US (2) US8552061B2 (da)
EP (2) EP2150256A4 (da)
JP (2) JP5456669B2 (da)
DK (1) DK2532648T3 (da)
ES (1) ES2461192T3 (da)
PL (1) PL2532648T3 (da)
PT (1) PT2532648E (da)
SI (1) SI2532648T1 (da)
WO (1) WO2008137038A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
KR102481319B1 (ko) * 2016-06-10 2022-12-26 유니버시티 오브 테네시 리서치 파운데이션 선택적 안드로겐 수용체 분해제(sard) 리간드 및 이의 사용 방법
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
CN113304157B (zh) * 2021-06-15 2022-02-11 黑龙江中医药大学 一种用于治疗多囊卵巢综合征(pcos)的活性组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR401994A (fr) 1909-01-04 1909-09-23 Lanston Monotype Corp Ltd Perfectionnements apportés au mécanisme de transmission de force motrice particulièrement applicable au mécanisme moteur ou de transmission pour machines à fondre les caractères et autres
US3875229A (en) 1972-11-24 1975-04-01 Schering Corp Substituted carboxanilides
FR2496669A1 (fr) * 1980-12-23 1982-06-25 Roussel Uclaf Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
DE69034035T2 (de) * 1989-07-07 2004-01-22 Endorecherche Inc., Ste-Foy Methode zur behandlung androgenbedingter krankheiten
JPH06273417A (ja) 1993-01-20 1994-09-30 Ono Pharmaceut Co Ltd メバロン酸に対する抗体、および該抗体を用いるメバロン酸の定量法
IT1271325B (it) * 1994-12-23 1997-05-27 Poli Ind Chimica Spa Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
WO2000031112A1 (en) 1998-11-20 2000-06-02 Akzo Nobel N.V. Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11
EP1219631A4 (en) 1999-08-23 2003-03-19 Chugai Pharmaceutical Co Ltd ANTIANDROGEN ACTIVE SUBSTANCES
ITMI20011762A1 (it) * 2001-08-10 2003-02-10 Cosmo Spa Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione
US7017295B2 (en) * 2004-08-09 2006-03-28 Clarence Hacker Device for handling fish

Also Published As

Publication number Publication date
ES2461192T3 (es) 2014-05-19
US8552061B2 (en) 2013-10-08
EP2532648B1 (en) 2014-03-19
PT2532648E (pt) 2014-04-24
EP2150256A1 (en) 2010-02-10
PL2532648T3 (pl) 2014-07-31
US20100184735A1 (en) 2010-07-22
WO2008137038A1 (en) 2008-11-13
US20140011785A1 (en) 2014-01-09
EP2150256A4 (en) 2010-04-28
EP2532648A1 (en) 2012-12-12
JP2010527380A (ja) 2010-08-12
SI2532648T1 (sl) 2014-05-30
JP5456669B2 (ja) 2014-04-02
JP2014094952A (ja) 2014-05-22

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