DK248075A - Fremgangsmade til elektrofil fluorering af mettede organiske forbindelser indeholdende et hydrogenatom bundet til et tertiert kulstofatom - Google Patents

Fremgangsmade til elektrofil fluorering af mettede organiske forbindelser indeholdende et hydrogenatom bundet til et tertiert kulstofatom

Info

Publication number
DK248075A
DK248075A DK248075A DK248075A DK248075A DK 248075 A DK248075 A DK 248075A DK 248075 A DK248075 A DK 248075A DK 248075 A DK248075 A DK 248075A DK 248075 A DK248075 A DK 248075A
Authority
DK
Denmark
Prior art keywords
tertiated
fluoration
electrophile
procedure
organic compounds
Prior art date
Application number
DK248075A
Other languages
Danish (da)
English (en)
Inventor
D H R Barton
R H Hesse
Original Assignee
Res Inst Medicine Chem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Inst Medicine Chem filed Critical Res Inst Medicine Chem
Publication of DK248075A publication Critical patent/DK248075A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK248075A 1974-06-04 1975-06-03 Fremgangsmade til elektrofil fluorering af mettede organiske forbindelser indeholdende et hydrogenatom bundet til et tertiert kulstofatom DK248075A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24734/74A GB1513135A (en) 1974-06-04 1974-06-04 Fluorination process and fluoro steroids

Publications (1)

Publication Number Publication Date
DK248075A true DK248075A (da) 1975-12-05

Family

ID=10216416

Family Applications (1)

Application Number Title Priority Date Filing Date
DK248075A DK248075A (da) 1974-06-04 1975-06-03 Fremgangsmade til elektrofil fluorering af mettede organiske forbindelser indeholdende et hydrogenatom bundet til et tertiert kulstofatom

Country Status (21)

Country Link
US (2) US4036864A (fr)
JP (1) JPS514102A (fr)
AU (1) AU498203B2 (fr)
BE (1) BE829809A (fr)
CA (1) CA1064475A (fr)
CH (1) CH616397A5 (fr)
DE (1) DE2524618A1 (fr)
DK (1) DK248075A (fr)
ES (1) ES438166A1 (fr)
FR (1) FR2275426A1 (fr)
GB (1) GB1513135A (fr)
IE (1) IE41545B1 (fr)
IL (1) IL47418A (fr)
IN (1) IN142193B (fr)
IT (1) IT1035927B (fr)
LU (1) LU72637A1 (fr)
NL (1) NL7506547A (fr)
NO (1) NO751939L (fr)
NZ (1) NZ177688A (fr)
SE (1) SE7506339L (fr)
ZA (1) ZA753588B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513135A (en) * 1974-06-04 1978-06-07 Res Inst For Med & Chem Inc Fluorination process and fluoro steroids
US5234680A (en) * 1989-07-31 1993-08-10 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
US5116599A (en) * 1989-07-31 1992-05-26 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri
PT870757E (pt) * 1997-04-10 2002-09-30 Pfizer Derivados de adamantano substituidos por fluoro
DE19738196A1 (de) * 1997-09-02 1999-03-04 Hoechst Ag Verfahren zur Herstellung von Fluor enthaltenden Verbindungen in hoher Reinheit
TW466266B (en) * 1997-12-18 2001-12-01 Central Glass Co Ltd Gas for removing deposit and removal method using same
GB9924705D0 (en) * 1999-10-20 1999-12-22 F2 Chemicals Ltd Preparation of selectively fluorinated organic compounds
US6455728B1 (en) * 1999-11-01 2002-09-24 Air Products And Chemicals, Inc. Direct fluorination process for preparing high purity 2-fluoro-1,3-dicarbonyl compounds using oxygen as a radical scavenger
US7488847B2 (en) 2002-12-11 2009-02-10 Asahi Glass Company, Limited Fluorinated adamantane and its derivatives
EP1574497B1 (fr) * 2002-12-11 2014-07-16 Asahi Glass Company, Limited Derives fluores de l'adamantane
WO2005123653A1 (fr) 2004-06-16 2005-12-29 Asahi Glass Company, Limited Dérivé de fluoroadamantane
WO2005123650A1 (fr) * 2004-06-16 2005-12-29 Asahi Glass Company, Limited Nouveau d)riv) d'adamantane fluor)
US20080275112A1 (en) * 2004-07-23 2008-11-06 Schreiner Peter R Invention Concerning Aminoadamantane Compounds
EP2053055A1 (fr) * 2007-10-24 2009-04-29 Bayer Schering Pharma Aktiengesellschaft 11.beta.-fluoro-3-acetoxyestra-3,5-dien-17-one et son procédé de fabrication
CN112979409B (zh) * 2019-12-13 2022-09-30 浙江省化工研究院有限公司 一种气相催化氯化制备3,3,3-三氯-1,1,1-三氟丙烷的方法
CN116003372B (zh) * 2022-09-14 2024-08-06 多氟多新材料股份有限公司 一种氟代碳酸乙烯酯的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH577949A5 (fr) * 1967-09-11 1976-07-30 Res Inst Medicine Chem
GB1513135A (en) * 1974-06-04 1978-06-07 Res Inst For Med & Chem Inc Fluorination process and fluoro steroids

Also Published As

Publication number Publication date
JPS514102A (fr) 1976-01-14
BE829809A (fr) 1975-12-03
DE2524618A1 (de) 1976-01-02
NZ177688A (en) 1978-03-06
AU498203B2 (en) 1979-02-22
IN142193B (fr) 1977-06-11
NO751939L (fr) 1975-12-05
ES438166A1 (es) 1977-02-01
GB1513135A (en) 1978-06-07
LU72637A1 (fr) 1976-03-17
CH616397A5 (fr) 1980-03-31
NL7506547A (nl) 1975-12-08
US4036864A (en) 1977-07-19
IL47418A0 (en) 1975-08-31
CA1064475A (fr) 1979-10-16
FR2275426B1 (fr) 1979-07-13
IE41545B1 (en) 1980-01-30
FR2275426A1 (fr) 1976-01-16
US4284558A (en) 1981-08-18
IL47418A (en) 1979-11-30
SE7506339L (sv) 1975-12-05
IE41545L (en) 1975-12-04
AU8179575A (en) 1976-12-09
ZA753588B (en) 1976-05-26
IT1035927B (it) 1979-10-20

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