DK2475354T3 - Implanterbar indretning til kontrolleret lægemiddelafgivelse - Google Patents
Implanterbar indretning til kontrolleret lægemiddelafgivelse Download PDFInfo
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- DK2475354T3 DK2475354T3 DK10755277.0T DK10755277T DK2475354T3 DK 2475354 T3 DK2475354 T3 DK 2475354T3 DK 10755277 T DK10755277 T DK 10755277T DK 2475354 T3 DK2475354 T3 DK 2475354T3
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1085—Bladder
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Claims (15)
1. Implanterbar medicinsk indretning (1200) til kontrolleret lægemiddelafgivelse omfattende: et første lægemiddelafsnit (1204), som omfatter et første lægemiddelhus fyldt med en første lægemiddelformulering omfattende et første lægemiddel i en fast eller halvfast form, hvor det første lægemiddelhus omfatter en første væg, som er gen-nemtrængelig for vand, men er i det væsentlige uigennemtrængelig for det første lægemiddel, og har i det mindste én passage (1210) igennem den første væg, idet det første lægemiddelafsnit frigiver det første lægemiddel in vivo i overensstemmelse med et første frigivelsesprofil; og et andet lægemiddelafsnit (1202), som omfatter et andet lægemiddelhus fyldt med en anden lægemiddelformulering omfattende et andet lægemiddel i en fast eller halvfast form, hvor det andet lægemiddelhus omfatter en anden væg, som er gen-nemtrængelig for vand og for det andet lægemiddel, idet det andet lægemiddelafsnit frigiver det andet lægemiddel in vivo i overensstemmelse med et andet frigivelsesprofil, hvor det andet frigivelsesprofil afviger fra det første frigivelsesprofil; og et retentionsafsnit, som er funktionsmæssigt knyttet til såvel det første som det andet lægemiddelafsnit (1202, 1204), hvor det første og andet lægemiddelhus er opdelte områder i et enkelt rørformet legeme, idet den første og anden væg omfatter en polymer valgt blandt silikone og medicinske kvaliteter af polyvinylchlorid, polyolefiner, og polyetherurethaner, hvor det første lægemiddel har en ladning og/eller molekylstørrelse, som gør den første væg uigennemtrængelig for det første lægemiddel, og hvor det andet lægemiddel har en ladning og/eller molekylstørrelse, som gør den anden væg gennemtrængelig for det andet lægemiddel.
2. Indretning ifølge krav 1, hvor den første lægemiddelformulering har en relativt højere opløselighed i vand end den anden lægemiddelformulering.
3. Indretning ifølge krav 1, hvor: det første lægemiddelhus (1204) er konfigureret til at frigive det første lægemiddel primært via osmotisk tryk; og det andet lægemiddelhus (1202) er konfigureret til at frigive den anden lægemiddelformulering primært via diffusion.
4. Indretning ifølge krav 3, hvor: det første lægemiddel foreligger i form af et salt med høj opløselighed i vand; og det andet lægemiddel er det samme lægemiddel som det første lægemiddel, men foreligger i en ikke-saltform med lav opløselighed i vand.
5. Indretning ifølge krav 1, hvor i det mindste én af lægemiddelformuleringerne omfatter adskillige faste lægemiddeltabletter anbragt i en række i det ene rørformede legeme.
6. Indretning ifølge krav 1, hvor retentionsafsnittet omfatter en retentionsramme og indretningen er deformerbar imellem en retentionsform og en indsætningsform.
7. Indretning ifølge krav 1, hvor det første lægemiddelhus (1204) omfatter adskillige frigivelsespassager og det første frigivelsesprofil i det mindste delvis afspejler diffusion af lægemidlet igemmen de adskillige frigivelsespassager.
8. Indretning ifølge krav 7, hvor hver frigivelsespassage (1210) omfatter enten en åbning, som strækker sig igennem en ikke porøs væg eller en passagepore, som strækker sig igennem en porøs væg.
9. Indretning ifølge krav 1, hvor den første lægemiddelformulering omfatter et farmaceutisk acceptablet salt af lidocain, og den anden lægemiddelformulering omfatter lido-cainbase.
10. Indretning ifølge krav 9, hvor det første lægemiddelhus (1204) tilvejebringer frigivelse af lidocainsaltet in vivo ved osmotisk tryk.
11. Indretning ifølge krav 9, hvor det andet lægemiddelhus (1202) tilvejebringer frigivelse af lidocainbasen in vivo ved diffusion.
12. Indretning ifølge krav 1, hvor i det mindste én af den første og anden lægemiddelformulering omfatter adskillige lægemiddeltabletter anbragt i en række i det ene rørformede legeme.
13. Indretning ifølge krav 12, hvor det ene rørformede legeme er dannet af silikone.
14. Indretning ifølge krav 10, hvor retentionsafsnittet omfatter en retentionsramme, således at indretningen er deformerbar imellem en retentionsform og en indsætningsform.
15. Indretning ifølge krav 14, hvor indretningen kan indsættes igennem en patients urinrør og ind i patientens blære, hvor indretningen (1200) er i indsætningsformen, og bliver fastholdt i blæren, når indretningen deformeres til retentionsformen.
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- 2010-09-09 AU AU2010292238A patent/AU2010292238A1/en not_active Abandoned
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- 2010-09-09 KR KR1020127009317A patent/KR20120069715A/ko not_active Application Discontinuation
- 2010-09-09 CN CN2010800507317A patent/CN102596174A/zh active Pending
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- 2010-09-09 WO PCT/US2010/048266 patent/WO2011031855A2/en active Application Filing
- 2010-09-09 ES ES10755277.0T patent/ES2606129T3/es active Active
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2012
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| US20150209277A1 (en) | 2015-07-30 |
| US20210401741A1 (en) | 2021-12-30 |
| CA2773491A1 (en) | 2011-03-17 |
| US20110060309A1 (en) | 2011-03-10 |
| IN2012DN02221A (da) | 2015-08-21 |
| CN102596174A (zh) | 2012-07-18 |
| AU2010292238A1 (en) | 2012-03-29 |
| SG179051A1 (en) | 2012-04-27 |
| EP2475354A2 (en) | 2012-07-18 |
| JP2013504584A (ja) | 2013-02-07 |
| BR112012005398A2 (pt) | 2016-04-05 |
| EA201270379A1 (ru) | 2012-10-30 |
| IL218459A0 (en) | 2012-04-30 |
| ES2606129T3 (es) | 2017-03-22 |
| WO2011031855A3 (en) | 2012-04-19 |
| MX2012002937A (es) | 2012-04-10 |
| WO2011031855A2 (en) | 2011-03-17 |
| EP2475354B1 (en) | 2016-11-02 |
| US20180071213A1 (en) | 2018-03-15 |
| KR20120069715A (ko) | 2012-06-28 |
| US11135161B2 (en) | 2021-10-05 |
| ZA201201751B (en) | 2013-08-28 |
| US9017312B2 (en) | 2015-04-28 |
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