DK2389587T3 - Diagnostiske og prognostiske fremgangsmåder relateret Alzheimers sygdom - Google Patents
Diagnostiske og prognostiske fremgangsmåder relateret Alzheimers sygdom Download PDFInfo
- Publication number
- DK2389587T3 DK2389587T3 DK10704840.7T DK10704840T DK2389587T3 DK 2389587 T3 DK2389587 T3 DK 2389587T3 DK 10704840 T DK10704840 T DK 10704840T DK 2389587 T3 DK2389587 T3 DK 2389587T3
- Authority
- DK
- Denmark
- Prior art keywords
- leu
- glu
- val
- ser
- gly
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Claims (10)
1. Fremgangsmåde til understøtning af diagnose af Alzheimers sygdom hos en person, hvilken fremgangsmåde omfatter: tilvejebringelse af en prøve af et blodderivat, hvori blodderivatet er serum eller plasma taget fra personen; undersøgelse af mængden af gelsolin i prøven; sammenligning af mængden af gelsolin til stede i prøven med en referencemængde af gelsolin til stede i en prøve fra en rask person, hvori registrering af et gelsolinniveau i prøven fra personen, som er lavere end gelsolinniveauet i referenceprøven, indikerer en øget sandsynlighed for Alzheimers sygdom hos personen.
2. Fremgangsmåde ifølge krav 1, hvori prøven omfatter blodplasma.
3. Fremgangsmåde ifølge krav 2, hvori dette blodplasma er udtyndet for en eller flere af albumin, transferrin, IgG, I g A, antitrypsin eller haptoglobin.
4. Fremgangsmåde ifølge krav 3, hvori dette blodplasma er udtyndet for hver af albumin, transferrin, IgG, I g A, antitrypsin eller haptoglobin.
5. Fremgangsmåde ifølge ethvert af de foregående krav, hvori proteinet registreres ved western-blot-teknik.
6. Fremgangsmåde ifølge ethvert af krav 1 til 4, hvori proteinet registreres ved kugleopslemningsarray.
7. Fremgangsmåde ifølge ethvert af krav 1 til 4, hvori proteinet registreres ved et planarray.
8. Fremgangsmåde ifølge ethvert af krav 1 til 4, hvori proteinet registreres ved isobarisk proteinmarkering eller ved isotopisk proteinmarkering.
9. Fremgangsmåde ifølge ethvert af krav 1 til 4 eller krav 8, hvori proteinet registreres ved massespektrometerbaseret analyse.
10. Fremgangsmåde ifølge ethvert af krav 1 til 4, 8 eller 9, hvori proteinet er gelsolin og registreres ved henvisning til en eller flere af følgende peptider i Tabel B: SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0901232A GB0901232D0 (en) | 2009-01-26 | 2009-01-26 | Methods |
GB0904209A GB0904209D0 (en) | 2009-03-11 | 2009-03-11 | Methods |
PCT/GB2010/000107 WO2010084327A2 (en) | 2009-01-26 | 2010-01-26 | Methods |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2389587T3 true DK2389587T3 (da) | 2014-03-03 |
Family
ID=42112229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10704840.7T DK2389587T3 (da) | 2009-01-26 | 2010-01-26 | Diagnostiske og prognostiske fremgangsmåder relateret Alzheimers sygdom |
Country Status (7)
Country | Link |
---|---|
US (1) | US20120071337A1 (da) |
EP (1) | EP2389587B1 (da) |
JP (1) | JP5755149B2 (da) |
CA (1) | CA2750076A1 (da) |
DK (1) | DK2389587T3 (da) |
ES (1) | ES2453106T3 (da) |
WO (1) | WO2010084327A2 (da) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2424426B1 (en) * | 2009-04-29 | 2020-01-08 | Abbott Diabetes Care, Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
JP6012923B2 (ja) * | 2010-12-22 | 2016-10-25 | 株式会社Mcbi | 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法 |
WO2013151726A1 (en) * | 2012-04-05 | 2013-10-10 | Integrated Diagnostics, Inc. | Srm methods in alzheimer's disease and neurological disease assays |
US9366678B2 (en) | 2012-10-25 | 2016-06-14 | Wisconsin Alumni Research Foundation | Neutron encoded mass tags for analyte quantification |
GB201310203D0 (en) * | 2013-06-07 | 2013-07-24 | Electrophoretics Ltd | Materials and methods relating to Alzheimer's disease |
GB201504432D0 (en) * | 2015-03-17 | 2015-04-29 | Electrophoretics Ltd | Materials and methods for diagnosis and treatment of alzheimers disease |
JP6947449B2 (ja) * | 2016-06-29 | 2021-10-13 | 学校法人自治医科大学 | バイオマーカー、診断用組成物、及び診断用キット |
JP6950952B2 (ja) * | 2017-12-20 | 2021-10-13 | 国立大学法人三重大学 | 脳アミロイド血管症の末梢血バイオマーカー |
WO2022145074A1 (ja) * | 2020-12-28 | 2022-07-07 | 株式会社Mcbi | 判定支援情報生成方法、判定支援情報生成システム、及び情報処理装置 |
CN114166924A (zh) * | 2021-12-03 | 2022-03-11 | 中国医学科学院北京协和医院 | 尿液蛋白标志物在诊断遗传性血管水肿中的用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
EP1379879A2 (en) * | 2000-12-08 | 2004-01-14 | Oxford GlycoSciences (UK) Limited | Diagnosis and treatment of alzheimer's disease |
US20080206737A1 (en) * | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
GB0421639D0 (en) * | 2004-09-29 | 2004-10-27 | Proteome Sciences Plc | Methods and compositions relating to alzheimer's disease |
GB0512401D0 (en) * | 2005-06-17 | 2005-07-27 | Randox Lab Ltd | Method |
GB2428240A (en) * | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
WO2007068985A2 (en) * | 2005-12-16 | 2007-06-21 | Electrophoretics Limited | Diagnosis and prognosis of colorectal cancer |
EP2097094A4 (en) * | 2006-11-01 | 2011-01-05 | George Mason Intellectual Prop | BIOMARKERS FOR NEUROLOGICAL SUFFERING |
-
2010
- 2010-01-26 CA CA2750076A patent/CA2750076A1/en not_active Abandoned
- 2010-01-26 ES ES10704840.7T patent/ES2453106T3/es active Active
- 2010-01-26 US US13/146,121 patent/US20120071337A1/en not_active Abandoned
- 2010-01-26 WO PCT/GB2010/000107 patent/WO2010084327A2/en active Application Filing
- 2010-01-26 DK DK10704840.7T patent/DK2389587T3/da active
- 2010-01-26 JP JP2011546943A patent/JP5755149B2/ja not_active Expired - Fee Related
- 2010-01-26 EP EP10704840.7A patent/EP2389587B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
EP2389587A2 (en) | 2011-11-30 |
ES2453106T3 (es) | 2014-04-04 |
WO2010084327A2 (en) | 2010-07-29 |
US20120071337A1 (en) | 2012-03-22 |
WO2010084327A3 (en) | 2010-09-23 |
CA2750076A1 (en) | 2010-07-29 |
EP2389587B1 (en) | 2013-12-25 |
JP5755149B2 (ja) | 2015-07-29 |
JP2012515915A (ja) | 2012-07-12 |
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