DK2381932T3 - Intracervikal indretning til frigivelsen af lægemidler i den lokale- regionale behandling af livmoderhalskræft - Google Patents
Intracervikal indretning til frigivelsen af lægemidler i den lokale- regionale behandling af livmoderhalskræft Download PDFInfo
- Publication number
- DK2381932T3 DK2381932T3 DK09785793.2T DK09785793T DK2381932T3 DK 2381932 T3 DK2381932 T3 DK 2381932T3 DK 09785793 T DK09785793 T DK 09785793T DK 2381932 T3 DK2381932 T3 DK 2381932T3
- Authority
- DK
- Denmark
- Prior art keywords
- icd
- shaft
- intracervical
- blocking element
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Claims (11)
1. Intrauterin indretning og mere specifikt en intracervikal indretning (ICD) til den lokale frigivelse af lægemidler i den lokoregionale behandling af tumorer i livmoderhalsen, omfattende: et langstrakt skaft (2) konfigureret til blive positioneret i livmoderkanalen (15), hvor dette skaft består af en indre hul kerne (3) der tillader passagen af menstruationsblod, når indretningen er på plads, og en coating (4) konfigureret til en gradvis lægemiddelfrigivelse; et første element (5) fastgjort til skaftet for at blokere skaftet (2) inden i livmoderhulrummet (12), og placeret ved den kraniale eller øvre ende; hvor det første blokeringselement (5) er i formen af en oppustelig silikonekugle i forbindelse med hulrummet (6) af den indre kerne (3) af skaftet (2), hvor kuglen (5) oppustes ved hjælp af et forbindelsesrør (8), der passerer igennem det andet blokeringselement (7) og er i forbindelse med hulrummet (6); og et andet blokeringselement (7, 71) fastgjort til skaftet og konfigureret til at blive positioneret inden i vaginaen (11), mod ektocervixen (16), placeret ved den kaudale eller nedre ende afskaffet (2).
2. Intrauterin indretning og mere specifikten intracervikal indretning (ICD) ifølge krav 1, kendetegnet ved, at det andet blokeringselement (7) også er en oppustelig silikonekugle.
3. Intrauterin indretning og mere specifikten intracervikal indretning (ICD) ifølge krav 1, kendetegnet ved, at det andet blokeringselement (7) omfatter en kop (71) coatet på sin konkave overflade der vender mod skaftet (2) med en skive (72) , som også er konkav og konfigureret til en gradvis lægemiddelfrigivelse.
4. Intrauterin indretning og mere specifikten intracervikal indretning (ICD) ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at kernen (3) af skaftet (2) og koppen (71) af det andet blokeringselement er lavet af plast.
5. Intrauterin indretning og mere specifikten intracervikal indretning (ICD) ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at coatingen (4) af skaftet (2) og coatingen (72) af det andet blokeringselement konfigureret til en gradvis lægemiddelfrigivelse er lavet af polymerisk eller lignende materiale.
6. Intrauterin indretning og mere specifikten intracervikal indretning (ICD) ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at skaftet (2) er i alt væsentligt cylindrisk i form og ved, at skaftet (2) er mellem 2 og 3 cm i længde, den indre kerne (3) har en diameter mellem 2,0 og 3,5 mm, mens coatingen (4) varierer mellem 3,0 mm og 3,5 mm i diameter.
7. Intrauterin indretning (IUD) ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at diameteren af de første (5) og anden kugler (7) varierer, når oppustet, mellem 3 og 6 mm og ved, at diameteren af skiven (72) af det andet blokeringselement (7) varierer mellem 1,5 og 5,0 cm.
8. Intracervikal indretning (ICD) ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at forbindelsesrøret (8) er udstyret med en kontraventil (9) indrettet til at tillade indførsel, men ikke lækagen af oppustningsfluid, vand og/eller luft, i hulrummet (6) af kernen (3), eventuelt hvor røret (8) er udstyret med en standardforbinder til engangssprøjter eller lignende ved sin frie ende (10).
9. Intracervikal indretning (ICD) ifølge et hvilket som helst af de foregående krav fra 1 til 9, kendetegnet ved, at lægemidlet er et lægemiddel til målrettet terapi eller et kemoterapimiddel såsom Cisplatin, Carboplatin, Taxol, Taxotere, Topotecan, Irinotecan, Adriamycin, Gemcitabin, Bleomycin, Ifosfamid, Vinorelbin, 5 Fluorouracil, VP 16, Metrotrexat, Mitomycin C, Vineristin, Vinblastin.
10. Intracervikal indretning (ICD) ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at lægemidlet er en forbindelse til radioimmunterapi eller en radiomærket forbindelse til eventuelt anvendelse i teknikkerne til identifikation af skildvagtslymfeknuder.
11. Intracervikal indretning (ICD) ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at lægemidlet af indretningen er et spermatocid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2009/000151 WO2010086681A1 (en) | 2009-01-29 | 2009-01-29 | Intra- cervical device for the local release of drugs in the local-regional treatment of cervical cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2381932T3 true DK2381932T3 (da) | 2018-11-19 |
Family
ID=40933562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09785793.2T DK2381932T3 (da) | 2009-01-29 | 2009-01-29 | Intracervikal indretning til frigivelsen af lægemidler i den lokale- regionale behandling af livmoderhalskræft |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8962011B2 (da) |
| EP (1) | EP2381932B1 (da) |
| CN (1) | CN102369003B (da) |
| CY (1) | CY1120766T1 (da) |
| DK (1) | DK2381932T3 (da) |
| ES (1) | ES2692147T3 (da) |
| HK (1) | HK1167808A1 (da) |
| HR (1) | HRP20181605T1 (da) |
| HU (1) | HUE040045T2 (da) |
| LT (1) | LT2381932T (da) |
| PL (1) | PL2381932T3 (da) |
| PT (1) | PT2381932T (da) |
| SI (1) | SI2381932T1 (da) |
| TR (1) | TR201815588T4 (da) |
| WO (1) | WO2010086681A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8961498B2 (en) | 2008-06-25 | 2015-02-24 | Medimetrics Personalized Drug Delivery | Electronic pill comprising a plurality of medicine reservoirs |
| JP5497176B2 (ja) | 2009-08-12 | 2014-05-21 | コーニンクレッカ フィリップス エヌ ヴェ | 圧縮可能な薬品貯槽を備える薬品送出装置 |
| JP5992330B2 (ja) * | 2009-09-29 | 2016-09-14 | メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ | 物質を投与するための子宮内電子カプセル |
| US20130211384A1 (en) * | 2010-07-28 | 2013-08-15 | Fondazione Irccs Istituto Nazionale Dei Tumori | Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system |
| US20140100530A1 (en) | 2012-10-05 | 2014-04-10 | Miguel A. Linares | Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device |
| US11857675B2 (en) | 2014-08-06 | 2024-01-02 | Barbara Sanders Esparza | Method for reducing the incidence and prevalence of human papilloma virus (HPV) and for providing protection against sexually transmitted infections |
| MX2014009494A (es) | 2014-08-06 | 2016-02-08 | Guillermo Sanders Acedo | Dispositivo cervico uterino que incrementa la protección del riesgo de contraer cáncer cervico uterino. |
| SG11202005186QA (en) | 2017-12-05 | 2020-07-29 | Jenny Colleen Mccloskey | Device for treatment of a body canal and adjacent surfaces |
| WO2019226519A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| WO2019222856A1 (en) | 2018-05-24 | 2019-11-28 | Nureva Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| SG11202005947RA (en) | 2018-05-24 | 2020-07-29 | Celanese Eva Performance Polymers Corp | Implantable device for sustained release of a macromolecular drug compound |
| EP3938020A1 (en) | 2019-03-15 | 2022-01-19 | Covidien LP | Devices for transcervical treatment of endometrial cancer and hyperplasia |
| US11844857B2 (en) | 2019-06-27 | 2023-12-19 | Covidien Lp | Treating gynecological malignancies with deployable implants |
| CN110575612A (zh) * | 2019-09-27 | 2019-12-17 | 赵志国 | 女用光动力凝胶封包敷料装置 |
| CN114681771B (zh) * | 2020-12-31 | 2024-04-02 | 中创振邦医疗科技(湖南)有限公司 | 一种一次性子宫颈治疗器 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069307A (en) | 1970-10-01 | 1978-01-17 | Alza Corporation | Drug-delivery device comprising certain polymeric materials for controlled release of drug |
| US3815600A (en) * | 1972-07-24 | 1974-06-11 | H Groves | Vaginal medicator |
| DE2244923A1 (de) * | 1972-09-13 | 1974-04-04 | Moyer Dean Laroche | Therapeutische intrauterineinrichtung |
| DE2424439A1 (de) * | 1974-05-20 | 1975-12-04 | Harvey Hugh Groves | Vaginalmedikator |
| US4126024A (en) * | 1977-03-24 | 1978-11-21 | Timmons David R | Bicycle cable lock |
| US4249531A (en) * | 1979-07-05 | 1981-02-10 | Alza Corporation | Bioerodible system for delivering drug manufactured from poly(carboxylic acid) |
| US5224493A (en) | 1991-01-30 | 1993-07-06 | Cadco Corporation | Contraceptive intracervical device and novel nonsystemic agents for the prevention of conception and disease |
| US5947991A (en) * | 1997-01-07 | 1999-09-07 | Cowan; Robert K. | Single balloon device for cervix |
| US6982091B2 (en) * | 2001-08-29 | 2006-01-03 | Umd, Inc. | Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy |
| WO1999022680A1 (en) | 1997-11-03 | 1999-05-14 | Deschutes Medical Products, Inc. | Pessary with medicated cartridge |
| JP4503208B2 (ja) * | 2000-04-25 | 2010-07-14 | インプレス メディカル， インコーポレイテッド | 子宮内での接着を生成するための方法および装置 |
| WO2003017971A1 (en) * | 2001-08-31 | 2003-03-06 | Schering Oy | Drug delivery system |
| WO2003022260A1 (en) | 2001-09-12 | 2003-03-20 | Slobodan Arsenijevic | Use of methotrexate and l-arginine for the preparation of a medicament for treatment of uterine myoma |
| US8062658B2 (en) | 2004-12-14 | 2011-11-22 | Poly-Med, Inc. | Multicomponent bioactive intravaginal ring |
-
2009
- 2009-01-29 SI SI200931883T patent/SI2381932T1/sl unknown
- 2009-01-29 LT LTEP09785793.2T patent/LT2381932T/lt unknown
- 2009-01-29 WO PCT/IB2009/000151 patent/WO2010086681A1/en active Application Filing
- 2009-01-29 TR TR2018/15588T patent/TR201815588T4/tr unknown
- 2009-01-29 CN CN200980155680.1A patent/CN102369003B/zh not_active Expired - Fee Related
- 2009-01-29 US US13/146,362 patent/US8962011B2/en not_active Expired - Fee Related
- 2009-01-29 DK DK09785793.2T patent/DK2381932T3/da active
- 2009-01-29 HU HUE09785793A patent/HUE040045T2/hu unknown
- 2009-01-29 PT PT09785793T patent/PT2381932T/pt unknown
- 2009-01-29 PL PL09785793T patent/PL2381932T3/pl unknown
- 2009-01-29 EP EP09785793.2A patent/EP2381932B1/en active Active
- 2009-01-29 ES ES09785793.2T patent/ES2692147T3/es active Active
-
2012
- 2012-08-30 HK HK12108482.4A patent/HK1167808A1/xx not_active IP Right Cessation
-
2018
- 2018-10-04 HR HRP20181605TT patent/HRP20181605T1/hr unknown
- 2018-10-17 CY CY181101067T patent/CY1120766T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LT2381932T (lt) | 2018-11-12 |
| CN102369003B (zh) | 2014-06-25 |
| SI2381932T1 (sl) | 2018-12-31 |
| TR201815588T4 (tr) | 2018-11-21 |
| ES2692147T3 (es) | 2018-11-30 |
| WO2010086681A1 (en) | 2010-08-05 |
| US8962011B2 (en) | 2015-02-24 |
| US20120020877A1 (en) | 2012-01-26 |
| HK1167808A1 (en) | 2012-12-14 |
| CY1120766T1 (el) | 2019-12-11 |
| PT2381932T (pt) | 2018-11-15 |
| EP2381932A1 (en) | 2011-11-02 |
| EP2381932B1 (en) | 2018-08-01 |
| HUE040045T2 (hu) | 2019-02-28 |
| CN102369003A (zh) | 2012-03-07 |
| HRP20181605T1 (hr) | 2018-11-30 |
| PL2381932T3 (pl) | 2019-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2381932T3 (da) | Intracervikal indretning til frigivelsen af lægemidler i den lokale- regionale behandling af livmoderhalskræft | |
| ES2269103T3 (es) | Procedimientos y dispositivos para el suministro de agentes a conductos galactoforos mamarios. | |
| ES2970224T3 (es) | Tinostamustina para su uso en el tratamiento del sarcoma | |
| US20130211384A1 (en) | Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system | |
| Eyol et al. | Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin | |
| Wang et al. | Dual-responsive nanodroplets combined with ultrasound-targeted microbubble destruction suppress tumor growth and metastasis via autophagy blockade | |
| Abhang et al. | Transmucosal drug delivery-an overview | |
| Elgeidie et al. | Pancreatic gastrointestinal stromal tumor: a case report | |
| EA026830B1 (ru) | Осмотически активная система вагинальной доставки | |
| CN103301558B (zh) | 一种感应性宫腔缓释系统 | |
| CN107635545A (zh) | 用于增强粘膜表面处活性剂的输送的低渗水凝胶制剂 | |
| CN108030997A (zh) | 可调速率药物递送可植入装置 | |
| Zipper et al. | Quinacrine sterilization: a retrospective | |
| McConville | The therapeutic potential of vaginal drug delivery in the treatment of cervical cancer | |
| US20190151625A1 (en) | Drug delivery apparatus and method | |
| Wang et al. | Characterization of highly proliferative secondary tumor clusters along host blood vessels in malignant glioma | |
| Batista et al. | A rare case of invasive vaginal carcinoma associated with vaginal prolapse | |
| Oprescu et al. | Urinary Tract Resections in Advanced-stage Cervical Cancer–A Series of Eight Cases | |
| Wong et al. | Hepatobiliary cystadenoma with mesenchymal stroma may mimic biliary smooth muscle neoplasms. | |
| Chituku et al. | The Development of Locoregional Therapies as a Strategy for Reducing Cervical Cancer Mortality in Low to Middle Income Countries. | |
| CN103096873B (zh) | 在人女性生殖系统的子宫颈中用于治疗子宫颈癌和/或用于预防肿瘤形成的治疗剂、包含所述治疗剂的组合物、可植入装置和方法 | |
| Chan | Drug therapy-related issues in patients who received bariatric surgery (Part I) | |
| Duraisamy et al. | Case series of rare ovarian malignancy: granulosa cell tumor | |
| Sharifian et al. | Liver cancer: New insights into surgical and nonsurgical treatments | |
| Tafish et al. | Gastroretentive drug delivery systems: A summarized overview. |