DK2303895T3 - Thiazolyl AND OXAZOLYLISOQUINOLINONER AND methods of use thereof - Google Patents
Thiazolyl AND OXAZOLYLISOQUINOLINONER AND methods of use thereof Download PDFInfo
- Publication number
- DK2303895T3 DK2303895T3 DK09767711.6T DK09767711T DK2303895T3 DK 2303895 T3 DK2303895 T3 DK 2303895T3 DK 09767711 T DK09767711 T DK 09767711T DK 2303895 T3 DK2303895 T3 DK 2303895T3
- Authority
- DK
- Denmark
- Prior art keywords
- thiazolo
- isoquinolin
- hydroxy
- pharmaceutically acceptable
- compound according
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 44
- 125000000335 thiazolyl group Chemical group 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 125
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- 239000001257 hydrogen Substances 0.000 claims description 35
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- 125000002947 alkylene group Chemical group 0.000 claims description 25
- 125000000217 alkyl group Chemical group 0.000 claims description 24
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- 238000011282 treatment Methods 0.000 claims description 24
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 22
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- -1 (dimethylamino) methyl [1,3] thiazolo [5,4-c] isoquinolin-5 (4H) -one Chemical compound 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7385708P | 2008-06-19 | 2008-06-19 | |
| PCT/US2009/047767 WO2009155402A1 (en) | 2008-06-19 | 2009-06-18 | Thiazolyl- and oxazolyl-isoquinolinones and methods for using them |
Publications (1)
| Publication Number | Publication Date |
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| DK2303895T3 true DK2303895T3 (en) | 2015-01-12 |
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| DK09767711.6T DK2303895T3 (en) | 2008-06-19 | 2009-06-18 | Thiazolyl AND OXAZOLYLISOQUINOLINONER AND methods of use thereof |
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|---|---|
| US (3) | US8299090B2 (enExample) |
| EP (2) | EP2303895B1 (enExample) |
| JP (2) | JP5564495B2 (enExample) |
| AR (1) | AR072265A1 (enExample) |
| AU (1) | AU2009260060B2 (enExample) |
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| DK (1) | DK2303895T3 (enExample) |
| ES (1) | ES2530815T3 (enExample) |
| HK (1) | HK1212698A1 (enExample) |
| SA (1) | SA109300394B1 (enExample) |
| TW (1) | TWI471329B (enExample) |
| WO (1) | WO2009155402A1 (enExample) |
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| SA109300394B1 (ar) * | 2008-06-19 | 2013-01-22 | ويث | ثيازوليل- وأوكسازوليل- أيزوكوينولينونات وطرق لاستخدامها |
| WO2009155413A1 (en) * | 2008-06-19 | 2009-12-23 | Wyeth | Thienyl- and furanyl-isoquinolinones and methods for using them |
| US9173395B2 (en) | 2011-07-04 | 2015-11-03 | Bayer Intellectual Property Gmbh | Use of substituted isoquinolinones, isoquinolindiones, isoquinolintriones and dihydroisoquinolinones or in each case salts thereof as active agents against abiotic stress in plants |
| RU2606635C2 (ru) * | 2011-07-13 | 2017-01-10 | Сантен Фармасьютикал Ко., Лтд. | Новое соединение, проявляющее ингибиторную активность в отношении parp |
| EP3325623B3 (en) | 2015-07-23 | 2021-01-20 | Institut Curie | Use of a combination of dbait molecule and parp inhibitors to treat cancer |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| KR20200130856A (ko) | 2018-03-13 | 2020-11-20 | 옹쎄오 | 암 치료에서 획득한 내성에 대한 디베이트 분자 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2024261243A1 (en) | 2023-06-21 | 2024-12-26 | Hemispherian As | Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer |
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| EP0005745B1 (en) * | 1978-05-26 | 1982-07-14 | Gruppo Lepetit S.P.A. | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, cns-depressant and anti-anxiety agents and pharmaceutical compositions thereof |
| ITMI20002358A1 (it) * | 2000-10-31 | 2002-05-01 | Flavio Moroni | Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi |
| AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| US7501412B2 (en) | 2002-11-22 | 2009-03-10 | Mitsubishi Tanabe Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
| ATE533812T1 (de) | 2005-08-01 | 2011-12-15 | Wietek Holding Gmbh | Verfahren zur rezyklierung von kunststoff |
| WO2007149907A2 (en) | 2006-06-20 | 2007-12-27 | Abbott Laboratories | Pyrazoloquinazolinones as parp inhibitors |
| SA109300394B1 (ar) * | 2008-06-19 | 2013-01-22 | ويث | ثيازوليل- وأوكسازوليل- أيزوكوينولينونات وطرق لاستخدامها |
| WO2009155413A1 (en) * | 2008-06-19 | 2009-12-23 | Wyeth | Thienyl- and furanyl-isoquinolinones and methods for using them |
-
2009
- 2009-06-17 SA SA109300394A patent/SA109300394B1/ar unknown
- 2009-06-18 EP EP09767711.6A patent/EP2303895B1/en active Active
- 2009-06-18 CA CA2728454A patent/CA2728454C/en active Active
- 2009-06-18 WO PCT/US2009/047767 patent/WO2009155402A1/en not_active Ceased
- 2009-06-18 AU AU2009260060A patent/AU2009260060B2/en not_active Ceased
- 2009-06-18 US US12/487,247 patent/US8299090B2/en not_active Expired - Fee Related
- 2009-06-18 DK DK09767711.6T patent/DK2303895T3/en active
- 2009-06-18 ES ES09767711T patent/ES2530815T3/es active Active
- 2009-06-18 EP EP14185672.4A patent/EP2896626A1/en not_active Withdrawn
- 2009-06-18 JP JP2011514801A patent/JP5564495B2/ja not_active Expired - Fee Related
- 2009-06-19 AR ARP090102266A patent/AR072265A1/es active IP Right Grant
- 2009-06-19 TW TW98120713A patent/TWI471329B/zh not_active IP Right Cessation
-
2012
- 2012-10-18 US US13/655,082 patent/US8906935B2/en active Active
-
2014
- 2014-03-28 JP JP2014067493A patent/JP2014122242A/ja not_active Withdrawn
- 2014-11-07 US US14/535,877 patent/US9265769B2/en active Active
-
2016
- 2016-01-21 HK HK16100665.6A patent/HK1212698A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI471329B (zh) | 2015-02-01 |
| JP2011525185A (ja) | 2011-09-15 |
| WO2009155402A1 (en) | 2009-12-23 |
| JP5564495B2 (ja) | 2014-07-30 |
| TW201002725A (en) | 2010-01-16 |
| US8299090B2 (en) | 2012-10-30 |
| HK1156310A1 (en) | 2012-06-08 |
| JP2014122242A (ja) | 2014-07-03 |
| US20130059843A1 (en) | 2013-03-07 |
| US20150133443A1 (en) | 2015-05-14 |
| AU2009260060A1 (en) | 2009-12-23 |
| AR072265A1 (es) | 2010-08-18 |
| EP2896626A1 (en) | 2015-07-22 |
| CA2728454C (en) | 2017-01-17 |
| HK1212698A1 (en) | 2016-06-17 |
| EP2303895B1 (en) | 2014-09-24 |
| CA2728454A1 (en) | 2009-12-23 |
| US20090318442A1 (en) | 2009-12-24 |
| AU2009260060B2 (en) | 2015-01-22 |
| US9265769B2 (en) | 2016-02-23 |
| SA109300394B1 (ar) | 2013-01-22 |
| EP2303895A1 (en) | 2011-04-06 |
| ES2530815T3 (es) | 2015-03-05 |
| US8906935B2 (en) | 2014-12-09 |
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