DK2209798T3 - Modificerede væksthormonpolypeptider - Google Patents
Modificerede væksthormonpolypeptider Download PDFInfo
- Publication number
- DK2209798T3 DK2209798T3 DK08788565T DK08788565T DK2209798T3 DK 2209798 T3 DK2209798 T3 DK 2209798T3 DK 08788565 T DK08788565 T DK 08788565T DK 08788565 T DK08788565 T DK 08788565T DK 2209798 T3 DK2209798 T3 DK 2209798T3
- Authority
- DK
- Denmark
- Prior art keywords
- ser
- leu
- glu
- thr
- gly
- Prior art date
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- 108010051696 Growth Hormone Proteins 0.000 claims description 99
- 102000018997 Growth Hormone Human genes 0.000 claims description 99
- 239000000122 growth hormone Substances 0.000 claims description 98
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 229920001184 polypeptide Polymers 0.000 claims description 28
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 28
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- 108020004707 nucleic acids Proteins 0.000 claims description 14
- 102000039446 nucleic acids Human genes 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 10
- 239000013598 vector Substances 0.000 claims description 10
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- 239000003814 drug Substances 0.000 claims description 7
- 239000000710 homodimer Substances 0.000 claims description 7
- 229940124013 Growth hormone receptor antagonist Drugs 0.000 claims description 4
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- 230000003442 weekly effect Effects 0.000 claims description 4
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- 229940124597 therapeutic agent Drugs 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
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- 239000012148 binding buffer Substances 0.000 description 1
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- 210000000988 bone and bone Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
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- 210000004899 c-terminal region Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
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- 230000010261 cell growth Effects 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
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- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 208000018554 digestive system carcinoma Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
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- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
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- 230000003118 histopathologic effect Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 108010021336 lanreotide Proteins 0.000 description 1
- 229960002437 lanreotide Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000003468 luciferase reporter gene assay Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
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- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000001426 native polyacrylamide gel electrophoresis Methods 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000004412 neuroendocrine cell Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229960002700 octreotide Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 210000004258 portal system Anatomy 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
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- 238000005215 recombination Methods 0.000 description 1
- 230000013878 renal filtration Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
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- 108010026333 seryl-proline Proteins 0.000 description 1
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- 230000019491 signal transduction Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940075620 somatostatin analogue Drugs 0.000 description 1
- 210000001875 somatotroph Anatomy 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
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- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
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- 210000002229 urogenital system Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (14)
1. Nukleinsyremolekyle omfattende en nukleinsyresekvens ifølge SEQ ID NO: 22 eller SEQ ID NO:23, kendetegnet ved, at nukleinsyremolekylet koder for et polypeptid, der har væksthormonreceptorantagonistaktivitet.
2. Polypeptid omfattende en aminosyresekvens udvalgt fra: en aminosyresekvens ifølge SEQ ID NO: 24 eller en aminosyresekvens ifølge SEQ ID NO: 32, hvor polypeptidet har væksthormonreceptorantagonistaktivitet.
3. Homodimer omfattende to polypeptider, der omfatter eller består af SEQ ID NO: 24 eller SEQ ID NO: 32.
4. Vektor omfattende en nukleinsyremolekyle ifølge krav 1.
5. Celle transficeret eller omdannet med et nukleinsyremolekyle ifølge krav 1 eller vektor ifølge krav 4.
6. Farmaceutisk sammensætning omfattende et polypeptid ifølge krav 2 eller homodimer ifølge krav 3, hvilken sammensætning indbefatter en excipiens eller et bærestof.
7. Sammensætning ifølge krav 6, hvor sammensætningen er kombineret med et yderligere terapeutisk middel.
8. Polypeptid eller homodimer ifølge krav 2 eller 3 til anvendelse i behandlingen af væksthormonoverskud.
9. Polypeptid til anvendelse ifølge krav 8, hvor polypeptidet administreres med ugentlige intervaller.
10. Polypeptid til anvendelse ifølge krav 8, hvor polypeptidet administreres med to ugentlige intervaller.
11. Polypeptid til anvendelse ifølge krav 8, hvor polypeptidet administreres med månedlige intervaller.
12. Polypeptid til anvendelse ifølge et hvilket som helst af kravene 8-11, hvor væksthormonoverskuddet er gigantisme eller akromegali.
13. Polypeptid ifølge krav 2 eller homodimer ifølge krav 3 til anvendelse i behandlingen af cancer.
14. Polypeptid til anvendelse ifølge krav 13, hvor canceren er prostatacancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97901007P | 2007-10-10 | 2007-10-10 | |
| GBGB0719818.7A GB0719818D0 (en) | 2007-10-11 | 2007-10-11 | Growth hormone fusion polypeptides |
| PCT/GB2008/003056 WO2009047474A2 (en) | 2007-10-10 | 2008-09-10 | Modified growth hormone polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2209798T3 true DK2209798T3 (da) | 2015-03-23 |
Family
ID=38787949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08788565T DK2209798T3 (da) | 2007-10-10 | 2008-09-10 | Modificerede væksthormonpolypeptider |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8273552B2 (da) |
| EP (2) | EP2209798B1 (da) |
| JP (1) | JP5697983B2 (da) |
| KR (1) | KR20100067686A (da) |
| CN (1) | CN101932600B (da) |
| AR (1) | AR068038A1 (da) |
| AU (1) | AU2008309386A1 (da) |
| BR (1) | BRPI0818639A2 (da) |
| CA (1) | CA2701369A1 (da) |
| DK (1) | DK2209798T3 (da) |
| ES (1) | ES2532600T3 (da) |
| GB (1) | GB0719818D0 (da) |
| IL (1) | IL203073A0 (da) |
| MX (1) | MX2010003892A (da) |
| RU (1) | RU2471808C2 (da) |
| TW (1) | TW200918098A (da) |
| WO (1) | WO2009047474A2 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0606946D0 (en) * | 2006-04-06 | 2006-05-17 | Asterion Ltd | Polypeptide antagonist |
| GB201104285D0 (en) | 2011-03-15 | 2011-04-27 | Asterion Ltd | Modified receptor fusion proteins |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH20A (fr) * | 1888-12-05 | Joseph Magnat | Une pompe à bière automatique fonctionnant par la pression de l'eau | |
| ES2190388T3 (es) * | 1995-09-21 | 2006-04-01 | Genentech, Inc. | Variantes de la hormona de crecimiento humana. |
| GB0018891D0 (en) * | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| EP1290170A2 (en) * | 2000-06-16 | 2003-03-12 | Asterion Limited | Binding agents: chimeric ligand/receptor proteins |
| EP2100955A3 (en) | 2001-11-21 | 2009-12-02 | The United States of America, represented by The Secretary, Dept. of Health and Human Services | Attenuated mutants of human parainfluenza virus type 1 (HPIV1) |
| GB2389115B (en) * | 2001-12-14 | 2005-03-16 | Asterion Ltd | Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone |
| WO2004090135A2 (en) * | 2003-04-09 | 2004-10-21 | Asterion Limited | Cytokine polypeptides and antibodies containing a signal sequence for the attachement of glycosylphosphatidylinositol |
| MX2007001180A (es) * | 2004-07-26 | 2007-04-13 | Asterion Ltd | Enlazantes. |
| GB0717985D0 (en) | 2007-07-20 | 2007-10-24 | Asterion Ltd | Growth hormone fusion proteins |
| JP2011512134A (ja) * | 2008-02-19 | 2011-04-21 | アステリオン・リミテッド | 修飾リンカー |
-
2007
- 2007-10-11 GB GBGB0719818.7A patent/GB0719818D0/en not_active Ceased
-
2008
- 2008-08-20 TW TW097131758A patent/TW200918098A/zh unknown
- 2008-08-26 AR ARP080103700A patent/AR068038A1/es not_active Application Discontinuation
- 2008-09-10 EP EP08788565.3A patent/EP2209798B1/en not_active Not-in-force
- 2008-09-10 BR BRPI0818639 patent/BRPI0818639A2/pt not_active Application Discontinuation
- 2008-09-10 EP EP14197613.4A patent/EP2886553A1/en not_active Withdrawn
- 2008-09-10 KR KR1020107010215A patent/KR20100067686A/ko not_active Application Discontinuation
- 2008-09-10 MX MX2010003892A patent/MX2010003892A/es not_active Application Discontinuation
- 2008-09-10 US US12/678,282 patent/US8273552B2/en not_active Expired - Fee Related
- 2008-09-10 WO PCT/GB2008/003056 patent/WO2009047474A2/en active Application Filing
- 2008-09-10 CA CA2701369A patent/CA2701369A1/en not_active Abandoned
- 2008-09-10 ES ES08788565.3T patent/ES2532600T3/es active Active
- 2008-09-10 DK DK08788565T patent/DK2209798T3/da active
- 2008-09-10 CN CN200880106595.1A patent/CN101932600B/zh not_active Expired - Fee Related
- 2008-09-10 AU AU2008309386A patent/AU2008309386A1/en not_active Abandoned
- 2008-09-10 RU RU2010103159/10A patent/RU2471808C2/ru not_active IP Right Cessation
- 2008-09-10 JP JP2010528468A patent/JP5697983B2/ja not_active Expired - Fee Related
-
2009
- 2009-12-31 IL IL203073A patent/IL203073A0/en unknown
-
2012
- 2012-08-22 US US13/592,252 patent/US20120322735A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2209798A2 (en) | 2010-07-28 |
| WO2009047474A2 (en) | 2009-04-16 |
| AU2008309386A1 (en) | 2009-04-16 |
| CN101932600B (zh) | 2014-05-28 |
| GB0719818D0 (en) | 2007-11-21 |
| BRPI0818639A2 (pt) | 2015-04-07 |
| KR20100067686A (ko) | 2010-06-21 |
| US20120322735A1 (en) | 2012-12-20 |
| CA2701369A1 (en) | 2009-04-16 |
| EP2886553A1 (en) | 2015-06-24 |
| RU2010103159A (ru) | 2011-11-20 |
| CN101932600A (zh) | 2010-12-29 |
| JP5697983B2 (ja) | 2015-04-08 |
| JP2011507487A (ja) | 2011-03-10 |
| TW200918098A (en) | 2009-05-01 |
| RU2471808C2 (ru) | 2013-01-10 |
| EP2209798B1 (en) | 2014-12-31 |
| US8273552B2 (en) | 2012-09-25 |
| WO2009047474A3 (en) | 2010-09-02 |
| IL203073A0 (en) | 2010-11-30 |
| AR068038A1 (es) | 2009-10-28 |
| MX2010003892A (es) | 2010-05-17 |
| ES2532600T3 (es) | 2015-03-30 |
| US20100197589A1 (en) | 2010-08-05 |
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