DK2175877T3 - Anvendelse af muterede antitrombiner til behandling eller forebyggelse af koagulationssygdomme - Google Patents
Anvendelse af muterede antitrombiner til behandling eller forebyggelse af koagulationssygdommeInfo
- Publication number
- DK2175877T3 DK2175877T3 DK08786266.0T DK08786266T DK2175877T3 DK 2175877 T3 DK2175877 T3 DK 2175877T3 DK 08786266 T DK08786266 T DK 08786266T DK 2175877 T3 DK2175877 T3 DK 2175877T3
- Authority
- DK
- Denmark
- Prior art keywords
- prevention
- treatment
- coagulation disorders
- mutated antithrombin
- antithrombin
- Prior art date
Links
- 206010053567 Coagulopathies Diseases 0.000 title abstract 2
- 239000004019 antithrombin Substances 0.000 title abstract 2
- 208000015294 blood coagulation disease Diseases 0.000 title abstract 2
- 230000009852 coagulant defect Effects 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07290913 | 2007-07-20 | ||
PCT/EP2008/059486 WO2009013251A1 (en) | 2007-07-20 | 2008-07-18 | Use of mutated antithrombins for treating or preventing coagulation disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2175877T3 true DK2175877T3 (da) | 2012-04-16 |
Family
ID=39111552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08786266.0T DK2175877T3 (da) | 2007-07-20 | 2008-07-18 | Anvendelse af muterede antitrombiner til behandling eller forebyggelse af koagulationssygdomme |
Country Status (7)
Country | Link |
---|---|
US (1) | US8741844B2 (da) |
EP (1) | EP2175877B1 (da) |
JP (1) | JP2010533684A (da) |
AT (1) | ATE539764T1 (da) |
CA (1) | CA2694047C (da) |
DK (1) | DK2175877T3 (da) |
WO (1) | WO2009013251A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5764499B2 (ja) * | 2009-01-16 | 2015-08-19 | ユニベルシテ パリ サッド 11Universite Paris Sud 11 | 変異アンチトロンビン、その製造方法及び薬剤としての使用 |
US20140356377A1 (en) * | 2011-08-25 | 2014-12-04 | Umc Utrecht Holding B.V. | Compounds for use in boosting coagulation |
CA2916421A1 (en) | 2013-03-14 | 2014-09-25 | Bayer Healthcare Llc | Monoclonal antibodies against antithrombin beta complexed with heparin |
GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
EP3212794B1 (en) | 2014-10-30 | 2021-04-07 | Genzyme Corporation | Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof |
IL259795B2 (en) | 2015-12-07 | 2024-04-01 | Genzyme Corp | Methods and preparations for the treatment of diseases related to SERPINC1 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3901917A1 (de) * | 1989-01-24 | 1990-07-26 | Behringwerke Ag | Mutanten von humanem antithrombin iii |
JP3479539B2 (ja) * | 1992-04-10 | 2003-12-15 | エーザイ株式会社 | ヒトアンチトロンビンiii変異体 |
JPH0971600A (ja) * | 1995-09-06 | 1997-03-18 | Eisai Co Ltd | ヒトアンチトロンビンiii 変異体 |
DE60037513T2 (de) | 1999-05-13 | 2009-02-05 | GTC Biotherapeutics, Inc., Framingham | Transgene hergestellte antithrombin iii und deren mutanten |
JP2007523876A (ja) * | 2003-07-17 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | Hit患者をアルガトロバンを用いて治療する方法 |
-
2008
- 2008-07-18 AT AT08786266T patent/ATE539764T1/de active
- 2008-07-18 US US12/669,855 patent/US8741844B2/en not_active Expired - Fee Related
- 2008-07-18 DK DK08786266.0T patent/DK2175877T3/da active
- 2008-07-18 EP EP08786266A patent/EP2175877B1/en not_active Not-in-force
- 2008-07-18 JP JP2010516522A patent/JP2010533684A/ja active Pending
- 2008-07-18 WO PCT/EP2008/059486 patent/WO2009013251A1/en active Application Filing
- 2008-07-18 CA CA2694047A patent/CA2694047C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20100298224A1 (en) | 2010-11-25 |
ATE539764T1 (de) | 2012-01-15 |
CA2694047C (en) | 2018-01-30 |
EP2175877B1 (en) | 2012-01-04 |
CA2694047A1 (en) | 2009-01-29 |
WO2009013251A1 (en) | 2009-01-29 |
JP2010533684A (ja) | 2010-10-28 |
US8741844B2 (en) | 2014-06-03 |
EP2175877A1 (en) | 2010-04-21 |
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