DK2102335T3 - Rensning af faktor XI - Google Patents

Rensning af faktor XI

Info

Publication number
DK2102335T3
DK2102335T3 DK08701217.5T DK08701217T DK2102335T3 DK 2102335 T3 DK2102335 T3 DK 2102335T3 DK 08701217 T DK08701217 T DK 08701217T DK 2102335 T3 DK2102335 T3 DK 2102335T3
Authority
DK
Denmark
Prior art keywords
factor
purification
methods
hcic
blood coagulation
Prior art date
Application number
DK08701217.5T
Other languages
English (en)
Inventor
Paul Henri Markus
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Application granted granted Critical
Publication of DK2102335T3 publication Critical patent/DK2102335T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6443—Coagulation factor XIa (3.4.21.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21027—Coagulation factor XIa (3.4.21.27)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
DK08701217.5T 2007-01-04 2008-01-03 Rensning af faktor XI DK2102335T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87850907P 2007-01-04 2007-01-04
EP07100123 2007-01-04
PCT/EP2008/050035 WO2008081025A1 (en) 2007-01-04 2008-01-03 Purification of factor xi

Publications (1)

Publication Number Publication Date
DK2102335T3 true DK2102335T3 (da) 2012-05-07

Family

ID=38038498

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08701217.5T DK2102335T3 (da) 2007-01-04 2008-01-03 Rensning af faktor XI

Country Status (5)

Country Link
US (1) US20100062512A1 (da)
EP (1) EP2102335B1 (da)
AT (1) ATE546520T1 (da)
DK (1) DK2102335T3 (da)
WO (1) WO2008081025A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2558436T3 (es) * 2008-07-15 2016-02-04 Crucell Holland B.V. Proceso escalable para cultivar células PER.C6 y producir productos a partir de estas
SE1050124A1 (sv) 2010-02-08 2011-08-09 Linkoping Biocontrols Ab Stabil lösning
ES2670827T3 (es) 2010-03-30 2018-06-01 Octapharma Ag Proceso para la purificación del factor estimulador de colonias de granulocitos, G-CSF
AU2011331208B2 (en) * 2010-11-16 2016-12-01 Octapharma Ag A process for reduction and/or removal of FXI and FXIa from solutions containing said coagulation factors
DE102012022233A1 (de) 2012-11-14 2014-05-15 Instraction Gmbh Verfahren zur Reinigung eines (Blut)plasmaproteins
DE102012022234A1 (de) 2012-11-14 2014-05-15 Instraction Gmbh Einstufiges Verfahren zur Reinigung von (Blut)Plasmaproteinen wie Albumin aus Gemischen
US10188965B2 (en) 2012-12-05 2019-01-29 Csl Behring Gmbh Hydrophobic charge induction chromatographic depletion of a protein from a solution
US20140154233A1 (en) * 2012-12-05 2014-06-05 Csl Limited Method of purifying therapeutic proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676231A1 (fr) * 1991-05-07 1992-11-13 Aetsrn Concentre de facteur xi de la coagulation sanguine a haute activite specifique, approprie a usage therapeutique et son procede de preparation.
EP1026172A4 (en) * 1997-10-23 2003-05-07 Fujimori Kogyo Co METHOD FOR CLEANING THROMBINE SUBSTRATES AND / OR INHIBITORS OR METHOD FOR ELIMINATING THEM
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
TWI319007B (en) * 2002-11-06 2010-01-01 Novozymes As Subtilase variants
KR20080006601A (ko) * 2005-04-11 2008-01-16 메다렉스, 인코포레이티드 단백질 정제 방법

Also Published As

Publication number Publication date
ATE546520T1 (de) 2012-03-15
WO2008081025A1 (en) 2008-07-10
EP2102335B1 (en) 2012-02-22
EP2102335A1 (en) 2009-09-23
US20100062512A1 (en) 2010-03-11

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