DK2078007T3 - Ikk-beta-serin-threonin-proteinkinasehæmmere - Google Patents
Ikk-beta-serin-threonin-proteinkinasehæmmereInfo
- Publication number
- DK2078007T3 DK2078007T3 DK07824358.1T DK07824358T DK2078007T3 DK 2078007 T3 DK2078007 T3 DK 2078007T3 DK 07824358 T DK07824358 T DK 07824358T DK 2078007 T3 DK2078007 T3 DK 2078007T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- ikk
- optionally substituted
- protein kinase
- kinase inhibitors
- Prior art date
Links
- 102000001284 I-kappa-B kinase Human genes 0.000 title 1
- 108060006678 I-kappa-B kinase Proteins 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0621720A GB0621720D0 (en) | 2006-11-01 | 2006-11-01 | Inhibitors of ikk- serine-threonine protein kinase |
| GB0715470A GB0715470D0 (en) | 2007-08-09 | 2007-08-09 | IKK- serine-threonine protein kinase inhibitors |
| PCT/GB2007/004114 WO2008053182A1 (en) | 2006-11-01 | 2007-10-29 | IKK-β SERINE-THREONINE PROTEIN KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2078007T3 true DK2078007T3 (da) | 2011-12-12 |
Family
ID=39015937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07824358.1T DK2078007T3 (da) | 2006-11-01 | 2007-10-29 | Ikk-beta-serin-threonin-proteinkinasehæmmere |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8003695B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2078007B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010508336A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20090077975A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE522516T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007315943A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0718056A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2668338A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2078007T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA200900616A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2372707T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL198267A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009004442A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ576705A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008053182A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| GB0803747D0 (en) | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
| WO2009130434A1 (en) * | 2008-04-23 | 2009-10-29 | Chroma Therapeutics Ltd. | INHIBITORS OF IKK-β SERINE-THREONINE PROTEIN KINASE |
| CA2722660A1 (en) * | 2008-04-26 | 2009-10-29 | Chroma Therapeutics Ltd. | Substituted thiophenecarboxamides as ikk-beta serine-, threonine-protein kinase inhibitors |
| WO2010060214A1 (en) * | 2008-11-26 | 2010-06-03 | Trt Pharma Inc . | Hybrid -ionone and curcumin molecules as anticancer agents |
| GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
| GB0907120D0 (en) * | 2009-04-24 | 2009-06-03 | Chroma Therapeutics Ltd | Inhibitors of IKK-ß serine-threonine protein kinase |
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| BR112015008167B1 (pt) | 2012-10-17 | 2020-11-17 | Macrophage Pharma Limited | composto, composição farmacêutica, métodos para a inibição da atividade de uma enzima quinase map p38, para o tratamento ou a prevenção de doença autoimune ou inflamatória em um indivíduo, e para o tratamento, a melhoria ou a redução da incidência de doença proliferativa de células em um indivíduo, uso de composto, e, ácido |
| HRP20181109T1 (hr) * | 2013-12-11 | 2018-11-02 | Biogen Ma Inc. | Spojevi biarila korisni za liječenje ljudskih bolesti u onkologiji, neurologiji i imunologiji |
| GB201713975D0 (en) | 2017-08-31 | 2017-10-18 | Macrophage Pharma Ltd | Medical use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| SE0300092D0 (sv) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
-
2007
- 2007-10-29 ES ES07824358T patent/ES2372707T3/es active Active
- 2007-10-29 BR BRPI0718056-0A patent/BRPI0718056A2/pt not_active IP Right Cessation
- 2007-10-29 MX MX2009004442A patent/MX2009004442A/es active IP Right Grant
- 2007-10-29 EP EP07824358A patent/EP2078007B1/en not_active Not-in-force
- 2007-10-29 DK DK07824358.1T patent/DK2078007T3/da active
- 2007-10-29 KR KR1020097011261A patent/KR20090077975A/ko not_active Withdrawn
- 2007-10-29 NZ NZ576705A patent/NZ576705A/en not_active IP Right Cessation
- 2007-10-29 CA CA002668338A patent/CA2668338A1/en not_active Abandoned
- 2007-10-29 JP JP2009535115A patent/JP2010508336A/ja not_active Withdrawn
- 2007-10-29 US US12/513,206 patent/US8003695B2/en not_active Expired - Fee Related
- 2007-10-29 WO PCT/GB2007/004114 patent/WO2008053182A1/en not_active Ceased
- 2007-10-29 AT AT07824358T patent/ATE522516T1/de not_active IP Right Cessation
- 2007-10-29 EA EA200900616A patent/EA200900616A1/ru unknown
- 2007-10-29 AU AU2007315943A patent/AU2007315943A1/en not_active Abandoned
-
2009
- 2009-04-21 IL IL198267A patent/IL198267A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010508336A (ja) | 2010-03-18 |
| KR20090077975A (ko) | 2009-07-16 |
| IL198267A0 (en) | 2009-12-24 |
| US20100087515A1 (en) | 2010-04-08 |
| AU2007315943A1 (en) | 2008-05-08 |
| CA2668338A1 (en) | 2008-05-08 |
| ATE522516T1 (de) | 2011-09-15 |
| EA200900616A1 (ru) | 2010-04-30 |
| ES2372707T3 (es) | 2012-01-25 |
| BRPI0718056A2 (pt) | 2013-11-05 |
| MX2009004442A (es) | 2009-05-22 |
| EP2078007B1 (en) | 2011-08-31 |
| WO2008053182A1 (en) | 2008-05-08 |
| EP2078007A1 (en) | 2009-07-15 |
| US8003695B2 (en) | 2011-08-23 |
| NZ576705A (en) | 2011-12-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2078007T3 (da) | Ikk-beta-serin-threonin-proteinkinasehæmmere | |
| ATE524454T1 (de) | Inhibitoren von ikk-beta serinthreoninproteinkinase | |
| EA200870192A1 (ru) | Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ | |
| ATE523492T1 (de) | Chinolin- und chinoxalinderivate als inhibitoren der enzymatischen kinaseaktivität | |
| EA200970050A1 (ru) | Ингибиторы пролилгидроксилаз | |
| MX2010008637A (es) | Derivado de fenilpirrol novedoso. | |
| PE20081353A1 (es) | Compuestos del inhibidor de fosfoinositida 3-cinasa | |
| AR083578A1 (es) | INHIBIDORES DE N/N-LACTAMA ACETIL-CoA CARBOXILASA | |
| EA200900519A1 (ru) | Ингибиторы hdac | |
| PE20150636A1 (es) | Dicianopiridinas alquilamino-sustituidas y sus profarmacos de ester de aminoacido | |
| UA95976C2 (en) | 2-ARYL-6-PHENYLIMIDAZO[1,2-b]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | |
| EA200970680A1 (ru) | N-замещенные производные глицина: ингибиторы гидроксилаз | |
| PE20140863A1 (es) | Compuestos de benceno sustituidos con arilo o heteroarilo | |
| IN2012DN01325A (cg-RX-API-DMAC7.html) | ||
| GB0509225D0 (en) | Inhibitors of enzymatic activity | |
| SI2091948T1 (sl) | Novi inhibitorji glutaminil ciklaze | |
| EA201190119A1 (ru) | ПРОИЗВОДНЫЕ ТРИАЗОЛОПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ МАР-КИНАЗЫ p38 | |
| ATE470663T1 (de) | N-hydroxy-3-(4-ä3-phenyl-3- oxopropenylüphenyl)acrylamidderivate und verwandte verbindungen als histondeacetylaseinhibitoren zur behandlung von krebs | |
| TW200716531A (en) | Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia | |
| EA200701779A1 (ru) | Производные (1,5-дифенил-1н-пиразол-3-ил)оксадиазола, их получение и их применение в терапии | |
| EA201070460A1 (ru) | 5,6-диарилпиридины, замещенные в положении 2 и 3, способ их получения и применение их в терапии | |
| CO6321159A2 (es) | Compuestos pirazina fusionados utiles para el tratamiento de enfermedades degenerativas e inflamatorias | |
| GB0903480D0 (en) | Enzyme Inhibitors | |
| MX2010007349A (es) | Derivados de n-heterociclico-imidazo[1,2-a]piridina-2-carboxamidas , su preparacion y su aplicacion terapeutica. | |
| EA201001708A1 (ru) | Замещённые тиофенкарбоксамиды их применение в качестве ингибиторов ikk-бета серин-треонин протеинкиназ |