DK206183A - Fremgangsmaade til fremstilling af derivater af ampicillin eller amoxicillin med beta-lactamase-inhibitorer eller farmaceutisk acceptable salte deraf og forbindelser der er nyttige som mellemprodukter derved - Google Patents
Fremgangsmaade til fremstilling af derivater af ampicillin eller amoxicillin med beta-lactamase-inhibitorer eller farmaceutisk acceptable salte deraf og forbindelser der er nyttige som mellemprodukter derved Download PDFInfo
- Publication number
- DK206183A DK206183A DK206183A DK206183A DK206183A DK 206183 A DK206183 A DK 206183A DK 206183 A DK206183 A DK 206183A DK 206183 A DK206183 A DK 206183A DK 206183 A DK206183 A DK 206183A
- Authority
- DK
- Denmark
- Prior art keywords
- amoxicillin
- ampicillin
- intermediates
- beta
- procedure
- Prior art date
Links
- 229960003022 amoxicillin Drugs 0.000 title 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 title 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical class C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 title 1
- 239000003781 beta lactamase inhibitor Substances 0.000 title 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/376,487 US4377590A (en) | 1982-05-10 | 1982-05-10 | Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK206183D0 DK206183D0 (da) | 1983-05-09 |
| DK206183A true DK206183A (da) | 1983-12-22 |
Family
ID=23485209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK206183A DK206183A (da) | 1982-05-10 | 1983-05-09 | Fremgangsmaade til fremstilling af derivater af ampicillin eller amoxicillin med beta-lactamase-inhibitorer eller farmaceutisk acceptable salte deraf og forbindelser der er nyttige som mellemprodukter derved |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4377590A (cs) |
| EP (1) | EP0094227B1 (cs) |
| JP (1) | JPS58213788A (cs) |
| DE (1) | DE3362396D1 (cs) |
| DK (1) | DK206183A (cs) |
| GR (1) | GR78248B (cs) |
| IE (1) | IE54771B1 (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4462934A (en) * | 1983-03-31 | 1984-07-31 | Pfizer Inc. | Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides |
| US4916230A (en) * | 1984-07-02 | 1990-04-10 | Merck & Co., Inc. | Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
| KR910009271B1 (ko) * | 1989-06-20 | 1991-11-08 | 김영설 | 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염 |
| GB8928373D0 (en) * | 1989-12-15 | 1990-02-21 | Erba Carlo Spa | Beta-lactam derivatives |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6818787B2 (en) * | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) * | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| CA2528065A1 (en) * | 2003-06-05 | 2004-12-16 | Pfizer Products Inc. | Beta-lactamase inhibitor prodrug |
| JP5013795B2 (ja) * | 2006-09-25 | 2012-08-29 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 経口投与用カルバペネム |
| EP3498717B1 (en) * | 2016-08-12 | 2022-05-04 | The Catholic University of Korea Industry-Academic Cooperation Foundation | Composition for hardening soft tissue |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2205310A1 (en) * | 1972-11-08 | 1974-05-31 | Aries Robert | Alpha penicillanamido penicillanic acids - long acting antibacterials prepd. by amidation of a mixed anhydride with an alpha amino penicillin |
| GB1493197A (en) * | 1975-07-04 | 1977-11-23 | Beecham Group Ltd | Amides of clavulanic acid |
| US4234579A (en) * | 1977-06-07 | 1980-11-18 | Pfizer Inc. | Penicillanic acid 1,1-dioxides as β-lactamase inhibitors |
| IE49880B1 (en) | 1979-02-13 | 1986-01-08 | Leo Pharm Prod Ltd | Penicillin derivatives |
| US4244951A (en) * | 1979-05-16 | 1981-01-13 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
| US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
| US4323499A (en) * | 1981-01-05 | 1982-04-06 | Pfizer Inc. | 6-(2-Aryl-2-(1,1-dioxopenicillanoyloxy-methoxycarbonyl)acetamido penicillanic acids |
-
1982
- 1982-05-10 US US06/376,487 patent/US4377590A/en not_active Expired - Lifetime
-
1983
- 1983-05-03 GR GR71278A patent/GR78248B/el unknown
- 1983-05-09 DE DE8383302585T patent/DE3362396D1/de not_active Expired
- 1983-05-09 DK DK206183A patent/DK206183A/da not_active Application Discontinuation
- 1983-05-09 EP EP83302585A patent/EP0094227B1/en not_active Expired
- 1983-05-09 IE IE1060/83A patent/IE54771B1/en unknown
- 1983-05-10 JP JP58081602A patent/JPS58213788A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0094227B1 (en) | 1986-03-05 |
| IE54771B1 (en) | 1990-01-31 |
| JPS58213788A (ja) | 1983-12-12 |
| DK206183D0 (da) | 1983-05-09 |
| IE831060L (en) | 1983-11-10 |
| US4377590A (en) | 1983-03-22 |
| EP0094227A1 (en) | 1983-11-16 |
| GR78248B (cs) | 1984-09-26 |
| DE3362396D1 (en) | 1986-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |