DK2046341T3 - Sammensætninger og fremgangsmåder til behandling af diabetes og neuropsykologisk dysfunktion - Google Patents

Sammensætninger og fremgangsmåder til behandling af diabetes og neuropsykologisk dysfunktion Download PDF

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Publication number
DK2046341T3
DK2046341T3 DK07788108.4T DK07788108T DK2046341T3 DK 2046341 T3 DK2046341 T3 DK 2046341T3 DK 07788108 T DK07788108 T DK 07788108T DK 2046341 T3 DK2046341 T3 DK 2046341T3
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Prior art keywords
diabetes
vol
mutations
channel
atp
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DK07788108.4T
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English (en)
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Michel Polak
Paul Czernichow
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Assist Publique - Hôpitaux De Paris
Univ Paris Descartes
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Claims (4)

1. Anvendelse af en ATP-sensitiv kaliumkanal-ligand valgt fra sulfamider og glinider, eller en hvilken som helst kombination deraf, til fremstillingen af en farmaceutisk sammensætning til behandling af diabetes mellitus og/eller en neurofysiologisk, muskulær og/eller neurologisk forstyrrelse hos et individ med et defekt, muteret SURl-polypeptid, hvor det muterede SURl-polypeptid udviser mindst én af følgende aminosyremutationer: L213R, I1424V, C435R, L582V, H1023Y, R1182Q og R1379C.
2. Anvendelsen ifølge krav 1, hvor liganden er valgt fra Carbutamid /Glucidoral); Clibenclamid; glyburid; Glibornurid /Glutril); Glicazid (Diamicron); Glimepirid fAmarel); Glipizid (Glibénése, Minidiab, Ozidia); Repaglinid (NovoNorm), enten alene eller i kombinationer.
3. Anvendelsen ifølge et hvilket som helst af de foregående krav, hvor individet er et barn eller en voksen.
4. Anvendelsen ifølge et hvilket som helst af kravene 1-3, hvor den neuropsykologiske og/eller muskulære og/eller neurologiske forstyrrelse er valgt fra epilepsi, udviklingsforsinkelse, muskelsvaghed, dyspraxi, dyslexi, dystoni, dysfasi, og okulære lidelser omfattende chorioretinale lidelser.
DK07788108.4T 2006-08-02 2007-08-01 Sammensætninger og fremgangsmåder til behandling af diabetes og neuropsykologisk dysfunktion DK2046341T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06291256A EP1884244A1 (en) 2006-08-02 2006-08-02 Potassium channel ligands for treating diabetes and neuropsychological dysfunction
PCT/EP2007/057937 WO2008015226A1 (en) 2006-08-02 2007-08-01 Compositions and methods for treating diabetes and neuropsychological dysfunction

Publications (1)

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DK2046341T3 true DK2046341T3 (da) 2016-08-29

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US (2) US8354452B2 (da)
EP (2) EP1884244A1 (da)
JP (1) JP5159779B2 (da)
AU (1) AU2007280476B2 (da)
CA (1) CA2657342C (da)
DK (1) DK2046341T3 (da)
ES (1) ES2589953T3 (da)
HU (1) HUE029479T2 (da)
IL (1) IL196561A (da)
NZ (1) NZ574892A (da)
PL (1) PL2046341T3 (da)
PT (1) PT2046341T (da)
WO (1) WO2008015226A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012095548A2 (es) * 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compuestos para el tratamiento de enfermedades neurodegenerativas
JP6496481B2 (ja) 2011-01-25 2019-04-03 モネル ケミカル センシズ センターＭｏｎｅｌｌ Ｃｈｅｍｉｃａｌ Ｓｅｎｓｅｓ Ｃｅｎｔｅｒ 甘味を提供若しくは調整するための組成物および方法ならびにそれらのスクリーニング方法
EP2520298A1 (en) * 2011-05-03 2012-11-07 Assistance Publique, Hopitaux De Paris Pharmaceutical composition comprising sulfonylureas (glibenclamide) or meglitinides for use for treating hyperglycaemia or for promoting growth of a premature infant
FR2987268B1 (fr) 2012-02-28 2014-07-11 Ammtek Formulations liquides de sulfamides hypoglycemiants
US20130273181A1 (en) * 2012-03-07 2013-10-17 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for diagnosing and treating muscle myopathy disorders
JP2015529254A (ja) 2012-09-21 2015-10-05 ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド 喘息における気道の過敏症及び炎症を制御するための新規なｇａｂａａアゴニスト及び使用方法
US11382881B2 (en) 2017-05-05 2022-07-12 Nino Sorgente Methods and compositions for diagnosing and treating glaucoma
US10780068B2 (en) 2017-05-05 2020-09-22 Nino Sorgente Methods and compositions for improving eye health

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010051361A1 (en) * 2000-05-15 2001-12-13 Wei Shao Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
US8980952B2 (en) * 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
WO2003103606A2 (en) * 2002-06-10 2003-12-18 Metabolex, Inc. Methods and compositions for treating and diagnosing diabetes
WO2006000608A1 (es) 2004-06-23 2006-01-05 Neurotec Pharma, S.L. Uso de bloqueantes del canal de katp (kcc), en especial sulfonilureas como la glibenclamida, para el tratamiento del daño agudo del sistema nervioso central causado por distintas enfermedades
ATE487484T1 (de) * 2004-09-18 2010-11-15 Univ Maryland Therapeutische mittel zum targeting des nc ca-atp-kanals und verwendungsverfahren dafür

Also Published As

Publication number Publication date
AU2007280476B2 (en) 2013-01-31
US20090306212A1 (en) 2009-12-10
PL2046341T3 (pl) 2017-02-28
HUE029479T2 (en) 2017-02-28
AU2007280476A1 (en) 2008-02-07
IL196561A0 (en) 2009-11-18
ES2589953T3 (es) 2016-11-17
EP2046341A1 (en) 2009-04-15
JP2009545562A (ja) 2009-12-24
IL196561A (en) 2015-08-31
US8354452B2 (en) 2013-01-15
CA2657342C (en) 2016-04-12
EP1884244A1 (en) 2008-02-06
NZ574892A (en) 2012-11-30
US20130184293A1 (en) 2013-07-18
PT2046341T (pt) 2016-08-31
CA2657342A1 (en) 2008-02-07
WO2008015226A1 (en) 2008-02-07
JP5159779B2 (ja) 2013-03-13
EP2046341B1 (en) 2016-07-13

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