DK204388A - Substituerede piperidiner til anvendelse som opioidantagonister og fremgangsmaade til fremstilling af saadenne forbindelser - Google Patents
Substituerede piperidiner til anvendelse som opioidantagonister og fremgangsmaade til fremstilling af saadenne forbindelserInfo
- Publication number
- DK204388A DK204388A DK204388A DK204388A DK204388A DK 204388 A DK204388 A DK 204388A DK 204388 A DK204388 A DK 204388A DK 204388 A DK204388 A DK 204388A DK 204388 A DK204388 A DK 204388A
- Authority
- DK
- Denmark
- Prior art keywords
- procedures
- compounds
- making
- opioid antagonists
- substituted piperidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3912187A | 1987-04-16 | 1987-04-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK204388D0 DK204388D0 (da) | 1988-04-14 |
| DK204388A true DK204388A (da) | 1989-01-05 |
Family
ID=21903800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK204388A DK204388A (da) | 1987-04-16 | 1988-04-14 | Substituerede piperidiner til anvendelse som opioidantagonister og fremgangsmaade til fremstilling af saadenne forbindelser |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0287339B1 (fr) |
| JP (1) | JP2661699B2 (fr) |
| KR (1) | KR960015087B1 (fr) |
| CN (1) | CN1017992B (fr) |
| AR (1) | AR245933A1 (fr) |
| AT (1) | ATE110057T1 (fr) |
| AU (1) | AU596290B2 (fr) |
| CA (1) | CA1321792C (fr) |
| DE (1) | DE3851081T2 (fr) |
| DK (1) | DK204388A (fr) |
| EG (1) | EG18864A (fr) |
| ES (1) | ES2058265T3 (fr) |
| HU (1) | HU202492B (fr) |
| IE (1) | IE64508B1 (fr) |
| IL (1) | IL86061A (fr) |
| MX (1) | MX11117A (fr) |
| NZ (1) | NZ224236A (fr) |
| PH (1) | PH24752A (fr) |
| PT (1) | PT87233B (fr) |
| SU (1) | SU1598869A3 (fr) |
| ZA (1) | ZA882640B (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0299549A3 (fr) * | 1987-07-09 | 1989-02-08 | Duphar International Research B.V | 3,5-Dialkyl-3-phényl-pipéridines avec une activité antagoniste des opiates |
| NZ242117A (en) * | 1991-03-29 | 1994-11-25 | Lilly Co Eli | 4-phenylpiperidine derivatives and medicaments containing them |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| PT711289E (pt) * | 1993-07-30 | 2001-02-28 | Delta Pharmaceuticals Inc | Compostos piperazina utilizados em terapia |
| GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| GB9815618D0 (en) * | 1998-07-18 | 1998-09-16 | Univ Manchester | Treatment of dyskinesia |
| TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912417D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912416D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| JP2003528819A (ja) * | 1999-11-29 | 2003-09-30 | アドラー コーポレーション | オピオイドおよびそのアンタゴニストに関する新規方法および組成物 |
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| BR0213464A (pt) | 2001-10-22 | 2004-11-09 | Pfizer Prod Inc | Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide |
| US7381719B2 (en) * | 2002-09-19 | 2008-06-03 | Eli Lilly And Company | Diaryl ethers as opioid receptor antagonist |
| US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
| WO2013012871A1 (fr) * | 2011-07-18 | 2013-01-24 | Adolor Corporation | Procédés de préparation de composés antagonistes des opioïdes périphériques et des intermédiaires de ceux-ci |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
-
1988
- 1988-04-13 ES ES88303302T patent/ES2058265T3/es not_active Expired - Lifetime
- 1988-04-13 AT AT88303302T patent/ATE110057T1/de not_active IP Right Cessation
- 1988-04-13 NZ NZ224236A patent/NZ224236A/xx unknown
- 1988-04-13 CA CA000563995A patent/CA1321792C/fr not_active Expired - Fee Related
- 1988-04-13 DE DE3851081T patent/DE3851081T2/de not_active Expired - Fee Related
- 1988-04-13 EP EP88303302A patent/EP0287339B1/fr not_active Expired - Lifetime
- 1988-04-13 PH PH36789A patent/PH24752A/en unknown
- 1988-04-13 IL IL86061A patent/IL86061A/xx not_active IP Right Cessation
- 1988-04-13 AR AR88310556A patent/AR245933A1/es active
- 1988-04-14 EG EG21388A patent/EG18864A/xx active
- 1988-04-14 AU AU14624/88A patent/AU596290B2/en not_active Ceased
- 1988-04-14 PT PT87233A patent/PT87233B/pt active IP Right Grant
- 1988-04-14 ZA ZA882640A patent/ZA882640B/xx unknown
- 1988-04-14 DK DK204388A patent/DK204388A/da not_active Application Discontinuation
- 1988-04-14 MX MX1111788A patent/MX11117A/es unknown
- 1988-04-14 KR KR1019880004245A patent/KR960015087B1/ko not_active IP Right Cessation
- 1988-04-14 SU SU884355530A patent/SU1598869A3/ru active
- 1988-04-14 IE IE112588A patent/IE64508B1/en not_active IP Right Cessation
- 1988-04-15 HU HU881968A patent/HU202492B/hu not_active IP Right Cessation
- 1988-04-15 JP JP63094395A patent/JP2661699B2/ja not_active Expired - Lifetime
- 1988-04-15 CN CN88102191A patent/CN1017992B/zh not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE881125L (en) | 1988-10-16 |
| DE3851081T2 (de) | 1995-02-16 |
| AU596290B2 (en) | 1990-04-26 |
| NZ224236A (en) | 1990-08-28 |
| CN88102191A (zh) | 1988-11-02 |
| SU1598869A3 (ru) | 1990-10-07 |
| ATE110057T1 (de) | 1994-09-15 |
| IL86061A0 (en) | 1988-09-30 |
| IE64508B1 (en) | 1995-08-09 |
| ES2058265T3 (es) | 1994-11-01 |
| PT87233A (pt) | 1988-05-01 |
| HU202492B (en) | 1991-03-28 |
| IL86061A (en) | 1992-07-15 |
| KR960015087B1 (ko) | 1996-10-24 |
| JP2661699B2 (ja) | 1997-10-08 |
| AU1462488A (en) | 1988-10-20 |
| EG18864A (en) | 1995-06-29 |
| HUT46892A (en) | 1988-12-28 |
| CN1017992B (zh) | 1992-08-26 |
| CA1321792C (fr) | 1993-08-31 |
| AR245933A1 (es) | 1994-03-30 |
| EP0287339A2 (fr) | 1988-10-19 |
| PT87233B (pt) | 1992-07-31 |
| PH24752A (en) | 1990-10-01 |
| EP0287339A3 (fr) | 1991-05-15 |
| ZA882640B (en) | 1989-12-27 |
| MX11117A (es) | 1993-11-01 |
| DK204388D0 (da) | 1988-04-14 |
| KR880012551A (ko) | 1988-11-28 |
| DE3851081D1 (de) | 1994-09-22 |
| EP0287339B1 (fr) | 1994-08-17 |
| JPS63277661A (ja) | 1988-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |