DK2043511T3 - Fremgangsmåder og materialer til stabilisering af analytsensorer - Google Patents

Fremgangsmåder og materialer til stabilisering af analytsensorer Download PDF

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Publication number
DK2043511T3
DK2043511T3 DK07810797.6T DK07810797T DK2043511T3 DK 2043511 T3 DK2043511 T3 DK 2043511T3 DK 07810797 T DK07810797 T DK 07810797T DK 2043511 T3 DK2043511 T3 DK 2043511T3
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DK
Denmark
Prior art keywords
sensor
cannula
sensor system
analyte
coating
Prior art date
Application number
DK07810797.6T
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English (en)
Inventor
Rajiv Shah
Udo Hoss
Antwerp Nannette M Van
Barry Pham
Gopikrishnan Soundararajan
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Medtronic Minimed Inc
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Publication of DK2043511T3 publication Critical patent/DK2043511T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A61B5/6849—Needles in combination with a needle set

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (13)

1. Sensorsystem omfattende: en sensor, som har en kemisk reaktiv overflade, som reagerer med en ana-lyt, der skal afføles, og en kanyle, som omfatter: et i alt væsentligt cylindrisk hus, som omgiver sensoren, i det mindste en åbning, som er placeret i huset og tillader analytten at diffundere derigennem, således at den går i kontakt med den kemisk reaktive overflade, et tilbehørsmateriale, som omfatter en hydrofil polymer, som er tilvejebragt i nærheden af den kemisk reaktive overflade, hvorved tilbehørsmaterialet modificerer det biologiske svar fra et væv, som er i kontakt med sensorsystemet, og hvorved den hydrofile polymer omfatter polyhydro-xyethylmethacrylat (PHEMA), polyurethan, polysaccharid, polyacryl-amid, polyurea eller polyethylenoxid (PEO), og en ende, som strækker sig ud over en ende af sensoren, kendetegnet ved, at tilbehørsmaterialet fylder det cylindriske hus’ i det mindste ene åbning.
2. Sensorsystem ifølge krav 1, hvorved kanylen omfatter polyurethan.
3. Sensorsystem ifølge krav 1, hvorved det biologiske svar omfatter proteinaflejring, inflammation eller proliferation af makrofager eller fremmedlegeme-kæmpeceller.
4. Sensorsystem ifølge krav 1, hvorved tilbehørsmaterialet omfatter en belægning, som er anbragt på kanylen.
5. Sensorsystem ifølge krav 4, hvorved belægningen er anbragt på kanylens hus.
6. Sensorsystem ifølge krav 4, hvorved belægningen omfatter dexamethason.
7. Sensorsystem ifølge ethvert af kravene 1 til 6, hvorved PEO’en omfatter en polyurethan, polyurea eller en krydsforbundet PEO.
8. Sensorsystem ifølge ethvert af kravene 1 til 7, og som yderligere omfatter et anker, som hjælper sensoren til at gå i kontakt med en persons subkutane væv ved indføring af sensoren i personens legeme.
9. Sensorsystem ifølge krav 8, hvorved ankeret omfatter modhager, som er anbragt på kanylen.
10. Sensorsystem ifølge krav 8, hvorved ankeret omfatter en eller flere spiraler, som er anbragt på kanylen.
11. Sensorsystem ifølge krav 8, hvorved ankeret udvider sig efter indføringen af sensoren i personens legeme.
12. Sensorsystem ifølge krav 1, og som omfatter en enzymatisk, molekylær genkendende, optokemisk eller elektrokemisk sensor.
13. Sensorsystem ifølge krav 1, og som omfatter en glucosesensor.
DK07810797.6T 2006-07-26 2007-07-26 Fremgangsmåder og materialer til stabilisering af analytsensorer DK2043511T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/493,054 US9492111B2 (en) 2002-04-22 2006-07-26 Methods and materials for stabilizing analyte sensors
PCT/US2007/016785 WO2008013881A2 (en) 2006-07-26 2007-07-26 Methods and materials for stabilizing analyte sensors

Publications (1)

Publication Number Publication Date
DK2043511T3 true DK2043511T3 (da) 2016-08-22

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Family Applications (1)

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DK07810797.6T DK2043511T3 (da) 2006-07-26 2007-07-26 Fremgangsmåder og materialer til stabilisering af analytsensorer

Country Status (6)

Country Link
US (1) US9492111B2 (da)
EP (1) EP2043511B1 (da)
JP (1) JP5231413B2 (da)
CA (1) CA2658759C (da)
DK (1) DK2043511T3 (da)
WO (1) WO2008013881A2 (da)

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Also Published As

Publication number Publication date
JP5231413B2 (ja) 2013-07-10
CA2658759A1 (en) 2008-01-31
US9492111B2 (en) 2016-11-15
EP2043511A2 (en) 2009-04-08
WO2008013881A2 (en) 2008-01-31
CA2658759C (en) 2016-10-25
EP2043511B1 (en) 2016-05-04
JP2009544409A (ja) 2009-12-17
US20080027287A1 (en) 2008-01-31
WO2008013881A3 (en) 2008-04-24

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