DK2032230T3 - Fremgangsmåde til optimering af kromatografiske oprensningsfremgangsmåder til biomolekyler - Google Patents

Fremgangsmåde til optimering af kromatografiske oprensningsfremgangsmåder til biomolekyler

Info

Publication number
DK2032230T3
DK2032230T3 DK07765375.6T DK07765375T DK2032230T3 DK 2032230 T3 DK2032230 T3 DK 2032230T3 DK 07765375 T DK07765375 T DK 07765375T DK 2032230 T3 DK2032230 T3 DK 2032230T3
Authority
DK
Denmark
Prior art keywords
biomolecules
purification methods
chromatographic purification
optimizing chromatographic
optimizing
Prior art date
Application number
DK07765375.6T
Other languages
English (en)
Inventor
Christian Eckermann
Sybille Ebert
Dorothee Ambrosius
Stefanie Rubenwolf
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK2032230T3 publication Critical patent/DK2032230T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/50Conditioning of the sorbent material or stationary liquid
    • G01N30/52Physical parameters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/50Conditioning of the sorbent material or stationary liquid
    • G01N30/56Packing methods or coating methods
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203Equilibration or regeneration
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009Extraction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/38Flow patterns
    • G01N30/46Flow patterns using more than one column
    • G01N30/466Flow patterns using more than one column with separation columns in parallel
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/86Signal analysis
    • G01N30/8658Optimising operation parameters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK07765375.6T 2006-06-14 2007-06-12 Fremgangsmåde til optimering af kromatografiske oprensningsfremgangsmåder til biomolekyler DK2032230T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006027496A DE102006027496B3 (de) 2006-06-14 2006-06-14 Verfahren zur Optimierung chromatographischer Reinigungsverfahren für Biomoleküle
PCT/EP2007/055776 WO2007144353A1 (de) 2006-06-14 2007-06-12 Verfahren zur optimierung chromatographischer reinigungsverfahren für biomoleküle

Publications (1)

Publication Number Publication Date
DK2032230T3 true DK2032230T3 (da) 2014-05-12

Family

ID=38529642

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07765375.6T DK2032230T3 (da) 2006-06-14 2007-06-12 Fremgangsmåde til optimering af kromatografiske oprensningsfremgangsmåder til biomolekyler

Country Status (10)

Country Link
US (1) US8349615B2 (da)
EP (1) EP2032230B1 (da)
JP (1) JP5168276B2 (da)
KR (1) KR101365474B1 (da)
CA (1) CA2655258C (da)
DE (1) DE102006027496B3 (da)
DK (1) DK2032230T3 (da)
ES (1) ES2462392T3 (da)
TW (1) TWI435753B (da)
WO (1) WO2007144353A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044727A1 (en) 2008-10-15 2010-04-22 Ge Healthcare Bio-Sciences Ab Micro titre plate
WO2012082933A1 (en) 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
WO2019165148A1 (en) * 2018-02-21 2019-08-29 Just Biotherapeutics, Inc. Determining conditions for purification of proteins
CN112843789A (zh) * 2020-12-29 2021-05-28 上海赛梵科分离技术有限公司 大麻二酚纯化中色谱填料和层析介质的再生方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19860354B4 (de) * 1998-12-24 2006-11-23 Universität Dortmund Eine Methode zur modellbasierten on-line Optimierung und Parameterschätzung von Batch-Chromatographieprozessen
US20050176937A1 (en) * 2000-02-23 2005-08-11 Rensselaer Polytechnic Institute High throughput screening of potential displacer molecules
DE10393819D2 (de) * 2002-09-19 2005-08-11 Charite Universitaetsmedizin Verfahren zum Auffinden geeigneter chromatographiebedingungen zur Trennung biologischer Moleküle

Also Published As

Publication number Publication date
TW200815079A (en) 2008-04-01
US20080066530A1 (en) 2008-03-20
WO2007144353A1 (de) 2007-12-21
ES2462392T3 (es) 2014-05-22
EP2032230B1 (de) 2014-04-02
JP5168276B2 (ja) 2013-03-21
CA2655258A1 (en) 2007-12-21
KR101365474B1 (ko) 2014-02-21
DE102006027496B3 (de) 2008-01-10
KR20090032082A (ko) 2009-03-31
TWI435753B (zh) 2014-05-01
US8349615B2 (en) 2013-01-08
CA2655258C (en) 2014-04-29
EP2032230A1 (de) 2009-03-11
JP2009539931A (ja) 2009-11-19

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