DK197279A - Fremgangsmaade til fremstilling af imidazolderivater - Google Patents

Fremgangsmaade til fremstilling af imidazolderivater

Info

Publication number
DK197279A
DK197279A DK197279A DK197279A DK197279A DK 197279 A DK197279 A DK 197279A DK 197279 A DK197279 A DK 197279A DK 197279 A DK197279 A DK 197279A DK 197279 A DK197279 A DK 197279A
Authority
DK
Denmark
Prior art keywords
procedure
preparation
imidazole derivatives
imidazole
derivatives
Prior art date
Application number
DK197279A
Other languages
Danish (da)
English (en)
Inventor
K Matsumura
H Hashimoto
Y Furukawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK197279A publication Critical patent/DK197279A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK197279A 1978-05-15 1979-05-14 Fremgangsmaade til fremstilling af imidazolderivater DK197279A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5791278A JPS54148788A (en) 1978-05-15 1978-05-15 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
DK197279A true DK197279A (da) 1979-11-16

Family

ID=13069193

Family Applications (1)

Application Number Title Priority Date Filing Date
DK197279A DK197279A (da) 1978-05-15 1979-05-14 Fremgangsmaade til fremstilling af imidazolderivater

Country Status (10)

Country Link
US (1) US4207324A (ja)
EP (1) EP0005528B1 (ja)
JP (1) JPS54148788A (ja)
AU (1) AU526302B2 (ja)
CA (1) CA1124244A (ja)
DE (1) DE2965062D1 (ja)
DK (1) DK197279A (ja)
ES (1) ES480542A1 (ja)
GR (1) GR68432B (ja)
NO (1) NO791597L (ja)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671073A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4338453A (en) * 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
DE3106150A1 (de) * 1981-02-13 1982-09-16 Schering Ag, 1000 Berlin Und 4619 Bergkamen "verfahren zur herstellung von imidazolessigsaeurederivaten"
CA1181082A (en) * 1981-11-20 1985-01-15 Toni Dockner Substituted benzylimidazolium salts and microbicides containing these compounds
JPS58157768A (ja) * 1982-03-16 1983-09-19 Takeda Chem Ind Ltd ４−クロロ−２−フエニルイミダゾ−ル−５−酢酸誘導体
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5189048A (en) * 1988-01-07 1993-02-23 E. I. Du Pont De Nemours And Company Substituted 1,2,3 triazole angiotensin II antagonists
US5081127A (en) * 1988-01-07 1992-01-14 E. I. Du Pont De Nemours And Company Substituted 1,2,3-triazole angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5093346A (en) * 1988-01-07 1992-03-03 E. I. Du Pont De Nemours And Company Substituted 1,2,4-triazole angiotensin II antagonists
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US5315013A (en) * 1988-01-07 1994-05-24 E. I. Du Pont De Nemours And Company Substituted pyrazole angiotensin II antagonists
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
KR950009860B1 (ko) 1989-06-30 1995-08-29 이. 아이. 듀퐁 드 네모아 앤드 캄파니 융합된 환 아릴 치환된 이미다졸과 약제학적으로 허용되는 이의 염, 이들의 제조방법 및 이들을 함유하는 약제학적 조성물
EP0409332A3 (en) * 1989-07-19 1991-08-07 Merck & Co. Inc. Substituted triazoles as angiotensin ii antagonists
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5166206A (en) * 1990-03-30 1992-11-24 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
JPH0441481A (ja) * 1990-06-05 1992-02-12 Nippon Synthetic Chem Ind Co Ltd:The イミダゾール類のハロゲン化方法
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
US5153347A (en) * 1991-01-31 1992-10-06 E. R. Squibb & Sons, Inc. Phosphonate, phosphinate derivatives useful as antihypertensive agents
US5191086A (en) * 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5506361A (en) * 1991-05-08 1996-04-09 Theupjohn Company Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same
GB9110636D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
US5294722A (en) * 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
CN1120837A (zh) * 1993-04-07 1996-04-17 日产化学工业株式会社 吡唑衍生物
DE4343613A1 (de) * 1993-12-21 1995-06-22 Bayer Ag N-substituierte Aryl-trifluormethylimidazole
WO1995033730A1 (fr) * 1994-06-09 1995-12-14 Nippon Soda Co., Ltd. Derive d'imidazole, procede de production et herbicide
US5859035A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
JP2000504024A (ja) * 1996-04-03 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
US20080200690A1 (en) * 2005-04-15 2008-08-21 Dishman Pharmaceuticals And Chemicals Ltd Preparation of 2-Substituted 4-Chloro-5-Formylimidazole and 5-Formylimidazole
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010014739A2 (en) * 2008-07-29 2010-02-04 Kalypsys, Inc. Heterocyclic modulators of tgr5
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH159795A (de) * 1931-12-19 1933-01-31 Hoffmann La Roche Verfahren zur Darstellung von Dijodimidazolessigsäure.
US3354173A (en) * 1964-04-16 1967-11-21 Janssen Pharmaceutica Nv Imidazole carboxylates
CH528514A (de) * 1969-05-22 1972-09-30 Bayer Ag Verfahren zur Herstellung von Acylimidazolen
US4042702A (en) * 1973-08-16 1977-08-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Halogen pyrazole derivatives, a method for producing these halogen pyrazole derivatives, medicaments containing and methods of using them
US3932445A (en) * 1974-06-26 1976-01-13 Mcneil Laboratories, Incorporated 2-Aryl-4-(R-methyl)-5-methylimidazoles
US3991072A (en) * 1975-03-10 1976-11-09 Janssen Pharmaceutica N.V. Racemization of lower alkyl imidazole carboxylates
US4038286A (en) * 1975-03-10 1977-07-26 Janssen Pharmaceutica N.V. Racemates and optical isomers of 1-(1-phenylethyl)-1h-imidazole-5-carboylic acid derivatives

Also Published As

Publication number Publication date
US4207324A (en) 1980-06-10
DE2965062D1 (en) 1983-04-28
EP0005528A3 (en) 1980-01-09
CA1124244A (en) 1982-05-25
EP0005528A2 (en) 1979-11-28
ES480542A1 (es) 1980-04-01
JPS54148788A (en) 1979-11-21
AU4657379A (en) 1979-11-22
AU526302B2 (en) 1983-01-06
NO791597L (no) 1979-11-16
JPS611022B2 (ja) 1986-01-13
EP0005528B1 (en) 1983-03-23
GR68432B (ja) 1981-12-30

Similar Documents

Publication Publication Date Title
DK197279A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK46079A (da) Fremgangsmaade til fremstilling af alkylendiaminderivater
DK406578A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK158225C (da) Analogifremgangsmaade til fremstilling af carbostyrilderivater
DK266479A (da) Fremgangsmaade til fremstilling af 3-aminopropoxyarylderivater
DK129879A (da) Fremgangsmaade til fremstilling af n-heterocyclyl-4-piperidinaminer
DK303079A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK310779A (da) Fremgangsmaade til fremstilling af pyrimidinonderivater
DK148879A (da) Fremgangsmaade til fremstilling af mercaptoimidazolderivater
DK186179A (da) Fremgangsmaade til fremstilling af carbapenemderivater
DK415379A (da) Fremgangsmaade til fremstilling af chromanolderivater
DK20279A (da) Fremgangsmaade til fremstilling af 4-pyridon-3-carboxylsyrederivater
DK331679A (da) Fremgangsmaade til fremstilling af phenylalkansyrederivater
DK257779A (da) Fremgangsmaade til fremstilling af chlor-styryl-cyclopropan-carboxylsyrederivater
DK150471C (da) Fremgangsmaade til fremstilling af trifluormethylphenoler
DK350079A (da) Fremgangsmaade til fremstilling af indolinderivater
DK186279A (da) Fremgangsmaade til fremstilling af alkylcarbapenemderivater
DK160281C (da) Fremgangsmaade til fremstilling af steroid-s-thioesterderivater
DK282379A (da) Fremgangsmaade til fremstilling af phenylpiperidinderivater isaer substituerede eventuelt enkeltmaettede 1-benzylphenylpiperidiner
DK145179A (da) Fremgangsmaade til fremstilling af 4-methyl-5-hydroxymethyl-imidazol
DK428079A (da) Fremgangsmaade til fremstilling af cyclohexadienderivater
DK348179A (da) Fremgangsmaade til fremstilling af carbazolyderivater
DK157017C (da) Analogifremgangsmaade til fremstilling af carbostyrilderivater
DK150879A (da) Fremgangsmaade til fremstilling af oximderivater af 3-azidomethyl-7-aminothiazolylacetamidocephalosporansyre
DK583578A (da) Fremgangsmaade til fremstilling af aminopropoxyarylderivater