DK196885A - Farmaceutiske praeparater indeholdende isoquinolinderivater og isoquinolinderivater indeholdende saadanne derivater - Google Patents

Farmaceutiske praeparater indeholdende isoquinolinderivater og isoquinolinderivater indeholdende saadanne derivater Download PDF

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Publication number
DK196885A
DK196885A DK196885A DK196885A DK196885A DK 196885 A DK196885 A DK 196885A DK 196885 A DK196885 A DK 196885A DK 196885 A DK196885 A DK 196885A DK 196885 A DK196885 A DK 196885A
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DK
Denmark
Prior art keywords
derivatives
isoquinolin
pharmaceutical preparations
preparations containing
isoquinolin derivatives
Prior art date
Application number
DK196885A
Other languages
English (en)
Other versions
DK160991C (da
DK196885D0 (da
DK160991B (da
Inventor
Gordon Hanley Phillipps
Stanley Frederick Dyke
Esme Joan Bailey
Peter David Howes
David Ian Carter Scopes
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848411407A external-priority patent/GB8411407D0/en
Priority claimed from GB848411408A external-priority patent/GB8411408D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK196885D0 publication Critical patent/DK196885D0/da
Publication of DK196885A publication Critical patent/DK196885A/da
Publication of DK160991B publication Critical patent/DK160991B/da
Application granted granted Critical
Publication of DK160991C publication Critical patent/DK160991C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Description

4 R hydrogen, halogen, C1-3 alkyl eller fenyl eventuelt substitueret med halogen, hydroxy, alkyl, alkoxy eller alkanoyloxy, og ringen A er en gruppe med formlen
Figure DK196885AD00021
hvor R^ og R^ hver er hydrogen, hydroxyl. C, » alkoxy eller 7 8 ι.~** C. . alkanoyloxy, R og R hver hydrogen eller metyl og 12 3 ét af X, X , X og X er nitrogen og de øvrige -CH-, dog således at når A er en gruppe (i) så er mindst ét af R^-R® forskellig fra hydrogen, sammen med mir farmaceutisk acceptabel bærer eller excipient.
Opfindelsen angår også selve forbindelserne, der kan fremstilles ved forskellige analogifremgangsmåder.
DK196885A 1984-05-03 1985-05-02 5,14-dihydrobenzoe5,6aaisoindolooe2,1-baaisoquinolin-8,13-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse DK160991C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848411407A GB8411407D0 (en) 1984-05-03 1984-05-03 Chemical compounds
GB8411407 1984-05-03
GB848411408A GB8411408D0 (en) 1984-05-03 1984-05-03 Chemical compounds
GB8411408 1984-05-03

Publications (4)

Publication Number Publication Date
DK196885D0 DK196885D0 (da) 1985-05-02
DK196885A true DK196885A (da) 1985-11-04
DK160991B DK160991B (da) 1991-05-13
DK160991C DK160991C (da) 1991-11-11

Family

ID=26287697

Family Applications (1)

Application Number Title Priority Date Filing Date
DK196885A DK160991C (da) 1984-05-03 1985-05-02 5,14-dihydrobenzoe5,6aaisoindolooe2,1-baaisoquinolin-8,13-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse

Country Status (9)

Country Link
US (1) US4835158A (da)
EP (1) EP0161102B1 (da)
AU (1) AU587184B2 (da)
CA (1) CA1268178A (da)
DE (1) DE3576066D1 (da)
DK (1) DK160991C (da)
IL (1) IL75083A (da)
NO (1) NO163330C (da)
NZ (1) NZ211960A (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109678798A (zh) * 2019-01-20 2019-04-26 湖南科技大学 一种异喹啉化合物的合成方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
EP0161102B1 (en) * 1984-05-03 1990-02-21 Glaxo Group Limited Isoquinoline derivatives
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
NO872963L (no) * 1986-07-29 1988-02-01 Glaxo Group Ltd Isokinolinderivater.
DK616087A (da) * 1986-11-27 1988-05-28 Glaxo Group Ltd Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process
GB9708119D0 (en) * 1997-04-22 1997-06-11 Glaxo Group Ltd Chemical compounds
IT1318986B1 (it) * 2000-10-09 2003-09-19 Archimica S P A Ora Clariant L Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
CN114805204B (zh) * 2022-04-01 2023-09-15 云南师范大学 一种制备4-碘异喹啉-1(2h)-酮类化合物的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1087222A (en) * 1963-03-16 1967-10-18 Geigy Uk Ltd 12-nitronaphthindolizinediones and processes for their manufacture
GB1459137A (en) * 1973-05-30 1976-12-22 Sandoz Ltd Naphthoquinone derivatives
US4033966A (en) * 1975-06-24 1977-07-05 Kanebo, Ltd. Novel berbine derivatives
US4087426A (en) * 1976-08-16 1978-05-02 Research Corporation Oxybisberberine and a process for its production
FR2387229A1 (fr) * 1977-04-13 1978-11-10 Anvar Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
FR2436786A1 (fr) * 1978-09-21 1980-04-18 Anvar Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS5942382A (ja) * 1982-09-02 1984-03-08 Yoshitomi Pharmaceut Ind Ltd サフラシン誘導体
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
EP0161102B1 (en) * 1984-05-03 1990-02-21 Glaxo Group Limited Isoquinoline derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109678798A (zh) * 2019-01-20 2019-04-26 湖南科技大学 一种异喹啉化合物的合成方法
CN109678798B (zh) * 2019-01-20 2023-01-17 湖南科技大学 一种异喹啉化合物的合成方法

Also Published As

Publication number Publication date
AU587184B2 (en) 1989-08-10
NZ211960A (en) 1989-05-29
US4835158A (en) 1989-05-30
CA1268178A (en) 1990-04-24
IL75083A0 (en) 1985-09-29
DK160991C (da) 1991-11-11
EP0161102A3 (en) 1987-03-04
NO163330C (no) 1990-05-09
EP0161102B1 (en) 1990-02-21
NO851758L (no) 1985-11-04
IL75083A (en) 1990-07-12
NO163330B (no) 1990-01-29
DK196885D0 (da) 1985-05-02
AU4196585A (en) 1985-11-07
DE3576066D1 (de) 1990-03-29
DK160991B (da) 1991-05-13
EP0161102A2 (en) 1985-11-13

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