DK1940387T3 - Fremgangsmåde til stereoselektiv fremstilling af (-)-halofenat og mellemprodukter deraf - Google Patents
Fremgangsmåde til stereoselektiv fremstilling af (-)-halofenat og mellemprodukter derafInfo
- Publication number
- DK1940387T3 DK1940387T3 DK06815150.5T DK06815150T DK1940387T3 DK 1940387 T3 DK1940387 T3 DK 1940387T3 DK 06815150 T DK06815150 T DK 06815150T DK 1940387 T3 DK1940387 T3 DK 1940387T3
- Authority
- DK
- Denmark
- Prior art keywords
- halophenate
- intermediates
- stereoselective production
- stereoselective
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72030005P | 2005-09-23 | 2005-09-23 | |
| US11/525,200 US7714131B2 (en) | 2005-09-23 | 2006-09-20 | Process for the stereoselective preparation of (−)-halofenate and derivatives thereof |
| PCT/US2006/036928 WO2007038243A1 (en) | 2005-09-23 | 2006-09-21 | Process for the stereoselective preparation of (-)-halofenate and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1940387T3 true DK1940387T3 (da) | 2013-01-02 |
Family
ID=37894903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06815150.5T DK1940387T3 (da) | 2005-09-23 | 2006-09-21 | Fremgangsmåde til stereoselektiv fremstilling af (-)-halofenat og mellemprodukter deraf |
Country Status (18)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009121940A1 (en) * | 2008-04-03 | 2009-10-08 | Janssen Pharmaceutica Nv | Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester |
| WO2009148046A1 (ja) * | 2008-06-03 | 2009-12-10 | 株式会社カネカ | 光学活性アミノ酸誘導体の製造方法 |
| US9060987B2 (en) | 2011-11-04 | 2015-06-23 | Cymabay Therapeutics, Inc. | Methods for treating gout flares |
| US9023856B2 (en) | 2011-11-04 | 2015-05-05 | Cymabay Therapeutics, Inc. | Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent |
| WO2021236394A1 (en) | 2020-05-18 | 2021-11-25 | Cymabay Therapeutics, Inc. | Cb-0406 tromethamine salt |
| US20210355066A1 (en) | 2020-05-18 | 2021-11-18 | Cymabay Therapeutics, Inc. | CB-0406 choline salt |
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| US3444299A (en) | 1964-02-07 | 1969-05-13 | American Cyanamid Co | Methods for the control and prevention of helminths with phenylbenzothiazolium compounds |
| GB1097053A (en) | 1964-03-16 | 1967-12-29 | Dow Chemical Co | Substituted benzothiazolium compounds and complexes thereof for use in animal husbandry |
| US3517051A (en) | 1964-03-20 | 1970-06-23 | Merck & Co Inc | Phenoxy substituted phenylacetic acids |
| US3378582A (en) | 1964-03-20 | 1968-04-16 | Merck & Co Inc | (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids |
| US3517050A (en) | 1966-10-03 | 1970-06-23 | Merck & Co Inc | Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid |
| NL6712585A (US07714131-20100511-C00024.png) | 1966-10-03 | 1968-04-04 | ||
| US3558778A (en) | 1966-10-27 | 1971-01-26 | Dow Chemical Co | Methods and compositions for use in animal husbandry |
| US3674836A (en) | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
| BE754245A (fr) | 1969-08-01 | 1970-12-31 | Sumitomo Chemical Co | Derives d'acides phenoxy carboxyliques |
| DK133742B (da) | 1970-10-30 | 1976-07-12 | Merck & Co Inc | Fremgangsmåde til fremstilling af 2-acetamidoethyl-(3-trifluormethylphenoxy)-(4-chlorphenyl)-acetat. |
| US3923855A (en) | 1972-07-13 | 1975-12-02 | Merck & Co Inc | 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate |
| US3953490A (en) | 1972-07-13 | 1976-04-27 | Merck & Co., Inc. | Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile |
| US3860628A (en) | 1972-07-13 | 1975-01-14 | Merck & Co Inc | Cyanomethyl(3-trifluoromethylphenoxy)(4-chlorophenyl)acetate |
| NL7309571A (US07714131-20100511-C00024.png) | 1972-07-28 | 1974-01-30 | ||
| US4110351A (en) | 1973-04-02 | 1978-08-29 | Richardson-Merrell Inc. | Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts |
| US3876791A (en) | 1973-11-30 | 1975-04-08 | Uniroyal Inc | Control of acarids using certain benzothiazoles or benzothiazolines |
| US4001268A (en) | 1974-08-07 | 1977-01-04 | The United States Of America As Represented By The Secretary Of The Air Force | Substituted phenyl-benzimidazo compounds |
| IL48707A0 (en) | 1974-12-30 | 1976-02-29 | Synthelabo | Novel phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
| JPS6039072B2 (ja) | 1976-07-28 | 1985-09-04 | 藤沢薬品工業株式会社 | Ｎ−置換フエニルアミノ脂肪酸誘導体 |
| JPS5371071A (en) | 1976-12-08 | 1978-06-24 | Teijin Ltd | Alpha-phenoxyacetic acid derivs. |
| US4250191A (en) | 1978-11-30 | 1981-02-10 | Edwards K David | Preventing renal failure |
| US4214095A (en) | 1979-01-25 | 1980-07-22 | Siegfried Aktiengesellschaft | Chlorobenzyl phenoxy alkoxylates |
| SE8003278L (sv) | 1979-05-04 | 1980-11-05 | Continental Pharma | Fenyletylaminderivat |
| US4532135A (en) | 1981-02-09 | 1985-07-30 | Edwards K David G | Renoprotective treatments employing vasodilator compounds |
| US4508882A (en) | 1981-08-24 | 1985-04-02 | Asahi Glass Company Ltd. | Benzotriazole compound and homopolymer or copolymers thereof |
| EP0077938A3 (en) | 1981-10-23 | 1983-08-24 | Mitsubishi Kasei Corporation | N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition |
| DE3236730A1 (de) | 1982-10-04 | 1984-04-05 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von benzoxazolyl- und benzthiazolyloxyphenoxypropionsaeurederivaten |
| US4528311A (en) | 1983-07-11 | 1985-07-09 | Iolab Corporation | Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles |
| JPS60109578A (ja) | 1983-11-17 | 1985-06-15 | Mitsubishi Chem Ind Ltd | ３−（置換フエニル）−５−置換−１，３，４−オキサゾリン−２−オン類およびこれを有効成分とする除草剤 |
| DE3525284A1 (de) | 1985-07-16 | 1987-01-29 | Boehringer Mannheim Gmbh | Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten |
| US4714762A (en) | 1986-10-31 | 1987-12-22 | Warner-Lambert Company | Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof |
| US4786731A (en) | 1987-08-05 | 1988-11-22 | The Dow Chemical Company | Resolution of enantiomers of 2-(phenyl or phenoxy/propionic acids using optically active alkanolamines |
| JPH0670025B2 (ja) | 1987-08-07 | 1994-09-07 | 鐘紡株式会社 | ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤 |
| GB8720365D0 (en) | 1987-08-28 | 1987-10-07 | Sandoz Ltd | Organic compounds |
| US4863802A (en) | 1987-12-31 | 1989-09-05 | General Electric Company | UV-stabilized coatings |
| JPH01305069A (ja) | 1988-05-31 | 1989-12-08 | Shionogi & Co Ltd | ベンゾトリアゾール誘導体およびそれを含有する発螢光試薬 |
| CA2034309C (en) | 1990-01-22 | 1997-04-01 | Takashi Iwaki | Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus |
| US5278314A (en) | 1991-02-12 | 1994-01-11 | Ciba-Geigy Corporation | 5-thio-substituted benzotriazole UV-absorbers |
| DE4111026A1 (de) | 1991-04-05 | 1992-10-08 | Boehringer Mannheim Gmbh | Optisch aktive carbonsaeuren sowie diese enthaltende arzneimittel |
| US5605930A (en) | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
| EP0559927B1 (en) | 1992-03-09 | 1997-03-05 | Hoechst Aktiengesellschaft | A simplified method for the production of vinyl glycine (2-aminobut-3-enioc acid) and a convenient resolution of a derivative |
| DE4303676A1 (de) | 1993-02-09 | 1994-08-11 | Bayer Ag | 1-Aryltriazolin(thi)one |
| US5874431A (en) | 1993-08-28 | 1999-02-23 | Cancer Research Campaign Technology Limited | Benzazole compounds |
| US5496826A (en) | 1994-09-02 | 1996-03-05 | Bristol-Myers Squibb Company | Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides |
| US5455152A (en) | 1994-09-27 | 1995-10-03 | Eastman Kodak Company | Benzotriazole based UV absorbing monomers and photographic elements containing polymers formed from them |
| US5700819A (en) | 1994-11-29 | 1997-12-23 | Grelan Pharmaceutical Co., Ltd. | 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications |
| US5783738A (en) | 1994-12-28 | 1998-07-21 | Rhone-Poulenc Chimie | Optically active diphosphines, preparation thereof according to a process for the resolution of the racemic mixture and use thereof |
| GB9503946D0 (en) | 1995-02-28 | 1995-04-19 | Cancer Res Campaign Tech | Benzazole compounds |
| US5500332A (en) | 1995-04-26 | 1996-03-19 | Eastman Kodak Company | Benzotriazole based UV absorbers and photographic elements containing them |
| US5708186A (en) * | 1995-12-12 | 1998-01-13 | Merck & Co Inc | Stereoselective process |
| US6242464B1 (en) | 1996-01-22 | 2001-06-05 | Chiroscience Limited | Single isomer methylphenidate and resolution process |
| US5859051A (en) | 1996-02-02 | 1999-01-12 | Merck & Co., Inc. | Antidiabetic agents |
| US5766834A (en) | 1996-05-17 | 1998-06-16 | Eastman Kodak Company | Photographic element containing ultraviolet absorbing polymer |
| US5716987A (en) | 1996-06-21 | 1998-02-10 | Bristol-Myers Squibb Company | Prophylactic and therapeutic treatment of skin sensitization and irritation |
| JP2000516611A (ja) | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体 |
| KR100496318B1 (ko) | 1996-11-22 | 2005-06-20 | 시바 스페셜티 케미칼스 홀딩 인크. | 사람 및 동물의 피부 및 모발을 자외선의 유해한 영향으로부터보호하기 위한, 선택된 벤조트리아졸 유도체의 용도 |
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| PT974589E (pt) | 1997-11-07 | 2004-05-31 | Taiho Pharmaceutical Co Ltd | Derivados de benzimidazol e os seus sais aceitaveis sob o ponto de vista farmaceutico |
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| US6013659A (en) | 1998-09-04 | 2000-01-11 | University Of Pittsburgh | Methods of reducing tumor colony number using novel benzothiazole compounds |
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| TR200103147T1 (tr) | 1999-12-27 | 2002-06-21 | Japan Tobacco Inc. | Kaynaşık halkalı bileşikler ve bunların ilaç olarak kullanımı. |
| WO2004078113A2 (en) | 2003-03-04 | 2004-09-16 | Pharmacia Corporation | Treatment and prevention of obesity with cox-2 inhibitors alone or in combination with weight-loss agents |
| CA2529774C (en) | 2003-06-20 | 2014-05-27 | Metabolex, Inc. | Resolution of .alpha.-(phenoxy)phenylacetic acid derivatives |
| US7199259B2 (en) | 2003-06-20 | 2007-04-03 | Metabolex, Inc. | Resolution of α-(phenoxy)phenylacetic acid derivatives |
-
2006
- 2006-09-20 US US11/525,200 patent/US7714131B2/en not_active Expired - Fee Related
- 2006-09-21 PL PL06815150T patent/PL1940387T3/pl unknown
- 2006-09-21 EP EP06815150A patent/EP1940387B1/en active Active
- 2006-09-21 ES ES06815150T patent/ES2394973T3/es active Active
- 2006-09-21 EA EA200800884A patent/EA015673B1/ru not_active IP Right Cessation
- 2006-09-21 SI SI200631502T patent/SI1940387T1/sl unknown
- 2006-09-21 JP JP2008532404A patent/JP2009515817A/ja not_active Withdrawn
- 2006-09-21 BR BRPI0616188-0A patent/BRPI0616188A2/pt not_active IP Right Cessation
- 2006-09-21 AU AU2006294950A patent/AU2006294950A1/en not_active Abandoned
- 2006-09-21 RS RS20130001A patent/RS52608B/en unknown
- 2006-09-21 WO PCT/US2006/036928 patent/WO2007038243A1/en active Application Filing
- 2006-09-21 KR KR1020087009709A patent/KR101309605B1/ko not_active IP Right Cessation
- 2006-09-21 DK DK06815150.5T patent/DK1940387T3/da active
- 2006-09-21 PT PT68151505T patent/PT1940387E/pt unknown
- 2006-09-21 CA CA2623350A patent/CA2623350C/en not_active Expired - Fee Related
-
2008
- 2008-03-20 IL IL190325A patent/IL190325A/en not_active IP Right Cessation
- 2008-12-29 HK HK08114045.8A patent/HK1119953A1/xx not_active IP Right Cessation
-
2013
- 2013-01-02 HR HRP20130001TT patent/HRP20130001T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS52608B (en) | 2013-04-30 |
| CA2623350A1 (en) | 2007-04-05 |
| PT1940387E (pt) | 2012-12-17 |
| IL190325A0 (en) | 2009-09-22 |
| EA015673B1 (ru) | 2011-10-31 |
| PL1940387T3 (pl) | 2013-02-28 |
| IL190325A (en) | 2013-04-30 |
| HRP20130001T1 (hr) | 2013-02-28 |
| EP1940387A1 (en) | 2008-07-09 |
| HK1119953A1 (en) | 2009-03-20 |
| EP1940387B1 (en) | 2012-11-28 |
| EA200800884A1 (ru) | 2008-12-30 |
| AU2006294950A1 (en) | 2007-04-05 |
| WO2007038243A1 (en) | 2007-04-05 |
| KR101309605B1 (ko) | 2013-09-17 |
| EP1940387A4 (en) | 2010-11-03 |
| BRPI0616188A2 (pt) | 2011-06-14 |
| KR20080050527A (ko) | 2008-06-05 |
| ES2394973T3 (es) | 2013-02-07 |
| US7714131B2 (en) | 2010-05-11 |
| CA2623350C (en) | 2014-08-19 |
| JP2009515817A (ja) | 2009-04-16 |
| SI1940387T1 (sl) | 2013-04-30 |
| US20070072858A1 (en) | 2007-03-29 |
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