DK186182A - 1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner fremgangsmaade til fremsilling heraf mellemprodukter til deres fremstilling samt deres anvendelse som laegemidler - Google Patents

1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner fremgangsmaade til fremsilling heraf mellemprodukter til deres fremstilling samt deres anvendelse som laegemidler Download PDF

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Publication number
DK186182A
DK186182A DK186182A DK186182A DK186182A DK 186182 A DK186182 A DK 186182A DK 186182 A DK186182 A DK 186182A DK 186182 A DK186182 A DK 186182A DK 186182 A DK186182 A DK 186182A
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DK
Denmark
Prior art keywords
phenylpiperidines
benzisoxazol
fluoro
propyl
hydroxy
Prior art date
Application number
DK186182A
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English (en)
Other versions
DK151019B (da
DK151019C (da
Inventor
L Davis
R C Effland
J T Klein
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/366,247 external-priority patent/US4396770A/en
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK186182A publication Critical patent/DK186182A/da
Publication of DK151019B publication Critical patent/DK151019B/da
Application granted granted Critical
Publication of DK151019C publication Critical patent/DK151019C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Description

Figure DK186182AD00021
(2) hvor X betyder hydrogen, lavere alkyl, lavere alkoxy, halogen eller trifluormethyl, og Y betyder hydrogen eller trifluormethyl under forudsætning af, at Y betyder hydrogen, når X har den anførte betydning, og Y betyder hydrogen, trifluormethyl, når X betyder halogen, med en forbindelse med formlen
Figure DK186182AD00022
(4) eller ved kondensation af en forbindelse med formlen
Figure DK186182AD00023
(5) med en forbindelse med formlen
Figure DK186182AD00024
(6) .
Udgangsforbindelsen (5) kan fremstilles ved cyclisering af et oximderivat med formlen
Figure DK186182AD00025
hvor R er en substituent valgt blandt
Figure DK186182AD00031
hvor alkyl betyder en ligekædet eller forgrenet carbon-hydridsubstituent med 1-6 carbonatomer, og
Figure DK186182AD00032
Forbindelserne (1) er anvendelige til behandling af psykoser og til lindring af smerte.
DK186182A 1981-04-27 1982-04-26 Analogifremgangsmaade til fremstilling af 1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner, samt 3-(gamma-chlorpropyl)-6-fluor-1,2-benzisoxazol til anvendelse herved DK151019C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25769881A 1981-04-27 1981-04-27
US25769881 1981-04-27
US36624782 1982-04-09
US06/366,247 US4396770A (en) 1982-04-09 1982-04-09 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines

Publications (3)

Publication Number Publication Date
DK186182A true DK186182A (da) 1982-10-28
DK151019B DK151019B (da) 1987-10-12
DK151019C DK151019C (da) 1988-03-14

Family

ID=26946142

Family Applications (1)

Application Number Title Priority Date Filing Date
DK186182A DK151019C (da) 1981-04-27 1982-04-26 Analogifremgangsmaade til fremstilling af 1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner, samt 3-(gamma-chlorpropyl)-6-fluor-1,2-benzisoxazol til anvendelse herved

Country Status (10)

Country Link
EP (2) EP0149229B1 (da)
AU (1) AU564572B2 (da)
DE (1) DE3267658D1 (da)
DK (1) DK151019C (da)
FI (1) FI821415L (da)
GR (1) GR75417B (da)
IL (1) IL65598A (da)
NO (1) NO821361L (da)
NZ (1) NZ200400A (da)
PT (1) PT74799B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
FR2588860B1 (fr) * 1985-10-21 1988-08-12 Isochem Sa (chloro-3 propionyl)-2 fluoro-4 phenol, procede pour sa preparation, et application a la preparation de la fluoro-6 chromanone-4
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
JPS54136666A (en) * 1978-04-15 1979-10-23 Matsushita Electric Works Ltd Leakage breaker
JPS6043064B2 (ja) * 1979-11-28 1985-09-26 ウェルファイド株式会社 新規イソオキサゾ−ル誘導体

Also Published As

Publication number Publication date
PT74799A (en) 1982-05-01
DK151019B (da) 1987-10-12
PT74799B (en) 1984-06-27
NZ200400A (en) 1987-04-30
EP0149229A2 (en) 1985-07-24
DK151019C (da) 1988-03-14
EP0063799A3 (en) 1982-12-15
EP0149229A3 (en) 1986-10-29
EP0149229B1 (en) 1989-06-14
AU564572B2 (en) 1987-08-20
NO821361L (no) 1982-10-28
EP0063799B1 (en) 1985-11-27
EP0063799A2 (en) 1982-11-03
FI821415A0 (fi) 1982-04-23
AU8300482A (en) 1982-11-04
DE3267658D1 (en) 1986-01-09
FI821415L (fi) 1982-10-28
GR75417B (da) 1984-07-16
IL65598A (en) 1985-12-31
IL65598A0 (en) 1982-07-30

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