DK1824481T3 - Anvendelse af ribose-cystein til behandling af hypoxia ved forhøjelse af tilførslen af glutathion og atp-koncentrationerne i celler - Google Patents

Anvendelse af ribose-cystein til behandling af hypoxia ved forhøjelse af tilførslen af glutathion og atp-koncentrationerne i celler

Info

Publication number
DK1824481T3
DK1824481T3 DK05823154.9T DK05823154T DK1824481T3 DK 1824481 T3 DK1824481 T3 DK 1824481T3 DK 05823154 T DK05823154 T DK 05823154T DK 1824481 T3 DK1824481 T3 DK 1824481T3
Authority
DK
Denmark
Prior art keywords
glutathion
cystein
ribose
cells
application
Prior art date
Application number
DK05823154.9T
Other languages
English (en)
Inventor
Herbert T Nagasawa
Original Assignee
Max International Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max International Llc filed Critical Max International Llc
Application granted granted Critical
Publication of DK1824481T3 publication Critical patent/DK1824481T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK05823154.9T 2004-11-17 2005-11-16 Anvendelse af ribose-cystein til behandling af hypoxia ved forhøjelse af tilførslen af glutathion og atp-koncentrationerne i celler DK1824481T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/990,933 US20060105972A1 (en) 2004-11-17 2004-11-17 Method to enhance delivery of glutathione and ATP levels in cells
PCT/US2005/041458 WO2006055597A1 (en) 2004-11-17 2005-11-16 Use of ribose-cysteine to treat hypoxia by enhancing delivery of glutathione and atp levels in cells

Publications (1)

Publication Number Publication Date
DK1824481T3 true DK1824481T3 (da) 2012-09-24

Family

ID=35759146

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05823154.9T DK1824481T3 (da) 2004-11-17 2005-11-16 Anvendelse af ribose-cystein til behandling af hypoxia ved forhøjelse af tilførslen af glutathion og atp-koncentrationerne i celler

Country Status (14)

Country Link
US (4) US20060105972A1 (da)
EP (1) EP1824481B1 (da)
JP (1) JP2008520681A (da)
KR (1) KR20070095900A (da)
CN (1) CN101060840A (da)
AU (1) AU2005307885B2 (da)
BR (1) BRPI0516814A (da)
CA (1) CA2587616C (da)
DK (1) DK1824481T3 (da)
EA (1) EA014076B1 (da)
ES (1) ES2390228T3 (da)
MX (1) MX2007005835A (da)
PL (1) PL1824481T3 (da)
WO (1) WO2006055597A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105972A1 (en) * 2004-11-17 2006-05-18 Nagasawa Herbert T Method to enhance delivery of glutathione and ATP levels in cells
JP4982755B2 (ja) * 2006-06-27 2012-07-25 国立大学法人 長崎大学 高速液体クロマトグラフィーによる糖及び類縁アルデヒド化合物の絶対配置決定法
US8685951B2 (en) * 2007-03-27 2014-04-01 The Board Of Trustees Of The University Of Arkansas Compositions and methods for cytoprotection
CN102387805A (zh) * 2008-04-02 2012-03-21 生物能公司 核糖在对于急性心肌梗塞的第一反应中的用途
TW201201712A (en) * 2010-01-28 2012-01-16 Max International Llc Compositions comprising sugar-cysteine products
TW201202209A (en) * 2010-01-28 2012-01-16 Max International Llc Methods of preparing thiazolidines
TW201204267A (en) * 2010-05-24 2012-02-01 Max International Llc Compositions and beverages comprising nutrients, vitamins, sugars, cysteine, and/or sugar-cysteine products
US20140348811A1 (en) * 2011-07-27 2014-11-27 Max International, Llc Compositions comprising sugar-cysteine products
KR102374024B1 (ko) * 2015-05-22 2022-03-11 디 에이2 밀크 컴퍼니 리미티드 베타-카세인 a2 및 항산화 능력
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1120033B (it) 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
US4335210A (en) * 1981-02-11 1982-06-15 Cornell Research Foundation Method of producing L-cysteine
US4647571A (en) 1981-02-11 1987-03-03 Cornell Research Foundation Cysteine delivery composition
US4719201A (en) * 1985-02-07 1988-01-12 Regents Of The University Of Minnesota Method for stimulating recovery from ischemia
US4605644A (en) * 1985-02-07 1986-08-12 Regents Of The University Of Minnesota Method for stimulating recovery from ischemia employing ribose and adenine
US4736060A (en) 1985-08-06 1988-04-05 Nippon Rikagakuyakuhin Co., Ltd. Method for optical resolution of DL-cysteine and (R,S)-1-(1-naphthyl) ethylamine
JPS63152325A (ja) 1986-08-20 1988-06-24 Yamanouchi Pharmaceut Co Ltd 脳虚血症予防治療剤
US4868114A (en) * 1987-08-05 1989-09-19 Regents Of The University Of Minnesota Method for elevating glutathione levels
US5095027A (en) * 1991-02-28 1992-03-10 Clintec Nutrition Co. Method for treating reperfusion injury employing L-2-oxothiazolidine-4-carboxylic acid
JP2873089B2 (ja) * 1991-04-15 1999-03-24 帝人株式会社 虚血・再灌流組織障害及び不整脈並びに活性酸素・フリーラジカルによる肺障害の予防又は治療剤
US5631234A (en) * 1991-04-15 1997-05-20 Teijin Limited Method for treating ischemia-reperfusion tissue injury
US5292538A (en) 1992-07-22 1994-03-08 Metagenics, Inc. Improved sustained energy and anabolic composition and method of making
JPH10139665A (ja) * 1996-09-12 1998-05-26 Sankyo Co Ltd トログリタゾンを含有するグルタチオン還元酵素活性増強剤
JP2001511153A (ja) 1997-02-04 2001-08-07 ブイ． コスバブ，ジョン 血管変性性疾患の予防および処置のための組成物および方法
US6730336B2 (en) 1998-01-30 2004-05-04 The Procter & Gamble Co. Fortified beverages with improved texture and flavor impact at lower dosage of solids
US6218366B1 (en) * 1998-06-19 2001-04-17 Bioenergy, Inc. Method for raising the hypoxic threshold
US7153503B1 (en) 1998-12-19 2006-12-26 Janeel Henderson Comprehensive dietary supplement
US6534480B2 (en) * 1999-06-17 2003-03-18 Bioenergy Inc. Compositions for increasing energy in vivo
US20040043013A1 (en) 2000-12-28 2004-03-04 Mccleary Edward Larry Metabolic uncoupling therapy
US6964969B2 (en) 2001-04-19 2005-11-15 Mccleary Edward Larry Composition and method for treating impaired or deteriorating neurological function
US6881425B2 (en) 2001-08-31 2005-04-19 Council Of Scientific And Industrial Research Custom made herbal health promotive formulation for females/expectant mothers
US6572899B1 (en) 2002-07-03 2003-06-03 Vitacost.Com, Inc. Memory loss treatment formulation
US7455857B2 (en) 2003-04-08 2008-11-25 Janeel Henderson Energy generating composition
GB0319463D0 (en) 2003-08-20 2003-09-17 Givaudan Sa Compounds
US20050100537A1 (en) 2003-11-10 2005-05-12 Evans Gregory S. Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals
US20060105972A1 (en) * 2004-11-17 2006-05-18 Nagasawa Herbert T Method to enhance delivery of glutathione and ATP levels in cells
US8962058B2 (en) 2005-11-23 2015-02-24 The Coca-Cola Company High-potency sweetener composition with antioxidant and compositions sweetened therewith
NZ570704A (en) 2006-02-10 2011-09-30 Mannatech Inc All natural multivitamin and multimineral dietary supplement formulations for enhanced absorption and biological utilization
US8685951B2 (en) 2007-03-27 2014-04-01 The Board Of Trustees Of The University Of Arkansas Compositions and methods for cytoprotection
US20100074969A1 (en) 2008-09-19 2010-03-25 Unicity International, Inc. Method of controlling blood sugar levels, insulin levels, cholesterol levels, body fat levels, and body weight by administering a nutrient fiber matrix
TW201201712A (en) 2010-01-28 2012-01-16 Max International Llc Compositions comprising sugar-cysteine products
TW201204267A (en) 2010-05-24 2012-02-01 Max International Llc Compositions and beverages comprising nutrients, vitamins, sugars, cysteine, and/or sugar-cysteine products

Also Published As

Publication number Publication date
AU2005307885A2 (en) 2006-05-26
ES2390228T3 (es) 2012-11-07
AU2005307885A1 (en) 2006-05-26
JP2008520681A (ja) 2008-06-19
US20130317072A1 (en) 2013-11-28
KR20070095900A (ko) 2007-10-01
EP1824481A1 (en) 2007-08-29
EA200701017A1 (ru) 2007-10-26
MX2007005835A (es) 2007-10-08
EP1824481B1 (en) 2012-08-29
PL1824481T3 (pl) 2012-11-30
WO2006055597A1 (en) 2006-05-26
US9144570B2 (en) 2015-09-29
EA014076B1 (ru) 2010-08-30
AU2005307885B2 (en) 2010-12-23
CN101060840A (zh) 2007-10-24
US20060105972A1 (en) 2006-05-18
US20090042822A1 (en) 2009-02-12
CA2587616A1 (en) 2006-05-26
BRPI0516814A (pt) 2008-09-23
CA2587616C (en) 2015-03-17
US8501700B2 (en) 2013-08-06
US20160082029A1 (en) 2016-03-24

Similar Documents

Publication Publication Date Title
DK1824481T3 (da) Anvendelse af ribose-cystein til behandling af hypoxia ved forhøjelse af tilførslen af glutathion og atp-koncentrationerne i celler
DE602005020913D1 (de) Optimierte expression von hpv-52-l1 in hefe
ATE472546T1 (de) 5-heteroarylthiazole und deren verwendung als pi3k-inhibitoren
EP1758450A4 (en) IMPROVEMENTS AT BZW. REGARDLESS PLANT TREATMENT AGENTS
HK1104087A1 (en) Method and arrangements relating to satellite-based positioning
AU2003202988A8 (en) Use of modified pyrimidine compounds to promote stem cell migration and proliferation
ATE452977T1 (de) Optimierte expression von hpv-58-l1 in hefe
DK4209510T3 (da) Anti-pd-l1-antistoffer og deres anvendelse til at fremme t-cellefunktion
DK1753748T3 (da) Prolinderivater og deres anvendelse som dipeptidyl-peptidase-IV-inhibitorer
DK3153526T3 (da) Antistoffer mod human cd39 og anvendelse deraf til inhibering af aktivitet af t-regulatoriske celler
DK1720972T3 (da) Fremgangsmåde til celledyrkning ved hjælp af fortløbende perfusion og vekslende tangentialt flow
DK2173173T3 (da) Substituerede 6-anilinpurinderivater som inhibitorer af cytokininoxidase/-dehydrogenase og præparater indeholdende disse derivater
ATE545641T1 (de) 2, 4 -diamino pyrimidine als inhibitoren von zellzykluskinasen
DK1896571T3 (da) Materialer og fremgangsmåder, der vedrører cellebaserede behandlinger
DK1499589T3 (da) Derivater af N-phenyl (pipiridin-2-yl) methylbenzamid, deres fremstillilng og deres anvendelse i terapeutika
IL174334A0 (en) Use of chk1 inhibitors to control cell proliferation
ATE524183T1 (de) Verwendung von sanglifehrin bei der hcv-therapie
DK2068930T3 (da) Sammensætninger og fremgangsmåder under anvendelse af anti-CS1-antistoffer til at behandle multiple myelomer
EP1993592A4 (en) COMPOSITIONS WITH LACTOFERRIN AND METHOD FOR USE THAT TO AIM IN THE GROWTH OF SKIN CELLS
DK1781296T3 (da) Quinazolinderivater og deres anvendelse ved behandlingen af thrombocytæmi
ATE517098T1 (de) Acylaminothiazolderivate und deren verwendung als beta-amyloid-inhibitoren
DK2040565T3 (da) Sammensætninger og fremgangsmåder til forebyggelse eller behandling af kardiovaskulære sygdomme i katte med hyperthyroidisme
DK1575951T3 (da) Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
ATE487245T1 (de) Rehydrierung von brennstoffzellen
DE602006016400D1 (de) Damit