DK180380B1 - Combination therapy compositions for use in treating a bacterial biofilm in a subject and methods for killing, inhibiting or preventing the growth of a bacterial biofilm in vitro - Google Patents
Combination therapy compositions for use in treating a bacterial biofilm in a subject and methods for killing, inhibiting or preventing the growth of a bacterial biofilm in vitro Download PDFInfo
- Publication number
- DK180380B1 DK180380B1 DKPA201870043A DKPA201870043A DK180380B1 DK 180380 B1 DK180380 B1 DK 180380B1 DK PA201870043 A DKPA201870043 A DK PA201870043A DK PA201870043 A DKPA201870043 A DK PA201870043A DK 180380 B1 DK180380 B1 DK 180380B1
- Authority
- DK
- Denmark
- Prior art keywords
- biofilm
- serine protease
- polypeptide
- protease activity
- use according
- Prior art date
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y304/21—Serine endopeptidases (3.4.21)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
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- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Otolaryngology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178209.1A EP3120866A1 (en) | 2015-07-24 | 2015-07-24 | Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms |
| PCT/EP2016/067570 WO2017017027A1 (en) | 2015-07-24 | 2016-07-22 | Combination therapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK201870043A1 DK201870043A1 (en) | 2018-02-05 |
| DK180380B1 true DK180380B1 (en) | 2021-03-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DKPA201870043A DK180380B1 (en) | 2015-07-24 | 2018-01-23 | Combination therapy compositions for use in treating a bacterial biofilm in a subject and methods for killing, inhibiting or preventing the growth of a bacterial biofilm in vitro |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11338021B2 (enExample) |
| EP (2) | EP3120866A1 (enExample) |
| JP (1) | JP2018521143A (enExample) |
| KR (1) | KR20180031704A (enExample) |
| CN (1) | CN107921102B (enExample) |
| AU (1) | AU2016301021B2 (enExample) |
| CA (1) | CA2992677A1 (enExample) |
| DK (1) | DK180380B1 (enExample) |
| ES (1) | ES2989635T3 (enExample) |
| MX (1) | MX2018000984A (enExample) |
| RU (1) | RU2725800C2 (enExample) |
| WO (1) | WO2017017027A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201701315D0 (en) | 2017-01-26 | 2017-03-15 | Enzymatica Ab | Novel treatments |
| WO2020229521A1 (en) * | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for inhibiting or reducing bacterial biofilms on a surface |
| JP7854397B2 (ja) * | 2020-05-13 | 2026-05-01 | ジーミキュー テクノロジー アクチエボラグ | 微生物感染治療のためのプロテアーゼ製剤 |
| CN119499437A (zh) * | 2024-11-27 | 2025-02-25 | 武汉大学中南医院 | 一种负载胰蛋白酶抗细菌生物膜的温敏性水凝胶敷料及其制备方法与应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US20020037260A1 (en) * | 1997-10-16 | 2002-03-28 | Budny John A. | Compositions for treating biofilm |
| ATE278417T1 (de) | 1999-06-18 | 2004-10-15 | Jon Bragi Bjarnason | Pharmazeutische- und kosmetischezusammensetzungen enthaldend serinproteasen aus kabeljau und deren pharmazeutische und kosmetische verwendung |
| GB0205593D0 (en) * | 2002-03-09 | 2002-04-24 | Univ Nottingham | Treatment of surfaces populated by bacteria |
| US9931381B2 (en) | 2009-11-23 | 2018-04-03 | Prothera, Inc. | Methods of comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions |
| KR102211724B1 (ko) | 2011-05-31 | 2021-02-03 | 허치슨 바이오필름 메디컬 솔루션스 리미티드 | 세포 응집물의 분산 및 분리 |
| CN103007258A (zh) | 2011-09-22 | 2013-04-03 | 安淇生物控释技术(苏州)有限公司 | 含鱼丝氨酸蛋白酶和抗菌化合物的医用组合物及其用途 |
| RU2014129910A (ru) * | 2011-12-21 | 2016-02-10 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта |
| CN103191491A (zh) | 2012-01-10 | 2013-07-10 | 查红梅 | 一种包装物及其用途和制法 |
| RU2646102C2 (ru) | 2012-05-09 | 2018-03-01 | Контрафект Корпорейшн | Предотвращение, разрушение и обработка биопленки лизином бактериофага |
| KR20150013280A (ko) | 2012-05-11 | 2015-02-04 | 스미스 앤드 네퓨, 인크. | 박테리아 균막을 제거하기 위한 세아프로제의 용도 |
| CN203090136U (zh) * | 2013-02-02 | 2013-07-31 | 成都玺汇科技有限公司 | 一种口鼻两用喷雾器 |
| GB201405784D0 (en) * | 2014-03-31 | 2014-05-14 | Enzymatica Ab | Novel methods, polypeptides and uses thereof |
| DK3099317T3 (en) * | 2014-01-29 | 2021-08-23 | Enzymatica Ab | Cod trypsin for use in the treatment of microbial infections in a subject with immunodeficiency |
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2015
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2016
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- 2016-07-22 KR KR1020187004149A patent/KR20180031704A/ko not_active Withdrawn
- 2016-07-22 US US15/746,888 patent/US11338021B2/en active Active
- 2016-07-22 AU AU2016301021A patent/AU2016301021B2/en not_active Ceased
- 2016-07-22 CN CN201680042973.9A patent/CN107921102B/zh active Active
- 2016-07-22 ES ES16751512T patent/ES2989635T3/es active Active
- 2016-07-22 CA CA2992677A patent/CA2992677A1/en active Pending
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- 2016-07-22 RU RU2018106490A patent/RU2725800C2/ru active
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2992677A1 (en) | 2017-02-02 |
| JP2018521143A (ja) | 2018-08-02 |
| KR20180031704A (ko) | 2018-03-28 |
| US20200085921A1 (en) | 2020-03-19 |
| BR112018001391A2 (en) | 2018-09-11 |
| MX2018000984A (es) | 2018-08-09 |
| US11338021B2 (en) | 2022-05-24 |
| WO2017017027A1 (en) | 2017-02-02 |
| ES2989635T3 (es) | 2024-11-27 |
| EP3325002C0 (en) | 2024-09-04 |
| CN107921102A (zh) | 2018-04-17 |
| EP3325002B1 (en) | 2024-09-04 |
| RU2018106490A3 (enExample) | 2020-01-24 |
| EP3120866A1 (en) | 2017-01-25 |
| AU2016301021B2 (en) | 2022-11-10 |
| RU2018106490A (ru) | 2019-08-26 |
| RU2725800C2 (ru) | 2020-07-06 |
| AU2016301021A1 (en) | 2018-02-01 |
| EP3325002A1 (en) | 2018-05-30 |
| DK201870043A1 (en) | 2018-02-05 |
| CN107921102B (zh) | 2022-09-09 |
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| PME | Patent granted |
Effective date: 20210317 |