DK179163B9 - An apparatus for the combined incubation and vitrification of a biological material - Google Patents

An apparatus for the combined incubation and vitrification of a biological material Download PDF

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Publication number
DK179163B9
DK179163B9 DKPA201600392A DKPA201600392A DK179163B9 DK 179163 B9 DK179163 B9 DK 179163B9 DK PA201600392 A DKPA201600392 A DK PA201600392A DK PA201600392 A DKPA201600392 A DK PA201600392A DK 179163 B9 DK179163 B9 DK 179163B9
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culture
culture dish
bowl
biological material
compartments
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DKPA201600392A
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English (en)
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Thomas William Pedersen
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Esco Medical Uab
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Priority to DKPA201600392A priority Critical patent/DK179163B9/en
Priority to AU2017201412A priority patent/AU2017201412B2/en
Priority to EP17161277.3A priority patent/EP3263694B1/en
Priority to DK17161277.3T priority patent/DK3263694T3/da
Priority to ES17161277T priority patent/ES2804600T3/es
Priority to US15/466,019 priority patent/US11584905B2/en
Priority to CN201710192742.2A priority patent/CN107557297B/zh
Priority to JP2017066774A priority patent/JP6766003B2/ja
Application granted granted Critical
Publication of DK179163B1 publication Critical patent/DK179163B1/en
Publication of DK201600392A1 publication Critical patent/DK201600392A1/en
Publication of DK179163B9 publication Critical patent/DK179163B9/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
    • A01N1/0257—Stationary or portable vessels generating cryogenic temperatures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/50—Means for positioning or orientating the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/20—Heating or cooling

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Computer Hardware Design (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Claims (19)

  1. Patentkrav
    1. Apparat (100) til kombineret inkubation og vitrifikation af et levedygtigt biologisk materiale;
    hvor apparatet omfatter:
    et hus (2) med en forlængelse i en langsgående retning (X) og en forlængelse i en tværgående retning (Y); hvor huset omfatter:
    et eller flere dyrkningsskålrum (4), der hver er indrettet til at rumme en eller flere dyrkningsskåle (6) omfattende et biologisk materiale, hvor hver dyrkningsskål omfatter en eller flere dyrkningsbrønde (8) til at huse det biologiske materiale;
    hvor apparatet omfatter en eller flere billedoptagelsesindretninger (10) indrettet til at optage billeder af et eller flere af de biologiske materialer, der er huset i den ene eller flere dyrkningsskåle;
    hvor apparatet omfatter kryogene midler (12) til afkøling ved kryogene temperaturer af et biologisk materiale, hvor de kryogene midler er arrangeret i et kryogent område (14) på et andet sted i forhold til det ene eller flere dyrkningsskålrum (4 );
    hvor et eller flere dyrkningsskålrum og det kryogene område tilsammen definerer et operationelt område (16);
    hvor apparatet omfatter en eller flere manipulationsenheder (18), hvor den ene eller de flere manipulationsenheDK 179163 B9 der hver omfatter en eller flere robotarme (20), hvor den ene eller de flere robotarme er konfigureret til at gribe og bevæge elementer og/eller kemisk/biologisk materiale inden for det operationelle område;
    hvor apparatet omfatter bevægelsesmidler (22), hvor bevægelsesmidlerne er konfigureret til at bevæge den billedoptagelsesindretningen i forhold til dyrkningsskålene;
    hvor apparatet omfatter et styresystem (24) til styring af dets drift, hvor styresystemet er konfigureret til at tillade en bruger at indlæse forudbestemte driftsprotokol (ler), der skal følges af apparatet; og hvor styresystemet er konfigureret til at styre apparatet ifølge protokol len/protokollerne.
  2. 2. Apparat (100) ifølge krav 1, hvor apparatet omfatter et eller flere individuelle dyrkningsskålrum; såsom 2 - 25, for eksempel 3 - 24, såsom 4 - 23, f.eks. 5-22, såsom 621, f.eks. 7-20 eller 8 - 19, for eksempel 9 - 18, såsom 10-17, for eksempel 11-16, såsom 12-15 eller 13-14 individuelle dyrkningsskålrum.
  3. 3. Apparat (100) ifølge et hvilket som helst af kravene 1 2, der endvidere omfatter temperaturregulerende midler til individuel regulering af temperaturen i et eller flere af de individuelle dyrkningsskålrum (4), fortrinsvis i alle de nævnte individuelle dyrkningsskålrum.
  4. 4. Apparat (100) ifølge krav 3, hvor temperaturreguleringsmidlerne omfatter opvarmningsmidler, såsom et eller flere elektriske varmeelementer; og/eller kølemidler, såsom en eller flere Peltier-elementer.
  5. 5. Apparat (100) ifølge et hvilket som helst af kravene 1 4, der endvidere omfatter gaskompositionsregulerende midler til individuel regulering af gaskompositionen, såsom koncentrationen af oxygen, carbondioxid og/eller nitrogen i en eller flere af de individuelle dyrkningsskålrum, fortrinsvis i alle de nævnte individuelle dyrkningsskålrum (4) .
  6. 6. Apparat (100) ifølge et hvilket som helst af kravene 1 5, hvor apparatet omfatter en billedoptagningsindretning (10) for hver enkelt dyrkningsskålrum.
  7. 7. Apparat (100) ifølge et hvilket som helst af kravene 1 6, hvor bevægelsesmidlerne (22) er udformet på en sådan måde, at billedoptagningsindretningen (10) er indrettet til at være bevægelig i forhold til dyrkningsskålen og derved tillade optagning af billeder af hvert biologisk materiale huset i dyrkningsskålen(e).
  8. 8. Apparat (100) ifølge et hvilket som helst af kravene 1 7, hvor dyrkningsskålrummet, i forhold til et eller flere dyrkningsskålrum (4), fortrinsvis alle dyrkningsskålrum, omfatter en hylde (28) til husning af en dyrkningsskål, hvor bevægelsesmidlerne er konfigureret på en måde der tillader, at hylden bevæges, fortrinsvis ved rotation, i forhold til billedoptagningsindretningen (10), hvorved der muliggøres optagning af billeder af hvert biologisk materiale, der er huset i dyrkningsskålene(e).
  9. 9. Apparat (100) ifølge et hvilket som helst af kravene 1 8, hvor apparatet, for eksempel med hensyn til et eller flere dyrkningsskålrum, fortrinsvis alle dyrkningsskålDK 179163 B9 rum, omfatter en pipettepumpe (32), hvor pipettepumpen er konfigureret til at pipettere væsker til og fra kulturbrøndene i dyrkningsskålene.
  10. 10. Apparat (100) ifølge et hvilket som helst af kravene 1 9, hvor dyrkningsskålrummet i forhold til et eller flere dyrkningsskålrum (4), fortrinsvis alle dyrkningsskålrum, omfatter en eller flere pipettestande omfattende en eller flere pipetter.
  11. 11. Apparat (100) ifølge et hvilket som helst af kravene 1 10, hvor dyrkningsskålrummet i forhold til et eller flere dyrkningsskålrum (4), fortrinsvis alle dyrkningsskålrum, omfatter en eller flere beholdere til opbevaring af inkubationsvæsker og/eller kryobeskyttelsesmidler.
  12. 12. Apparat (100) ifølge krav 11, hvor den ene eller flere beholdere omfatter en forseglingssprøjte ende hætte.
  13. 13. Apparat (100) ifølge et hvilket som helst af kravene 1 12, hvor en eller flere individuelle dyrkningsskålrum omfatter transparente vægge og, hvor billedoptagningsindretningen (10) er udformet til at være bevægelig langs det ene eller flere individuelle dyrkningsskålrum ved stillinger uden for nævnte transparente væg(e) i forhold til det indre af de nævnte individuelle dyrkningsskålrum.
  14. 14. Apparat (100) ifølge et hvilket som helst af kravene 1 13, hvor de kryogene midler (12) omfatter en beholder til opbevaring af en flydende gas, såsom flydende nitrogen; hvor beholderen til opbevaring af en flydende gas adskilles fra det ene eller flere dyrkningsskålrum.
  15. 15. Apparat (100) ifølge et hvilket som helst af de foregående krav, hvor apparatet omfatter en billedbehandlingsenhed til behandling af billeder optaget af billedoptagningsindretningen (10).
  16. 16. Apparat (100) ifølge et hvilket som helst af de foregående krav, hvor billedoptagningsindretningen (10) består af et mikroskop til optagning af nærbilleder af det biologiske materiale.
  17. 17. Apparat (100) ifølge et hvilket som helst af de foregående krav, hvor en af de ene eller flere manipulationsenheder (18) omfatter en robotskålforseglingssarm (86), hvor robotskålforseglingssarmen er konfigureret til at forsegle en eller flere dyrkningsskåle (6) eller til at forsegle en brønd (8) i en dyrkningsskål, der er tilpasset inden i dyrkningsskålrummet (4).
  18. 18. Apparat (100) ifølge et hvilket som helst af de foregående krav, hvor en af de ene eller flere manipulationsenheder (18) omfatter en robotpipetteringsarm (58), hvilken robotpipetteringsarm omfatter en pipette (66), og hvor den nævnte robotpipetteringsarm er konfigureret til at bevæge den nævnte pipette inden i dyrkningsskålrummet (4), for at tillade fratrækning og/eller tilsætning af væsker og/eller suspensioner til eller fra en eller flere dyrkningsbrønde (8) i en dyrkningsskål (6), der er huset inden i dyrkningsskålrummet.
  19. 19. Apparat (100) ifølge et hvilket som helst af de foregående krav, hvor en af de ene eller flere manipulationsenheder (18) omfatter en robotdyrkningsskålbevægende arm, hvor den robotdyrkningsskålbevægende arm er konfigureret til at gribe en dyrkningsskål og til at bevæge den mellem dyrkningsskålrummet og det kryogene område af apparatet.
    3/8
DKPA201600392A 2016-07-01 2016-07-01 An apparatus for the combined incubation and vitrification of a biological material DK179163B9 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DKPA201600392A DK179163B9 (en) 2016-07-01 2016-07-01 An apparatus for the combined incubation and vitrification of a biological material
AU2017201412A AU2017201412B2 (en) 2016-07-01 2017-03-01 An apparatus for the combined incubation and vitrification of a biological material
DK17161277.3T DK3263694T3 (da) 2016-07-01 2017-03-16 Apparat til kombineret inkubation og vitrifikation af et biologisk materiale
ES17161277T ES2804600T3 (es) 2016-07-01 2017-03-16 Un aparato para la incubación y vitrificación combinadas de un material biológico
EP17161277.3A EP3263694B1 (en) 2016-07-01 2017-03-16 An apparatus for the combined incubation and vitrification of a biological material
US15/466,019 US11584905B2 (en) 2016-07-01 2017-03-22 Apparatus for the combined incubation and vitrification of a biological material
CN201710192742.2A CN107557297B (zh) 2016-07-01 2017-03-28 用于生物材料的联合式培育和玻璃化的设备
JP2017066774A JP6766003B2 (ja) 2016-07-01 2017-03-30 生物学的材料のインキュベーション及びガラス化のための装置

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DKPA201600392A DK179163B9 (en) 2016-07-01 2016-07-01 An apparatus for the combined incubation and vitrification of a biological material

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DK179163B1 DK179163B1 (en) 2017-12-18
DK201600392A1 DK201600392A1 (en) 2017-12-18
DK179163B9 true DK179163B9 (en) 2018-04-03

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DK17161277.3T DK3263694T3 (da) 2016-07-01 2017-03-16 Apparat til kombineret inkubation og vitrifikation af et biologisk materiale

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US (1) US11584905B2 (da)
EP (1) EP3263694B1 (da)
JP (1) JP6766003B2 (da)
CN (1) CN107557297B (da)
AU (1) AU2017201412B2 (da)
DK (2) DK179163B9 (da)
ES (1) ES2804600T3 (da)

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Publication number Priority date Publication date Assignee Title
DK179163B9 (en) * 2016-07-01 2018-04-03 Esco Medical Uab An apparatus for the combined incubation and vitrification of a biological material
US10989636B2 (en) 2017-11-28 2021-04-27 Coopersurgical, Inc. Specimen containers and related methods
JP2021521797A (ja) * 2018-04-23 2021-08-30 ユニバーセルズ テクノロジーズ エス．エー．Ｕｎｉｖｅｒｃｅｌｌｓ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｓ．Ａ． 高い生成物回収率を有する冷凍−融解性を備えたバイオリアクター
CN110387325A (zh) * 2019-08-13 2019-10-29 广州市华南医学研究中心 一种极速pcr反应检测装置及检测方法
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