DK1745052T3 - HIV-intergrase-inhibitorer: cykliske pyrimidinonforbindelser - Google Patents
HIV-intergrase-inhibitorer: cykliske pyrimidinonforbindelserInfo
- Publication number
- DK1745052T3 DK1745052T3 DK05738619T DK05738619T DK1745052T3 DK 1745052 T3 DK1745052 T3 DK 1745052T3 DK 05738619 T DK05738619 T DK 05738619T DK 05738619 T DK05738619 T DK 05738619T DK 1745052 T3 DK1745052 T3 DK 1745052T3
- Authority
- DK
- Denmark
- Prior art keywords
- intergrase
- hiv
- inhibitors
- pyrimidinone compounds
- cyclic
- Prior art date
Links
- -1 cyclic pyrimidinone compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57034804P | 2004-05-12 | 2004-05-12 | |
PCT/US2005/013911 WO2005113562A1 (fr) | 2004-05-12 | 2005-04-22 | Inhibiteurs de l’intégrase du vih: composés cycliques de la pyrimidinone |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1745052T3 true DK1745052T3 (da) | 2009-01-05 |
Family
ID=34967012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05738619T DK1745052T3 (da) | 2004-05-12 | 2005-04-22 | HIV-intergrase-inhibitorer: cykliske pyrimidinonforbindelser |
Country Status (26)
Country | Link |
---|---|
US (2) | US7273859B2 (fr) |
EP (1) | EP1745052B9 (fr) |
JP (1) | JP2007537251A (fr) |
KR (1) | KR20070014173A (fr) |
CN (1) | CN1984917A (fr) |
AR (1) | AR049498A1 (fr) |
AT (1) | ATE405570T1 (fr) |
AU (1) | AU2005245789A1 (fr) |
BR (1) | BRPI0511078A (fr) |
CA (1) | CA2566755A1 (fr) |
DE (1) | DE602005009172D1 (fr) |
DK (1) | DK1745052T3 (fr) |
ES (1) | ES2310823T3 (fr) |
HR (1) | HRP20080531T3 (fr) |
IL (1) | IL179161A0 (fr) |
MX (1) | MXPA06013023A (fr) |
NO (1) | NO20065443L (fr) |
NZ (1) | NZ550698A (fr) |
PE (1) | PE20060238A1 (fr) |
PL (1) | PL1745052T3 (fr) |
PT (1) | PT1745052E (fr) |
RU (1) | RU2006143683A (fr) |
SI (1) | SI1745052T1 (fr) |
TW (1) | TW200540173A (fr) |
WO (1) | WO2005113562A1 (fr) |
ZA (1) | ZA200609181B (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7115601B2 (en) | 2004-05-18 | 2006-10-03 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
AU2006228278C1 (en) * | 2005-03-31 | 2011-06-23 | Msd Italia S.R.L. | HIV integrase inhibitors |
US7494984B2 (en) * | 2005-08-31 | 2009-02-24 | Bristol-Myers Squibb Company | Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors |
WO2007058646A1 (fr) * | 2005-11-15 | 2007-05-24 | Bristol-Myers Squibb Company | Inhibiteurs d’integrase du vih : composes cycliques de la pyrimidinone |
US7897592B2 (en) * | 2005-11-15 | 2011-03-01 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US7902182B2 (en) * | 2005-11-16 | 2011-03-08 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
WO2007064502A1 (fr) * | 2005-12-01 | 2007-06-07 | Bristol-Myers Squibb Company | Formes du n-[(4-fluorophényl)méthyl]-4,6,7,9-tétrahydro-3-hydroxy-9,9-diméthyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide |
US7897593B2 (en) * | 2006-05-30 | 2011-03-01 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US7893055B2 (en) * | 2006-06-28 | 2011-02-22 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
CA2729656A1 (fr) * | 2008-07-02 | 2010-01-07 | Avexa Limited | Imidazopyrimidinones et leurs utilisations |
PL2212324T3 (pl) * | 2008-07-02 | 2014-11-28 | Avexa Ltd | Związki posiadające właściwości przeciwwirusowe |
EA201170537A1 (ru) * | 2008-10-06 | 2011-12-30 | Мерк Шарп Энд Домэ Корп. | Ингибиторы вич-интегразы |
JP2012516333A (ja) * | 2009-01-28 | 2012-07-19 | メルク・シャープ・エンド・ドーム・コーポレイション | Hivインテグラーゼ阻害剤としての架橋化合物 |
US8143244B2 (en) * | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
EP2470014A4 (fr) * | 2009-08-26 | 2013-01-16 | Merck Sharp & Dohme | Inhibiteurs de l intégrase du vih |
US8383639B2 (en) | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
WO2011075747A1 (fr) * | 2009-12-18 | 2011-06-23 | Glaxosmithkline Llc | Composés thérapeutiques |
US9328075B2 (en) * | 2011-05-05 | 2016-05-03 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for treating influenza |
US10699038B2 (en) | 2012-03-30 | 2020-06-30 | Litmus Blue Technology LLC | Configurable representation of domain models |
WO2014008636A1 (fr) * | 2012-07-11 | 2014-01-16 | Merck Sharp & Dohme Corp. | Composés macrocycliques en tant qu'inhibiteurs de l'intégrase du vih |
WO2014099586A1 (fr) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | Dérivés 4-pyridinonetriazines en tant qu'inhibiteurs de l'intégrase du vih |
MD4841B1 (ro) | 2012-12-21 | 2023-01-31 | Gilead Sciences, Inc. | Compuşi policiclici de carbamoilpiridonă şi utilizarea lor farmaceutică |
RU2015131006A (ru) | 2012-12-27 | 2017-01-30 | Джапан Тобакко Инк. | ЗАМЕЩЕННОЕ ПРОИЗВОДНОЕ СПИРОПИРИДО[1,2-a]ПИРАЗИНА И ЕГО ПРИМЕНЕНИЕ В МЕДИЦИНЕ В КАЧЕСТВЕ ИНГИБИТОРА ИНТЕГРАЗЫ ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА (ВИЧ) |
US9493479B2 (en) | 2013-04-16 | 2016-11-15 | Merck Sharp & Dohme Corp. | Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors |
ME02977B (fr) | 2013-05-17 | 2018-10-20 | Merck Sharp & Dohme | Composés hétérocycliques tricycliques fusionnés utiles en tant qu'inhibiteurs de l'intégrase du vih |
US9951079B2 (en) | 2013-06-13 | 2018-04-24 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as HIV integrase inhibitors |
EP3252058B1 (fr) | 2013-07-12 | 2021-01-20 | Gilead Sciences, Inc. | Composés polycycliques-carbamoylpyridone et leur utilisation pour le traitement des infections par vih |
NO2865735T3 (fr) | 2013-07-12 | 2018-07-21 | ||
EA030695B1 (ru) | 2013-09-27 | 2018-09-28 | Мерк Шарп И Доум Корп. | Замещенные производные хинолизина, которые можно использовать как ингибиторы интегразы вич |
EP3087060B1 (fr) | 2013-12-23 | 2020-05-13 | Merck Sharp & Dohme Corp. | Composés pyrimidone carboxamide utilisés en tant qu'inhibiteurs de pde2 |
TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
NO2717902T3 (fr) | 2014-06-20 | 2018-06-23 | ||
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
WO2016145614A1 (fr) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Composés de triazolyl pyrimidinone en tant qu'inhibiteurs de pde2 |
WO2016154081A1 (fr) | 2015-03-26 | 2016-09-29 | Merck Sharp & Dohme Corp. | Composés pyrazolyle pyrimidinone utilisés en tant qu'inhibiteurs de pde2 |
SG11201707905WA (en) | 2015-04-02 | 2017-10-30 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
WO2016187788A1 (fr) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles pour traiter l'infection au vih |
EP3313852B1 (fr) | 2015-06-25 | 2021-01-20 | Merck Sharp & Dohme Corp. | Composés bicycliques pyrazolo/imidazolo substitués en tant qu'inhibiteurs de pde2 |
WO2017000277A1 (fr) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclo-composés de triazole substitués utilisés en tant qu'inhibiteurs de pde2 |
WO2017087257A1 (fr) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Dérivés de pyridotriazine amido-substitués utiles en tant qu'inhibiteurs de l'intégrase du vih |
US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
WO2017113288A1 (fr) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih |
JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
RU2749043C2 (ru) | 2016-12-02 | 2021-06-03 | Мерк Шарп И Доум Корп. | Трициклические гетероциклические соединения, полезные в качестве ингибиторов интегразы вич |
EP3573984A4 (fr) | 2017-01-26 | 2020-07-29 | Merck Sharp & Dohme Corp. | Dérivés de quinolizine substitués utiles en tant qu'inhibiteurs de l'intégrase du vih |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9201803D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Corp | Methods |
US7232819B2 (en) | 2001-10-26 | 2007-06-19 | Istituto Di Ricerche Di Biologia P. Angeletti S.P.A. | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase |
GEP20063848B (en) | 2001-10-26 | 2006-06-12 | Inst Di Richerche Di Biolog Moltcolare P Angeletti Spa | N-substituted hydroxypyrimi-dinone carboxamide inhibitors of hiv integrase |
US7094783B2 (en) | 2002-06-26 | 2006-08-22 | Bristol-Myers Squibb Company | Bicyclic pyrimidinones as coagulation cascade inhibitors |
US7414045B2 (en) | 2002-12-27 | 2008-08-19 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Substituted pyrimido[1,2-a]azepines useful as HIV integrase inhibitors |
AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
AU2005206511A1 (en) | 2004-01-12 | 2005-08-04 | Gilead Sciences, Inc. | Pyrimidyl phosphonate antiviral compounds and methods of use |
US7173022B2 (en) * | 2004-05-28 | 2007-02-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
AU2006228278C1 (en) * | 2005-03-31 | 2011-06-23 | Msd Italia S.R.L. | HIV integrase inhibitors |
EP3372281B1 (fr) * | 2005-04-28 | 2021-07-07 | VIIV Healthcare Company | Dérivé de carbamoylpyridone polycyclique doté d'une activité inhibitrice de l'intégrase du vih |
-
2005
- 2005-04-20 US US11/110,589 patent/US7273859B2/en active Active
- 2005-04-22 PT PT05738619T patent/PT1745052E/pt unknown
- 2005-04-22 CN CNA2005800236418A patent/CN1984917A/zh active Pending
- 2005-04-22 KR KR1020067023555A patent/KR20070014173A/ko not_active Application Discontinuation
- 2005-04-22 WO PCT/US2005/013911 patent/WO2005113562A1/fr active Application Filing
- 2005-04-22 AU AU2005245789A patent/AU2005245789A1/en not_active Abandoned
- 2005-04-22 CA CA002566755A patent/CA2566755A1/fr not_active Abandoned
- 2005-04-22 AT AT05738619T patent/ATE405570T1/de not_active IP Right Cessation
- 2005-04-22 DE DE602005009172T patent/DE602005009172D1/de not_active Expired - Fee Related
- 2005-04-22 NZ NZ550698A patent/NZ550698A/en unknown
- 2005-04-22 BR BRPI0511078-5A patent/BRPI0511078A/pt not_active IP Right Cessation
- 2005-04-22 SI SI200530425T patent/SI1745052T1/sl unknown
- 2005-04-22 ES ES05738619T patent/ES2310823T3/es active Active
- 2005-04-22 MX MXPA06013023A patent/MXPA06013023A/es not_active Application Discontinuation
- 2005-04-22 RU RU2006143683/04A patent/RU2006143683A/ru not_active Application Discontinuation
- 2005-04-22 PL PL05738619T patent/PL1745052T3/pl unknown
- 2005-04-22 DK DK05738619T patent/DK1745052T3/da active
- 2005-04-22 JP JP2007513169A patent/JP2007537251A/ja active Pending
- 2005-04-22 EP EP05738619A patent/EP1745052B9/fr active Active
- 2005-05-09 TW TW094114913A patent/TW200540173A/zh unknown
- 2005-05-11 AR ARP050101931A patent/AR049498A1/es not_active Application Discontinuation
- 2005-05-11 PE PE2005000520A patent/PE20060238A1/es not_active Application Discontinuation
- 2005-11-14 US US11/273,671 patent/US7419969B2/en active Active
-
2006
- 2006-11-03 ZA ZA200609181A patent/ZA200609181B/en unknown
- 2006-11-09 IL IL179161A patent/IL179161A0/en unknown
- 2006-11-27 NO NO20065443A patent/NO20065443L/no not_active Application Discontinuation
-
2008
- 2008-11-17 HR HR20080531T patent/HRP20080531T3/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NZ550698A (en) | 2009-05-31 |
EP1745052A1 (fr) | 2007-01-24 |
HRP20080531T3 (en) | 2009-03-31 |
JP2007537251A (ja) | 2007-12-20 |
EP1745052B9 (fr) | 2009-10-28 |
BRPI0511078A (pt) | 2007-12-26 |
ES2310823T3 (es) | 2009-01-16 |
KR20070014173A (ko) | 2007-01-31 |
ATE405570T1 (de) | 2008-09-15 |
PE20060238A1 (es) | 2006-03-31 |
DE602005009172D1 (de) | 2008-10-02 |
AR049498A1 (es) | 2006-08-09 |
NO20065443L (no) | 2006-11-27 |
PT1745052E (pt) | 2008-11-14 |
US20050256109A1 (en) | 2005-11-17 |
US7273859B2 (en) | 2007-09-25 |
US20060106007A1 (en) | 2006-05-18 |
CN1984917A (zh) | 2007-06-20 |
SI1745052T1 (sl) | 2009-04-30 |
US7419969B2 (en) | 2008-09-02 |
IL179161A0 (en) | 2007-03-08 |
PL1745052T3 (pl) | 2009-01-30 |
RU2006143683A (ru) | 2008-06-20 |
EP1745052B1 (fr) | 2008-08-20 |
CA2566755A1 (fr) | 2005-12-01 |
WO2005113562A1 (fr) | 2005-12-01 |
ZA200609181B (en) | 2008-06-25 |
TW200540173A (en) | 2005-12-16 |
MXPA06013023A (es) | 2006-12-20 |
AU2005245789A1 (en) | 2005-12-01 |
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EE00444U1 (et) | Fosforiühend | |
SE0402103D0 (sv) | Novel compounds | |
AT7051U3 (de) | Bob | |
ITLI20040005A1 (it) | Progetto autospesa | |
SE0402391D0 (sv) | Novelheterocyclic compounds | |
DOP2004000959A (es) | Compuestos |