DK171489A - Process for preparing a biologically active, post- translationally modified protein hormone which is composed of several subunits, a eucaryotic cell which is transfected with one or more expression vectors and is able to produce such a hormone, and expression vector which comprises heterologous DNA which encodes the subunits of the hormone, a set of expression vectors in which each vector comprises heterologous DNA which encodes a different one of the subunits of the hormone, and a process for producing a pharmacetuial preparation. - Google Patents

Process for preparing a biologically active, post- translationally modified protein hormone which is composed of several subunits, a eucaryotic cell which is transfected with one or more expression vectors and is able to produce such a hormone, and expression vector which comprises heterologous DNA which encodes the subunits of the hormone, a set of expression vectors in which each vector comprises heterologous DNA which encodes a different one of the subunits of the hormone, and a process for producing a pharmacetuial preparation.

Info

Publication number
DK171489A
DK171489A DK171489A DK171489A DK171489A DK 171489 A DK171489 A DK 171489A DK 171489 A DK171489 A DK 171489A DK 171489 A DK171489 A DK 171489A DK 171489 A DK171489 A DK 171489A
Authority
DK
Denmark
Prior art keywords
hormone
subunits
encodes
heterologous dna
expression vectors
Prior art date
Application number
DK171489A
Other languages
Danish (da)
Other versions
DK171489D0 (en
Inventor
Rainer Albert
Wilfried Bauer
Francois Cardinaux
Janos Pless
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888808442A external-priority patent/GB8808442D0/en
Priority claimed from GB888826452A external-priority patent/GB8826452D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK171489D0 publication Critical patent/DK171489D0/en
Publication of DK171489A publication Critical patent/DK171489A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK171489A 1988-04-11 1989-04-10 Process for preparing a biologically active, post- translationally modified protein hormone which is composed of several subunits, a eucaryotic cell which is transfected with one or more expression vectors and is able to produce such a hormone, and expression vector which comprises heterologous DNA which encodes the subunits of the hormone, a set of expression vectors in which each vector comprises heterologous DNA which encodes a different one of the subunits of the hormone, and a process for producing a pharmacetuial preparation. DK171489A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888808442A GB8808442D0 (en) 1988-04-11 1988-04-11 Peptide derivatives
GB888826452A GB8826452D0 (en) 1988-11-11 1988-11-11 Peptide derivatives

Publications (2)

Publication Number Publication Date
DK171489D0 DK171489D0 (en) 1989-04-10
DK171489A true DK171489A (en) 1989-10-12

Family

ID=26293760

Family Applications (1)

Application Number Title Priority Date Filing Date
DK171489A DK171489A (en) 1988-04-11 1989-04-10 Process for preparing a biologically active, post- translationally modified protein hormone which is composed of several subunits, a eucaryotic cell which is transfected with one or more expression vectors and is able to produce such a hormone, and expression vector which comprises heterologous DNA which encodes the subunits of the hormone, a set of expression vectors in which each vector comprises heterologous DNA which encodes a different one of the subunits of the hormone, and a process for producing a pharmacetuial preparation.

Country Status (14)

Country Link
JP (1) JPH01305098A (en)
AU (1) AU3263989A (en)
BE (1) BE1003200A4 (en)
CH (1) CH677795A5 (en)
DE (1) DE3910667A1 (en)
DK (1) DK171489A (en)
ES (1) ES2013431A6 (en)
FR (1) FR2629824B1 (en)
GB (1) GB2224280B (en)
IL (1) IL89897A0 (en)
IT (1) IT1231943B (en)
LU (1) LU87496A1 (en)
NL (1) NL8900882A (en)
SE (1) SE8901278L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139526A (en) * 1977-12-01 1979-02-13 Merck & Co., Inc. Somatostatin analogs
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
JPH085913B2 (en) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド Therapeutic somatostatin congeners
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols

Also Published As

Publication number Publication date
NL8900882A (en) 1989-11-01
JPH01305098A (en) 1989-12-08
DE3910667A1 (en) 1989-10-19
IL89897A0 (en) 1989-12-15
GB8907902D0 (en) 1989-05-24
IT8947833A0 (en) 1989-04-10
IT1231943B (en) 1992-01-16
BE1003200A4 (en) 1992-01-14
FR2629824B1 (en) 1995-03-10
SE8901278L (en) 1989-10-12
AU3263989A (en) 1989-10-12
LU87496A1 (en) 1989-11-14
DK171489D0 (en) 1989-04-10
ES2013431A6 (en) 1990-05-01
GB2224280A (en) 1990-05-02
SE8901278D0 (en) 1989-04-10
FR2629824A1 (en) 1989-10-13
GB2224280B (en) 1992-07-08
CH677795A5 (en) 1991-06-28

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 2001 00019, 20010528, EXPIRES: 20091031

CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 2001 00024, 20010718, EXPIRES: 20091031