DK169031B1 - 1,2,3,4-Tetrahydro-3-carbamoyl-2-thioxo/oxo-5-pyrimidencarboxylsyre-derivater og farmaceutiske præparater indeholdende sådanne - Google Patents
1,2,3,4-Tetrahydro-3-carbamoyl-2-thioxo/oxo-5-pyrimidencarboxylsyre-derivater og farmaceutiske præparater indeholdende sådanne Download PDFInfo
- Publication number
- DK169031B1 DK169031B1 DK131887A DK131887A DK169031B1 DK 169031 B1 DK169031 B1 DK 169031B1 DK 131887 A DK131887 A DK 131887A DK 131887 A DK131887 A DK 131887A DK 169031 B1 DK169031 B1 DK 169031B1
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- nitrophenyl
- mmol
- alkyl
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83976786A | 1986-03-14 | 1986-03-14 | |
| US83976786 | 1986-03-14 | ||
| US91734986A | 1986-10-09 | 1986-10-09 | |
| US91734986 | 1986-10-09 | ||
| US803787 | 1987-02-09 | ||
| US07/008,037 US4855301A (en) | 1986-10-09 | 1987-02-09 | 1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK131887D0 DK131887D0 (da) | 1987-03-13 |
| DK131887A DK131887A (da) | 1987-09-15 |
| DK169031B1 true DK169031B1 (da) | 1994-08-01 |
Family
ID=27358497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK131887A DK169031B1 (da) | 1986-03-14 | 1987-03-13 | 1,2,3,4-Tetrahydro-3-carbamoyl-2-thioxo/oxo-5-pyrimidencarboxylsyre-derivater og farmaceutiske præparater indeholdende sådanne |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0237347B1 (no) |
| JP (1) | JPH0819113B2 (no) |
| KR (1) | KR900005014B1 (no) |
| CA (1) | CA1337655C (no) |
| DE (1) | DE3770661D1 (no) |
| DK (1) | DK169031B1 (no) |
| ES (1) | ES2039234T3 (no) |
| FI (1) | FI96683C (no) |
| GR (1) | GR3002715T3 (no) |
| HU (1) | HU206091B (no) |
| IE (1) | IE60114B1 (no) |
| IL (1) | IL81800A0 (no) |
| NO (1) | NO871044L (no) |
| PH (1) | PH27052A (no) |
| PL (1) | PL153727B1 (no) |
| PT (1) | PT84479B (no) |
| SU (1) | SU1713437A3 (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62267272A (ja) * | 1986-05-15 | 1987-11-19 | Sanwa Kagaku Kenkyusho Co Ltd | 新規なジヒドロピリミジン化合物及びその塩、これらの製法並びに該化合物を有効成分とする循環器系作用剤 |
| US4847379A (en) * | 1987-11-30 | 1989-07-11 | E. R. Squibb & Sons, Inc. | 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters |
| NZ297278A (en) | 1994-11-16 | 1999-06-29 | Synaptic Pharma Corp | 4-aryl dihydropyrimidine derivatives end medicaments |
| US6268369B1 (en) | 1994-11-16 | 2001-07-31 | Synaptic Pharmaceutical Corporation | 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines |
| JP2000500470A (ja) * | 1995-11-16 | 2000-01-18 | シナプティック・ファーマスーティカル・コーポレーション | ジヒドロピリミジンおよびその使用 |
| US6228861B1 (en) | 1995-11-16 | 2001-05-08 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
| US6172066B1 (en) | 1996-05-16 | 2001-01-09 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
| US6245773B1 (en) | 1996-05-16 | 2001-06-12 | Synaptic Pharmaceutical Corporation | 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines |
| WO1998033791A1 (en) * | 1997-02-04 | 1998-08-06 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as npy antagonists |
| US6680323B2 (en) | 1998-12-23 | 2004-01-20 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
| US6274585B1 (en) | 1998-12-23 | 2001-08-14 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
| AU5568400A (en) * | 1999-06-23 | 2001-01-09 | Ajinomoto Co., Inc. | Novel dihydropyrimidine derivatives |
| US6720324B2 (en) | 2000-07-05 | 2004-04-13 | Synaptic Pharmaceutical Corporation | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
| JP4897217B2 (ja) * | 2002-09-12 | 2012-03-14 | ダイアクロン ファーマシューティカルズ インコーポレイテッド | カルシウムチャンネル遮断薬 |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| US7157461B2 (en) | 2003-07-23 | 2007-01-02 | Bristol-Myers Squibb Co. | Substituted dihydropyrimidine inhibitors of calcium channel function |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60214778A (ja) * | 1984-03-08 | 1985-10-28 | Suntory Ltd | Ν置換３，４−ジヒドロピリミジン誘導体ならびにその製造法および用途 |
| HUT42077A (en) * | 1985-06-03 | 1987-06-29 | Squibb & Sons Inc | Process for producing diesters of 2-tioxo- or 2-oxo-pyrimidine-1,5-dicarboxylic acid and 1-acyl-pyrimidine-5-carboxylic acids and esters |
| US4675321A (en) * | 1986-02-07 | 1987-06-23 | Merck & Co., Inc. | Substituted pyrimidines useful as calcium channel blockers |
| NZ219299A (en) * | 1986-03-14 | 1989-01-06 | Squibb & Sons Inc | Pyrimidine derivatives |
-
1987
- 1987-03-05 IL IL81800A patent/IL81800A0/xx not_active IP Right Cessation
- 1987-03-06 PH PH34991A patent/PH27052A/en unknown
- 1987-03-11 IE IE63387A patent/IE60114B1/en not_active IP Right Cessation
- 1987-03-11 JP JP62057890A patent/JPH0819113B2/ja not_active Expired - Lifetime
- 1987-03-12 DE DE8787302130T patent/DE3770661D1/de not_active Expired - Fee Related
- 1987-03-12 EP EP87302130A patent/EP0237347B1/en not_active Expired - Lifetime
- 1987-03-12 ES ES198787302130T patent/ES2039234T3/es not_active Expired - Lifetime
- 1987-03-12 FI FI871087A patent/FI96683C/fi not_active IP Right Cessation
- 1987-03-13 KR KR1019870002239A patent/KR900005014B1/ko not_active IP Right Cessation
- 1987-03-13 PL PL1987264629A patent/PL153727B1/pl unknown
- 1987-03-13 PT PT84479A patent/PT84479B/pt not_active IP Right Cessation
- 1987-03-13 NO NO871044A patent/NO871044L/no unknown
- 1987-03-13 DK DK131887A patent/DK169031B1/da not_active IP Right Cessation
- 1987-03-13 HU HU871127A patent/HU206091B/hu not_active IP Right Cessation
- 1987-03-13 SU SU874202205A patent/SU1713437A3/ru active
- 1987-03-16 CA CA000532125A patent/CA1337655C/en not_active Expired - Fee Related
-
1991
- 1991-09-12 GR GR91401319T patent/GR3002715T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT84479B (pt) | 1990-08-31 |
| PL264629A1 (en) | 1988-07-21 |
| PH27052A (en) | 1993-02-01 |
| FI871087A0 (fi) | 1987-03-12 |
| EP0237347B1 (en) | 1991-06-12 |
| IL81800A0 (en) | 1987-10-20 |
| DK131887A (da) | 1987-09-15 |
| EP0237347A2 (en) | 1987-09-16 |
| SU1713437A3 (ru) | 1992-02-15 |
| JPH0819113B2 (ja) | 1996-02-28 |
| EP0237347A3 (en) | 1988-11-02 |
| HU206091B (en) | 1992-08-28 |
| KR900005014B1 (ko) | 1990-07-16 |
| FI871087A (fi) | 1987-09-15 |
| NO871044L (no) | 1987-09-15 |
| HUT43832A (en) | 1987-12-28 |
| DK131887D0 (da) | 1987-03-13 |
| KR870008856A (ko) | 1987-10-21 |
| FI96683B (fi) | 1996-04-30 |
| IE60114B1 (en) | 1994-06-01 |
| IE870633L (en) | 1987-09-14 |
| CA1337655C (en) | 1995-11-28 |
| NO871044D0 (no) | 1987-03-13 |
| PL153727B1 (en) | 1991-05-31 |
| GR3002715T3 (en) | 1993-01-25 |
| ES2039234T3 (es) | 1993-09-16 |
| PT84479A (en) | 1987-04-01 |
| JPS62265271A (ja) | 1987-11-18 |
| DE3770661D1 (de) | 1991-07-18 |
| FI96683C (fi) | 1996-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed | ||
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |