DK167149B1 - Analogifremgangsmaade til fremstilling af 14-amino-3-monosaccharidsubstituerede steroidderivater - Google Patents
Analogifremgangsmaade til fremstilling af 14-amino-3-monosaccharidsubstituerede steroidderivater Download PDFInfo
- Publication number
- DK167149B1 DK167149B1 DK379383A DK379383A DK167149B1 DK 167149 B1 DK167149 B1 DK 167149B1 DK 379383 A DK379383 A DK 379383A DK 379383 A DK379383 A DK 379383A DK 167149 B1 DK167149 B1 DK 167149B1
- Authority
- DK
- Denmark
- Prior art keywords
- group
- amino
- monosaccharide
- derivative
- pregnanediol
- Prior art date
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- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 210000005242 cardiac chamber Anatomy 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 229940125846 compound 25 Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- WSFSSNUMVMOOMR-DICFDUPASA-N dideuteriomethanone Chemical compound [2H]C([2H])=O WSFSSNUMVMOOMR-DICFDUPASA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- KDCIHNCMPUBDKT-UHFFFAOYSA-N hexane;propan-2-one Chemical compound CC(C)=O.CCCCCC KDCIHNCMPUBDKT-UHFFFAOYSA-N 0.000 description 1
- 150000002402 hexoses Chemical group 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 150000002972 pentoses Chemical group 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 150000003128 pregnanes Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000010517 secondary reaction Methods 0.000 description 1
- 231100000161 signs of toxicity Toxicity 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8214425A FR2531964A1 (fr) | 1982-08-20 | 1982-08-20 | Derives d'amino-14 steroides, procede de preparation, et application en therapeutique |
| FR8214425 | 1982-08-20 | ||
| FR8310150A FR2547586B1 (fr) | 1983-06-20 | 1983-06-20 | Derives d'amino-14 steroides, procede de preparation et application en therapeutique |
| FR8310150 | 1983-06-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK379383D0 DK379383D0 (da) | 1983-08-19 |
| DK379383A DK379383A (da) | 1984-02-21 |
| DK167149B1 true DK167149B1 (da) | 1993-09-06 |
Family
ID=26223055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK379383A DK167149B1 (da) | 1982-08-20 | 1983-08-19 | Analogifremgangsmaade til fremstilling af 14-amino-3-monosaccharidsubstituerede steroidderivater |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0101659B1 (enrdf_load_stackoverflow) |
| AU (1) | AU575783B2 (enrdf_load_stackoverflow) |
| CA (1) | CA1216282A (enrdf_load_stackoverflow) |
| DE (1) | DE3362189D1 (enrdf_load_stackoverflow) |
| DK (1) | DK167149B1 (enrdf_load_stackoverflow) |
| GR (1) | GR78668B (enrdf_load_stackoverflow) |
| IE (1) | IE56018B1 (enrdf_load_stackoverflow) |
| NZ (1) | NZ205293A (enrdf_load_stackoverflow) |
| PT (1) | PT77214B (enrdf_load_stackoverflow) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2621316B1 (fr) * | 1987-10-02 | 1991-06-21 | Nativelle Sa Ets | Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant |
| US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
| US5338837A (en) * | 1991-12-13 | 1994-08-16 | The Trustees Of Princeton University | Glycosylated steroid derivatives for transport across biological membranes and process for making same |
| US5639866A (en) * | 1993-02-23 | 1997-06-17 | Princeton University | Single-step formation of multiple glycosidic linkages |
| CA2156717C (en) * | 1993-02-23 | 2001-05-29 | Daniel E. Kahne | Solution and solid-phase formation of glycosidic linkages |
| NZ274082A (en) * | 1993-09-24 | 1998-07-28 | Procter & Gamble | 14-aminosteroid derivatives substituted in position-3 by a deoxy and oxygen substituted monosaccharide residue |
| US5922703A (en) * | 1993-09-24 | 1999-07-13 | The Procter & Gamble Company | Urethane-containing aminosteroid compounds |
| JPH09502982A (ja) * | 1993-09-24 | 1997-03-25 | ザ、プロクター、エンド、ギャンブル、カンパニー | 新規なオリゴ糖含有１４‐アミノステロイド化合物および新規なジアステレオ選択的アミノステロイド法の化学 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2464270A1 (fr) * | 1979-08-31 | 1981-03-06 | Nativelle Sa Ets | Nouveaux derives d'amino-14 steroides, et procede pour leur preparation |
| JPS56113799A (en) * | 1980-02-08 | 1981-09-07 | Nippon Shinyaku Co Ltd | Glucoside derivative |
| US4331802A (en) * | 1980-10-01 | 1982-05-25 | Advance Biofactures Corporation | Organometallic reagents and their use in the synthesis of cardenolides and isocardenolides |
-
1983
- 1983-08-16 NZ NZ205293A patent/NZ205293A/en unknown
- 1983-08-17 CA CA000434788A patent/CA1216282A/fr not_active Expired
- 1983-08-17 PT PT77214A patent/PT77214B/pt not_active IP Right Cessation
- 1983-08-17 GR GR72235A patent/GR78668B/el unknown
- 1983-08-19 DK DK379383A patent/DK167149B1/da not_active IP Right Cessation
- 1983-08-19 EP EP83401686A patent/EP0101659B1/fr not_active Expired
- 1983-08-19 IE IE1941/83A patent/IE56018B1/en not_active IP Right Cessation
- 1983-08-19 DE DE8383401686T patent/DE3362189D1/de not_active Expired
- 1983-08-19 AU AU18137/83A patent/AU575783B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA1216282A (fr) | 1987-01-06 |
| IE831941L (en) | 1984-02-20 |
| PT77214A (fr) | 1983-09-01 |
| EP0101659B1 (fr) | 1986-02-19 |
| DK379383D0 (da) | 1983-08-19 |
| NZ205293A (en) | 1986-12-05 |
| DE3362189D1 (en) | 1986-03-27 |
| EP0101659A2 (fr) | 1984-02-29 |
| GR78668B (enrdf_load_stackoverflow) | 1984-09-27 |
| EP0101659A3 (en) | 1984-03-28 |
| AU1813783A (en) | 1984-02-23 |
| AU575783B2 (en) | 1988-08-11 |
| IE56018B1 (en) | 1991-03-27 |
| DK379383A (da) | 1984-02-21 |
| PT77214B (fr) | 1986-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |