DK166320C - Eddikesyreesteren af haloperidol, fremgangsmaade til fremstilling heraf og farmaceutiske kompositioner deraf - Google Patents
Eddikesyreesteren af haloperidol, fremgangsmaade til fremstilling heraf og farmaceutiske kompositioner derafInfo
- Publication number
- DK166320C DK166320C DK479587A DK479587A DK166320C DK 166320 C DK166320 C DK 166320C DK 479587 A DK479587 A DK 479587A DK 479587 A DK479587 A DK 479587A DK 166320 C DK166320 C DK 166320C
- Authority
- DK
- Denmark
- Prior art keywords
- haloperidol
- pharmaceutical compositions
- acetic acid
- estate
- preparing
- Prior art date
Links
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003878 haloperidol Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000002168 ethanoic acid esters Chemical class 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 abstract 1
- XAMUDJHXFNRLCY-UHFFFAOYSA-N phenthoate Chemical compound CCOC(=O)C(SP(=S)(OC)OC)C1=CC=CC=C1 XAMUDJHXFNRLCY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000011803 sesame oil Nutrition 0.000 abstract 1
- 239000008159 sesame oil Substances 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868621892A GB8621892D0 (en) | 1986-09-11 | 1986-09-11 | Organic compound |
| GB8621892 | 1986-09-11 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK479587D0 DK479587D0 (da) | 1987-09-11 |
| DK479587A DK479587A (da) | 1988-03-12 |
| DK166320B DK166320B (da) | 1993-04-05 |
| DK166320C true DK166320C (da) | 1993-08-23 |
Family
ID=10604021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK479587A DK166320C (da) | 1986-09-11 | 1987-09-11 | Eddikesyreesteren af haloperidol, fremgangsmaade til fremstilling heraf og farmaceutiske kompositioner deraf |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4855307A (da) |
| EP (1) | EP0260070B1 (da) |
| JP (1) | JPS6377857A (da) |
| AT (1) | ATE92917T1 (da) |
| AU (1) | AU591334B2 (da) |
| DE (1) | DE3786966T2 (da) |
| DK (1) | DK166320C (da) |
| ES (1) | ES2058120T3 (da) |
| FI (1) | FI88155C (da) |
| GB (1) | GB8621892D0 (da) |
| IE (1) | IE60902B1 (da) |
| IL (1) | IL83819A (da) |
| NO (1) | NO169893C (da) |
| NZ (1) | NZ221711A (da) |
| PT (1) | PT85678B (da) |
| ZA (1) | ZA876819B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3742580C1 (de) * | 1987-12-16 | 1989-05-11 | Schaper & Bruemmer Gmbh | Verwendung des alpha,alpha-Diphenyl-alpha-(3-carboxy-propionyloxy)-essigsaeure-4-(N-methylpiperidyl)-esters zur Behandlung hypertoner Funktionszustaende im Bereich der Harnblase |
| US5776963A (en) | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| DK238190D0 (da) * | 1990-10-03 | 1990-10-03 | Lundbeck & Co As H | Depotderivater |
| EP1787984B1 (en) * | 2000-03-06 | 2016-10-19 | Acadia Pharmaceuticals Inc. | Azacyclic compounds for use in the treatment of serotonin related diseases |
| RU2398765C1 (ru) | 2000-03-06 | 2010-09-10 | Акадиа Фармасьютикалз, Инк. | Азациклические соединения для применения при лечении опосредованных серотонином заболеваний |
| CN101050215A (zh) | 2001-12-28 | 2007-10-10 | 阿卡蒂亚药品公司 | 作为单胺受体调节剂的螺氮杂环化合物 |
| US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7253186B2 (en) | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| BR0312217A (pt) | 2002-06-24 | 2005-05-10 | Acadia Pharm Inc | Compostos, métodos de inibição da atividade/ativação de um receptor monoaminérgico e método de tratamento de condição doentia associada a um receptor de monoaminergético |
| CN101780080B (zh) | 2003-01-16 | 2014-06-04 | 阿卡蒂亚药品公司 | 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂 |
| US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US7790899B2 (en) | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| KR20070083800A (ko) | 2004-09-27 | 2007-08-24 | 아카디아 파마슈티칼스 인코포레이티드 | Ｎ－(４－플루오로벤질)－ｎ－(１－메틸피페리딘－４－일)－ｎ＇－(４－(２－메틸프로필옥시)페닐메틸)카르바미드의염류 및 이들의 제조 방법 |
| JP2010522198A (ja) | 2007-03-19 | 2010-07-01 | アカドイア プハルマセウチカルス インコーポレーテッド | ５−ｈｔ２ａインバースアゴニスト及びアンタゴニストの抗精神病薬との併用 |
| PT3325444T (pt) | 2015-07-20 | 2021-09-22 | Acadia Pharm Inc | Métodos para preparar n-(4-fluorobenzil)-n-(1-metilpiperidina-4-il)-n'-(4-(2-metilpropiloxi)fenilmetil)carbamida e o seu sal de tartarato e forma polimórfica c |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
| WO2018118626A1 (en) | 2016-12-20 | 2018-06-28 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
| WO2018200977A1 (en) | 2017-04-28 | 2018-11-01 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| EP3675827A1 (en) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB895309A (en) * | 1959-11-18 | 1962-05-02 | Res Lab Dr C Janssen Nv | Pyrrolidine and piperidine derivatives |
| US3408356A (en) * | 1965-08-31 | 1968-10-29 | Squibb & Sons Inc | Long chain esters of 4'-fluoro-4-[4-hydroxy-4-(alpha, alpha, alpha-trifluorotolyl)piperi-dino]butyrophenone and the like |
| DE1695194A1 (de) * | 1966-07-11 | 1971-03-18 | Hoffmann La Roche | Verfahren zur Herstellung von Piperidinderivaten |
| US4070473A (en) * | 1973-01-26 | 1978-01-24 | Ab Ferrosan | Piperidino-butyrophenones |
| JPS568318A (en) * | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
-
1986
- 1986-09-11 GB GB868621892A patent/GB8621892D0/en active Pending
-
1987
- 1987-09-03 DE DE87307799T patent/DE3786966T2/de not_active Expired - Lifetime
- 1987-09-03 EP EP87307799A patent/EP0260070B1/en not_active Expired - Lifetime
- 1987-09-03 AT AT87307799T patent/ATE92917T1/de not_active IP Right Cessation
- 1987-09-03 ES ES87307799T patent/ES2058120T3/es not_active Expired - Lifetime
- 1987-09-03 IE IE236687A patent/IE60902B1/en not_active IP Right Cessation
- 1987-09-04 US US07/093,404 patent/US4855307A/en not_active Expired - Lifetime
- 1987-09-08 NZ NZ221711A patent/NZ221711A/xx unknown
- 1987-09-08 IL IL83819A patent/IL83819A/xx not_active IP Right Cessation
- 1987-09-10 FI FI873924A patent/FI88155C/fi not_active IP Right Cessation
- 1987-09-10 PT PT85678A patent/PT85678B/pt not_active IP Right Cessation
- 1987-09-10 NO NO873785A patent/NO169893C/no unknown
- 1987-09-10 AU AU78232/87A patent/AU591334B2/en not_active Ceased
- 1987-09-11 JP JP62226744A patent/JPS6377857A/ja active Pending
- 1987-09-11 DK DK479587A patent/DK166320C/da not_active IP Right Cessation
- 1987-09-11 ZA ZA876819A patent/ZA876819B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2058120T3 (es) | 1994-11-01 |
| DE3786966T2 (de) | 1994-03-17 |
| FI88155C (fi) | 1993-04-13 |
| NZ221711A (en) | 1989-11-28 |
| DK479587D0 (da) | 1987-09-11 |
| IL83819A0 (en) | 1988-02-29 |
| NO169893B (no) | 1992-05-11 |
| NO169893C (no) | 1992-08-19 |
| PT85678A (en) | 1987-10-01 |
| JPS6377857A (ja) | 1988-04-08 |
| DK479587A (da) | 1988-03-12 |
| IE60902B1 (en) | 1994-08-24 |
| GB8621892D0 (en) | 1986-10-15 |
| EP0260070B1 (en) | 1993-08-11 |
| AU7823287A (en) | 1988-03-17 |
| IE872366L (en) | 1988-03-11 |
| ZA876819B (en) | 1988-06-29 |
| ATE92917T1 (de) | 1993-08-15 |
| FI873924A0 (fi) | 1987-09-10 |
| DK166320B (da) | 1993-04-05 |
| DE3786966D1 (de) | 1993-09-16 |
| FI873924L (fi) | 1988-03-12 |
| EP0260070A1 (en) | 1988-03-16 |
| NO873785D0 (no) | 1987-09-10 |
| AU591334B2 (en) | 1989-11-30 |
| US4855307A (en) | 1989-08-08 |
| IL83819A (en) | 1992-02-16 |
| PT85678B (pt) | 1990-05-31 |
| NO873785L (no) | 1988-03-14 |
| FI88155B (fi) | 1992-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |