DK1631312T3 - Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom - Google Patents

Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom

Info

Publication number
DK1631312T3
DK1631312T3 DK04750581T DK04750581T DK1631312T3 DK 1631312 T3 DK1631312 T3 DK 1631312T3 DK 04750581 T DK04750581 T DK 04750581T DK 04750581 T DK04750581 T DK 04750581T DK 1631312 T3 DK1631312 T3 DK 1631312T3
Authority
DK
Denmark
Prior art keywords
inflammatory bowel
bowel disease
treatment
composition
type
Prior art date
Application number
DK04750581T
Other languages
Danish (da)
English (en)
Inventor
Lesley B Pickford
Christopher R Bebbington
Geoffrey T Yarranton
David King
Original Assignee
Medarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medarex Inc filed Critical Medarex Inc
Application granted granted Critical
Publication of DK1631312T3 publication Critical patent/DK1631312T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
DK04750581T 2003-04-23 2004-04-23 Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom DK1631312T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46515503P 2003-04-23 2003-04-23
PCT/US2004/012651 WO2004093908A2 (en) 2003-04-23 2004-04-23 Compositions and methods for the therapy of inflammatory bowel disease

Publications (1)

Publication Number Publication Date
DK1631312T3 true DK1631312T3 (da) 2009-01-19

Family

ID=33311000

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04750581T DK1631312T3 (da) 2003-04-23 2004-04-23 Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom

Country Status (22)

Country Link
US (2) US7939076B2 (de)
EP (1) EP1631312B1 (de)
JP (1) JP4628357B2 (de)
KR (1) KR100817351B1 (de)
CN (2) CN100409897C (de)
AT (1) ATE407698T1 (de)
AU (1) AU2004232362C1 (de)
BR (1) BRPI0410495A (de)
CA (2) CA2522957C (de)
DE (1) DE602004016499D1 (de)
DK (1) DK1631312T3 (de)
ES (1) ES2313039T3 (de)
HK (1) HK1082200A1 (de)
IL (1) IL171356A (de)
MX (1) MXPA05011409A (de)
NZ (1) NZ542866A (de)
PL (1) PL1631312T3 (de)
PT (1) PT1631312E (de)
SG (1) SG173919A1 (de)
SI (1) SI1631312T1 (de)
WO (1) WO2004093908A2 (de)
ZA (1) ZA200508390B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1631312B1 (de) 2003-04-23 2008-09-10 Medarex, Inc. Zusammensetzungen und verfahren zur behandlung von entzündlicher darmerkrankung
ATE517920T1 (de) * 2003-04-23 2011-08-15 Medarex Inc Humanisierte antikörper gegen interferon-alpha- rezeptor-1 (ifnar-1)
US9107864B2 (en) 2004-06-07 2015-08-18 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
US8501198B2 (en) 2004-06-07 2013-08-06 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
DK2662390T3 (da) 2004-06-21 2017-11-06 Squibb & Sons Llc Interferon alpha receptor 1-antistoffer og anvendelse heraf
KR101166901B1 (ko) 2010-04-16 2012-07-19 송영완 임플란트용 주입기
AU2011261323A1 (en) * 2010-06-04 2013-01-24 The Brigham And Women's Hospital, Inc. Treatment of inflammatory disorders
CA2804709A1 (en) * 2010-07-26 2012-02-02 Qu Biologics Inc. Immunogenic anti-inflammatory compositions
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
CN110917220A (zh) 2013-02-04 2020-03-27 赛里斯治疗公司 治疗组合物及其使用方法
EP3904502A3 (de) 2013-02-04 2022-02-23 Seres Therapeutics, Inc. Zusammensetzungen und verfahren
AU2014232370B2 (en) 2013-03-15 2018-11-01 Seres Therapeutics, Inc. Network-based microbial compositions and methods
RU2722482C2 (ru) 2013-11-25 2020-06-01 Серес Терапеутикс, Инк. Синергические бактериальные композиции и способы их получения и применения
US9956282B2 (en) 2013-12-16 2018-05-01 Seres Therapeutics, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
WO2015164979A1 (en) 2014-05-02 2015-11-05 Qu Biologics Inc. Anti-microbial immunomodulation
WO2016025911A1 (en) * 2014-08-14 2016-02-18 Brown University Compositions for stabilizing and delivering proteins
US11097005B2 (en) 2014-12-15 2021-08-24 The Brigham And Women's Hospital, Inc. Use of cadherin-11 antagonists to treat metabolic disorders and/or increase insulin sensitivity
WO2018010140A1 (zh) 2016-07-14 2018-01-18 中国科学院生物物理研究所 I型干扰素受体抗体及其用途
US20230149497A1 (en) * 2017-06-02 2023-05-18 Goodgut S.L. Grape skin for use in the treatment of dysbiosis
CN111212655A (zh) 2017-08-14 2020-05-29 赛里斯治疗公司 用于治疗胆汁淤积性疾病的组合物和方法
MX2020002070A (es) 2017-08-22 2020-03-24 Sanabio Llc Receptores solubles de interferon y usos de los mismos.
CN112056275B (zh) * 2020-09-27 2022-05-10 澎立生物医药技术（上海）有限公司 一种肠粘膜炎动物模型及其构建方法和应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5516515A (en) * 1986-02-05 1996-05-14 Interferon Sciences, Inc. Separation of alpha interferon receptor proteins and antibodies therefor
IL78444A (en) * 1986-04-08 1992-05-25 Yeda Res & Dev Human gamma interferon-specific receptor protein,antibody against said protein,and compositions containing said protein and antibody
IL88377A (en) 1988-11-14 1996-09-12 Yeda Res & Dev Cloning and expression of a protein which modulates cellular response to type I interferon
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5889151A (en) * 1989-10-20 1999-03-30 Societe Leb-Tech Purified human alpha interferon receptor
FR2653445B1 (fr) 1989-10-20 1994-07-29 Centre Nat Rech Scient Fragment d'adnc codant pour le gene du recepteur de l'interferon alpha et procede de preparation d'une proteine correspondante.
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
DE69214656T2 (de) 1991-08-30 1997-03-13 Genentech Inc Therapeutisches verfahren zur behandlung von iddm
EP0563487A1 (de) * 1992-03-31 1993-10-06 Laboratoire Europeen De Biotechnologie S.A. Monoklonale Antikörper gegen den Interferonrezeptor, mit neutralisierender Aktivität gegen Typ I-Interferon
US5821078A (en) * 1992-09-03 1998-10-13 Yeda Research And Development Co. Ltd. Nucleic acid encoding interferon-α/β binding protein
DK0695189T3 (da) 1992-12-29 1999-08-09 Genentech Inc Behandling af inflammatorisk tarmsygdom med IFN-gammainhibitorer
US5888511A (en) * 1993-02-26 1999-03-30 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS
CA2171955A1 (en) * 1993-09-17 1995-03-23 Michael G. Tovey Pharmaceutical composition comprising monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon
AU1289595A (en) 1993-11-15 1995-06-06 Cell Therapeutics, Inc. Method for selectively inhibiting il-2 signal transduction
US7285526B2 (en) * 1995-07-14 2007-10-23 Meiogen Biotechnology Corporation Interferon antagonists useful for the treatment of interferon related diseases
IL118096A0 (en) 1996-05-01 1996-09-12 Yeda Res & Dev Antibodies against interferon alpha/beta receptor
US6713609B1 (en) * 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
EP1724282B1 (de) 1997-05-21 2013-05-15 Merck Patent GmbH Verfahren zur Herstellung von nicht-immunogenen Proteinen
FR2769505B1 (fr) 1997-10-10 2000-06-30 Michael Gerard Tovey Compositions de cytokines a administrer a la muqueuse buccale, et leurs utilisations
JP4292262B2 (ja) 1998-01-30 2009-07-08 アラタイン セラピューティクス， エルエルシー 予後アレルギー試験または予後炎症試験
AUPP670698A0 (en) 1998-10-23 1998-11-19 Monash University A method of regulation
US6329159B1 (en) 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
NZ517372A (en) 1999-07-29 2004-04-30 Medarex Inc Human monoclonal antibodies to HER2/neu
EP1212422B1 (de) 1999-08-24 2007-02-21 Medarex, Inc. Humane antikörper gegen ctla-4 und deren verwendungen
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
GB0001710D0 (en) 2000-01-25 2000-03-15 Pharma Pacific Pty Ltd Therapeutic treatment
GB0001712D0 (en) 2000-01-25 2000-03-15 Pharma Pacific Pty Ltd Therapeutic peptides
ATE378403T1 (de) 2000-11-30 2007-11-15 Medarex Inc Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern
US7087726B2 (en) * 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
JP4156324B2 (ja) 2002-09-30 2008-09-24 ローム株式会社 直流−交流変換装置、及び交流電力供給方法
ATE517920T1 (de) * 2003-04-23 2011-08-15 Medarex Inc Humanisierte antikörper gegen interferon-alpha- rezeptor-1 (ifnar-1)
EP1631312B1 (de) 2003-04-23 2008-09-10 Medarex, Inc. Zusammensetzungen und verfahren zur behandlung von entzündlicher darmerkrankung
NZ547157A (en) * 2003-12-10 2009-07-31 Medarex Inc Interferon Alpha Antibodies and their uses
DK2662390T3 (da) * 2004-06-21 2017-11-06 Squibb & Sons Llc Interferon alpha receptor 1-antistoffer og anvendelse heraf

Also Published As

Publication number Publication date
NZ542866A (en) 2009-07-31
AU2004232362B2 (en) 2007-09-06
KR100817351B1 (ko) 2008-03-26
KR20060015531A (ko) 2006-02-17
CN100409897C (zh) 2008-08-13
CN101318019B (zh) 2012-08-29
MXPA05011409A (es) 2005-12-12
CN1777444A (zh) 2006-05-24
CA2823468A1 (en) 2004-11-04
WO2004093908A3 (en) 2005-06-02
JP2006524703A (ja) 2006-11-02
CA2522957A1 (en) 2004-11-04
BRPI0410495A (pt) 2006-06-13
HK1082200A1 (en) 2006-06-02
WO2004093908A2 (en) 2004-11-04
CN101318019A (zh) 2008-12-10
IL171356A (en) 2010-11-30
AU2004232362A1 (en) 2004-11-04
EP1631312B1 (de) 2008-09-10
AU2004232362C1 (en) 2008-05-29
US8828393B2 (en) 2014-09-09
PT1631312E (pt) 2008-12-22
US20050152901A1 (en) 2005-07-14
SG173919A1 (en) 2011-09-29
EP1631312A2 (de) 2006-03-08
PL1631312T3 (pl) 2009-02-27
SI1631312T1 (sl) 2009-02-28
JP4628357B2 (ja) 2011-02-09
DE602004016499D1 (de) 2008-10-23
US7939076B2 (en) 2011-05-10
CA2522957C (en) 2013-10-22
ZA200508390B (en) 2006-06-28
ATE407698T1 (de) 2008-09-15
ES2313039T3 (es) 2009-03-01
US20110165158A1 (en) 2011-07-07

Similar Documents

Publication Publication Date Title
IL171356A (en) Anti-interferon receptor antibody for treatment of inflammatory bowel disease
DK3530673T3 (da) Humaniserede anti-beta7-antagonister og anvendelser deraf
NO20091734L (no) Glucagonreseptorantagonistforbindelser, preparater inneholdende slike forbindelser, og metoder for anvendelse
EA200601555A1 (ru) Замещенные индазол-о-глюкозиды
EA200601554A1 (ru) Замещенные индол-о-глюкозиды
DE602006021292D1 (de) Tgf-beta-1-spezifische antikörper
DE60142614D1 (de) Inität
PE20061115A1 (es) Anticuerpos anti-il-12, epitopos, composiciones, metodos y usos
NO339997B1 (no) Diarylhydantoinforbindelse, farmasøytisk sammensetning og anvendelse derav
ATE387435T1 (de) Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren
DK1836169T3 (da) Sammensætninger og fremgangsmåder til behandling af celleproliferationslidelser
NO20063193L (no) Fusjonerte pyrrolokarbazoler og fremgangsmater for fremstilling derav
ATE517920T1 (de) Humanisierte antikörper gegen interferon-alpha- rezeptor-1 (ifnar-1)
DK1383919T3 (da) Fremgangsmåder og sammensætninger til anvendelse af MHC klasse II-invariant kædepolypeptid som en receptor for makrofag migrationsinhiberede faktor
EA200702078A1 (ru) Способ обработки и строительства скважин
NO20054238D0 (no) Inhibitorer av antigenpresentasjon ved MHC klasse II-molekyler og fremgangsmate for anvendelse av disse
EA200601220A1 (ru) Анти-trkc антитела-агонисты и способы их применения
NO20065569L (no) Saltsammensetning til bruk sammen med smeltet magnesium.