DK1622656T3 - Biomateriale - Google Patents

Biomateriale Download PDF

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Publication number
DK1622656T3
DK1622656T3 DK04731212.9T DK04731212T DK1622656T3 DK 1622656 T3 DK1622656 T3 DK 1622656T3 DK 04731212 T DK04731212 T DK 04731212T DK 1622656 T3 DK1622656 T3 DK 1622656T3
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DK
Denmark
Prior art keywords
biomaterial
biomaterial according
micropores
ceramic
macropores
Prior art date
Application number
DK04731212.9T
Other languages
English (en)
Inventor
Wei J Orthogem Limited Lo
Original Assignee
Orthogem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orthogem Ltd filed Critical Orthogem Ltd
Application granted granted Critical
Publication of DK1622656T3 publication Critical patent/DK1622656T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Porous Artificial Stone Or Porous Ceramic Products (AREA)

Claims (14)

  1. - i - BIOMATERIALE
    1. Biomateriale omfattende et keramisk materiale, hvilket 5 keramisk materiale har en flerhed af forbundne mikroporer med en gennemsnitlig diameter på mellem 1 mm og 10 mm i alt væsentligt jævnt fordelt gennem det keramiske materiale og omfattende en flerhed af aflange makroporer med en gennemsnitlig diameter på mellem 150 mm og 500 mm og en 10 gennemsnitlig længde på mellem 300-3000 mm.
  2. 2. Biomateriale ifølge krav 1 sammensat af en flerhed af keramiske partikler, hvor hver partikel er delvis sammensmeltet med en eller flere tilstødende keramiske 15 partikler, så der dannes et gitter, der definerer mikroporerne.
  3. 3. Biomateriale ifølge krav 1 eller krav 2, hvori hver partikel har en gennemsnitlig diameter på 1 mm til 10 mm. 20
  4. 4. Biomateriale ifølge et hvilket som helst af de foregående krav med en gennemsnitlig porøsitet på mindst 50 %.
  5. 5. Biomateriale ifølge et hvilket som helst af de foregående krav med en trykstyrke på mindst 1,0 MPa.
  6. 6. Biomateriale ifølge et hvilket som helst af de foregående krav, hvori makroporerne er forbundet med 30 hinanden via en flerhed af mikroporer. - Δ -
  7. 7. Biomateriale ifølge et hvilket som helst af de foregående krav, hvori den gennemsnitlige tykkelse af det keramiske materiale mellem hver makropore er 20 til 200 mm.
  8. 8. Biomateriale ifølge et hvilket som helst af de foregående krav yderligere omfattende en flerhed af i alt væsentligt kugleformede midi-porer med en gennemsnitlig diameter på 5 mm til 150 mm.
  9. 9. Biomateriale ifølge et hvilket som helst af de foregående krav yderligere omfattende en eller flere biologisk eller farmaceutisk aktive forbindelser.
  10. 10. Biomateriale ifølge krav 9, hvori den farmaceutisk 15 aktive forbindelse er en cellevækstfaktor eller et knoglemorfogent protein.
  11. 11. Biomateriale ifølge et hvilket som helst af de foregående krav, hvori det keramiske materiale er mindst én 20 type calciumphosphat.
  12. 12. Biomateriale ifølge krav 11, hvori calciumphosphaten er ex- eller β-tricalciumphosphat eller hydroxyapatit eller en blanding deraf. 25
  13. 13. Knogleimplantat, dentalt implantat eller et øre-, næseeller hals- (ØNH)-implantat omfattende et biomateriale ifølge et hvilket som helst af kravene 1 til 12.
  14. 14. Biomateriale ifølge et hvilket som helst af kravene 1 til 12 til anvendelse som en knogleerstatning ved dental implantation eller materiale til kæbe-ansigts-reparation.
DK04731212.9T 2003-05-15 2004-05-05 Biomateriale DK1622656T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0311221.6A GB0311221D0 (en) 2003-05-15 2003-05-15 Biomaterial
PCT/GB2004/001946 WO2004101013A1 (en) 2003-05-15 2004-05-05 Biomaterial

Publications (1)

Publication Number Publication Date
DK1622656T3 true DK1622656T3 (da) 2016-08-22

Family

ID=9958162

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04731212.9T DK1622656T3 (da) 2003-05-15 2004-05-05 Biomateriale

Country Status (7)

Country Link
US (1) US8288452B2 (da)
EP (1) EP1622656B8 (da)
CA (1) CA2524982C (da)
DK (1) DK1622656T3 (da)
ES (1) ES2584187T3 (da)
GB (1) GB0311221D0 (da)
WO (1) WO2004101013A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8282678B2 (en) 2002-11-13 2012-10-09 Allium Medical Solutions Ltd. Endoluminal lining
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
AU2005212339B2 (en) 2004-02-06 2010-11-25 Georgia Tech Research Corporation Load bearing biocompatible device
CA2558623C (en) 2004-02-06 2013-04-16 Georgia Tech Research Corporation Surface directed cellular attachment
GB0502493D0 (en) * 2005-02-07 2005-03-16 Orthogem Ltd Bone cement
US7531190B2 (en) * 2005-05-25 2009-05-12 Biomet Manufacturing Corp. Porous ceramic structure containing biologics
WO2007030616A2 (en) 2005-09-09 2007-03-15 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
WO2007056185A2 (en) * 2005-11-04 2007-05-18 Ceramatec, Inc. Process of making ceramic, mineral and metal beads from powder
US20070254798A1 (en) * 2006-03-31 2007-11-01 Addiego William P Peroxide containing compounds as pore formers in the manufacture of ceramic articles
GB0610333D0 (en) * 2006-05-24 2006-07-05 Orthogem Ltd Bone repair or augmentation device
NL1032851C2 (nl) * 2006-11-10 2008-05-14 Fondel Finance B V Kit en werkwijze voor het fixeren van een prothese of deel daarvan en/of het vullen van benige defecten.
CA2689675A1 (en) * 2007-02-07 2008-08-14 Mcgill University Bioceramic implants having bioactive substance
US20080293927A1 (en) * 2007-05-21 2008-11-27 The Xim Group, Llc Method for preparing pelleted lignocellulosic ion exchange materials
US8066770B2 (en) * 2007-05-31 2011-11-29 Depuy Products, Inc. Sintered coatings for implantable prostheses
JP2010528765A (ja) * 2007-06-07 2010-08-26 スミス アンド ネフュー インコーポレーテッド 医用インプラント用途のための網状粒子多孔質被覆
JP2011509157A (ja) * 2008-01-09 2011-03-24 イノベイテイブ ヘルス テクノロジーズ エルエルシー 骨造成および保存のためのインプラントペレットおよび方法
GB0912855D0 (en) 2009-07-23 2009-08-26 Orthogem Ltd Composite delivery device
WO2011022642A1 (en) * 2009-08-21 2011-02-24 Malshe Ajay P Nanostructured hydroxyapatite coating for dental and orthopedic implants
WO2012162552A1 (en) 2011-05-26 2012-11-29 Cartiva, Inc. Tapered joint implant and related tools
US9642935B1 (en) * 2012-01-27 2017-05-09 Robert L. Bundy Synthetic, composite osteogenic bone graft
EP3034033A1 (en) 2014-12-16 2016-06-22 Nobel Biocare Services AG Dental implant
WO2016161025A1 (en) 2015-03-31 2016-10-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
WO2016161026A1 (en) 2015-03-31 2016-10-06 Cartiva, Inc. Carpometacarpal (cmc) implants and methods
AU2016248062B2 (en) 2015-04-14 2020-01-23 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705118A (en) * 1992-08-27 1998-01-06 Polyceramics, Inc. Process for producing a ceramic body
US6376573B1 (en) * 1994-12-21 2002-04-23 Interpore International Porous biomaterials and methods for their manufacture
US6846493B2 (en) * 1995-09-01 2005-01-25 Millenium Biologix Inc. Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity
AU1673797A (en) * 1996-02-20 1997-09-10 Mikuni Corporation Method for producing granulated material
US6472210B1 (en) * 1997-11-14 2002-10-29 Bonetec Corporation Polymer scaffold having microporous polymer struts defining interconnected macropores
CA2221195A1 (en) * 1997-11-14 1999-05-14 Chantal E. Holy Biodegradable polymer matrix
KR100652511B1 (ko) * 1998-01-29 2006-11-30 밀레늄 바이올로직스 인코포레이티드 합성 생체 물질 화합물
AU766735B2 (en) * 1998-09-15 2003-10-23 Isotis N.V. Osteoinduction
AU1916200A (en) * 1998-11-20 2000-06-13 Board Of Trustees Of Michigan State University Porous ceramic composites
US6605648B1 (en) * 1999-04-06 2003-08-12 Phillips Plastics Corporation Sinterable structures and method
AU778651B2 (en) * 1999-12-16 2004-12-16 Isotis N.V. Porous ceramic body
WO2002011781A1 (en) 2000-08-04 2002-02-14 Orthogem Limited Porous synthetic bone graft and method of manufacture thereof
GB0020610D0 (en) * 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US6626950B2 (en) * 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US20050119742A1 (en) * 2001-06-30 2005-06-02 Richter Paul W. Orbital implant
US7875342B2 (en) * 2001-09-24 2011-01-25 Warsaw Orthopedic, Inc. Porous ceramic composite bone grafts

Also Published As

Publication number Publication date
ES2584187T3 (es) 2016-09-26
CA2524982A1 (en) 2004-11-25
EP1622656A1 (en) 2006-02-08
EP1622656B8 (en) 2016-09-14
WO2004101013A1 (en) 2004-11-25
EP1622656B1 (en) 2016-07-13
CA2524982C (en) 2013-07-30
US20060122706A1 (en) 2006-06-08
US8288452B2 (en) 2012-10-16
GB0311221D0 (en) 2003-06-18

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