DK158310C - Analogifremgangsmaade til fremstilling af substituerede 2,4-diamino-5-piperazinyl-pyrimidiner samt mellemprodukter til brug herved - Google Patents
Analogifremgangsmaade til fremstilling af substituerede 2,4-diamino-5-piperazinyl-pyrimidiner samt mellemprodukter til brug hervedInfo
- Publication number
- DK158310C DK158310C DK407383A DK407383A DK158310C DK 158310 C DK158310 C DK 158310C DK 407383 A DK407383 A DK 407383A DK 407383 A DK407383 A DK 407383A DK 158310 C DK158310 C DK 158310C
- Authority
- DK
- Denmark
- Prior art keywords
- pyrimidines
- diamino
- piperazinyl
- intermediates
- preparing substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41640482A | 1982-09-09 | 1982-09-09 | |
| US41640482 | 1982-09-09 | ||
| US06/520,653 US4532240A (en) | 1982-09-09 | 1983-08-09 | Diaminopyrimidines |
| US52065383 | 1983-08-09 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK407383D0 DK407383D0 (da) | 1983-09-08 |
| DK407383A DK407383A (da) | 1984-03-10 |
| DK158310B DK158310B (da) | 1990-04-30 |
| DK158310C true DK158310C (da) | 1990-10-15 |
Family
ID=27023342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK407383A DK158310C (da) | 1982-09-09 | 1983-09-08 | Analogifremgangsmaade til fremstilling af substituerede 2,4-diamino-5-piperazinyl-pyrimidiner samt mellemprodukter til brug herved |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4532240A (es) |
| EP (1) | EP0103464B1 (es) |
| AU (2) | AU560971B2 (es) |
| CA (1) | CA1251447A (es) |
| DE (1) | DE3378469D1 (es) |
| DK (1) | DK158310C (es) |
| ES (2) | ES525490A0 (es) |
| GR (1) | GR79058B (es) |
| IE (1) | IE56148B1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5099019A (en) * | 1985-09-12 | 1992-03-24 | Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| USRE35053E (en) * | 1985-09-12 | 1995-10-10 | The Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| LU86695A1 (fr) * | 1986-12-01 | 1988-07-14 | Oreal | Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique |
| HUT64323A (en) * | 1992-06-09 | 1993-12-28 | Richter Gedeon Vegyeszet | Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives |
| DE4320570C2 (de) * | 1993-02-26 | 2002-07-11 | Max Delbrueck Centrum | Verfahren zur Herstellung von C-Nukleosiden und C-Nukleosid-Analoga, neue C-Nukleoside und C-Nukleosid-Analoga sowie deren Verwendung |
| ATE166347T1 (de) * | 1993-02-26 | 1998-06-15 | Max Delbrueck Centrum | Verfahren zur herstellung von c-nukleosiden und c-nukleosid-analoga, neue c-nukleoside und c- nukleosid-analoga, sowie ihre verwendung |
| GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| AU2076299A (en) | 1998-01-30 | 1999-08-16 | Meiji Seika Kaisha Ltd. | Phenylpiperazine derivatives as integrin alphavbeta3 antagonists |
| AU4690999A (en) * | 1998-08-13 | 2000-03-06 | Warner-Lambert Company | Diaminopyrimidines and combination therapies effective for treatment of p-glycoprotein positive cancers |
| US20040006042A1 (en) * | 1998-08-13 | 2004-01-08 | Berry David Allen | Diaminopyrimidines and combination therapies effective for treatment of P-glycoprotein positive cancers |
| IL158941A0 (en) * | 2001-05-22 | 2004-05-12 | Neurogen Corp | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
| GB0412072D0 (en) * | 2004-05-28 | 2004-06-30 | Syngenta Participations Ag | Chemical compounds |
| EP3411367A4 (en) * | 2016-02-05 | 2019-07-10 | Vyera Pharmaceuticals, LLC | COMPOSITIONS AND METHOD FOR THE TREATMENT OF INFECTIONS |
| US20200270233A1 (en) * | 2017-08-07 | 2020-08-27 | Vyera Pharmaceuticais LLC | Dhfr inhibitors, compositions, and methods related thereto |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US416404A (en) | 1889-12-03 | Automatic lath-feeder for paper-carriers | ||
| NL72956C (es) * | 1947-11-12 | |||
| US2748125A (en) * | 1954-04-26 | 1956-05-29 | American Cyanamid Co | 1-substituted-4-sulfamylpiperazine and method of preparing the same |
| AT340933B (de) * | 1973-08-20 | 1978-01-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze |
| US4166852A (en) * | 1974-08-09 | 1979-09-04 | Produits Chimiques Ugine Kuhlmann | Piperazino-pyrimidines and their use as spasmolytic agents |
| US4287338A (en) * | 1980-03-10 | 1981-09-01 | The Upjohn Company | Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts |
| US4351832A (en) * | 1980-04-18 | 1982-09-28 | American Home Products Corporation | 2-(Piperazinyl)-4-pyrimidinamines |
-
1983
- 1983-08-09 US US06/520,653 patent/US4532240A/en not_active Expired - Lifetime
- 1983-08-16 IE IE1920/83A patent/IE56148B1/en not_active IP Right Cessation
- 1983-09-05 AU AU18699/83A patent/AU560971B2/en not_active Ceased
- 1983-09-07 GR GR72395A patent/GR79058B/el unknown
- 1983-09-08 EP EP83305229A patent/EP0103464B1/en not_active Expired
- 1983-09-08 DE DE8383305229T patent/DE3378469D1/de not_active Expired
- 1983-09-08 CA CA000436240A patent/CA1251447A/en not_active Expired
- 1983-09-08 ES ES525490A patent/ES525490A0/es active Granted
- 1983-09-08 DK DK407383A patent/DK158310C/da not_active IP Right Cessation
-
1984
- 1984-03-27 ES ES531004A patent/ES8504775A1/es not_active Expired
-
1987
- 1987-02-13 AU AU68787/87A patent/AU568997B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GR79058B (es) | 1984-10-02 |
| ES531004A0 (es) | 1985-05-01 |
| AU560971B2 (en) | 1987-04-30 |
| DE3378469D1 (en) | 1988-12-22 |
| DK158310B (da) | 1990-04-30 |
| DK407383A (da) | 1984-03-10 |
| EP0103464B1 (en) | 1988-11-17 |
| CA1251447A (en) | 1989-03-21 |
| DK407383D0 (da) | 1983-09-08 |
| EP0103464A2 (en) | 1984-03-21 |
| ES8502989A1 (es) | 1985-02-01 |
| EP0103464A3 (en) | 1985-07-03 |
| ES525490A0 (es) | 1985-02-01 |
| AU568997B2 (en) | 1988-01-14 |
| AU6878787A (en) | 1987-05-14 |
| ES8504775A1 (es) | 1985-05-01 |
| IE831920L (en) | 1984-03-09 |
| US4532240A (en) | 1985-07-30 |
| AU1869983A (en) | 1984-03-15 |
| IE56148B1 (en) | 1991-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |