DK157540C - METHOD OF ANALOGUE FOR THE PREPARATION OF SECONDARY 2-AMINOALKYL-5-PYRIDINOLS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS. - Google Patents
METHOD OF ANALOGUE FOR THE PREPARATION OF SECONDARY 2-AMINOALKYL-5-PYRIDINOLS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.Info
- Publication number
- DK157540C DK157540C DK193180A DK193180A DK157540C DK 157540 C DK157540 C DK 157540C DK 193180 A DK193180 A DK 193180A DK 193180 A DK193180 A DK 193180A DK 157540 C DK157540 C DK 157540C
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- preparation
- xii
- pyridinols
- aminoalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Building Environments (AREA)
- Paper (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
There is described a process for preparing an enamine of formula (IX): <IMAGE> where R<2> is a carboxylic acid protecting group and R<3> is the residue of a carboxylic acid derived acyl group and where R<5> and R<6> are the same or different C1-4 alkyl or C1-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): <IMAGE> with an amine of formula HNR<5>R<6>, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3- hydroxycephalosporins. The compounds of formula (XII) are novel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3566879A | 1979-05-03 | 1979-05-03 | |
| US3566879 | 1979-05-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK193180A DK193180A (en) | 1980-11-04 |
| DK157540B DK157540B (en) | 1990-01-22 |
| DK157540C true DK157540C (en) | 1990-06-11 |
Family
ID=21884070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK193180A DK157540C (en) | 1979-05-03 | 1980-05-01 | METHOD OF ANALOGUE FOR THE PREPARATION OF SECONDARY 2-AMINOALKYL-5-PYRIDINOLS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0019739B1 (en) |
| JP (1) | JPS55149260A (en) |
| AT (1) | ATE8501T1 (en) |
| DD (1) | DD150461A5 (en) |
| DE (1) | DE3068577D1 (en) |
| DK (1) | DK157540C (en) |
| ES (1) | ES491055A0 (en) |
| FI (1) | FI70212C (en) |
| GB (1) | GB2050380B (en) |
| GR (1) | GR68206B (en) |
| HU (1) | HU181115B (en) |
| IE (1) | IE49712B1 (en) |
| IL (1) | IL59978A (en) |
| MA (1) | MA18964A1 (en) |
| NO (1) | NO154130C (en) |
| OA (1) | OA06528A (en) |
| PL (1) | PL223984A1 (en) |
| PT (1) | PT71176A (en) |
| ZW (1) | ZW9680A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746670A (en) * | 1986-04-11 | 1988-05-24 | Ciba-Geigy Corporation | Use of 2-aminoalkyl-5-pyridinols as nootropic agents and antidepressants |
| JP4732662B2 (en) * | 2000-04-06 | 2011-07-27 | セイコーインスツル株式会社 | Battery holding structure for electronic watch |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3952101A (en) * | 1975-04-14 | 1976-04-20 | Smithkline Corporation | α-Amino methyl-5-hydroxy-2-pyridinemethanols |
-
1980
- 1980-04-30 HU HU80801080A patent/HU181115B/en not_active IP Right Cessation
- 1980-04-30 NO NO801267A patent/NO154130C/en unknown
- 1980-04-30 PT PT71176A patent/PT71176A/en unknown
- 1980-04-30 DE DE8080102347T patent/DE3068577D1/en not_active Expired
- 1980-04-30 FI FI801411A patent/FI70212C/en not_active IP Right Cessation
- 1980-04-30 ZW ZW96/80A patent/ZW9680A1/en unknown
- 1980-04-30 ES ES491055A patent/ES491055A0/en active Granted
- 1980-04-30 AT AT80102347T patent/ATE8501T1/en not_active IP Right Cessation
- 1980-04-30 EP EP80102347A patent/EP0019739B1/en not_active Expired
- 1980-05-01 IL IL59978A patent/IL59978A/en unknown
- 1980-05-01 DK DK193180A patent/DK157540C/en not_active IP Right Cessation
- 1980-05-02 JP JP5800280A patent/JPS55149260A/en active Granted
- 1980-05-02 IE IE899/80A patent/IE49712B1/en not_active IP Right Cessation
- 1980-05-02 MA MA19024A patent/MA18964A1/en unknown
- 1980-05-02 GR GR61845A patent/GR68206B/el unknown
- 1980-05-02 GB GB8014705A patent/GB2050380B/en not_active Expired
- 1980-05-02 DD DD80220844A patent/DD150461A5/en not_active IP Right Cessation
- 1980-05-03 PL PL22398480A patent/PL223984A1/xx unknown
- 1980-05-03 OA OA57107A patent/OA06528A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK193180A (en) | 1980-11-04 |
| FI70212C (en) | 1986-09-15 |
| IL59978A0 (en) | 1980-07-31 |
| ATE8501T1 (en) | 1984-08-15 |
| IE49712B1 (en) | 1985-11-27 |
| GR68206B (en) | 1981-11-10 |
| OA06528A (en) | 1981-07-31 |
| FI801411A (en) | 1980-11-04 |
| JPS6365662B2 (en) | 1988-12-16 |
| PT71176A (en) | 1980-05-01 |
| ES8104229A1 (en) | 1981-04-01 |
| EP0019739B1 (en) | 1984-07-18 |
| HU181115B (en) | 1983-06-28 |
| DK157540B (en) | 1990-01-22 |
| GB2050380A (en) | 1981-01-07 |
| DE3068577D1 (en) | 1984-08-23 |
| JPS55149260A (en) | 1980-11-20 |
| ZW9680A1 (en) | 1980-11-26 |
| GB2050380B (en) | 1983-07-20 |
| DD150461A5 (en) | 1981-09-02 |
| NO801267L (en) | 1980-11-04 |
| NO154130C (en) | 1986-07-23 |
| IL59978A (en) | 1984-03-30 |
| MA18964A1 (en) | 1980-12-31 |
| IE800899L (en) | 1980-11-03 |
| EP0019739A1 (en) | 1980-12-10 |
| PL223984A1 (en) | 1981-02-13 |
| FI70212B (en) | 1986-02-28 |
| NO154130B (en) | 1986-04-14 |
| ES491055A0 (en) | 1981-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |