OA06528A - 2-aminoalkyl-5-pyridinols, process for their preparation, pharmaceutical compositions containing these compounds and their therapeutic uses. - Google Patents
2-aminoalkyl-5-pyridinols, process for their preparation, pharmaceutical compositions containing these compounds and their therapeutic uses.Info
- Publication number
- OA06528A OA06528A OA57107A OA57107A OA06528A OA 06528 A OA06528 A OA 06528A OA 57107 A OA57107 A OA 57107A OA 57107 A OA57107 A OA 57107A OA 06528 A OA06528 A OA 06528A
- Authority
- OA
- OAPI
- Prior art keywords
- formula
- xii
- compounds
- preparation
- pyridinols
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
There is described a process for preparing an enamine of formula (IX): <IMAGE> where R<2> is a carboxylic acid protecting group and R<3> is the residue of a carboxylic acid derived acyl group and where R<5> and R<6> are the same or different C1-4 alkyl or C1-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): <IMAGE> with an amine of formula HNR<5>R<6>, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3- hydroxycephalosporins. The compounds of formula (XII) are novel.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3566879A | 1979-05-03 | 1979-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA06528A true OA06528A (en) | 1981-07-31 |
Family
ID=21884070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA57107A OA06528A (en) | 1979-05-03 | 1980-05-03 | 2-aminoalkyl-5-pyridinols, process for their preparation, pharmaceutical compositions containing these compounds and their therapeutic uses. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0019739B1 (en) |
| JP (1) | JPS55149260A (en) |
| AT (1) | ATE8501T1 (en) |
| DD (1) | DD150461A5 (en) |
| DE (1) | DE3068577D1 (en) |
| DK (1) | DK157540C (en) |
| ES (1) | ES8104229A1 (en) |
| FI (1) | FI70212C (en) |
| GB (1) | GB2050380B (en) |
| GR (1) | GR68206B (en) |
| HU (1) | HU181115B (en) |
| IE (1) | IE49712B1 (en) |
| IL (1) | IL59978A (en) |
| MA (1) | MA18964A1 (en) |
| NO (1) | NO154130C (en) |
| OA (1) | OA06528A (en) |
| PL (1) | PL223984A1 (en) |
| PT (1) | PT71176A (en) |
| ZW (1) | ZW9680A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746670A (en) * | 1986-04-11 | 1988-05-24 | Ciba-Geigy Corporation | Use of 2-aminoalkyl-5-pyridinols as nootropic agents and antidepressants |
| JP4732662B2 (en) * | 2000-04-06 | 2011-07-27 | セイコーインスツル株式会社 | Battery holding structure for electronic watch |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3952101A (en) * | 1975-04-14 | 1976-04-20 | Smithkline Corporation | α-Amino methyl-5-hydroxy-2-pyridinemethanols |
-
1980
- 1980-04-30 AT AT80102347T patent/ATE8501T1/en not_active IP Right Cessation
- 1980-04-30 HU HU80801080A patent/HU181115B/en not_active IP Right Cessation
- 1980-04-30 ZW ZW96/80A patent/ZW9680A1/en unknown
- 1980-04-30 DE DE8080102347T patent/DE3068577D1/en not_active Expired
- 1980-04-30 NO NO801267A patent/NO154130C/en unknown
- 1980-04-30 EP EP80102347A patent/EP0019739B1/en not_active Expired
- 1980-04-30 FI FI801411A patent/FI70212C/en not_active IP Right Cessation
- 1980-04-30 PT PT71176A patent/PT71176A/en unknown
- 1980-04-30 ES ES491055A patent/ES8104229A1/en not_active Expired
- 1980-05-01 IL IL59978A patent/IL59978A/en unknown
- 1980-05-01 DK DK193180A patent/DK157540C/en not_active IP Right Cessation
- 1980-05-02 GR GR61845A patent/GR68206B/el unknown
- 1980-05-02 JP JP5800280A patent/JPS55149260A/en active Granted
- 1980-05-02 MA MA19024A patent/MA18964A1/en unknown
- 1980-05-02 IE IE899/80A patent/IE49712B1/en not_active IP Right Cessation
- 1980-05-02 GB GB8014705A patent/GB2050380B/en not_active Expired
- 1980-05-02 DD DD80220844A patent/DD150461A5/en not_active IP Right Cessation
- 1980-05-03 OA OA57107A patent/OA06528A/en unknown
- 1980-05-03 PL PL22398480A patent/PL223984A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK193180A (en) | 1980-11-04 |
| IE49712B1 (en) | 1985-11-27 |
| EP0019739A1 (en) | 1980-12-10 |
| GB2050380B (en) | 1983-07-20 |
| ATE8501T1 (en) | 1984-08-15 |
| DD150461A5 (en) | 1981-09-02 |
| PT71176A (en) | 1980-05-01 |
| IL59978A (en) | 1984-03-30 |
| FI70212C (en) | 1986-09-15 |
| NO154130C (en) | 1986-07-23 |
| GB2050380A (en) | 1981-01-07 |
| JPS55149260A (en) | 1980-11-20 |
| PL223984A1 (en) | 1981-02-13 |
| DK157540B (en) | 1990-01-22 |
| ZW9680A1 (en) | 1980-11-26 |
| ES491055A0 (en) | 1981-04-01 |
| NO154130B (en) | 1986-04-14 |
| EP0019739B1 (en) | 1984-07-18 |
| FI801411A (en) | 1980-11-04 |
| MA18964A1 (en) | 1980-12-31 |
| FI70212B (en) | 1986-02-28 |
| NO801267L (en) | 1980-11-04 |
| JPS6365662B2 (en) | 1988-12-16 |
| GR68206B (en) | 1981-11-10 |
| IL59978A0 (en) | 1980-07-31 |
| ES8104229A1 (en) | 1981-04-01 |
| DK157540C (en) | 1990-06-11 |
| IE800899L (en) | 1980-11-03 |
| HU181115B (en) | 1983-06-28 |
| DE3068577D1 (en) | 1984-08-23 |
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