DK1556029T3 - Thiomolybdatsalte og anvendelser deraf - Google Patents
Thiomolybdatsalte og anvendelser deraf Download PDFInfo
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- DK1556029T3 DK1556029T3 DK03765973.7T DK03765973T DK1556029T3 DK 1556029 T3 DK1556029 T3 DK 1556029T3 DK 03765973 T DK03765973 T DK 03765973T DK 1556029 T3 DK1556029 T3 DK 1556029T3
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- tetrathiomolybdate
- bis
- compound
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- cancer
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic System
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- C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
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- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
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- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/037—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Claims (12)
1. Thiomolybdatforbindelse, eller et solvat eller hydrat deraf valgt fra gruppen bestående af propan-l,3-bis (trimethylamnnoniunn)tetrathionnolybdat; bis(l-ethyl-3-methyl-l/7-imidazolium)tetrathionnolybdat; bis(trinnethylphenylannnnoniunn)tetrathiomolybdat; bis(tetrapropylammoniunn)tetrathionnolybdat; bis(cholin)tetrathiomolybdat; bis(triethylphenylannnnonium)tetrathiomolybdat; bis(methyltriethylammonium)tetrathiomolybdat; bis(l,l-dimethylpyrrolidinium)-tetrathiomolybdat; bis(trimethylbenzylammonium)tetrathiomolybdat; pentan-l,5-bis (trimethylammonium)tetrathiomolybdat; bis(vinyltrimethylammonium)tetrathiomolybdat; bis(cyclopropylmethyltrimethylammonium)tetrathiomolybdat; hexan-l,6-bis(trimethyl-ammonium)tetrathiomolybdat; bis(acetylcholin)tetrathiomolybdat; bis(l,4-dimethylpyridinium)tetrathiomolybdat; ethylenbis(trimethylammonium)tetra-thiomolybdat; butan-l,4-bis(trimethylammonium)tetrathiomolybdat.
2. Thiomolybdatforbindelse, eller et solvat eller hydrat deraf, ifølge krav 1, der har øget stabilitet under atmosfæriske betingelser som sammenlignet med bis(ammonium)tetrathiomolybdat, valgt fra gruppen bestående af propan-1, 3-bis (trimethylammonium)tetrathiomolybdat; bis(l-ethyl-3-methyl-lH-imidazolium)tetrathio-molybdat; bis(trimethylphenylammonium)tetrathiomolybdat; bis(tetrapropylammonium)tetrathiomolybdat; bis(cholin)tetrathiomolybdat; bis(triethylphenylammonium)tetrathiomolybdat; bis(methyltriethylammonium)tetrathiomolybdat; bis(l,l-dimethylpyrrolidinium)tetra-thiomolybdat; bis(trimethylbenzylammonium)tetrathiomolybdat; pentan-l,5-bis (trimethylammonium)tetrathiomolybdat; bis(vinyltrimethylammonium)tetrathiomolybdat; bis(cyclopropylmethyltrimethylammonium)tetrathiomolybdat; hexan-l,6-bis (trimethylammonium)tetrathiomolybdat.
3. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse som et medikament.
4. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse i en fremgangsmåde til behandling af en sygdom eller tilstand valgt fra gruppen bestående af cancer, våd macula degeneration, rheumatoid arthritis, afvigende vaskularisering, forhøjede kobberniveauer, kobbermetabolismeforstyrrelser, og fedme.
5. Tetrathiomolybdatforbindelsen ifølge krav 4, til anvendelse i en fremgangsmåde til behandling af en cancer valgt fra gruppen bestående af brystcancer, nyrecancer, hjernecancer, tarmcancer, prostatacancer, chondrosarcom, angiosarcom, og lungecarcinom.
6. Tetrathiomolybdatforbindelsen ifølge krav 4, til anvendelse i en fremgangsmåde til behandling af en neurodegerativ sygdom valgt fra gruppen bestående af Alzheimer's sygdom, amyotrof lateral sklerose, og prionsygdom.
7. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse i en fremgangsmåde til behandling af Wilson's sygdom.
8. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse som et medikament i kombination med mindst et andet terapeutisk middel.
9. Tetrathiomolybdatforbindelsen ifølge krav 8, hvor det andet terapeutiske middel er valgt fra kemoterapeutiske midler, antimetabolitter, purinanaloger, naturprodukter, platinkoordineringskomplekser, mitoxantron, hydroxyu ri nstof, procarbazin, hormoner, antagonister, anti-angiogenesemidler, anti-angiogeneseinhibitorer, apoptose-inducerende midler og anti-fedmemidler.
10. Tetrathiomolybdatforbindelsen ifølge et hvilket som helst af kravene 1-9, hvor tetrathiomolybdatforbindelsen er bis(cholin)tetrathiomolybdat.
11. Bis(cholin)tetrathiomolybdat til anvendelse i en fremgangsmåde til behandling af Wilson's sygdom.
12. Thiomolybdatforbindelse valgt fra gruppen bestående af tetrathiomolybdatforbindelser ifølge krav 1 eller 2 til anvendelse i en fremgangsmåde til behandling af det humane eller dyriske legeme, hvor forbindelsen administreres én eller to gange pr. dag ved oral forsinket frigivelses-administration.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/202,346 US20040019043A1 (en) | 2002-07-23 | 2002-07-23 | Thiomolybdate analogues and uses thereof |
US43474202P | 2002-12-18 | 2002-12-18 | |
US43695803A | 2003-05-12 | 2003-05-12 | |
US10/447,585 US7189865B2 (en) | 2002-07-23 | 2003-05-28 | Thiomolybdate analogues and uses thereof |
PCT/US2003/023031 WO2004009034A2 (en) | 2002-07-23 | 2003-07-22 | Thiomolybdate analogues and uses thereof |
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DK1556029T3 true DK1556029T3 (da) | 2014-03-10 |
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DK03765973.7T DK1556029T3 (da) | 2002-07-23 | 2003-07-22 | Thiomolybdatsalte og anvendelser deraf |
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US (1) | US7189865B2 (da) |
EP (1) | EP1556029B1 (da) |
JP (1) | JP2006506466A (da) |
KR (1) | KR20050053596A (da) |
CN (1) | CN100531732C (da) |
AU (1) | AU2003256704A1 (da) |
BR (1) | BR0312851A (da) |
CA (1) | CA2493127A1 (da) |
DK (1) | DK1556029T3 (da) |
EA (1) | EA200500250A1 (da) |
ES (1) | ES2448800T3 (da) |
HR (1) | HRP20050174A2 (da) |
IL (1) | IL166448A0 (da) |
MX (1) | MXPA05000870A (da) |
NO (1) | NO20050917L (da) |
PL (1) | PL374821A1 (da) |
PT (1) | PT1556029E (da) |
SI (1) | SI1556029T1 (da) |
WO (1) | WO2004009034A2 (da) |
Families Citing this family (31)
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EP1115389B1 (en) * | 1998-09-25 | 2014-03-12 | PhilERA New Zealand Limited | Fructosamine oxidase: antagonists and inhibitors |
AU4678300A (en) * | 1999-04-30 | 2000-11-17 | Slil Biomedical Corporation | Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
WO2002038105A2 (en) * | 2000-11-08 | 2002-05-16 | Slil Biomedical Corporation | Novel polyamine analog-amino acid conjugates useful as anticancer agents |
EP1177197B1 (en) * | 1999-04-30 | 2006-08-09 | Cellgate, Inc. | Polyamines and their use in therapy |
CA2458622A1 (en) * | 2001-08-24 | 2003-03-06 | Maine Medical Center Research Institute | Copper-dependent non-traditional pro-inflammatory cytokine export and methods, compositions and kits relating thereto |
AU2002340224B2 (en) * | 2001-10-16 | 2008-11-27 | Progen Pharmaceuticals, Inc | Oligoamine compounds and derivatives thereof for cancer therapy |
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-
2003
- 2003-05-28 US US10/447,585 patent/US7189865B2/en not_active Expired - Lifetime
- 2003-07-22 KR KR1020057001310A patent/KR20050053596A/ko not_active Application Discontinuation
- 2003-07-22 CN CNB038225557A patent/CN100531732C/zh not_active Expired - Lifetime
- 2003-07-22 JP JP2005505545A patent/JP2006506466A/ja active Pending
- 2003-07-22 MX MXPA05000870A patent/MXPA05000870A/es active IP Right Grant
- 2003-07-22 EP EP03765973.7A patent/EP1556029B1/en not_active Expired - Lifetime
- 2003-07-22 EA EA200500250A patent/EA200500250A1/ru unknown
- 2003-07-22 PL PL03374821A patent/PL374821A1/xx not_active Application Discontinuation
- 2003-07-22 AU AU2003256704A patent/AU2003256704A1/en not_active Abandoned
- 2003-07-22 WO PCT/US2003/023031 patent/WO2004009034A2/en active Application Filing
- 2003-07-22 CA CA002493127A patent/CA2493127A1/en not_active Abandoned
- 2003-07-22 ES ES03765973.7T patent/ES2448800T3/es not_active Expired - Lifetime
- 2003-07-22 PT PT37659737T patent/PT1556029E/pt unknown
- 2003-07-22 SI SI200332340T patent/SI1556029T1/sl unknown
- 2003-07-22 BR BR0312851-2A patent/BR0312851A/pt not_active IP Right Cessation
- 2003-07-22 DK DK03765973.7T patent/DK1556029T3/da active
-
2005
- 2005-01-23 IL IL16644805A patent/IL166448A0/xx unknown
- 2005-02-21 NO NO20050917A patent/NO20050917L/no not_active Application Discontinuation
- 2005-02-22 HR HR20050174A patent/HRP20050174A2/hr not_active Application Discontinuation
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EA200500250A1 (ru) | 2005-12-29 |
US7189865B2 (en) | 2007-03-13 |
PL374821A1 (en) | 2005-10-31 |
EP1556029A4 (en) | 2008-06-25 |
MXPA05000870A (es) | 2005-08-29 |
IL166448A0 (en) | 2006-01-15 |
SI1556029T1 (sl) | 2014-06-30 |
JP2006506466A (ja) | 2006-02-23 |
NO20050917L (no) | 2005-04-20 |
CN100531732C (zh) | 2009-08-26 |
US20040019087A1 (en) | 2004-01-29 |
KR20050053596A (ko) | 2005-06-08 |
WO2004009034A3 (en) | 2004-09-10 |
HRP20050174A2 (en) | 2005-10-31 |
ES2448800T3 (es) | 2014-03-17 |
EP1556029A2 (en) | 2005-07-27 |
EP1556029B1 (en) | 2013-11-27 |
CA2493127A1 (en) | 2004-01-29 |
CN1684678A (zh) | 2005-10-19 |
BR0312851A (pt) | 2005-07-12 |
WO2004009034A2 (en) | 2004-01-29 |
PT1556029E (pt) | 2014-03-04 |
AU2003256704A1 (en) | 2004-02-09 |
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