DK1512015T3 - Fremgangsmåder til forbedring af bindingsegenskaber hos et molekyle - Google Patents
Fremgangsmåder til forbedring af bindingsegenskaber hos et molekyleInfo
- Publication number
- DK1512015T3 DK1512015T3 DK03760249T DK03760249T DK1512015T3 DK 1512015 T3 DK1512015 T3 DK 1512015T3 DK 03760249 T DK03760249 T DK 03760249T DK 03760249 T DK03760249 T DK 03760249T DK 1512015 T3 DK1512015 T3 DK 1512015T3
- Authority
- DK
- Denmark
- Prior art keywords
- molecule
- methods
- improving
- binding properties
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38838602P | 2002-06-12 | 2002-06-12 | |
| PCT/US2003/018187 WO2003107009A2 (en) | 2002-06-12 | 2003-06-09 | Methods for improving a binding characteristic of a molecule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1512015T3 true DK1512015T3 (da) | 2009-07-06 |
Family
ID=29736463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03760249T DK1512015T3 (da) | 2002-06-12 | 2003-06-09 | Fremgangsmåder til forbedring af bindingsegenskaber hos et molekyle |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060088838A1 (de) |
| EP (2) | EP2107116A3 (de) |
| AT (1) | ATE426815T1 (de) |
| AU (1) | AU2003248652A1 (de) |
| CA (1) | CA2489022C (de) |
| DE (1) | DE60326839D1 (de) |
| DK (1) | DK1512015T3 (de) |
| WO (1) | WO2003107009A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1942203A (zh) * | 2004-06-04 | 2007-04-04 | 金克克国际有限公司 | 使用抗体重链的筛选方法 |
| WO2006116076A2 (en) | 2005-04-28 | 2006-11-02 | Genencor International, Inc. | Tab molecules |
| EP4238993A3 (de) | 2008-04-11 | 2023-11-29 | Chugai Seiyaku Kabushiki Kaisha | Antigenbindendes molekül zur wiederholten bindung an zwei oder mehr antigenmoleküle |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| SG190727A1 (en) | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| KR102147548B1 (ko) | 2011-02-25 | 2020-08-24 | 추가이 세이야쿠 가부시키가이샤 | ＦｃγＲＩＩｂ 특이적 Ｆｃ 항체 |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| EP3517550A1 (de) | 2011-11-30 | 2019-07-31 | Chugai Seiyaku Kabushiki Kaisha | Arzneimittelhaltiger träger in zellen zur bildung eines immunkomplexes |
| LT2825036T (lt) | 2012-03-16 | 2018-07-10 | Regeneron Pharmaceuticals, Inc. | Histidino pakeitimus lengvoje grandinėje turintys antikūnai ir genetiškai modifikuoti graužikai, išvesti ju gamybai |
| RS59076B1 (sr) | 2012-03-16 | 2019-09-30 | Regeneron Pharma | Glodari koji eksprimiraju imunoglobulinske sekvence senzitivne na ph |
| TWI808330B (zh) | 2014-12-19 | 2023-07-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
| SG11201607165YA (en) | 2014-12-19 | 2016-09-29 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
| TW202248212A (zh) | 2015-02-05 | 2022-12-16 | 日商中外製藥股份有限公司 | 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途 |
| TW202339800A (zh) | 2015-02-27 | 2023-10-16 | 日商中外製藥股份有限公司 | Il-6受體抗體用於製備醫藥組成物的用途 |
| EP3394098A4 (de) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin-antikörper und verfahren zur verwendung |
| EP3494991A4 (de) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Zusammensetzung zur vorbeugung oder behandlung von erkrankungen im zusammenhang mit il-8 |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2207301A (en) | 1937-05-15 | 1940-07-09 | Nat Electric Prod Corp | Underfloor duct |
| US2209701A (en) | 1938-03-08 | 1940-07-30 | Andrew J Mcgann | Device for cutting or scoring necks of bottles |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US5200313A (en) * | 1983-08-05 | 1993-04-06 | Miles Inc. | Nucleic acid hybridization assay employing detectable anti-hybrid antibodies |
| US4711845A (en) | 1984-08-31 | 1987-12-08 | Cetus Corporation | Portable temperature-sensitive control cassette |
| US4666848A (en) | 1984-08-31 | 1987-05-19 | Cetus Corporation | Polypeptide expression using a portable temperature sensitive control cassette with a positive retroregulatory element |
| EP0196864A3 (de) | 1985-03-25 | 1988-03-23 | Cetus Corporation | Behandlung und Sekretion von rekombinanten Proteinen mittels alkalischer Phosphatase, dazu verwendbare DNA-Sequenzen und mittels dieser Sequenzen transformierte Zellen |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5677136A (en) | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
| EP2369007B1 (de) * | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Erkennung von Nukleinsäuresequenz-Unterschieden mittels der gleichzeitigen Ligaseerkennungs- und Polymerasekettenreaktion |
| JP3935509B2 (ja) * | 1997-02-12 | 2007-06-27 | ワイ． チャン，ユージーン | ポリマー分析のための方法および製品 |
| AU2002351193A1 (en) * | 2001-11-28 | 2003-06-10 | Mj Bioworks Incorporated | Parallel polymorphism scoring by amplification and error correction |
| WO2004031408A1 (en) * | 2002-09-30 | 2004-04-15 | F.Hoffmann-La Roche Ag | Oligonucleotides for genotyping thymidylate synthase gene |
| US7354706B2 (en) * | 2003-09-09 | 2008-04-08 | The Regents Of The University Of Colorado, A Body Corporate | Use of photopolymerization for amplification and detection of a molecular recognition event |
| WO2005047521A2 (en) * | 2003-11-10 | 2005-05-26 | Investigen, Inc. | Methods of preparing nucleic acid for detection |
-
2003
- 2003-06-09 CA CA2489022A patent/CA2489022C/en not_active Expired - Fee Related
- 2003-06-09 DK DK03760249T patent/DK1512015T3/da active
- 2003-06-09 DE DE60326839T patent/DE60326839D1/de not_active Expired - Lifetime
- 2003-06-09 EP EP09001498A patent/EP2107116A3/de not_active Withdrawn
- 2003-06-09 AT AT03760249T patent/ATE426815T1/de not_active IP Right Cessation
- 2003-06-09 AU AU2003248652A patent/AU2003248652A1/en not_active Abandoned
- 2003-06-09 WO PCT/US2003/018187 patent/WO2003107009A2/en not_active Application Discontinuation
- 2003-06-09 EP EP03760249A patent/EP1512015B1/de not_active Expired - Lifetime
- 2003-06-09 US US10/514,446 patent/US20060088838A1/en not_active Abandoned
-
2007
- 2007-12-18 US US11/958,592 patent/US20080146456A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1512015B1 (de) | 2009-03-25 |
| WO2003107009A3 (en) | 2004-04-15 |
| DE60326839D1 (de) | 2009-05-07 |
| US20060088838A1 (en) | 2006-04-27 |
| US20080146456A1 (en) | 2008-06-19 |
| CA2489022A1 (en) | 2003-12-24 |
| EP2107116A3 (de) | 2009-12-09 |
| AU2003248652A1 (en) | 2003-12-31 |
| CA2489022C (en) | 2012-10-16 |
| EP2107116A2 (de) | 2009-10-07 |
| WO2003107009A2 (en) | 2003-12-24 |
| EP1512015A2 (de) | 2005-03-09 |
| ATE426815T1 (de) | 2009-04-15 |
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