DK1492881T3 - Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanaler - Google Patents
Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanalerInfo
- Publication number
- DK1492881T3 DK1492881T3 DK03727297T DK03727297T DK1492881T3 DK 1492881 T3 DK1492881 T3 DK 1492881T3 DK 03727297 T DK03727297 T DK 03727297T DK 03727297 T DK03727297 T DK 03727297T DK 1492881 T3 DK1492881 T3 DK 1492881T3
- Authority
- DK
- Denmark
- Prior art keywords
- light
- controlled ion
- direct light
- ion channels
- biological
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/405—Assays involving biological materials from specific organisms or of a specific nature from algae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Magnetic Treatment Devices (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10216005A DE10216005A1 (de) | 2002-04-11 | 2002-04-11 | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
PCT/EP2003/003799 WO2003084994A2 (fr) | 2002-04-11 | 2003-04-11 | Utilisation de photorecepteurs biologiques comme canaux ioniques commandes directement par la lumiere |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1492881T3 true DK1492881T3 (da) | 2009-02-16 |
Family
ID=28684950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03727297T DK1492881T3 (da) | 2002-04-11 | 2003-04-11 | Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanaler |
Country Status (8)
Country | Link |
---|---|
US (3) | US7824869B2 (fr) |
EP (2) | EP2055714B1 (fr) |
AT (1) | ATE412063T1 (fr) |
AU (1) | AU2003233968A1 (fr) |
DE (2) | DE10216005A1 (fr) |
DK (1) | DK1492881T3 (fr) |
ES (1) | ES2315495T3 (fr) |
WO (1) | WO2003084994A2 (fr) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10216005A1 (de) * | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
US20090093403A1 (en) | 2007-03-01 | 2009-04-09 | Feng Zhang | Systems, methods and compositions for optical stimulation of target cells |
US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
WO2007024391A2 (fr) * | 2005-07-22 | 2007-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Canaux cationiques activees par la lumiere et leurs utilisations |
US20190321651A1 (en) * | 2005-07-22 | 2019-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | System for Optical Stimulation of Target Cells |
US8926959B2 (en) * | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
JP2009536219A (ja) * | 2006-05-04 | 2009-10-08 | ウェイン・ステート・ユニバーシティー | ロドプシン拡散のインビボ送達による視覚応答の回復 |
EP1891976A1 (fr) * | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Usage des genes sensibles à la lumière |
US8398692B2 (en) | 2007-01-10 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
WO2008101128A1 (fr) * | 2007-02-14 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Système, procédé et applications comprenant l'identification de circuits biologiques tels que des caractéristiques neurologiques |
US8910638B2 (en) | 2007-05-09 | 2014-12-16 | Massachusetts Institute Of Technology | Methods and apparatus for high-throughput neural screening |
US20140324138A1 (en) * | 2007-05-09 | 2014-10-30 | Massachusetts Institute Of Technology | Wirelessly-powered illumination of biological tissue |
US9138596B2 (en) * | 2007-08-22 | 2015-09-22 | Cardiac Pacemakers, Inc. | Optical depolarization of cardiac tissue |
US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
PT2271369E (pt) | 2008-04-18 | 2014-07-10 | Novartis Forschungsstiftung | Novas ferramentas terapêuticas e métodos para tratar a cegueira |
DE102008020152B4 (de) * | 2008-04-22 | 2012-04-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
BRPI0911448A2 (pt) | 2008-04-23 | 2019-02-26 | The Board Of Trustees For The Leland Stanford Junior University | sistemas, métodos e composições para simulação óticas de células alvo |
WO2010011404A2 (fr) | 2008-05-20 | 2010-01-28 | Eos Neuroscience, Inc. | Vecteurs pour la délivrance de protéines photosensibles et procédés d’utilisation |
CN102076866A (zh) | 2008-05-29 | 2011-05-25 | 利兰·斯坦福青年大学托管委员会 | 光学控制第二信使的细胞系、系统和方法 |
SG191604A1 (en) | 2008-06-17 | 2013-07-31 | Univ Leland Stanford Junior | Apparatus and methods for controlling cellular development |
JP2011525130A (ja) | 2008-06-17 | 2011-09-15 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | 光伝送素子を用いた標的細胞の光刺激のための方法、システム、および装置 |
US9101759B2 (en) | 2008-07-08 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
WO2011116238A2 (fr) | 2010-03-17 | 2011-09-22 | The Board Of Trustees Of The Leland Stanford Junior University. | Molécules laissant passer les ions sensibles à la lumière |
WO2011127088A2 (fr) | 2010-04-05 | 2011-10-13 | Eos Neuroscience, Inc. | Procédés et compositions destinés à diminuer la douleur chronique |
US9453241B2 (en) | 2010-05-04 | 2016-09-27 | Wayne State University | AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
US9207237B2 (en) | 2010-08-23 | 2015-12-08 | President And Fellows Of Harvard College | Systems, methods, and workflows for optogenetics analysis |
WO2012027358A1 (fr) | 2010-08-23 | 2012-03-01 | President And Fellows Of Harvard College | Sondes optogénétiques pour mesurer le potentiel de membrane |
RU2595384C2 (ru) | 2010-09-08 | 2016-08-27 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Мутантный канальный родопсин-2 |
US20140099284A1 (en) | 2010-10-15 | 2014-04-10 | Eos Neuroscience, Inc | Modulation neural pathways |
ES2684307T3 (es) | 2010-11-05 | 2018-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Proteínas estabilizadas de tipo opsina de función escalonada y métodos de uso de las mismas |
AU2011323235B2 (en) | 2010-11-05 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of reward-related behaviors |
CN106106368A (zh) | 2010-11-05 | 2016-11-16 | 斯坦福大学托管董事会 | 光控cns功能障碍 |
ES2661093T3 (es) | 2010-11-05 | 2018-03-27 | The Board Of Trustees Of The University Of The Leland Stanford Junior University | Control y caracterización de la función de la memoria |
JP6145043B2 (ja) | 2010-11-05 | 2017-06-07 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 光遺伝的方法で使用するための光の上方変換 |
AU2011323226B2 (en) * | 2010-11-05 | 2015-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
US20120214188A1 (en) * | 2010-11-12 | 2012-08-23 | Nathan Klapoetke | Light-activated ion channel molecules and uses thereof |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
US8973531B2 (en) * | 2010-12-09 | 2015-03-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Automated continuous zooplankton culture system |
SI3693025T1 (sl) | 2011-04-22 | 2022-04-29 | The Regents Of The University Of California | Virioni adeno-povezanega virusa z varianto kapsida in postopki za njihovo uporabo |
US9163094B2 (en) | 2011-09-27 | 2015-10-20 | Massachusetts Institute Of Technology | Light-activated fusion proteins and uses therefor |
ES2801679T3 (es) * | 2011-11-12 | 2021-01-12 | Massachusetts Inst Technology | Canalrodopsinas para el control óptico de células |
JP6406581B2 (ja) | 2011-12-16 | 2018-10-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | オプシンポリペプチドおよびその使用法 |
ES2728077T3 (es) | 2012-02-21 | 2019-10-22 | Univ Leland Stanford Junior | Composiciones para el tratamiento de trastornos neurogénicos del suelo pélvico |
ES2703324T3 (es) | 2012-03-05 | 2019-03-08 | Univ Wayne State | Identificación de mutaciones de canalrodopsina-2 (Chop2) y métodos de uso |
AU2014227600B2 (en) | 2013-03-15 | 2018-10-04 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of behavioral state |
US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
EP2991491B1 (fr) | 2013-04-29 | 2019-12-25 | The Board of Trustees of the Leland Stanford Junior University | Dispositifs, systèmes et procédés pour la modulation optogénétique de potentiels d'action dans des cellules cibles |
EP3033427A4 (fr) | 2013-08-14 | 2017-05-31 | The Board Of Trustees Of The University Of the Leland Stanford Junior University | Compositions et procédés pour réguler une douleur |
EP3102290A1 (fr) | 2014-02-07 | 2016-12-14 | Massachusetts Institute Of Technology | Molécules de canaux ioniques activés par la lumière bleue et utilisations de celles-ci |
CA2946514C (fr) | 2014-04-22 | 2023-08-29 | Q-State Biosciences, Inc. | Analyse optogenetique de composes |
WO2015195769A2 (fr) | 2014-06-18 | 2015-12-23 | President And Fellows Of Harvard College | Sondes optogénétiques pour mesurer un potentiel membranaire |
US10882892B2 (en) | 2014-08-05 | 2021-01-05 | Massachusetts Institute Of Technology | Channelrhodopsin variants and uses thereof |
WO2016115333A1 (fr) | 2015-01-15 | 2016-07-21 | President And Fellows Of Harvard College | Sélection des cellules par voie optique |
US10048275B2 (en) | 2015-03-13 | 2018-08-14 | Q-State Biosciences, Inc. | Cardiotoxicity screening methods |
US10519205B2 (en) | 2015-03-19 | 2019-12-31 | The Board Of Regents Of The University Of Texas System | Compositions and methods for use of anion channel rhodopsins |
CA2986583A1 (fr) | 2015-05-21 | 2016-11-24 | Q-State Biosciences, Inc. | Microscope optogenetique |
WO2016209654A1 (fr) | 2015-06-22 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Procédés et dispositifs pour l'imagerie et/ou la commande optogénétique de neurones réagissant à la lumière |
EP4119667A1 (fr) | 2015-09-15 | 2023-01-18 | Friedrich Miescher Institute for Biomedical Research | Nouveaux outils et procédés thérapeutiques pour le traitement de la cécité par ciblage de photorécepteurs |
CA3025975A1 (fr) | 2016-04-29 | 2017-11-02 | Gensight Biologics Sa | Restauration visuelle optogenetique a l'aide de chrimson |
EP3458476A1 (fr) | 2016-05-17 | 2019-03-27 | Friedrich Miescher Institute for Biomedical Research | Nouveaux outils thérapeutiques et méthodes de traitement de la cécité |
CN109476720A (zh) * | 2016-06-03 | 2019-03-15 | 马克斯-普朗克科学促进协会 | 通道视紫红质的突变型光诱导离子通道 |
JP7175880B2 (ja) * | 2016-06-03 | 2022-11-21 | マックス-プランク-ゲゼルシャフト ツア フェルデルンク デア ヴィッセンシャフテン エー.ファウ. | Chrimsonの変異型光誘導性イオンチャネル |
WO2018134168A1 (fr) | 2017-01-17 | 2018-07-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés d'expression d'un polynucléotide d'intérêt dans les photorécepteurs à cônes |
US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
CN111867635A (zh) | 2017-10-20 | 2020-10-30 | 法国国家卫生及研究医学协会 | 包括视网膜下递送治疗有效量的重组aav9衍生载体的在对象的视锥细胞光感受器中表达目的多核苷酸的方法 |
KR102048458B1 (ko) * | 2018-01-26 | 2019-11-25 | 한국과학기술연구원 | 테트라셀미스를 포함하는 눈 건강 개선용 조성물 |
EP4223768A1 (fr) | 2022-02-04 | 2023-08-09 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Nouveau canal mutant de type bactériorhodopsine canal ionique de type rhodopsine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2580277B1 (fr) * | 1985-04-15 | 1988-06-10 | Oreal | Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant |
US5041224A (en) * | 1988-03-28 | 1991-08-20 | Canon Kabushiki Kaisha | Ion permeable membrane and ion transport method by utilizing said membrane |
JP3128386B2 (ja) | 1993-04-07 | 2001-01-29 | 三洋電機株式会社 | 神経モデル素子 |
US7144733B2 (en) * | 2001-08-16 | 2006-12-05 | Sloan-Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
DE10216005A1 (de) * | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
-
2002
- 2002-04-11 DE DE10216005A patent/DE10216005A1/de not_active Ceased
-
2003
- 2003-04-11 US US10/510,628 patent/US7824869B2/en active Active
- 2003-04-11 ES ES03727297T patent/ES2315495T3/es not_active Expired - Lifetime
- 2003-04-11 WO PCT/EP2003/003799 patent/WO2003084994A2/fr not_active Application Discontinuation
- 2003-04-11 DE DE50310674T patent/DE50310674D1/de not_active Expired - Lifetime
- 2003-04-11 AU AU2003233968A patent/AU2003233968A1/en not_active Abandoned
- 2003-04-11 DK DK03727297T patent/DK1492881T3/da active
- 2003-04-11 AT AT03727297T patent/ATE412063T1/de active
- 2003-04-11 EP EP08016563.2A patent/EP2055714B1/fr not_active Expired - Lifetime
- 2003-04-11 EP EP03727297A patent/EP1492881B1/fr not_active Expired - Lifetime
-
2010
- 2010-05-18 US US12/781,962 patent/US8202699B2/en not_active Expired - Fee Related
-
2012
- 2012-04-23 US US13/453,154 patent/US8647870B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7824869B2 (en) | 2010-11-02 |
US20050202398A1 (en) | 2005-09-15 |
EP2055714B1 (fr) | 2014-05-07 |
EP1492881A2 (fr) | 2005-01-05 |
WO2003084994A3 (fr) | 2004-02-05 |
EP2055714A3 (fr) | 2009-08-12 |
ES2315495T3 (es) | 2009-04-01 |
ATE412063T1 (de) | 2008-11-15 |
WO2003084994A2 (fr) | 2003-10-16 |
US8202699B2 (en) | 2012-06-19 |
US8647870B2 (en) | 2014-02-11 |
AU2003233968A8 (en) | 2003-10-20 |
AU2003233968A1 (en) | 2003-10-20 |
US20130017597A1 (en) | 2013-01-17 |
US20110086421A1 (en) | 2011-04-14 |
EP2055714A2 (fr) | 2009-05-06 |
DE50310674D1 (de) | 2008-12-04 |
EP1492881B1 (fr) | 2008-10-22 |
DE10216005A1 (de) | 2003-10-30 |
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