DK147918C - METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF - Google Patents

METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Info

Publication number
DK147918C
DK147918C DK169478A DK169478A DK147918C DK 147918 C DK147918 C DK 147918C DK 169478 A DK169478 A DK 169478A DK 169478 A DK169478 A DK 169478A DK 147918 C DK147918 C DK 147918C
Authority
DK
Denmark
Prior art keywords
alfa1
thymosine
analogue
preparation
acceptable salts
Prior art date
Application number
DK169478A
Other languages
Danish (da)
Other versions
DK169478A (en
DK147918B (en
Inventor
Su-Sun Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/871,563 external-priority patent/US4116951A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK169478A publication Critical patent/DK169478A/en
Publication of DK147918B publication Critical patent/DK147918B/en
Application granted granted Critical
Publication of DK147918C publication Critical patent/DK147918C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK169478A 1977-04-22 1978-04-18 METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF DK147918C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78989877A 1977-04-22 1977-04-22
US78989877 1977-04-22
US87156378 1978-01-23
US05/871,563 US4116951A (en) 1977-04-22 1978-01-23 [Asn2 ]-thymosin α1 and analogs thereof

Publications (3)

Publication Number Publication Date
DK169478A DK169478A (en) 1978-10-23
DK147918B DK147918B (en) 1985-01-07
DK147918C true DK147918C (en) 1985-08-19

Family

ID=27120967

Family Applications (1)

Application Number Title Priority Date Filing Date
DK169478A DK147918C (en) 1977-04-22 1978-04-18 METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Country Status (18)

Country Link
JP (1) JPS53137914A (en)
AT (1) AT364470B (en)
CA (1) CA1113088A (en)
CH (3) CH641152A5 (en)
DE (1) DE2817082A1 (en)
DK (1) DK147918C (en)
ES (1) ES469016A1 (en)
FI (1) FI781241A (en)
FR (2) FR2401134A1 (en)
GB (1) GB1590668A (en)
GR (1) GR71886B (en)
HU (1) HU180783B (en)
IT (1) IT1113134B (en)
LU (1) LU79488A1 (en)
NL (1) NL7804364A (en)
NO (2) NO781404L (en)
PT (1) PT67937B (en)
SE (1) SE447262B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
DE2919592A1 (en) * 1979-05-15 1981-01-15 Max Planck Gesellschaft METHOD FOR PRODUCING THYMOSINE ALPHA 1 AND DERIVATIVES THEREOF
EP0033384B1 (en) * 1980-01-18 1984-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Medicaments containing fragments of thymosin-alpha-1 with immunostimulating activity, and thymosin-alpha-1 fragments
US4339427A (en) * 1980-04-14 1982-07-13 Hoffmann-La Roche Inc. Radioimmunoassay of thymosinα
EP0056594B1 (en) * 1981-01-14 1984-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1 fragments and pharmaceutical compositions with immunoregulating action containing them
CN1058500C (en) * 1993-02-03 2000-11-15 施塞克龙药品公司 Thymosin alpha-1 derivatives
US6262230B1 (en) * 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1

Also Published As

Publication number Publication date
FR2401134A1 (en) 1979-03-23
DK169478A (en) 1978-10-23
FR2405926B1 (en) 1983-09-09
GR71886B (en) 1983-08-04
ATA286178A (en) 1981-03-15
IT7822629A0 (en) 1978-04-21
FR2401134B1 (en) 1983-09-30
NO148924C (en) 1984-01-11
LU79488A1 (en) 1979-05-25
FI781241A (en) 1978-10-23
CH640218A5 (en) 1983-12-30
GB1590668A (en) 1981-06-03
IT1113134B (en) 1986-01-20
DE2817082A1 (en) 1978-11-02
FR2405926A1 (en) 1979-05-11
JPS53137914A (en) 1978-12-01
HU180783B (en) 1983-04-29
AT364470B (en) 1981-10-27
PT67937B (en) 1980-04-07
SE447262B (en) 1986-11-03
NO148924B (en) 1983-10-03
DK147918B (en) 1985-01-07
ES469016A1 (en) 1980-01-01
CA1113088A (en) 1981-11-24
SE7804612L (en) 1978-12-20
NL7804364A (en) 1978-10-24
NO781404L (en) 1978-10-24
CH641153A5 (en) 1984-02-15
PT67937A (en) 1978-05-01
NO821608L (en) 1978-10-24
CH641152A5 (en) 1984-02-15

Similar Documents

Publication Publication Date Title
DK149449C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF CARBOSTYRIC DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK152753C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2-HYDROXYMETHYL-3,4,5-TRIHYDROXYPIPERIDE INGREDIENTS OR PHARMACEUTICAL ACCEPTABLE SALTS OR STEREOISOMERS THEREOF
DK145339C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-5-HEXENIC ACID OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK152495C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N2-ARYLSULPHONYL-L-ARGININAMIDES OR PHARMACEUTICAL TOLERABLE SALTS THEREOF
DK163244C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 7-OE2- (2-AMINOTHIAZOL-4-YL) -2-OXYIMINO-ACETAMIDOAA-CEPH-3-EM-4-CARBOXYLIC ACID DERIVATIVES OR PHYSIOLOGICALLY ACCEPTABLE SALTS
DK152114C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF PROPENYLAMINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK161968C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZO-PYRAZOLO-PYRIMIDINES OR PHARMACEUTICAL ACCEPTABLE SALTS
DK146160C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N- (5-TETRAZOLYL) -4-OXO-4H-PYRIMIDO (2,1-B) BENZOTHIAZOL-3-CARBOXAMIDES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK158658C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 9-AMINOAL COOLFluorens OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK155670C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF SESQUITER PENDING DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK161699C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-ARYL-4-PIPERIDINE CARBINOLS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK150196C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 0- (3-AMINO-2-HYDROXYPROPYL) AMIDOXIME DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK145263C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZOTHIAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK151805C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 20,21-DI-NOR-EBURNAMENIN DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ADDITIONAL SALTS THEREOF
DK149611C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF TRH-ANALOGUE TRIPEPTIDAMIDES OR THERAPEUTICALLY ACCEPTABLE COMPLEXES OR SALTS THEREOF
DK152208C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2-PHENYLAMINO-PHENYLEDIC ACETIC ACID AMOIDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK147918C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK144033C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF L-3- (3,4-DIHYDROXY-PHENYL) -2-METHYL-ALANINE PEPTIDES OR PHARMACOLOGICAL ACCEPTABLE SALTS THEREOF
DK162102C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 3-O- (BETA-D-GLUCORONOPYRANOSYL) -SOJASAPOGENOL B OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK149093C (en) METHOD OF ANALOGUE FOR PREPARING PENTAPEPTIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK148019C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2-PYRIDYLAMINOBENOIC ACIDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK232677A (en) PROCEDURE FOR THE PREPARATION OF DIHYDRO OR TETRAHYDROIMINOTHIAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK150521C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N2-ARYLSULPHONYL-L-ARGININAMIDES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK164169C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 7-ALFA METHOXYCEPHALOSPORINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF AND AN INTERMEDIATE USE FOR USE THEREOF
DK232877A (en) PROCEDURE FOR THE PREPARATION OF 2-IMINO-3-AMINOTHIAZOLIDINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Legal Events

Date Code Title Description
PBP Patent lapsed
B1 Patent granted (law 1993)
PBP Patent lapsed