IT1113134B - PROCEDURE FOR THE PREPARATION OF THYMINE ALPHA-1 AND ANALOGUE - Google Patents

PROCEDURE FOR THE PREPARATION OF THYMINE ALPHA-1 AND ANALOGUE

Info

Publication number
IT1113134B
IT1113134B IT22629/78A IT2262978A IT1113134B IT 1113134 B IT1113134 B IT 1113134B IT 22629/78 A IT22629/78 A IT 22629/78A IT 2262978 A IT2262978 A IT 2262978A IT 1113134 B IT1113134 B IT 1113134B
Authority
IT
Italy
Prior art keywords
thymine
analogue
alpha
procedure
preparation
Prior art date
Application number
IT22629/78A
Other languages
Italian (it)
Other versions
IT7822629A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/871,563 external-priority patent/US4116951A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IT7822629A0 publication Critical patent/IT7822629A0/en
Application granted granted Critical
Publication of IT1113134B publication Critical patent/IT1113134B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT22629/78A 1977-04-22 1978-04-21 PROCEDURE FOR THE PREPARATION OF THYMINE ALPHA-1 AND ANALOGUE IT1113134B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78989877A 1977-04-22 1977-04-22
US05/871,563 US4116951A (en) 1977-04-22 1978-01-23 [Asn2 ]-thymosin α1 and analogs thereof

Publications (2)

Publication Number Publication Date
IT7822629A0 IT7822629A0 (en) 1978-04-21
IT1113134B true IT1113134B (en) 1986-01-20

Family

ID=27120967

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22629/78A IT1113134B (en) 1977-04-22 1978-04-21 PROCEDURE FOR THE PREPARATION OF THYMINE ALPHA-1 AND ANALOGUE

Country Status (18)

Country Link
JP (1) JPS53137914A (en)
AT (1) AT364470B (en)
CA (1) CA1113088A (en)
CH (3) CH641152A5 (en)
DE (1) DE2817082A1 (en)
DK (1) DK147918C (en)
ES (1) ES469016A1 (en)
FI (1) FI781241A (en)
FR (2) FR2401134A1 (en)
GB (1) GB1590668A (en)
GR (1) GR71886B (en)
HU (1) HU180783B (en)
IT (1) IT1113134B (en)
LU (1) LU79488A1 (en)
NL (1) NL7804364A (en)
NO (2) NO781404L (en)
PT (1) PT67937B (en)
SE (1) SE447262B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
DE2919592A1 (en) * 1979-05-15 1981-01-15 Max Planck Gesellschaft METHOD FOR PRODUCING THYMOSINE ALPHA 1 AND DERIVATIVES THEREOF
EP0033384B1 (en) * 1980-01-18 1984-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Medicaments containing fragments of thymosin-alpha-1 with immunostimulating activity, and thymosin-alpha-1 fragments
US4339427A (en) * 1980-04-14 1982-07-13 Hoffmann-La Roche Inc. Radioimmunoassay of thymosinα
EP0056594B1 (en) * 1981-01-14 1984-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1 fragments and pharmaceutical compositions with immunoregulating action containing them
CN1058500C (en) * 1993-02-03 2000-11-15 施塞克龙药品公司 Thymosin alpha-1 derivatives
US6262230B1 (en) * 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1

Also Published As

Publication number Publication date
NL7804364A (en) 1978-10-24
DK147918C (en) 1985-08-19
FR2405926A1 (en) 1979-05-11
DK169478A (en) 1978-10-23
CH641152A5 (en) 1984-02-15
NO148924C (en) 1984-01-11
SE447262B (en) 1986-11-03
AT364470B (en) 1981-10-27
PT67937B (en) 1980-04-07
IT7822629A0 (en) 1978-04-21
ES469016A1 (en) 1980-01-01
JPS53137914A (en) 1978-12-01
CA1113088A (en) 1981-11-24
DK147918B (en) 1985-01-07
NO148924B (en) 1983-10-03
DE2817082A1 (en) 1978-11-02
FI781241A (en) 1978-10-23
FR2401134B1 (en) 1983-09-30
CH641153A5 (en) 1984-02-15
HU180783B (en) 1983-04-29
CH640218A5 (en) 1983-12-30
GB1590668A (en) 1981-06-03
SE7804612L (en) 1978-12-20
FR2405926B1 (en) 1983-09-09
FR2401134A1 (en) 1979-03-23
GR71886B (en) 1983-08-04
NO781404L (en) 1978-10-24
NO821608L (en) 1978-10-24
PT67937A (en) 1978-05-01
ATA286178A (en) 1981-03-15
LU79488A1 (en) 1979-05-25

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