DK169478A - PROCEDURE FOR THE PREPARATION OF THYMOSIN ALFA1 AND AN ANALOG - Google Patents

PROCEDURE FOR THE PREPARATION OF THYMOSIN ALFA1 AND AN ANALOG

Info

Publication number
DK169478A
DK169478A DK169478A DK169478A DK169478A DK 169478 A DK169478 A DK 169478A DK 169478 A DK169478 A DK 169478A DK 169478 A DK169478 A DK 169478A DK 169478 A DK169478 A DK 169478A
Authority
DK
Denmark
Prior art keywords
alfa1
thymosin
analog
procedure
preparation
Prior art date
Application number
DK169478A
Other languages
Danish (da)
Other versions
DK147918B (en
DK147918C (en
Inventor
S S Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/871,563 external-priority patent/US4116951A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK169478A publication Critical patent/DK169478A/en
Publication of DK147918B publication Critical patent/DK147918B/en
Application granted granted Critical
Publication of DK147918C publication Critical patent/DK147918C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK169478A 1977-04-22 1978-04-18 METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF DK147918C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78989877A 1977-04-22 1977-04-22
US78989877 1977-04-22
US87156378 1978-01-23
US05/871,563 US4116951A (en) 1977-04-22 1978-01-23 [Asn2 ]-thymosin α1 and analogs thereof

Publications (3)

Publication Number Publication Date
DK169478A true DK169478A (en) 1978-10-23
DK147918B DK147918B (en) 1985-01-07
DK147918C DK147918C (en) 1985-08-19

Family

ID=27120967

Family Applications (1)

Application Number Title Priority Date Filing Date
DK169478A DK147918C (en) 1977-04-22 1978-04-18 METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Country Status (18)

Country Link
JP (1) JPS53137914A (en)
AT (1) AT364470B (en)
CA (1) CA1113088A (en)
CH (3) CH641152A5 (en)
DE (1) DE2817082A1 (en)
DK (1) DK147918C (en)
ES (1) ES469016A1 (en)
FI (1) FI781241A (en)
FR (2) FR2401134A1 (en)
GB (1) GB1590668A (en)
GR (1) GR71886B (en)
HU (1) HU180783B (en)
IT (1) IT1113134B (en)
LU (1) LU79488A1 (en)
NL (1) NL7804364A (en)
NO (2) NO781404L (en)
PT (1) PT67937B (en)
SE (1) SE447262B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
DE2919592A1 (en) * 1979-05-15 1981-01-15 Max Planck Gesellschaft METHOD FOR PRODUCING THYMOSINE ALPHA 1 AND DERIVATIVES THEREOF
EP0033384B1 (en) * 1980-01-18 1984-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Medicaments containing fragments of thymosin-alpha-1 with immunostimulating activity, and thymosin-alpha-1 fragments
US4339427A (en) * 1980-04-14 1982-07-13 Hoffmann-La Roche Inc. Radioimmunoassay of thymosinα
EP0056594B1 (en) * 1981-01-14 1984-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1 fragments and pharmaceutical compositions with immunoregulating action containing them
CN1058500C (en) * 1993-02-03 2000-11-15 施塞克龙药品公司 Thymosin alpha-1 derivatives
US6262230B1 (en) * 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1

Also Published As

Publication number Publication date
ATA286178A (en) 1981-03-15
IT7822629A0 (en) 1978-04-21
PT67937B (en) 1980-04-07
JPS53137914A (en) 1978-12-01
CA1113088A (en) 1981-11-24
CH641153A5 (en) 1984-02-15
SE447262B (en) 1986-11-03
DK147918B (en) 1985-01-07
FR2401134B1 (en) 1983-09-30
NO821608L (en) 1978-10-24
GR71886B (en) 1983-08-04
NO148924B (en) 1983-10-03
GB1590668A (en) 1981-06-03
DE2817082A1 (en) 1978-11-02
NO148924C (en) 1984-01-11
SE7804612L (en) 1978-12-20
DK147918C (en) 1985-08-19
LU79488A1 (en) 1979-05-25
NL7804364A (en) 1978-10-24
FI781241A (en) 1978-10-23
FR2401134A1 (en) 1979-03-23
FR2405926A1 (en) 1979-05-11
NO781404L (en) 1978-10-24
IT1113134B (en) 1986-01-20
PT67937A (en) 1978-05-01
AT364470B (en) 1981-10-27
HU180783B (en) 1983-04-29
ES469016A1 (en) 1980-01-01
FR2405926B1 (en) 1983-09-09
CH640218A5 (en) 1983-12-30
CH641152A5 (en) 1984-02-15

Similar Documents

Publication Publication Date Title
DK3880A (en) PROCEDURE FOR THE PREPARATION OF PEPTIDYLARGININAL HYDINAL DERIVATIVES AND THEIR USE
DK353378A (en) PROCEDURE FOR THE PREPARATION OF PHOSPHONOACYL PROLINES AND RELATED PARTICULARS
DK173778A (en) PROCEDURE FOR THE PREPARATION OF MERCAPTOALKYLSULPHONYLPROLINE DERIVATIVES AND RELATED COMPOSITIONS
DK131878A (en) PROCEDURE FOR PREPARING PEPTIDES AND INTERMEDIATE USE FOR THE PROCEDURE
DK101078A (en) FALLEROER AND PROCEDURE FOR MAKING THE SAME
DK372878A (en) THIADIAZOLYLCEPHALOSPORINE ANALOG AND METHOD OF PREPARATION
DK180878A (en) PROCEDURE FOR THE PREPARATION OF IMIDAZOAZINES AND IMIDAZODIAZINES
DK275178A (en) PROCEDURE FOR PREPARING LIPOPE PITIDE AND ITS USE
DK132779A (en) PROCEDURE FOR THE PREPARATION OF CISHEXAHYDRODIBENZOEPYRANONES AND TETRAHYDROBENZOXOINES
DK194678A (en) PROCEDURE AND APPARATUS FOR THE MANUFACTURE OF THE ZIPPER
DK553978A (en) PROCEDURE FOR THE PREPARATION OF DETOXIFIED CYTOSTATIC PREPARATIONS
DK11578A (en) PROCEDURE FOR THE PREPARATION OF HETEROMONOCYCLIC AND HETEROBICICLIC DERIVATIVES OF UNSaturated 7-ACYLAMIDO-3-CEPHEM-4-CARBOXYLIC ACID
DK445078A (en) PROCEDURE FOR THE PREPARATION OF 4,5-DIHYDRO-2-ALCOXYCARBONYLAMINO-5-CARBOCYCLIC ARYLIMIDAZOLES AND DERIVATIVES THEREOF
DK113079A (en) PROCEDURE FOR THE PREPARATION AND USE OF THE N-OXACYCLYLALKYL-PIPERIDYL-DIAZA COMPOUNDS
DK313878A (en) CONTAINING DERIVATIVES AND PROCEDURE FOR THE PREPARATION THEREOF
NO783487L (en) BINDING AND PROCEDURE FOR THE PREPARATION OF THE SAME
DK121776A (en) PROCEDURE FOR THE PREPARATION OF TRICOSEN- (9) AND HENEICOSEN- (9)
DK267078A (en) PROCEDURE FOR THE PREPARATION OF N1-GLUCOFURANOSIDE-6-YL-N3-N3-NITROSOUR SUBSTANCES AND DERIVATIVES THEREOF
DK169478A (en) PROCEDURE FOR THE PREPARATION OF THYMOSIN ALFA1 AND AN ANALOG
DK530978A (en) PROCEDURE FOR THE PREPARATION OF 3-IODO AND 3-BROMORIFAMYCINE S.
DK268478A (en) MERCAPTOACYLAMIDOBENZOYLGLYCIN AND PREPARATION FOR IT
DK249179A (en) PROCEDURE FOR THE PREPARATION OF 10-DEAZAAMINOPTERIN AND RELATED PARTICULARS
DK150497C (en) PROCEDURE FOR THE PREPARATION OF WATER SOLUBLE GYCOPROTEIN WITH ANTI-DISABLISHING AND IMMUNOSTIMULATIVE EFFECT
DK12478A (en) DITHIENYLALKYLAMINES AND METHODS OF PREPARATION
DK458977A (en) PROCEDURE FOR THE PREPARATION OF MAYTANSINOL AND ITS DERIVATIVES

Legal Events

Date Code Title Description
PBP Patent lapsed
B1 Patent granted (law 1993)
PBP Patent lapsed