DK143398C - Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner - Google Patents

Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner

Info

Publication number
DK143398C
DK143398C DK235369A DK235369A DK143398C DK 143398 C DK143398 C DK 143398C DK 235369 A DK235369 A DK 235369A DK 235369 A DK235369 A DK 235369A DK 143398 C DK143398 C DK 143398C
Authority
DK
Denmark
Prior art keywords
diamino
pyrazinthiol
chlorpyrazinoylguanidines
chlorpyrazinamidoguanidines
carboxylate
Prior art date
Application number
DK235369A
Other languages
Danish (da)
English (en)
Other versions
DK143398B (da
Inventor
Jr E J Cragoe
J B Bicking
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK143398B publication Critical patent/DK143398B/da
Application granted granted Critical
Publication of DK143398C publication Critical patent/DK143398C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK235369A 1968-04-30 1969-04-29 Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner DK143398C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72550868A 1968-04-30 1968-04-30
US72550868 1968-04-30

Publications (2)

Publication Number Publication Date
DK143398B DK143398B (da) 1981-08-17
DK143398C true DK143398C (da) 1981-12-14

Family

ID=24914845

Family Applications (1)

Application Number Title Priority Date Filing Date
DK235369A DK143398C (da) 1968-04-30 1969-04-29 Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner

Country Status (9)

Country Link
US (1) US3506662A (de)
AT (1) AT289136B (de)
BR (1) BR6908430D0 (de)
CH (1) CH511862A (de)
DK (1) DK143398C (de)
ES (1) ES366470A1 (de)
GB (1) GB1225714A (de)
NL (1) NL6902280A (de)
SE (1) SE367630B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) * 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
BR112015014178A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida
PT2931713T (pt) 2012-12-17 2017-02-22 Parion Sciences Inc Derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por insuficiente hidratação das mucosas
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432502A (en) * 1966-08-25 1969-03-11 Merck & Co Inc Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products

Also Published As

Publication number Publication date
DK143398B (da) 1981-08-17
AT289136B (de) 1971-04-13
CH511862A (de) 1971-08-31
SE367630B (de) 1974-06-04
BR6908430D0 (pt) 1973-01-04
GB1225714A (de) 1971-03-24
NL6902280A (de) 1969-11-03
US3506662A (en) 1970-04-14
ES366470A1 (es) 1971-03-16

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Legal Events

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PUP Patent expired