DK143398C - Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner - Google Patents

Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner

Info

Publication number
DK143398C
DK143398C DK235369A DK235369A DK143398C DK 143398 C DK143398 C DK 143398C DK 235369 A DK235369 A DK 235369A DK 235369 A DK235369 A DK 235369A DK 143398 C DK143398 C DK 143398C
Authority
DK
Denmark
Prior art keywords
diamino
pyrazinthiol
chlorpyrazinoylguanidines
chlorpyrazinamidoguanidines
carboxylate
Prior art date
Application number
DK235369A
Other languages
English (en)
Other versions
DK143398B (da
Inventor
Jr E J Cragoe
J B Bicking
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK143398B publication Critical patent/DK143398B/da
Application granted granted Critical
Publication of DK143398C publication Critical patent/DK143398C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK235369A 1968-04-30 1969-04-29 Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner DK143398C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72550868A 1968-04-30 1968-04-30
US72550868 1968-04-30

Publications (2)

Publication Number Publication Date
DK143398B DK143398B (da) 1981-08-17
DK143398C true DK143398C (da) 1981-12-14

Family

ID=24914845

Family Applications (1)

Application Number Title Priority Date Filing Date
DK235369A DK143398C (da) 1968-04-30 1969-04-29 Pyrazinthiolcarboxylat til brug som mellemprodukt ved fremstilling af 3,5-diamino-6-chlorpyrazinoylguanidiner og 3,5-diamino-6-chlorpyrazinamidoguanidiner

Country Status (9)

Country Link
US (1) US3506662A (da)
AT (1) AT289136B (da)
BR (1) BR6908430D0 (da)
CH (1) CH511862A (da)
DK (1) DK143398C (da)
ES (1) ES366470A1 (da)
GB (1) GB1225714A (da)
NL (1) NL6902280A (da)
SE (1) SE367630B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) * 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
WO2014099676A1 (en) 2012-12-17 2014-06-26 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
EP3428153A1 (en) 2012-12-17 2019-01-16 Parion Sciences, Inc. 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432502A (en) * 1966-08-25 1969-03-11 Merck & Co Inc Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products

Also Published As

Publication number Publication date
BR6908430D0 (pt) 1973-01-04
GB1225714A (da) 1971-03-24
CH511862A (de) 1971-08-31
NL6902280A (da) 1969-11-03
AT289136B (de) 1971-04-13
US3506662A (en) 1970-04-14
DK143398B (da) 1981-08-17
ES366470A1 (es) 1971-03-16
SE367630B (da) 1974-06-04

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Legal Events

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PUP Patent expired