DK139101B - Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser. - Google Patents
Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser.Info
- Publication number
- DK139101B DK139101B DK358875AA DK358875A DK139101B DK 139101 B DK139101 B DK 139101B DK 358875A A DK358875A A DK 358875AA DK 358875 A DK358875 A DK 358875A DK 139101 B DK139101 B DK 139101B
- Authority
- DK
- Denmark
- Prior art keywords
- 14beta
- 5beta
- 17beta
- 3beta
- pyridazinyl
- Prior art date
Links
- XEKVAPRUFOGRRI-UUSJCSPQSA-N (3s,5r,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-pyridazin-4-yl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,14-diol Chemical class C1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)=CC=NN=C1 XEKVAPRUFOGRRI-UUSJCSPQSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1085574A CH621803A5 (enExample) | 1974-08-08 | 1974-08-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK358875A DK358875A (enExample) | 1976-02-09 |
| DK139101B true DK139101B (da) | 1978-12-18 |
| DK139101C DK139101C (enExample) | 1979-05-21 |
Family
ID=4367535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK358875AA DK139101B (da) | 1974-08-08 | 1975-08-07 | Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4000125A (enExample) |
| JP (1) | JPS5141372A (enExample) |
| AR (1) | AR217617A1 (enExample) |
| BE (1) | BE832271A (enExample) |
| CA (1) | CA1049499A (enExample) |
| CH (1) | CH621803A5 (enExample) |
| DE (1) | DE2534981A1 (enExample) |
| DK (1) | DK139101B (enExample) |
| ES (1) | ES440110A1 (enExample) |
| FR (1) | FR2281124A1 (enExample) |
| GB (1) | GB1484655A (enExample) |
| SE (1) | SE418401B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1144136B (it) * | 1980-03-05 | 1986-10-29 | Zenyaku Kogyo Kk | Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione |
| US5373095A (en) * | 1985-10-18 | 1994-12-13 | The Upjohn Company | Steroid compounds |
| IT1262931B (it) * | 1992-01-16 | 1996-07-22 | Zambon Spa | Composti steroidei 17(piridazin-n-ossido)-sostituiti attivi sul sistema cardiovascolare |
| DE4227616C2 (de) * | 1992-08-20 | 1995-04-13 | Sigma Tau Ind Farmaceuti | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
| ATE482969T1 (de) * | 2005-03-02 | 2010-10-15 | Univ Maryland | 3-beta-hydroxy-17-(1h-benzimidazol-1-yl)androst - 5,16-dien zur anwendung in der behandlung von prostata-erkrankungen |
| GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
| US20100048913A1 (en) * | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| GB2470700B (en) | 2008-03-25 | 2012-08-08 | Univ Maryland | C-17 heteroaryl steroidal CYP17 inhibitors |
| US8785423B2 (en) * | 2008-04-14 | 2014-07-22 | University Of Maryland, Baltimore | Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases |
| US8791095B2 (en) | 2009-02-05 | 2014-07-29 | Tokai Pharmaceuticals, Inc. | Steroidal CYP17 inhibitors/antiandrogens |
| US20110312916A1 (en) | 2009-02-05 | 2011-12-22 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| US8791094B2 (en) * | 2009-08-07 | 2014-07-29 | Tokai Pharmaceuticals, Inc. | Treatment of prostate cancer |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| EP3033088A4 (en) | 2013-08-12 | 2017-03-08 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| WO2017001204A1 (en) * | 2015-06-29 | 2017-01-05 | Universiteit Gent | Methods for the site-selective coupling of a first agent to a second agent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3838163A (en) * | 1968-11-22 | 1974-09-24 | Hoffmann La Roche | Substituted isoxazole derivatives as steroid intermediates |
-
1974
- 1974-08-08 CH CH1085574A patent/CH621803A5/it not_active IP Right Cessation
-
1975
- 1975-07-29 GB GB31789/75A patent/GB1484655A/en not_active Expired
- 1975-07-30 US US05/600,485 patent/US4000125A/en not_active Expired - Lifetime
- 1975-08-05 DE DE19752534981 patent/DE2534981A1/de not_active Ceased
- 1975-08-07 DK DK358875AA patent/DK139101B/da unknown
- 1975-08-07 CA CA233,045A patent/CA1049499A/en not_active Expired
- 1975-08-07 FR FR7524701A patent/FR2281124A1/fr active Granted
- 1975-08-07 SE SE7508908A patent/SE418401B/xx unknown
- 1975-08-07 AR AR259928A patent/AR217617A1/es active
- 1975-08-07 JP JP50095475A patent/JPS5141372A/ja active Pending
- 1975-08-08 BE BE159066A patent/BE832271A/xx unknown
- 1975-08-08 ES ES440110A patent/ES440110A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2281124B1 (enExample) | 1980-05-16 |
| CA1049499A (en) | 1979-02-27 |
| BE832271A (fr) | 1975-12-01 |
| US4000125A (en) | 1976-12-28 |
| JPS5141372A (enExample) | 1976-04-07 |
| DE2534981A1 (de) | 1976-02-19 |
| ES440110A1 (es) | 1977-02-16 |
| CH621803A5 (enExample) | 1981-02-27 |
| SE7508908L (sv) | 1976-02-09 |
| DK358875A (enExample) | 1976-02-09 |
| FR2281124A1 (fr) | 1976-03-05 |
| SE418401B (sv) | 1981-05-25 |
| GB1484655A (en) | 1977-09-01 |
| DK139101C (enExample) | 1979-05-21 |
| AR217617A1 (es) | 1980-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK138655B (da) | Fremgangsmåde til fremstilling af N-phosphonomethyl-glycin. | |
| DK136718B (da) | Analogifremgangsmåde til fremstilling af substituerede hexahydro-dibenzo(b,d)-pyran-9-oner. | |
| DK138800B (da) | Analogifremgangsmåde til fremstilling af 4-aminoquinazolinderivater. | |
| DK135716B (da) | Analogifremgangsmåde til fremstilling af methyl-5-propylthio-2-benzimidazolcarbamat. | |
| DK136719B (da) | Analogifremgangsmåde til fremstilling af substituerede hexahydro-dibenzo(b,d)-pyraner. | |
| DK136075B (da) | Analogifremgangsmåde til fremstilling af 11beta-hydroxy-16-methyl-3-oxo-17alfa-acyloxyandrosta-1,4,15-trien-17beta-carboxylater. | |
| DK135376B (da) | Fremgangsmåde til fremstilling af piperazinylquinazolin-forbindelser. | |
| DK139101B (da) | Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser. | |
| DK135711B (da) | Analogifremgangsmåde til fremstilling af hidtil ukendte, hjerteaktive substituerede fenoxyisopropanolaminer. | |
| DK137277B (da) | Analogifremgangsmåde til fremstilling af ferrocenforbindelser. | |
| DK137835B (da) | Analogifremgangsmåde til fremstilling af thienothiazinderivater. | |
| DK135796B (da) | Fremgangsmåde til fremstilling af alkyl-tert-alkylethere. | |
| DK139846B (da) | Analogifremgangsmåde til fremstilling af 3-alkoxypyrazin-2-carboxamider. | |
| DK138321B (da) | Analogifremgangsmåde til fremstilling af 5-halogen-2,3-kresotinsyrederivater. | |
| DK137389B (da) | Analogifremgangsmåde til fremstilling af 11beta-substituerede delta4-østrener. | |
| DK136529B (da) | Analogifremgangsmåde til fremstilling af benzofuranderivater. | |
| DK135723B (da) | Analogifremgangsmåde til fremstilling af 7alfa-acylthio-3-oxo-D-homo-21,24-dinor-17aalfa-chlo-4-en-23,17a-lactoner. | |
| DK138227B (da) | Analogifremgangsmåde til fremstilling af substituerede xanthon-2-carboxylsyreforbindelser. | |
| DK139682B (da) | Analogifremgangsmåde til fremstilling af eburnameninderivater. | |
| DK137043B (da) | Analogifremgangsmåde til fremstilling af nitrocarbostyrilforbindelser. | |
| DK132328B (da) | Analogifremgangsmåde til fremstilling af 17beta-hydroxy-16,16-dimethylestr-4-en-3-on. | |
| DK135167B (da) | Analogifremgangsmåde til fremstilling af 7,7'-ditheophyllinderivater. | |
| DK137449B (da) | Fremgangsmåde til fremstilling af N,N-diallyldichloracetamid. | |
| DK137646B (da) | Fremgangsmåde til fremstilling af 6-chlor-2-chlormethyl-4-phenylquinazolin-3-oxid. | |
| DK138694B (da) | Fremgangsmåde til fremstilling af phenylphosphonothiodichlorid. |