DK139101B - Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser. - Google Patents
Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser.Info
- Publication number
- DK139101B DK139101B DK358875AA DK358875A DK139101B DK 139101 B DK139101 B DK 139101B DK 358875A A DK358875A A DK 358875AA DK 358875 A DK358875 A DK 358875A DK 139101 B DK139101 B DK 139101B
- Authority
- DK
- Denmark
- Prior art keywords
- 14beta
- 5beta
- 17beta
- 3beta
- pyridazinyl
- Prior art date
Links
- XEKVAPRUFOGRRI-UUSJCSPQSA-N (3s,5r,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-pyridazin-4-yl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,14-diol Chemical class C1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)=CC=NN=C1 XEKVAPRUFOGRRI-UUSJCSPQSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1085574A CH621803A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-08 | 1974-08-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK358875A DK358875A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-02-09 |
| DK139101B true DK139101B (da) | 1978-12-18 |
| DK139101C DK139101C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-05-21 |
Family
ID=4367535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK358875AA DK139101B (da) | 1974-08-08 | 1975-08-07 | Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser. |
Country Status (12)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1144136B (it) * | 1980-03-05 | 1986-10-29 | Zenyaku Kogyo Kk | Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione |
| US5373095A (en) * | 1985-10-18 | 1994-12-13 | The Upjohn Company | Steroid compounds |
| IT1262931B (it) * | 1992-01-16 | 1996-07-22 | Zambon Spa | Composti steroidei 17(piridazin-n-ossido)-sostituiti attivi sul sistema cardiovascolare |
| DE4227616C2 (de) * | 1992-08-20 | 1995-04-13 | Sigma Tau Ind Farmaceuti | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
| KR101380959B1 (ko) * | 2005-03-02 | 2014-04-04 | 유니버시티 오브 매릴랜드, 발티모어 | 신규 ｃ-17-헤테로아릴 스테로이드성 ｃｙｐ17억제제／항안드로겐：합성, 시험관내 생물학적 활성,약물동태학 및 항종양 활성 |
| WO2009114658A2 (en) * | 2008-03-12 | 2009-09-17 | University Of Maryland, Baltimore | Androgen receptor inactivation contributes to antitumor efficacy of cyp17 inhibitors in prostate cancer |
| US20100048912A1 (en) * | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009120565A2 (en) | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| US8785423B2 (en) * | 2008-04-14 | 2014-07-22 | University Of Maryland, Baltimore | Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases |
| GB2479693B (en) | 2009-02-05 | 2014-04-09 | Tokai Pharmaceuticals Inc | Steroidal CYP17 inhibitors and their use in the treatment of cancer and prostate hyperplasia |
| AU2010210422A1 (en) | 2009-02-05 | 2011-08-18 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens |
| JP2013501722A (ja) * | 2009-08-07 | 2013-01-17 | トーカイ ファーマシューティカルズ，インク． | 前立腺癌の処置 |
| EP4066841A1 (en) | 2013-03-14 | 2022-10-05 | University of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
| CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
| EP3313858B1 (en) * | 2015-06-29 | 2019-09-25 | Universiteit Gent | Methods for the site-selective coupling of a first agent to a second agent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3838163A (en) * | 1968-11-22 | 1974-09-24 | Hoffmann La Roche | Substituted isoxazole derivatives as steroid intermediates |
-
1974
- 1974-08-08 CH CH1085574A patent/CH621803A5/it not_active IP Right Cessation
-
1975
- 1975-07-29 GB GB31789/75A patent/GB1484655A/en not_active Expired
- 1975-07-30 US US05/600,485 patent/US4000125A/en not_active Expired - Lifetime
- 1975-08-05 DE DE19752534981 patent/DE2534981A1/de not_active Ceased
- 1975-08-07 SE SE7508908A patent/SE418401B/xx unknown
- 1975-08-07 FR FR7524701A patent/FR2281124A1/fr active Granted
- 1975-08-07 DK DK358875AA patent/DK139101B/da unknown
- 1975-08-07 AR AR259928A patent/AR217617A1/es active
- 1975-08-07 CA CA233,045A patent/CA1049499A/en not_active Expired
- 1975-08-07 JP JP50095475A patent/JPS5141372A/ja active Pending
- 1975-08-08 ES ES440110A patent/ES440110A1/es not_active Expired
- 1975-08-08 BE BE159066A patent/BE832271A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5141372A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-04-07 |
| AR217617A1 (es) | 1980-04-15 |
| SE7508908L (sv) | 1976-02-09 |
| FR2281124B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-05-16 |
| DE2534981A1 (de) | 1976-02-19 |
| DK358875A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-02-09 |
| BE832271A (fr) | 1975-12-01 |
| US4000125A (en) | 1976-12-28 |
| DK139101C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-05-21 |
| SE418401B (sv) | 1981-05-25 |
| FR2281124A1 (fr) | 1976-03-05 |
| GB1484655A (en) | 1977-09-01 |
| CH621803A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-02-27 |
| CA1049499A (en) | 1979-02-27 |
| ES440110A1 (es) | 1977-02-16 |
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